CN107428833B - Ror1特异性抗体和嵌合抗原受体 - Google Patents

Ror1特异性抗体和嵌合抗原受体 Download PDF

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CN107428833B
CN107428833B CN201680016204.1A CN201680016204A CN107428833B CN 107428833 B CN107428833 B CN 107428833B CN 201680016204 A CN201680016204 A CN 201680016204A CN 107428833 B CN107428833 B CN 107428833B
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cdr
seq
antibody
amino acid
antigen
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CN107428833A (zh
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Y·陈
S·M·沙马
C·帕兹玛尼
J·都塔-西蒙斯
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Juno Therapeutics Inc
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

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CN201680016204.1A 2015-01-16 2016-01-18 Ror1特异性抗体和嵌合抗原受体 Active CN107428833B (zh)

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US201562104664P 2015-01-16 2015-01-16
US62/104,664 2015-01-16
PCT/US2016/013808 WO2016115559A1 (en) 2015-01-16 2016-01-18 Antibodies and chimeric antigen receptors specific for ror1

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CN107428833B true CN107428833B (zh) 2021-11-02

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US (3) US20160208018A1 (OSRAM)
EP (2) EP3245231B1 (OSRAM)
JP (2) JP6865688B2 (OSRAM)
KR (1) KR20170128234A (OSRAM)
CN (1) CN107428833B (OSRAM)
AR (1) AR103442A1 (OSRAM)
AU (1) AU2016206457B2 (OSRAM)
CA (1) CA2973964A1 (OSRAM)
ES (1) ES2818103T3 (OSRAM)
MX (2) MX2017009254A (OSRAM)
NZ (1) NZ733841A (OSRAM)
TW (2) TW202126682A (OSRAM)
WO (1) WO2016115559A1 (OSRAM)

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