CN1075070C - 取代的氮－及二氮杂环庚烷及－环辛烷化合物及其用途 - Google Patents

取代的氮－及二氮杂环庚烷及－环辛烷化合物及其用途

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Publication number
CN1075070C
CN1075070C CN97192755A CN97192755A CN1075070C CN 1075070 C CN1075070 C CN 1075070C CN 97192755 A CN97192755 A CN 97192755A CN 97192755 A CN97192755 A CN 97192755A CN 1075070 C CN1075070 C CN 1075070C
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CN
China
Prior art keywords
tbut
alkyl
iprop
compound
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN97192755A
Other languages
English (en)
Chinese (zh)
Other versions
CN1212692A (zh
Inventor
H·－J·特雷贝
S·布兰克
D·斯塔克
L·温格
H·－J·特申多尔夫
K·维克
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BASF SE
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BASF SE
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Publication of CN1212692A publication Critical patent/CN1212692A/zh
Application granted granted Critical
Publication of CN1075070C publication Critical patent/CN1075070C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Luminescent Compositions (AREA)
CN97192755A 1996-01-12 1997-01-10 取代的氮－及二氮杂环庚烷及－环辛烷化合物及其用途 Expired - Lifetime CN1075070C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19600934A DE19600934A1 (de) 1996-01-12 1996-01-12 Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung
DE19600934.0 1996-01-12

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNB011170697A Division CN1146551C (zh) 1996-01-12 2001-04-20 取代的二氮杂环庚烷化合物、含有其的药物组合物及用途

Publications (2)

Publication Number Publication Date
CN1212692A CN1212692A (zh) 1999-03-31
CN1075070C true CN1075070C (zh) 2001-11-21

Family

ID=7782613

Family Applications (2)

Application Number Title Priority Date Filing Date
CN97192755A Expired - Lifetime CN1075070C (zh) 1996-01-12 1997-01-10 取代的氮－及二氮杂环庚烷及－环辛烷化合物及其用途
CNB011170697A Expired - Lifetime CN1146551C (zh) 1996-01-12 2001-04-20 取代的二氮杂环庚烷化合物、含有其的药物组合物及用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB011170697A Expired - Lifetime CN1146551C (zh) 1996-01-12 2001-04-20 取代的二氮杂环庚烷化合物、含有其的药物组合物及用途

Country Status (26)

