CN1072661C - 新的取代[2－(1－哌嗪基)乙氧基]甲基化合物 - Google Patents

新的取代[2－(1－哌嗪基)乙氧基]甲基化合物 Download PDF

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Publication number
CN1072661C
CN1072661C CN97193721A CN97193721A CN1072661C CN 1072661 C CN1072661 C CN 1072661C CN 97193721 A CN97193721 A CN 97193721A CN 97193721 A CN97193721 A CN 97193721A CN 1072661 C CN1072661 C CN 1072661C
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CN
China
Prior art keywords
piperazinyl
group
formula
piperazine
ethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN97193721A
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English (en)
Chinese (zh)
Other versions
CN1215395A (zh
Inventor
G·杜切尼
M·德尔斯
G·伯德逊
G·莫特
F·鲁奎恩
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UCB SA
Original Assignee
UCB SA
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Publication of CN1215395A publication Critical patent/CN1215395A/zh
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Publication of CN1072661C publication Critical patent/CN1072661C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN97193721A 1996-04-10 1997-03-28 新的取代[2－(1－哌嗪基)乙氧基]甲基化合物 Expired - Fee Related CN1072661C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BE9600310A BE1010094A3 (fr) 1996-04-10 1996-04-10 Nouveaux [2-(1-piperazinyl)ethoxy] methyle substitues.
BE9600310 1996-04-10

Publications (2)

Publication Number Publication Date
CN1215395A CN1215395A (zh) 1999-04-28
CN1072661C true CN1072661C (zh) 2001-10-10

Family

ID=3889663

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97193721A Expired - Fee Related CN1072661C (zh) 1996-04-10 1997-03-28 新的取代[2－(1－哌嗪基)乙氧基]甲基化合物

Country Status (25)

Country Link
US (2) US6140501A (enExample)
EP (1) EP0927173B1 (enExample)
JP (1) JP2000508634A (enExample)
CN (1) CN1072661C (enExample)
AR (1) AR006761A1 (enExample)
AT (1) ATE219067T1 (enExample)
AU (1) AU710835B2 (enExample)
BE (1) BE1010094A3 (enExample)
BR (1) BR9708763A (enExample)
CZ (1) CZ295068B6 (enExample)
DE (1) DE69713352T2 (enExample)
DK (1) DK0927173T3 (enExample)
EA (1) EA000831B1 (enExample)
ES (1) ES2177965T3 (enExample)
HU (1) HU225478B1 (enExample)
IN (1) IN186873B (enExample)
MY (1) MY118237A (enExample)
NO (1) NO311615B1 (enExample)
NZ (1) NZ332057A (enExample)
PL (1) PL188819B1 (enExample)
PT (1) PT927173E (enExample)
RS (1) RS49574B (enExample)
TR (1) TR199802025T2 (enExample)
WO (1) WO1997037982A1 (enExample)
ZA (1) ZA972973B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0919550A1 (en) 1997-11-26 1999-06-02 Ucb, S.A. Pseudopolymorphic forms of 2-2-4-bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxy acetic acid dihydrochloride
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
HRP20020470B1 (hr) * 1999-11-30 2009-04-30 Egis Gy�gyszergy�r RT POSTUPAK PRIREĐIVANJA {2-[4-(α-FENIL-p-KLORBENZIL)-PIPERAZIN-1-IL]ETOKSI} OCTENE KISELINE I NOVIH INTERMEDIJERA
US7199241B1 (en) 2001-05-29 2007-04-03 Ucb, S.A. Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
US6977301B1 (en) 2001-05-29 2005-12-20 Ucb, S.A. Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
US6838052B2 (en) 2001-06-29 2005-01-04 Symyx Technologies, Inc. In-situ injection and materials screening device
CA2454564A1 (en) * 2001-07-26 2003-02-06 Ucb, S.A. Process for the preparation of 2-(2-(4-(bis(4-fluorophenyl)methyl)-piperazin-1-yl)ethoxy)acetic acid derivatives or corresponding salt forms thereof and intermediates therefor
US7160513B2 (en) 2002-12-20 2007-01-09 Symyx Technologies, Inc. Batch reactor with injection system
US20050020608A1 (en) * 2003-03-25 2005-01-27 Dr. Reddy's Laboratories Limited Crystalline cetirizine monohydrochloride
US20040266787A1 (en) * 2003-03-25 2004-12-30 Dr. Reddy's Laboratories Limited Novel amorphous form of [2-[4-[(4-chlorophenyl)-phenyl methyl]-1-piperazinyl]ethoxy]acetic acid and process for the preparation thereof
WO2004103982A1 (en) * 2003-05-21 2004-12-02 Wockhardt Limited 2-[2-[4-[(4-chlorophenyl) phenylmethyl]-1-piperazinyl]ethoxy]acetic acid monohydrochloride as anti-allergenic compound and process for its production
KR100503443B1 (ko) * 2004-02-02 2005-07-22 한림제약(주) 광학적으로 활성인 세티리진 또는 그의 염의 제조방법
WO2006050909A1 (en) * 2004-11-10 2006-05-18 Ucb Farchim Sa Novel forms of efletirizine dihydrochloride, processes for making them and pharmaceutical compositions including them
EP1845088B1 (en) * 2006-04-10 2009-07-22 Ranbaxy Laboratories Limited An improved process for the preparation of aripipirazole
US20110172425A1 (en) * 2008-09-17 2011-07-14 Calyx Chemicals And Pharmaceuticals Pvt. Ltd. Novel water based process for the preparation of substituted diphenylmethyl piperazines
KR101418404B1 (ko) 2012-01-06 2014-07-10 한미약품 주식회사 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제
KR102226833B1 (ko) 2013-06-28 2021-03-12 한미약품 주식회사 레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1199918A (en) * 1981-02-06 1986-01-28 Ludovic Rodriguez 2-¬4-(diphenylmethyl)-1-piperazinyl|-acetic acids and their amides
CA1317300C (en) * 1988-11-23 1993-05-04 Eric Cossement Process for the preparation of 2-¬2-¬4-¬(4-chlorophenyl) phenylmethyl|-1-piperazinyl|ethoxy|-acetic acid and its dihydrochloride

