CN1071743C - 磺酰基或亚磺酰基苯甲酰基胍衍生物 - Google Patents

磺酰基或亚磺酰基苯甲酰基胍衍生物 Download PDF

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Publication number
CN1071743C
CN1071743C CN96109414A CN96109414A CN1071743C CN 1071743 C CN1071743 C CN 1071743C CN 96109414 A CN96109414 A CN 96109414A CN 96109414 A CN96109414 A CN 96109414A CN 1071743 C CN1071743 C CN 1071743C
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CN
China
Prior art keywords
methyl
ethyl
diamino methylene
sulphonyl
methylsulfonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN96109414A
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English (en)
Chinese (zh)
Other versions
CN1148590A (zh
Inventor
R·吉里克
M·巴格斯
K·O·米克
N·贝尔
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Merck Patent GmbH
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Merck Patent GmbH
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Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of CN1148590A publication Critical patent/CN1148590A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Leads Or Probes (AREA)
CN96109414A 1995-08-11 1996-08-09 磺酰基或亚磺酰基苯甲酰基胍衍生物 Expired - Lifetime CN1071743C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19529612.5 1995-08-11
DE19529612A DE19529612A1 (de) 1995-08-11 1995-08-11 Sulfonyl- oder Sulfinyl-benzoylguanidin-Derivate

Publications (2)

Publication Number Publication Date
CN1148590A CN1148590A (zh) 1997-04-30
CN1071743C true CN1071743C (zh) 2001-09-26

Family

ID=7769293

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96109414A Expired - Lifetime CN1071743C (zh) 1995-08-11 1996-08-09 磺酰基或亚磺酰基苯甲酰基胍衍生物

Country Status (25)

Country Link
US (1) US5744641A (es)
EP (1) EP0758644B1 (es)
JP (1) JP3901766B2 (es)
KR (1) KR100447111B1 (es)
CN (1) CN1071743C (es)
AR (1) AR004677A1 (es)
AT (1) ATE252075T1 (es)
AU (1) AU709800B2 (es)
BR (1) BR9603377B1 (es)
CA (1) CA2183050C (es)
CZ (1) CZ292974B6 (es)
DE (2) DE19529612A1 (es)
DK (1) DK0758644T3 (es)
ES (1) ES2206534T3 (es)
HU (1) HU226134B1 (es)
MX (1) MX9603300A (es)
NO (1) NO306858B1 (es)
PL (1) PL184320B1 (es)
PT (1) PT758644E (es)
RU (1) RU2159232C2 (es)
SI (1) SI0758644T1 (es)
SK (1) SK281661B6 (es)
TW (1) TW432039B (es)
UA (1) UA45965C2 (es)
ZA (1) ZA966773B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4328352A1 (de) * 1993-08-24 1995-03-02 Hoechst Ag Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19833118C2 (de) 1998-07-23 2000-07-27 Merck Patent Gmbh Verfahren zur Herstellung von orthoalkylierten Benzoesäurederivaten
DE19903275A1 (de) * 1999-01-28 2000-08-03 Merck Patent Gmbh Lyophilisate mit verbesserter Rekonstituierbarkeit
DE19951418A1 (de) * 1999-10-26 2001-05-03 Merck Patent Gmbh Verfahren zur Herstellung von N-(4,5-Bismethansulfonyl-2-methyl-benzoyl) -guanidin, Hydrochlorid
DE10001879A1 (de) 2000-01-19 2001-07-19 Aventis Pharma Gmbh Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE10023405A1 (de) * 2000-05-12 2001-11-15 Merck Patent Gmbh Verfahren zur Herstellung von Sulfonyl-benzoylguanidinum-Salzen
KR100643561B1 (ko) * 2000-12-08 2006-11-10 엘지.필립스 엘시디 주식회사 액정표시장치용 어레이기판과 어레이기판의 제조방법
DE10305070A1 (de) * 2003-02-07 2004-08-26 Merck Patent Gmbh Verwendung von N-(4,5-Methansulfonyl-2-methyl-benzoyl)-guanidin
CA2524718A1 (en) * 2003-05-06 2004-11-18 Michael Kirschbaum Method for crystallizing guanidinium salts
DE102004045825A1 (de) * 2004-09-22 2006-03-23 Merck Patent Gmbh Lyophilisat enthaltend N-Diaminomethylen-2-methyl-4,5-di-(methylsulfonyl)-benzamid
ES2804574T3 (es) * 2008-05-09 2021-02-08 Merck Patent Gmbh Composición farmacéutica para tratar enfermedades asociadas con la resistencia a la insulina y la disfunción de células beta
JP5745406B2 (ja) 2008-09-02 2015-07-08 サノフイ 置換アミノインダン及びそのアナログ、及びその医薬使用
FR2948028B1 (fr) 2009-07-17 2011-12-02 Merck Sante Sas Association d'un inhibiteur de l'echangeur sodium-proton et d'un derive amine de dihydro-1,3,5-triazine
ES2970232T3 (es) * 2016-02-08 2024-05-27 Merck Patent Gmbh Modificaciones cristalinas de clorhidrato de N-(4,5-bismetansulfonil-2-metilbenzoil)guanidina y sales de N-(4,5-bismetansulfonil-2-metilbenzoil)guanidina
EP4230196A1 (en) 2022-02-21 2023-08-23 Som Innovation Biotech, S.A. Compounds for use in the treatment of dystrophinopathies

