ATE466856T1 - Verbindungen und methoden zum behandeln oder vorbeugen von flavivirus infektionen - Google Patents

Verbindungen und methoden zum behandeln oder vorbeugen von flavivirus infektionen

Info

Publication number
ATE466856T1
ATE466856T1 AT03767343T AT03767343T ATE466856T1 AT E466856 T1 ATE466856 T1 AT E466856T1 AT 03767343 T AT03767343 T AT 03767343T AT 03767343 T AT03767343 T AT 03767343T AT E466856 T1 ATE466856 T1 AT E466856T1
Authority
AT
Austria
Prior art keywords
treating
compounds
methods
flavivirus infections
preventing flavivirus
Prior art date
Application number
AT03767343T
Other languages
English (en)
Inventor
Chun Kong Laval Chan
Sanjoy Das
Nghe Nguyen-Ba
Liliane Halab
Bettina Hamelin
Oswy Pereira
Carl Poisson
Melanie Proulx
Thumkunta Reddy
Ming-Qiang Zhang
Original Assignee
Virochem Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virochem Pharma Inc filed Critical Virochem Pharma Inc
Application granted granted Critical
Publication of ATE466856T1 publication Critical patent/ATE466856T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D333/40—Thiophene-2-carboxylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT03767343T 2002-12-10 2003-12-09 Verbindungen und methoden zum behandeln oder vorbeugen von flavivirus infektionen ATE466856T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43196402P 2002-12-10 2002-12-10
PCT/CA2003/001912 WO2004052885A1 (en) 2002-12-10 2003-12-09 Compounds and methods for the treatment or prevention of flavivirus infections

Publications (1)

Publication Number Publication Date
ATE466856T1 true ATE466856T1 (de) 2010-05-15

Family

ID=42828817

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03767343T ATE466856T1 (de) 2002-12-10 2003-12-09 Verbindungen und methoden zum behandeln oder vorbeugen von flavivirus infektionen

Country Status (10)

Country Link
EP (1) EP1569929B9 (de)
JP (1) JP4926403B2 (de)
AT (1) ATE466856T1 (de)
AU (1) AU2003291885A1 (de)
BR (1) BR0316771A (de)
CA (1) CA2508990C (de)
DK (1) DK1569929T3 (de)
MX (1) MXPA05006196A (de)
NZ (1) NZ540799A (de)
WO (1) WO2004052885A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004061746A1 (de) * 2004-12-22 2006-07-06 Bayer Healthcare Ag Alkinyl-substituierte Thiophene
US7569600B2 (en) * 2005-05-13 2009-08-04 Virochem Pharma Inc. Compounds and methods for the treatment of prevention of Flavivirus infections
PE20070814A1 (es) * 2005-12-22 2007-08-16 Smithkline Beecham Corp Compuestos derivados de 2-carboxitiofeno como inhibidores de la polimerasa del virus de la hepatitis c (hcv)
WO2008017688A1 (en) * 2006-08-11 2008-02-14 Smithkline Beecham Corporation 2-carboxy thiophene derivatives as anti-viral agents
WO2008043791A2 (en) * 2006-10-13 2008-04-17 Smithkline Beecham Corporation Thiophene derivatives for treating hepatitis c
CN102675279A (zh) 2006-11-15 2012-09-19 Viro化学制药公司 用于治疗或预防黄病毒属感染的噻吩类似物
EP2494991A1 (de) 2007-05-04 2012-09-05 Vertex Pharmaceuticals Incorporated Kombinationstherapie zur Behandlung von HIV-Infektionen
GB0712393D0 (en) * 2007-06-26 2007-08-01 Smithkline Beecham Corp Compounds
US9962368B2 (en) 2009-01-09 2018-05-08 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
US8362277B2 (en) 2009-01-09 2013-01-29 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
CN102405043B (zh) 2009-01-09 2017-08-22 得克萨斯州大学系统董事会 前神经原性化合物
US9162980B2 (en) 2009-01-09 2015-10-20 Board Of Regents Of The University Of Texas System Anti-depression compounds
AU2010276441B2 (en) 2009-07-21 2015-07-02 Gilead Sciences, Inc. Inhibitors of Flaviviridae viruses
EP2507249B1 (de) * 2009-09-09 2015-11-11 Gilead Sciences, Inc. Hemmer von flaviviridae-viren
MX2012006026A (es) * 2009-11-25 2012-08-15 Vertex Pharma Derivados de acido 5-alquinil-tiofen-2-carboxilico y usos para tratamiento o prevencion de infecciones por flavivirus.
PT2523951E (pt) * 2010-01-15 2015-09-14 Gilead Sciences Inc Inibidores de vírus flaviviridae
AU2011205744B2 (en) 2010-01-15 2015-06-25 Gilead Sciences, Inc. Inhibitors of Flaviviridae viruses
WO2012006070A1 (en) * 2010-06-28 2012-01-12 Vertex Pharmaceuticals Incorporated Compounds and methods for the treatment or prevention of flavivirus infections
WO2012006419A2 (en) 2010-07-07 2012-01-12 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
AU2011292040A1 (en) * 2010-08-17 2013-03-07 Vertex Pharmaceuticals Incorporated Compounds and methods for the treatment or prevention of Flaviviridae viral infections
TW201307334A (zh) 2010-12-17 2013-02-16 Cocrystal Discovery Inc Ｃ型肝炎病毒聚合酶抑制劑
EP2734515B1 (de) * 2011-07-13 2015-11-04 Gilead Sciences, Inc. Thiophen-2-carbonsäure derivate als inhibitoren von flaviviridae-viren
AU2012286853A1 (en) 2011-07-26 2013-05-02 Vertex Pharmaceuticals Incorporated Thiophene compounds
WO2014055142A1 (en) 2012-06-20 2014-04-10 Cocrystal Discovery, Inc. Inhibitors of hepatitis c virus polymerase
US8759544B2 (en) 2012-08-17 2014-06-24 Gilead Sciences, Inc. Synthesis of an antiviral compound
US8841340B2 (en) 2012-08-17 2014-09-23 Gilead Sciences, Inc. Solid forms of an antiviral compound
US8927741B2 (en) 2012-08-17 2015-01-06 Gilead Sciences, Inc. Synthesis of an antiviral compound
WO2014031986A1 (en) 2012-08-24 2014-02-27 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
WO2015070237A1 (en) 2013-11-11 2015-05-14 Board Of Regents Of The University Of Texas System Neuroprotective chemicals and methods for identifying and using same
WO2015070234A2 (en) 2013-11-11 2015-05-14 Board Of Regents Of The University Of Texas System Neuroprotective compounds and use thereof
TWI731854B (zh) 2015-03-23 2021-07-01 美商共結晶製藥公司 Ｃ型肝炎病毒聚合酶之抑制劑
TWI833753B (zh) 2018-05-09 2024-03-01 美商共結晶製藥公司 用於治療hcv之組合療法
US12274700B1 (en) 2020-10-30 2025-04-15 Accencio LLC Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995005170A1 (en) * 1993-08-13 1995-02-23 Warner-Lambert Company Methods of inhibiting hiv and inhibiting the activation of hiv
US5734081A (en) * 1994-08-05 1998-03-31 Warner-Lambert Company Arylthio compounds
GEP20053476B (en) * 1999-08-12 2005-03-25 Upjohn Co 3(5)-Amino-Pyrazole Derivatives, Process for Their Preparation and Their Use as Antitumor Agents
EP1381602A1 (de) * 2001-04-19 2004-01-21 Vertex Pharmaceuticals Incorporated Heterocyclylbiscarbonsäureamide als caspasehemmer
CN101624391A (zh) * 2001-06-11 2010-01-13 病毒化学医药公司 用作黄病毒感染抗病毒剂的噻吩衍生物
US6887877B2 (en) * 2001-06-11 2005-05-03 Virochem Pharma Inc. Compounds and methods for the treatment or prevention of Flavivirus infections