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH505116A (it) * 1966-11-21 1971-03-31 Crc Ricerca Chim Metodo per l'ottenimento di derivati della piperazina
GB1184395A (en) * 1967-03-08 1970-03-18 Egyt Gyogyszervegyeszeti Gyar Substituted Piperazine Derivatives
GB8827390D0 (en) * 1988-11-23 1988-12-29 Ucb Sa Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1199918A (en) * 1981-02-06 1986-01-28 Ludovic Rodriguez 2-¬4-(diphenylmethyl)-1-piperazinyl|-acetic acids and their amides
CA1317300C (en) * 1988-11-23 1993-05-04 Eric Cossement Process for the preparation of 2-¬2-¬4-¬(4-chlorophenyl) phenylmethyl|-1-piperazinyl|ethoxy|-acetic acid and its dihydrochloride

Also Published As

Publication number Publication date
CN1215395A (zh) 1999-04-28
BR9708763A (pt) 1999-08-03
IN186873B (enExample) 2001-12-01
EA199800879A1 (ru) 1999-02-25
HU225478B1 (en) 2006-12-28
HUP9901804A2 (hu) 1999-09-28
NZ332057A (en) 2000-03-27
ATE219067T1 (de) 2002-06-15
ES2177965T3 (es) 2002-12-16
EA000831B1 (ru) 2000-04-24
HK1018779A1 (en) 2000-01-07
DE69713352T2 (de) 2003-02-20
TR199802025T2 (xx) 1999-01-18
PL188819B1 (pl) 2005-04-29
YU44198A (sh) 1999-07-28
US6255487B1 (en) 2001-07-03
EP0927173B1 (fr) 2002-06-12
DE69713352D1 (en) 2002-07-18
EP0927173A1 (fr) 1999-07-07
PT927173E (pt) 2002-11-29
BE1010094A3 (fr) 1997-12-02
AR006761A1 (es) 1999-09-29
AU2281897A (en) 1997-10-29
HUP9901804A3 (en) 2000-06-28
NO984738D0 (no) 1998-10-09
WO1997037982A1 (fr) 1997-10-16
US6140501A (en) 2000-10-31
CZ315198A3 (cs) 1999-03-17
PL329307A1 (en) 1999-03-15
NO984738L (no) 1998-12-08
JP2000508634A (ja) 2000-07-11
NO311615B1 (no) 2001-12-17
DK0927173T3 (da) 2002-09-16
AU710835B2 (en) 1999-09-30
CZ295068B6 (cs) 2005-05-18
RS49574B (sr) 2007-04-10
ZA972973B (en) 1997-11-03
MY118237A (en) 2004-09-30

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