ES2177965T3 - Derivados de (2-1-piperazinil)etoxi)metilo sustituidos. - Google Patents
Derivados de (2-1-piperazinil)etoxi)metilo sustituidos.Info
- Publication number
- ES2177965T3 ES2177965T3 ES97915205T ES97915205T ES2177965T3 ES 2177965 T3 ES2177965 T3 ES 2177965T3 ES 97915205 T ES97915205 T ES 97915205T ES 97915205 T ES97915205 T ES 97915205T ES 2177965 T3 ES2177965 T3 ES 2177965T3
- Authority
- ES
- Spain
- Prior art keywords
- etoxi
- renting
- radical
- preparation
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A COMPUESTOS NUEVOS, [2 (1 - PIPERACINIL) ETOXI]METILO SUSTITUIDOS DE FORMULA (I), EN LA QUE R 1 REPRESENTA UN GRUPO - CONH 2 , - CN, COOH, - COOM O - COOR 3 , SIENDO M UN METAL ALCALINO Y R 3 UN RADICAL QUE TIENE ENTRE 1 Y 4 ATOMOS DE CARBONO; Y R 2 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO COR 4 O - R SUB,5 , DONDE R 4 SE ELIGE ENTRE LOS GRUPOS - OR 6 O - R 7 , EN LOS QUE R 5 REPRESENTA UN RADICAL ALQUILO O ALQUILARILO, R 6 REPRESENTA UN RADICAL ALQUILO LINEAL O RAMIFICADO QUE TIENE ENTRE 1 Y 4 ATOMOS DE CARBONO, UN RADICAL HALOGENOALQUILO, ALQUILARILO, ALQUILNITROARILO O ALQUILHALOGENOARILO, Y R 7 REPRESENTA UN HALOGENOALQUILO. LA INVENCION SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION DE ESTOS COMPUESTOS, ASI COMO A SU UTILIZACION PARA LA PREPARACION DE COMPUESTOS QUE SON ELLOS MISMOS PRODUCTOS INTERMEDIOS VALIOSOS PARA LA PREPARACION DEL ACIDO 2 - [2 - [4 - [(4 - CLOROFENIL) FENILMETIL] - 1 PIPERACINIL] ETOXI] ACETICO O ACIDO 2 - [2 - [4 - [BIS(4 FLUOROFENIL) METIL] - 1 - PIPERACINIL] ETOXI] ACETICO Y/O SUS SALES FARMACEUTICAMENTE ACEPTABLES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BE9600310A BE1010094A3 (fr) | 1996-04-10 | 1996-04-10 | Nouveaux [2-(1-piperazinyl)ethoxy] methyle substitues. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2177965T3 true ES2177965T3 (es) | 2002-12-16 |
Family
ID=3889663
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97915205T Expired - Lifetime ES2177965T3 (es) | 1996-04-10 | 1997-03-28 | Derivados de (2-1-piperazinil)etoxi)metilo sustituidos. |
Country Status (26)
Country | Link |
---|---|
US (2) | US6140501A (es) |
EP (1) | EP0927173B1 (es) |
JP (1) | JP2000508634A (es) |
CN (1) | CN1072661C (es) |
AR (1) | AR006761A1 (es) |
AT (1) | ATE219067T1 (es) |
AU (1) | AU710835B2 (es) |
BE (1) | BE1010094A3 (es) |
BR (1) | BR9708763A (es) |
CZ (1) | CZ295068B6 (es) |
DE (1) | DE69713352T2 (es) |
DK (1) | DK0927173T3 (es) |
EA (1) | EA000831B1 (es) |
ES (1) | ES2177965T3 (es) |
HK (1) | HK1018779A1 (es) |
HU (1) | HU225478B1 (es) |
IN (1) | IN186873B (es) |
MY (1) | MY118237A (es) |
NO (1) | NO311615B1 (es) |
NZ (1) | NZ332057A (es) |
PL (1) | PL188819B1 (es) |
PT (1) | PT927173E (es) |
RS (1) | RS49574B (es) |
TR (1) | TR199802025T2 (es) |
WO (1) | WO1997037982A1 (es) |
ZA (1) | ZA972973B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0919550A1 (en) * | 1997-11-26 | 1999-06-02 | Ucb, S.A. | Pseudopolymorphic forms of 2-2-4-bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxy acetic acid dihydrochloride |
IL124195A (en) * | 1998-04-23 | 2000-08-31 | Chemagis Ltd | Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid |
WO2001040211A1 (en) * | 1999-11-30 | 2001-06-07 | EGIS Gyógyszergyár Rt. | A PROCESS FOR THE PREPARATION OF {2-[4-(α-PHENYL-p-CHLOROBENZYL)PIPERAZIN-1-YL]ETHOXY}ACETIC ACID AND NOVEL INTERMEDIATES THEREFOR |
US6977301B1 (en) | 2001-05-29 | 2005-12-20 | Ucb, S.A. | Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide |
US7199241B1 (en) | 2001-05-29 | 2007-04-03 | Ucb, S.A. | Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide |
US6838052B2 (en) | 2001-06-29 | 2005-01-04 | Symyx Technologies, Inc. | In-situ injection and materials screening device |
CA2454564A1 (en) * | 2001-07-26 | 2003-02-06 | Ucb, S.A. | Process for the preparation of 2-(2-(4-(bis(4-fluorophenyl)methyl)-piperazin-1-yl)ethoxy)acetic acid derivatives or corresponding salt forms thereof and intermediates therefor |