Also Published As

Publication number Publication date
NZ540799A (en) 2008-09-26
MXPA05006196A (es) 2006-01-27
BR0316771A (pt) 2005-10-25
EP1569929B1 (de) 2010-05-05
WO2004052885A1 (en) 2004-06-24
JP4926403B2 (ja) 2012-05-09
AU2003291885A1 (en) 2004-06-30
CA2508990C (en) 2013-05-28
CA2508990A1 (en) 2004-06-24
EP1569929B9 (de) 2011-09-14
DK1569929T3 (da) 2010-08-16
EP1569929A1 (de) 2005-09-07
JP2006510636A (ja) 2006-03-30

Similar Documents

Publication Publication Date Title
ATE466856T1 (de) Verbindungen und methoden zum behandeln oder vorbeugen von flavivirus infektionen
EA200400022A1 (ru) Соединения и способы лечения или предупреждения инфекций flavivirus
PE20050204A1 (es) Compuestos inhibidores de la hepatitis c
EA200702493A1 (ru) Соединения и способы лечения или предотвращения флавивирусных инфекций
NO20062146L (no) Nukleosidforbindelser for behandling av virusinfeksjoner
IN2012DN00999A (de)
NO20063479L (no) Fosfonater, monofosfonamidater og bis-fosfonamidater for behandling av virussykdommer
BR0305258A (pt) Inibidores de polimerase de ns5b de hcv
ATE402180T1 (de) Verbindungen zur behandlung von dyslipidemie
ATE491459T1 (de) Modifizierte nukleoside zur behandlung von virusinfektionen und abnormaler zellulärer proliferation
ATE373005T1 (de) Thienopyrrole als antivirale mittel
DK1836201T4 (da) Pyrrolidininhibitorer af IAP.
MX2012007420A (es) Analogos para el tratamiento o prevencion de infecciones de flavivirus.
SG164376A1 (en) Hcv ns3 protease inhibitors
MXPA04006041A (es) Antivirales de piridoquinoxalina.
DE602005010607D1 (de) Zyklosporinanalog
ECSP034840A (es) Compuestos de n-formil-hidroxilamina como inhibidores de pdf
TH148534A (th) ไซโคลโพรพิลฟิวสด์อินโดโลเบนซาซิพีนซึ่งคือตัวยับยั้งสำหรับ hcv ns5b
MY142331A (en) Bicyclic heteroaryl derivatives for treating viruses

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1569929

Country of ref document: EP

EEIH Change in the person of patent owner