Country Link
US (2) US6214822B1 (enExample)
EP (1) EP0877744B1 (enExample)
JP (1) JP4349657B2 (enExample)
KR (1) KR100441073B1 (enExample)
CN (2) CN1075070C (enExample)
AR (1) AR005868A1 (enExample)
AT (1) ATE273301T1 (enExample)
AU (1) AU717726B2 (enExample)
BG (1) BG64098B1 (enExample)
CA (1) CA2241787C (enExample)
CO (1) CO4790173A1 (enExample)
CZ (1) CZ297981B6 (enExample)
DE (2) DE19600934A1 (enExample)
ES (1) ES2225947T3 (enExample)
HR (1) HRP970021A2 (enExample)
HU (1) HU228457B1 (enExample)
IL (1) IL125076A (enExample)
MX (1) MX9805499A (enExample)
NO (1) NO316753B1 (enExample)
NZ (1) NZ326332A (enExample)
PL (1) PL327692A1 (enExample)
SK (1) SK284987B6 (enExample)
TR (1) TR199801302T2 (enExample)
TW (1) TW475929B (enExample)
WO (1) WO1997025324A1 (enExample)
ZA (1) ZA97209B (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19728996A1 (de) 1997-07-07 1999-01-14 Basf Ag Triazolverbindungen und deren Verwendung
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
KR20010085898A (ko) 1998-10-08 2001-09-07 피터 기딩스 도파민 ｄ3 수용체 조절제 (정신병 치료제)로서 유용한테트라히드로벤즈아제핀 유도체
AR022228A1 (es) 1999-01-12 2002-09-04 Abbott Gmbh & Co Kg Compuestos de triazol, composicion farmaceutica que los comprende y uso de los mismos para la preparar dicha composicion
DE19922443A1 (de) * 1999-05-07 2000-11-09 Basf Ag Verwendung von Dopamin-D3-Rezeptorliganden zur Herstellung von Arzneimittel für die Behandlung von Nierenfunktionsstörungen
US7037916B2 (en) 1999-07-15 2006-05-02 Pharmacopeia Drug Discovery, Inc. Pyrimidine derivatives as IL-8 receptor antagonists
ES2311012T3 (es) * 2000-03-27 2009-02-01 ABBOTT GMBH & CO. KG Ligandos del receptor d3 de la dopamina para el tratamiento de la adiccion.
ATE455108T1 (de) 2001-02-16 2010-01-15 Aventis Pharma Inc Heterocyclische substituierte carbonyl derivate und ihre verwendung als dopamin d3 rezeptor liganden
DE10109866A1 (de) * 2001-03-01 2002-09-05 Abbott Gmbh & Co Kg Triazolverbindungen und deren Verwendung zur Prophylaxe und Therapie neurodegenerativer Erkrankungen, Hirntrauma und zerebraler Ischämie
DE10131543A1 (de) * 2001-06-29 2003-01-16 Abbott Lab Pyrimidinoxyalkylpiperazine und ihre therapeutische Verwendung
BR0214553A (pt) * 2001-11-28 2004-10-13 Sod Conseils Rech Applic Compostos, processo de preparação, em fase lìquida, dos compostos, e, composições farmacêuticas
ATE366045T1 (de) * 2002-03-15 2007-07-15 Ciba Sc Holding Ag Verwendung von 4-aminopyrimidinen zur antimikrobiellen behandlung von oberflächen
DE10304870A1 (de) * 2003-02-06 2004-08-19 Abbott Gmbh & Co. Kg Triazolverbindungen und ihre therapeutische Verwendung
TW200507841A (en) * 2003-03-27 2005-03-01 Glaxo Group Ltd Antibacterial agents
DE10358004A1 (de) * 2003-12-11 2005-07-14 Abbott Gmbh & Co. Kg Ketolactam-Verbindungen und ihre Verwendung
DE102004027358A1 (de) 2004-06-04 2005-12-29 Abbott Gmbh & Co. Kg Pyrimidinverbindungen und ihre Verwendung
FR2877005A1 (fr) * 2004-10-22 2006-04-28 Bioprojet Soc Civ Ile Nouveaux derives d'arylpiperazine
WO2006081289A2 (en) * 2005-01-25 2006-08-03 Glaxo Group Limited Antibacterial agents
JP2007106746A (ja) * 2005-09-13 2007-04-26 Tosoh Corp 新規アリールホモピペラジン類、またはその塩と製造方法
WO2007099828A1 (ja) * 2006-02-23 2007-09-07 Shionogi & Co., Ltd. 環式基で置換された含窒素複素環誘導体
WO2007120528A2 (en) * 2006-03-31 2007-10-25 La Jolla Pharmaceutical Company Inhibitors of semicarbazide-sensitive amine oxidase (ssao) and vap-1 mediated adhesion useful for treatment and prevention of diseases
EP1882688A1 (en) * 2006-07-25 2008-01-30 EPFL Ecole Polytechnique Fédérale de Lausanne Labelling of fusion proteins with synthetic probes
JP4840440B2 (ja) * 2008-12-24 2011-12-21 ソニー株式会社 画像処理装置およびその方法、並びにプログラム
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
JP2013518046A (ja) * 2010-01-25 2013-05-20 シーエイチディーアイ ファウンデーション，インコーポレーテッド 特定のキヌレニン−３−モノオキシゲナーゼインヒビターおよびその医薬組成物ならびにこれらの使用方法
US9156822B2 (en) * 2010-07-02 2015-10-13 The University Of North Carolina At Chapel Hill Functionally selective ligands of dopamine D2 receptors
JP2013542243A (ja) 2010-11-15 2013-11-21 カトリーケ ウニヴェルシテイト ルーヴェン 新規な抗ウイルス性化合物
US9428464B2 (en) 2011-08-30 2016-08-30 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
EA032526B1 (ru) 2011-08-30 2019-06-28 Схди Фаундейшн, Инк. Применение ингибитора кинуренин-3-монооксигеназы для лечения заболеваний и состояний, опосредованных активностью кинуренин-3-монооксигеназы
US10208032B2 (en) 2013-12-24 2019-02-19 Oncotartis Inc. Benzamide and nicotinamide compounds and methods of using same
UA120856C2 (uk) 2014-07-17 2020-02-25 Кхді Фаундейшн, Інк. Способи та композиції для лікування розладів, пов'язаних з віл

