FR2948028B1 - Association d'un inhibiteur de l'echangeur sodium-proton et d'un derive amine de dihydro-1,3,5-triazine - Google Patents

Association d'un inhibiteur de l'echangeur sodium-proton et d'un derive amine de dihydro-1,3,5-triazine

Info

Publication number
FR2948028B1
FR2948028B1 FR0954978A FR0954978A FR2948028B1 FR 2948028 B1 FR2948028 B1 FR 2948028B1 FR 0954978 A FR0954978 A FR 0954978A FR 0954978 A FR0954978 A FR 0954978A FR 2948028 B1 FR2948028 B1 FR 2948028B1
Authority
FR
France
Prior art keywords
aminous
triazine
dihydro
derivative
association
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0954978A
Other languages
English (en)
Other versions
FR2948028A1 (fr
Inventor
Didier Mesangeau
Xavier Leverve
Daniel Cravo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Merck Sante SAS
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Merck Sante SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0954978A priority Critical patent/FR2948028B1/fr
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM, Merck Sante SAS filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Priority to EP10725627A priority patent/EP2453897A1/fr
Priority to US13/383,907 priority patent/US20120115872A1/en
Priority to BR112012000976A priority patent/BR112012000976A2/pt
Priority to PCT/EP2010/003696 priority patent/WO2011006573A1/fr
Priority to CA2768104A priority patent/CA2768104A1/fr
Priority to SG2011095932A priority patent/SG176982A1/en
Priority to AU2010272926A priority patent/AU2010272926A1/en
Priority to CN2010800320828A priority patent/CN102470138A/zh
Priority to MX2012000659A priority patent/MX2012000659A/es
Priority to KR1020127004126A priority patent/KR20120037014A/ko
Priority to ARP100102624A priority patent/AR077489A1/es
Publication of FR2948028A1 publication Critical patent/FR2948028A1/fr
Application granted granted Critical
Publication of FR2948028B1 publication Critical patent/FR2948028B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR0954978A 2009-07-17 2009-07-17 Association d'un inhibiteur de l'echangeur sodium-proton et d'un derive amine de dihydro-1,3,5-triazine Expired - Fee Related FR2948028B1 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
FR0954978A FR2948028B1 (fr) 2009-07-17 2009-07-17 Association d'un inhibiteur de l'echangeur sodium-proton et d'un derive amine de dihydro-1,3,5-triazine
CN2010800320828A CN102470138A (zh) 2009-07-17 2010-06-18 钠-质子交换蛋白抑制剂和二氢-1,3,5-三嗪胺衍生物的组合产品
BR112012000976A BR112012000976A2 (pt) 2009-07-17 2010-06-18 combinação de um inibidor de trocador de próton de sódio e de um derivado de amina di-hidro-1,3,5-triazina
PCT/EP2010/003696 WO2011006573A1 (fr) 2009-07-17 2010-06-18 Combinaison d'un inhibiteur d'échangeur sodium-proton et d'un dérivé de dihydro-1,3,5-triazine amine
CA2768104A CA2768104A1 (fr) 2009-07-17 2010-06-18 Combinaison d'un inhibiteur d'echangeur sodium-proton et d'un derive de dihydro-1,3,5-triazine amine
SG2011095932A SG176982A1 (en) 2009-07-17 2010-06-18 Combination of a sodium-proton exchanger inhibitor and of a dihydro-1,3,5-triazine amine derivative
EP10725627A EP2453897A1 (fr) 2009-07-17 2010-06-18 Combinaison d'un inhibiteur d'échangeur sodium-proton et d'un dérivé de dihydro-1,3,5-triazine amine
US13/383,907 US20120115872A1 (en) 2009-07-17 2010-06-18 Combination of a sodium-proton exchanger inhibitor and of a dihydro-1,3,5-triazine amine derivative
MX2012000659A MX2012000659A (es) 2009-07-17 2010-06-18 Combinacion de un inhibidor del intercambiador de protones-sodio y de un derivado de dihidro-1,3,5-triazinamina.
KR1020127004126A KR20120037014A (ko) 2009-07-17 2010-06-18 나트륨-양자 교환체 억제제 및 디히드로-1,3,5-트리아진 아민 유도체의 조합물
AU2010272926A AU2010272926A1 (en) 2009-07-17 2010-06-18 Combination of a sodium-proton exchanger inhibitor and of a dihydro-1,3,5-triazine amine derivative
ARP100102624A AR077489A1 (es) 2009-07-17 2010-07-19 Combinacion de un inhibidor del intercambiador de protones-sodio y de un derivado de dihidro-1,3,5-triazinamina

