MXPA05006196A - Compuestos y metodos para el tratamiento o prevencion de infecciones por flavivirus. - Google Patents

Compuestos y metodos para el tratamiento o prevencion de infecciones por flavivirus.

Info

Publication number
MXPA05006196A
MXPA05006196A MXPA05006196A MXPA05006196A MXPA05006196A MX PA05006196 A MXPA05006196 A MX PA05006196A MX PA05006196 A MXPA05006196 A MX PA05006196A MX PA05006196 A MXPA05006196 A MX PA05006196A MX PA05006196 A MXPA05006196 A MX PA05006196A
Authority
MX
Mexico
Prior art keywords
flavivirus
prevention
compounds
treatment
methods
Prior art date
Application number
MXPA05006196A
Other languages
English (en)
Inventor
Ming-Qiang Zhang
Original Assignee
Virochem Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virochem Pharma Inc filed Critical Virochem Pharma Inc
Publication of MXPA05006196A publication Critical patent/MXPA05006196A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D333/40—Thiophene-2-carboxylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invencion describe compuestos novedosos representados por la formula (I) o sales farmaceuticamente aceptables de los mismos utiles para el tratamiento de alguna infeccion viral por flaviviridae.
MXPA05006196A 2002-12-10 2003-12-09 Compuestos y metodos para el tratamiento o prevencion de infecciones por flavivirus. MXPA05006196A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43196402P 2002-12-10 2002-12-10
PCT/CA2003/001912 WO2004052885A1 (en) 2002-12-10 2003-12-09 Compounds and methods for the treatment or prevention of flavivirus infections

Publications (1)

Publication Number Publication Date
MXPA05006196A true MXPA05006196A (es) 2006-01-27

Family

ID=42828817

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05006196A MXPA05006196A (es) 2002-12-10 2003-12-09 Compuestos y metodos para el tratamiento o prevencion de infecciones por flavivirus.

Country Status (10)