US7160513B2 (en) | 2002-12-20 | 2007-01-09 | Symyx Technologies, Inc. | Batch reactor with injection system |
US20040266787A1 (en) * | 2003-03-25 | 2004-12-30 | Dr. Reddy's Laboratories Limited | Novel amorphous form of [2-[4-[(4-chlorophenyl)-phenyl methyl]-1-piperazinyl]ethoxy]acetic acid and process for the preparation thereof |
US20050020608A1 (en) * | 2003-03-25 | 2005-01-27 | Dr. Reddy's Laboratories Limited | Crystalline cetirizine monohydrochloride |
AU2003228011A1 (en) * | 2003-05-21 | 2004-12-13 | Wockhardt Limited | 2-(2-(4-((4-chlorophenyl) phenylmethyl)-1-piperazinyl)ethoxy)acetic acid monohydrochloride as anti-allergenic compound and process for its production |
KR100503443B1 (ko) * | 2004-02-02 | 2005-07-22 | 한림제약(주) | 광학적으로 활성인 세티리진 또는 그의 염의 제조방법 |
WO2006050909A1 (en) * | 2004-11-10 | 2006-05-18 | Ucb Farchim Sa | Novel forms of efletirizine dihydrochloride, processes for making them and pharmaceutical compositions including them |
US20070238876A1 (en) * | 2006-04-10 | 2007-10-11 | Neera Tewari | Process for the preparation of aripiprazole |
US20110172425A1 (en) * | 2008-09-17 | 2011-07-14 | Calyx Chemicals And Pharmaceuticals Pvt. Ltd. | Novel water based process for the preparation of substituted diphenylmethyl piperazines |
KR101418404B1 (ko) | 2012-01-06 | 2014-07-10 | 한미약품 주식회사 | 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제 |
KR102226833B1 (ko) | 2013-06-28 | 2021-03-12 | 한미약품 주식회사 | 레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH505116A (it) * | 1966-11-21 | 1971-03-31 | Crc Ricerca Chim | Metodo per l'ottenimento di derivati della piperazina |
GB1184395A (en) * | 1967-03-08 | 1970-03-18 | Egyt Gyogyszervegyeszeti Gyar | Substituted Piperazine Derivatives |
NO155805C (no) * | 1981-02-06 | 1987-06-10 | Ucb Sa | Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter. |
GB8827391D0 (en) * | 1988-11-23 | 1988-12-29 | Ucb Sa | Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride |
GB8827390D0 (en) * | 1988-11-23 | 1988-12-29 | Ucb Sa | Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride |
-
1996
- 1996-04-10 BE BE9600310A patent/BE1010094A3/fr active
-
1997
- 1997-03-28 US US09/155,977 patent/US6140501A/en not_active Expired - Lifetime
- 1997-03-28 DE DE69713352T patent/DE69713352T2/de not_active Expired - Fee Related
- 1997-03-28 EA EA199800879A patent/EA000831B1/ru not_active IP Right Cessation
- 1997-03-28 BR BR9708763A patent/BR9708763A/pt active Search and Examination
- 1997-03-28 CN CN97193721A patent/CN1072661C/zh not_active Expired - Fee Related
- 1997-03-28 JP JP9535681A patent/JP2000508634A/ja not_active Ceased
- 1997-03-28 PL PL97329307A patent/PL188819B1/pl not_active IP Right Cessation
- 1997-03-28 EP EP97915205A patent/EP0927173B1/fr not_active Expired - Lifetime
- 1997-03-28 TR TR1998/02025T patent/TR199802025T2/xx unknown
- 1997-03-28 PT PT97915205T patent/PT927173E/pt unknown
- 1997-03-28 AT AT97915205T patent/ATE219067T1/de not_active IP Right Cessation
- 1997-03-28 HU HU9901804A patent/HU225478B1/hu not_active IP Right Cessation
- 1997-03-28 NZ NZ332057A patent/NZ332057A/xx unknown
- 1997-03-28 AU AU22818/97A patent/AU710835B2/en not_active Ceased
- 1997-03-28 DK DK97915205T patent/DK0927173T3/da active
- 1997-03-28 ES ES97915205T patent/ES2177965T3/es not_active Expired - Lifetime
- 1997-03-28 WO PCT/BE1997/000038 patent/WO1997037982A1/fr active IP Right Grant
- 1997-03-28 CZ CZ19983151A patent/CZ295068B6/cs not_active IP Right Cessation
- 1997-04-08 MY MYPI97001510A patent/MY118237A/en unknown
- 1997-04-08 ZA ZA9702973A patent/ZA972973B/xx unknown
- 1997-04-08 AR ARP970101379A patent/AR006761A1/es active IP Right Grant
- 1997-04-09 IN IN919DE1997 patent/IN186873B/en unknown
-
1998
- 1998-03-28 RS YUP-441/98A patent/RS49574B/sr unknown
- 1998-10-09 NO NO19984738A patent/NO311615B1/no unknown
-
1999
- 1999-09-02 HK HK99103797A patent/HK1018779A1/xx not_active IP Right Cessation
-
2000
- 2000-03-21 US US09/532,159 patent/US6255487B1/en not_active Expired - Lifetime
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