MX9603300A - Derivados de la 4-sulfonilbenzoilguanidina o la 4-sulfinilbenzoilguanidina. - Google Patents

Derivados de la 4-sulfonilbenzoilguanidina o la 4-sulfinilbenzoilguanidina.

Info

Publication number
MX9603300A
MX9603300A MX9603300A MX9603300A MX9603300A MX 9603300 A MX9603300 A MX 9603300A MX 9603300 A MX9603300 A MX 9603300A MX 9603300 A MX9603300 A MX 9603300A MX 9603300 A MX9603300 A MX 9603300A
Authority
MX
Mexico
Prior art keywords
sulfonylbenzoylguanidine
sulfinylbenzoylguanidine
derivatives
refers
formula
Prior art date
Application number
MX9603300A
Other languages
English (en)
Inventor
Rolf Gericke
Manfred Baumgarth
Klaus-Otto Minck
Norbert Beier
Original Assignee
Merck Patent Gmbh
Haftung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7769293&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9603300(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent Gmbh, Haftung filed Critical Merck Patent Gmbh
Publication of MX9603300A publication Critical patent/MX9603300A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Leads Or Probes (AREA)

Abstract

El invento se refiere a las 4-sulfonilbenzoilguanidinas o 4-sulfinilbenzoliguanidinas de formula I (Ver Formula) en la que R1, R2, R3, R6 y n tienen los significados indicados en la reivindicacion 1, y a sus sales aceptables desde el punto de vista fisiologico. También se refiere a un procedimiento para preparar dichos compuestos, a preparaciones farmacéuticas que los contienen y al empleo de los mismos para el tratamiento de las arritmias, de la angina de pecho, infartos y también para el tratamiento preventivo de estas enfermedades. Los nuevos compuestos del invento poseen propiedades antiarritmicas y un efecto inhibidor del mecanismo de intercambio de Na+/H+ de las células.
MX9603300A 1995-08-11 1996-08-09 Derivados de la 4-sulfonilbenzoilguanidina o la 4-sulfinilbenzoilguanidina. MX9603300A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19529612A DE19529612A1 (de) 1995-08-11 1995-08-11 Sulfonyl- oder Sulfinyl-benzoylguanidin-Derivate

Publications (1)

Publication Number Publication Date
MX9603300A true MX9603300A (es) 1997-03-29

Family

ID=7769293

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9603300A MX9603300A (es) 1995-08-11 1996-08-09 Derivados de la 4-sulfonilbenzoilguanidina o la 4-sulfinilbenzoilguanidina.

Country Status (25)

Country Link
US (1) US5744641A (es)
EP (1) EP0758644B1 (es)
JP (1) JP3901766B2 (es)
KR (1) KR100447111B1 (es)
CN (1) CN1071743C (es)
AR (1) AR004677A1 (es)
AT (1) ATE252075T1 (es)
AU (1) AU709800B2 (es)
BR (1) BR9603377B1 (es)
CA (1) CA2183050C (es)
CZ (1) CZ292974B6 (es)
DE (2) DE19529612A1 (es)
DK (1) DK0758644T3 (es)
ES (1) ES2206534T3 (es)
HU (1) HU226134B1 (es)
MX (1) MX9603300A (es)
NO (1) NO306858B1 (es)
PL (1) PL184320B1 (es)
PT (1) PT758644E (es)
RU (1) RU2159232C2 (es)
SI (1) SI0758644T1 (es)
SK (1) SK281661B6 (es)
TW (1) TW432039B (es)
UA (1) UA45965C2 (es)
ZA (1) ZA966773B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4328352A1 (de) * 1993-08-24 1995-03-02 Hoechst Ag Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19833118C2 (de) 1998-07-23 2000-07-27 Merck Patent Gmbh Verfahren zur Herstellung von orthoalkylierten Benzoesäurederivaten
DE19903275A1 (de) * 1999-01-28 2000-08-03 Merck Patent Gmbh Lyophilisate mit verbesserter Rekonstituierbarkeit
DE19951418A1 (de) * 1999-10-26 2001-05-03 Merck Patent Gmbh Verfahren zur Herstellung von N-(4,5-Bismethansulfonyl-2-methyl-benzoyl) -guanidin, Hydrochlorid
DE10001879A1 (de) 2000-01-19 2001-07-19 Aventis Pharma Gmbh Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE10023405A1 (de) * 2000-05-12 2001-11-15 Merck Patent Gmbh Verfahren zur Herstellung von Sulfonyl-benzoylguanidinum-Salzen
KR100643561B1 (ko) * 2000-12-08 2006-11-10 엘지.필립스 엘시디 주식회사 액정표시장치용 어레이기판과 어레이기판의 제조방법
DE10305070A1 (de) * 2003-02-07 2004-08-26 Merck Patent Gmbh Verwendung von N-(4,5-Methansulfonyl-2-methyl-benzoyl)-guanidin
MXPA05011840A (es) * 2003-05-06 2006-01-26 Merck Patent Gmbh Procedimiento para cristalizar sales de guanidinio.
DE102004045825A1 (de) * 2004-09-22 2006-03-23 Merck Patent Gmbh Lyophilisat enthaltend N-Diaminomethylen-2-methyl-4,5-di-(methylsulfonyl)-benzamid
JP5634985B2 (ja) * 2008-05-09 2014-12-03 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ インスリン抵抗性およびβ−細胞機能障害に関連する疾患を治療するためのリメポリドを含む医薬組成物
JP5745406B2 (ja) 2008-09-02 2015-07-08 サノフイ 置換アミノインダン及びそのアナログ、及びその医薬使用
FR2948028B1 (fr) 2009-07-17 2011-12-02 Merck Sante Sas Association d'un inhibiteur de l'echangeur sodium-proton et d'un derive amine de dihydro-1,3,5-triazine
CA3013648C (en) 2016-02-08 2024-03-19 Merck Patent Gmbh Crystalline modifications of n-(4,5-bismethanesulfonyl-2-methylbenzoyl)guanidine hydrochloride and n-(4,5-bismethanesulfonyl-2-methylbenzoyl)guanidine salts
EP4230196A1 (en) 2022-02-21 2023-08-23 Som Innovation Biotech, S.A. Compounds for use in the treatment of dystrophinopathies