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0416499A2 (de) * 1989-09-06 1991-03-13 Hoechst Aktiengesellschaft Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltendes Medikament
EP0589336A1 (de) * 1992-09-22 1994-03-30 Hoechst Aktiengesellschaft Benzoylguanidine, Verfahren zu ihrer Herstellung, sowie ihre Verwendung als Antiarrythmika
EP0604852A1 (de) * 1992-12-28 1994-07-06 Hoechst Aktiengesellschaft 2,4-Substituierte 5-(N-substituierte-Sulfamoyl)-Benzoylguanidine, als Antiarrythmika, Inhibitoren der Proliferationen von Zellen, und Inhibitoren des Natrium-Protonen-Antiporters

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4430916A1 (de) * 1994-08-31 1996-03-07 Merck Patent Gmbh Alkyl-benzoylguanidin-Derivate

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0416499A2 (de) * 1989-09-06 1991-03-13 Hoechst Aktiengesellschaft Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltendes Medikament
EP0589336A1 (de) * 1992-09-22 1994-03-30 Hoechst Aktiengesellschaft Benzoylguanidine, Verfahren zu ihrer Herstellung, sowie ihre Verwendung als Antiarrythmika
EP0604852A1 (de) * 1992-12-28 1994-07-06 Hoechst Aktiengesellschaft 2,4-Substituierte 5-(N-substituierte-Sulfamoyl)-Benzoylguanidine, als Antiarrythmika, Inhibitoren der Proliferationen von Zellen, und Inhibitoren des Natrium-Protonen-Antiporters

Also Published As

Publication number Publication date
BR9603377A (pt) 1998-05-12
CA2183050C (en) 2008-09-30
ES2206534T3 (es) 2004-05-16
DE59610773D1 (de) 2003-11-20
JP3901766B2 (ja) 2007-04-04
ATE252075T1 (de) 2003-11-15
PL184320B1 (pl) 2002-10-31
AU709800B2 (en) 1999-09-09
EP0758644A1 (de) 1997-02-19
HU226134B1 (en) 2008-05-28
BR9603377B1 (pt) 2009-01-13
KR100447111B1 (ko) 2004-12-08
CZ292974B6 (cs) 2004-01-14
CN1148590A (zh) 1997-04-30
HUP9602196A2 (en) 1997-05-28
MX9603300A (es) 1997-03-29
DK0758644T3 (da) 2003-12-22
JPH0952876A (ja) 1997-02-25
NO963340D0 (no) 1996-08-09
NO306858B1 (no) 2000-01-03
RU2159232C2 (ru) 2000-11-20
US5744641A (en) 1998-04-28
SK103396A3 (en) 1997-03-05
DE19529612A1 (de) 1997-02-13
SK281661B6 (sk) 2001-06-11
AR004677A1 (es) 1999-03-10
ZA966773B (en) 1997-02-19
CA2183050A1 (en) 1997-02-12
TW432039B (en) 2001-05-01
CZ231296A3 (en) 1997-02-12
AU6191796A (en) 1997-02-13
KR970010740A (ko) 1997-03-27
UA45965C2 (uk) 2002-05-15
NO963340L (no) 1997-02-12
HUP9602196A3 (en) 1998-07-28
PL315611A1 (en) 1997-02-17
SI0758644T1 (en) 2004-04-30
PT758644E (pt) 2004-02-27
HU9602196D0 (en) 1996-10-28
EP0758644B1 (de) 2003-10-15

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