Country Link
EP (1) EP1569929B9 (es)
JP (1) JP4926403B2 (es)
AT (1) ATE466856T1 (es)
AU (1) AU2003291885A1 (es)
BR (1) BR0316771A (es)
CA (1) CA2508990C (es)
DK (1) DK1569929T3 (es)
MX (1) MXPA05006196A (es)
NZ (1) NZ540799A (es)
WO (1) WO2004052885A1 (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004061746A1 (de) * 2004-12-22 2006-07-06 Bayer Healthcare Ag Alkinyl-substituierte Thiophene
EP2546246A3 (en) 2005-05-13 2013-04-24 Virochem Pharma Inc. Compounds and methods for the treatment or prevention of flavivirus infections
AR058586A1 (es) * 2005-12-22 2008-02-13 Smithkline Beecham Corp Compuesto de 2-carboxitiofeno, formulacion farmaceutica que lo comprende, su uso para la preparacion de un medicamento y combinacion de dicho compuesto con otro agente terapeuticamente activo
WO2008017688A1 (en) * 2006-08-11 2008-02-14 Smithkline Beecham Corporation 2-carboxy thiophene derivatives as anti-viral agents
WO2008043791A2 (en) * 2006-10-13 2008-04-17 Smithkline Beecham Corporation Thiophene derivatives for treating hepatitis c
CA2670260A1 (en) * 2006-11-15 2008-05-22 Virochem Pharma Inc. Thiophene analogues for the treatment or prevention of flavivirus infections
WO2008137126A2 (en) 2007-05-04 2008-11-13 Vertex Pharmaceuticals Incorporated Combination therapy for the treatment of hcv infection
GB0712393D0 (en) * 2007-06-26 2007-08-01 Smithkline Beecham Corp Compounds
US8362277B2 (en) 2009-01-09 2013-01-29 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
US9162980B2 (en) 2009-01-09 2015-10-20 Board Of Regents Of The University Of Texas System Anti-depression compounds
US9095572B2 (en) 2009-01-09 2015-08-04 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
US9962368B2 (en) 2009-01-09 2018-05-08 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
CN102405043B (zh) 2009-01-09 2017-08-22 得克萨斯州大学系统董事会 前神经原性化合物
MX2012000959A (es) 2009-07-21 2012-03-06 Gilead Sciences Inc Inhibidores de los virus flaviviridae.
ES2559437T3 (es) 2009-09-09 2016-02-12 Gilead Sciences, Inc. Inhibidores de virus de la familia Flaviviridae
WO2011068715A1 (en) 2009-11-25 2011-06-09 Vertex Pharmaceuticals Incorporated 5-alkynyl-thiophene-2-carboxylic acid derivatives and their use for the treatment or prevention of flavivirus infections
SG182478A1 (en) * 2010-01-15 2012-08-30 Gilead Sciences Inc Inhibitors of flaviviridae viruses
JP5868872B2 (ja) 2010-01-15 2016-02-24 ギリアード サイエンシーズ， インコーポレイテッド フラビウイルス科ウイルスのインヒビター
WO2012006070A1 (en) * 2010-06-28 2012-01-12 Vertex Pharmaceuticals Incorporated Compounds and methods for the treatment or prevention of flavivirus infections
WO2012024363A2 (en) * 2010-08-17 2012-02-23 Vertex Pharmaceuticals Incorporated Compounds and methods for the treatment or prevention of flaviviridae viral infections
US8771665B2 (en) 2010-12-17 2014-07-08 Cocrystal Discovery, Inc. Inhibitors of hepatitis C virus polymerase
EP2734515B1 (en) * 2011-07-13 2015-11-04 Gilead Sciences, Inc. Thiophen-2-carboxylic acid derivatives useful as inhibitors of flaviviridae viruses
TW201317223A (zh) 2011-07-26 2013-05-01 Vertex Pharma 噻吩化合物
WO2014055142A1 (en) 2012-06-20 2014-04-10 Cocrystal Discovery, Inc. Inhibitors of hepatitis c virus polymerase
US8927741B2 (en) 2012-08-17 2015-01-06 Gilead Sciences, Inc. Synthesis of an antiviral compound
US8759544B2 (en) 2012-08-17 2014-06-24 Gilead Sciences, Inc. Synthesis of an antiviral compound
US8841340B2 (en) 2012-08-17 2014-09-23 Gilead Sciences, Inc. Solid forms of an antiviral compound
US9701676B2 (en) 2012-08-24 2017-07-11 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
WO2015070237A1 (en) 2013-11-11 2015-05-14 Board Of Regents Of The University Of Texas System Neuroprotective chemicals and methods for identifying and using same
US9902713B2 (en) 2013-11-11 2018-02-27 Board Of Regents Of The University Of Texas System Neuroprotective compounds and use thereof
TWI731854B (zh) 2015-03-23 2021-07-01 美商共結晶製藥公司 Ｃ型肝炎病毒聚合酶之抑制劑
TWI833753B (zh) 2018-05-09 2024-03-01 美商共結晶製藥公司 用於治療hcv之組合療法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995005170A1 (en) * 1993-08-13 1995-02-23 Warner-Lambert Company Methods of inhibiting hiv and inhibiting the activation of hiv
US5734081A (en) * 1994-08-05 1998-03-31 Warner-Lambert Company Arylthio compounds
DE60023012T2 (de) * 1999-08-12 2006-07-20 Pharmacia Italia S.P.A. 3(5)-amino-pyrazolderivate, deren herstellungsverfahren und verwendung als krebshemmende mittel
WO2002085899A1 (en) * 2001-04-19 2002-10-31 Vertex Pharmaceuticals Incorporated Heterocyclyldicarbamides as caspase inhibitors
ATE438637T1 (de) * 2001-06-11 2009-08-15 Virochem Pharma Inc Thiophenderivate als antivirale mittel gegen flavivirus-infektion
CA2449999C (en) * 2001-06-11 2012-07-31 Shire Biochem Inc. Compounds and methods for the treatment or prevention of flavivirus infections

Also Published As

Publication number Publication date
EP1569929A1 (en) 2005-09-07
ATE466856T1 (de) 2010-05-15
AU2003291885A1 (en) 2004-06-30
EP1569929B9 (en) 2011-09-14
JP2006510636A (ja) 2006-03-30
JP4926403B2 (ja) 2012-05-09
NZ540799A (en) 2008-09-26
CA2508990A1 (en) 2004-06-24
CA2508990C (en) 2013-05-28
DK1569929T3 (da) 2010-08-16
WO2004052885A1 (en) 2004-06-24
EP1569929B1 (en) 2010-05-05
BR0316771A (pt) 2005-10-25

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