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3929582A1 (de) * 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
ES2097409T3 (es) * 1992-09-22 1997-04-01 Hoechst Ag Benzoilguanidinas, procedimiento para su preparacion, asi como su empleo como antiarritmicos.
EP0604852A1 (de) * 1992-12-28 1994-07-06 Hoechst Aktiengesellschaft 2,4-Substituierte 5-(N-substituierte-Sulfamoyl)-Benzoylguanidine, als Antiarrythmika, Inhibitoren der Proliferationen von Zellen, und Inhibitoren des Natrium-Protonen-Antiporters
DE4430916A1 (de) * 1994-08-31 1996-03-07 Merck Patent Gmbh Alkyl-benzoylguanidin-Derivate

Also Published As

Publication number Publication date
CA2183050A1 (en) 1997-02-12
EP0758644A1 (de) 1997-02-19
CN1148590A (zh) 1997-04-30
ES2206534T3 (es) 2004-05-16
JP3901766B2 (ja) 2007-04-04
DE59610773D1 (de) 2003-11-20
NO963340L (no) 1997-02-12
PL184320B1 (pl) 2002-10-31
NO963340D0 (no) 1996-08-09
ATE252075T1 (de) 2003-11-15
CA2183050C (en) 2008-09-30
CZ292974B6 (cs) 2004-01-14
SI0758644T1 (en) 2004-04-30
ZA966773B (en) 1997-02-19
SK281661B6 (sk) 2001-06-11
CN1071743C (zh) 2001-09-26
AU709800B2 (en) 1999-09-09
BR9603377B1 (pt) 2009-01-13
UA45965C2 (uk) 2002-05-15
HUP9602196A3 (en) 1998-07-28
CZ231296A3 (en) 1997-02-12
PL315611A1 (en) 1997-02-17
DE19529612A1 (de) 1997-02-13
BR9603377A (pt) 1998-05-12
HUP9602196A2 (en) 1997-05-28
NO306858B1 (no) 2000-01-03
AU6191796A (en) 1997-02-13
JPH0952876A (ja) 1997-02-25
SK103396A3 (en) 1997-03-05
TW432039B (en) 2001-05-01
HU9602196D0 (en) 1996-10-28
KR100447111B1 (ko) 2004-12-08
AR004677A1 (es) 1999-03-10
PT758644E (pt) 2004-02-27
KR970010740A (ko) 1997-03-27
HU226134B1 (en) 2008-05-28
DK0758644T3 (da) 2003-12-22
RU2159232C2 (ru) 2000-11-20
US5744641A (en) 1998-04-28
EP0758644B1 (de) 2003-10-15

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