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0954978A FR2948028B1 (fr) 2009-07-17 2009-07-17 Association d'un inhibiteur de l'echangeur sodium-proton et d'un derive amine de dihydro-1,3,5-triazine

Publications (2)

Publication Number Publication Date
FR2948028A1 FR2948028A1 (fr) 2011-01-21
FR2948028B1 true FR2948028B1 (fr) 2011-12-02

Family

ID=41466911

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0954978A Expired - Fee Related FR2948028B1 (fr) 2009-07-17 2009-07-17 Association d'un inhibiteur de l'echangeur sodium-proton et d'un derive amine de dihydro-1,3,5-triazine

Country Status (12)

Country Link
US (1) US20120115872A1 (fr)
EP (1) EP2453897A1 (fr)
KR (1) KR20120037014A (fr)
CN (1) CN102470138A (fr)
AR (1) AR077489A1 (fr)
AU (1) AU2010272926A1 (fr)
BR (1) BR112012000976A2 (fr)
CA (1) CA2768104A1 (fr)
FR (1) FR2948028B1 (fr)
MX (1) MX2012000659A (fr)
SG (1) SG176982A1 (fr)
WO (1) WO2011006573A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101953727B1 (ko) 2008-08-18 2019-03-05 프로덕티브 리서치 엘엘씨 성형가능한 경량 복합체
FR2948027A1 (fr) * 2009-07-17 2011-01-21 Merck Sante Sas Derives amines de dihydro-1,3,5-triazine pour leur utilisation dans le traitement des maladies associees a une ischemie et/ou une reperfusion
EP2536559B1 (fr) 2010-02-15 2016-04-20 Productive Research LLC. Systèmes et méthodes des matériaux composites légers malléables
US11338552B2 (en) 2019-02-15 2022-05-24 Productive Research Llc Composite materials, vehicle applications and methods thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19529612A1 (de) 1995-08-11 1997-02-13 Merck Patent Gmbh Sulfonyl- oder Sulfinyl-benzoylguanidin-Derivate
FR2804113B1 (fr) 2000-01-26 2004-06-18 Lipha Derives animes de dihydro-1,3,5-triazine et leurs applications en therapeutique
FR2896160B1 (fr) * 2006-01-13 2008-04-25 Merck Sante Soc Par Actions Si Combinaison de derives de triazine et d'agonistes du ppar alpha.
FR2896157B1 (fr) * 2006-01-13 2008-09-12 Merck Sante Soc Par Actions Si Combinaison de derives de triazine et d'agents de stimulation de secretion d'insuline.
FR2896158B1 (fr) * 2006-01-13 2008-09-12 Merck Sante Soc Par Actions Si Combinaison de derives de triazine et d'inhibiteurs de la hmg-coa reductase.

Also Published As

Publication number Publication date
MX2012000659A (es) 2012-03-07
US20120115872A1 (en) 2012-05-10
KR20120037014A (ko) 2012-04-18
EP2453897A1 (fr) 2012-05-23
CN102470138A (zh) 2012-05-23
WO2011006573A1 (fr) 2011-01-20
FR2948028A1 (fr) 2011-01-21
BR112012000976A2 (pt) 2019-09-24
AU2010272926A1 (en) 2012-03-08
CA2768104A1 (fr) 2011-01-20
AR077489A1 (es) 2011-08-31
SG176982A1 (en) 2012-02-28

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20140331