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE628766A (enExample) 1962-12-26
BE792206A (enExample) 1971-12-02 1973-06-01 Byk Gulden Lomberg Chem Fab
US5139998A (en) 1988-08-31 1992-08-18 Superconductor Technologies, Inc. Controlled thallous oxide evaporation for thallium superconductor films and reactor design
SE8803429D0 (sv) * 1988-09-28 1988-09-28 Pharmacia Ab Novel pyridyl- and pyrimidyl derivatives
US5008267A (en) 1988-10-29 1991-04-16 Mitsui Toatsu Chemicals, Incorporated Pyrimidinedione compounds, method of producing the same and antiarrythmic agents containing the same
JP2815218B2 (ja) 1990-04-13 1998-10-27 三井化学株式会社 ピリミジンジオン誘導体、およびそれを含有する抗不整脈剤
FR2663638B2 (fr) 1990-04-06 1995-02-10 Institut Nal Sante Recherc Medic Polypeptides ayant une activite de recepteur dopaminergique, acides nucleiques codant pour ces polypeptides et utilisation de ces polypeptides pour le criblage de substances actives sur ces polypeptides.
JP2518965B2 (ja) 1990-09-21 1996-07-31 三井東圧化学株式会社 新規ピリジン誘導体及びそれを有効成分として含有する制癌剤効果増強剤
FR2668771B1 (fr) 1990-11-06 1995-03-17 Inst Nat Sante Rech Med Acides nucleiques codant pour des polypeptides ayant une activite de recepteur dopaminergique humain et utilisation de ces polypeptides pour le criblage de substances actives sur ces polypeptides.
DE4425143A1 (de) 1994-07-15 1996-01-18 Basf Ag Substituierte Pyrimidinverbindungen und deren Verwendung
DE4425144A1 (de) 1994-07-15 1996-01-18 Basf Ag Triazolverbindungen und deren Verwendung
DE4425146A1 (de) 1994-07-15 1996-01-18 Basf Ag Verwendung heterocyclischer Verbindungen
DE4425145A1 (de) 1994-07-15 1996-01-18 Basf Ag Verwendung von Thiazol- und Thiadiazolverbindungen
US5635503A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Company Dihydropyridine npy antagonists: piperazine derivatives
FR2742149B1 (fr) 1995-12-11 1998-02-13 Inst Nat Sante Rech Med Nouveaux derives de 2-naphtamides et leurs applications therapeutiques

Also Published As

Publication number Publication date
TW475929B (en) 2002-02-11
HUP9901590A2 (hu) 1999-08-30
AU1440797A (en) 1997-08-01
CO4790173A1 (es) 1999-05-31
SK94198A3 (en) 1999-03-12
AU717726B2 (en) 2000-03-30
CA2241787A1 (en) 1997-07-17
NO316753B1 (no) 2004-04-26
KR100441073B1 (ko) 2004-11-16
BG102616A (en) 1999-04-30
CZ215998A3 (cs) 1999-05-12
HUP9901590A3 (en) 2002-01-28
CN1348956A (zh) 2002-05-15
MX9805499A (es) 1998-11-30
DE59711847D1 (de) 2004-09-16
EP0877744A1 (de) 1998-11-18
AR005868A1 (es) 1999-07-21
DE19600934A1 (de) 1997-07-17
US6352981B1 (en) 2002-03-05
US6214822B1 (en) 2001-04-10
HU228457B1 (en) 2013-03-28
TR199801302T2 (xx) 1998-11-23
PL327692A1 (en) 1998-12-21
CA2241787C (en) 2006-04-04
CN1212692A (zh) 1999-03-31
HRP970021A2 (en) 1998-04-30
IL125076A0 (en) 1999-01-26
WO1997025324A1 (de) 1997-07-17
CZ297981B6 (cs) 2007-05-16
SK284987B6 (sk) 2006-04-06
NO983187L (no) 1998-09-09
JP2000505072A (ja) 2000-04-25
NZ326332A (en) 1999-04-29
BG64098B1 (bg) 2003-12-31
CN1146551C (zh) 2004-04-21
EP0877744B1 (de) 2004-08-11
ES2225947T3 (es) 2005-03-16
ATE273301T1 (de) 2004-08-15
KR19990077127A (ko) 1999-10-25
IL125076A (en) 2001-05-20
ZA97209B (en) 1998-07-10
JP4349657B2 (ja) 2009-10-21

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