CN1071423A - 双环羧酸衍生物 - Google Patents

双环羧酸衍生物 Download PDF

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Publication number
CN1071423A
CN1071423A CN92111386A CN92111386A CN1071423A CN 1071423 A CN1071423 A CN 1071423A CN 92111386 A CN92111386 A CN 92111386A CN 92111386 A CN92111386 A CN 92111386A CN 1071423 A CN1071423 A CN 1071423A
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CN
China
Prior art keywords
formula
oxygen
compound
group
gram
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN92111386A
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English (en)
Chinese (zh)
Inventor
N·科恩
李国贞
K·A·亚加洛夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN1071423A publication Critical patent/CN1071423A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
    • C07C57/50—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid containing condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
CN92111386A 1991-09-10 1992-09-09 双环羧酸衍生物 Pending CN1071423A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75710091A 1991-09-10 1991-09-10
US757,100 1991-09-10
US07/898,852 US5273999A (en) 1991-09-10 1992-06-15 Carboxylic acid leukotriene B4 antagonists
US898,852 1992-06-15

Publications (1)

Publication Number Publication Date
CN1071423A true CN1071423A (zh) 1993-04-28

Family

ID=27116327

Family Applications (1)

Application Number Title Priority Date Filing Date
CN92111386A Pending CN1071423A (zh) 1991-09-10 1992-09-09 双环羧酸衍生物

Country Status (15)

Country Link
US (2) US5273999A (enExample)
EP (1) EP0531823A1 (enExample)
JP (1) JPH05201915A (enExample)
KR (1) KR930005998A (enExample)
CN (1) CN1071423A (enExample)
AU (1) AU655057B2 (enExample)
CA (1) CA2077213A1 (enExample)
CZ (1) CZ265492A3 (enExample)
FI (1) FI924048L (enExample)
HU (1) HUT66238A (enExample)
IL (1) IL103058A0 (enExample)
NO (1) NO923508L (enExample)
NZ (1) NZ244218A (enExample)
RU (1) RU2067973C1 (enExample)
TW (1) TW218013B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105431405A (zh) * 2013-03-14 2016-03-23 澳门大学 分离自益智仁的新抗神经变性天然化合物及其全合成
CN105418576A (zh) * 2015-11-16 2016-03-23 黄林海 一种伪麻黄碱类衍生物及其抗过敏应用

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5457124A (en) * 1993-12-07 1995-10-10 Hoffmann-La Roche Inc. Carboxylic acid Leukotriene B4 antagonists
US5753702A (en) * 1996-05-22 1998-05-19 University Of Vermont Arachidonic acid metabolite, 16-hete
US6004808A (en) * 1996-06-21 1999-12-21 Aurora Biosciences Corporation Promiscuous G-protein compositions and their use
US6416733B1 (en) 1996-10-07 2002-07-09 Bristol-Myers Squibb Pharma Company Radiopharmaceuticals for imaging infection and inflammation
CA2332272A1 (en) 1998-05-15 1999-11-25 University Of Vermont Novel analogs of 16-hydroxyeicosatetraenoic acid
NZ511489A (en) 1998-11-05 2003-08-29 Toyama Chemical Co Ltd A benzene derivative useful as an AP-1 inhibitor
US6019992A (en) * 1998-12-04 2000-02-01 Chesebrough-Pond's Usa Co. Cosmetic skin care compositions containing 4-chromanone
FR2791344B1 (fr) * 1999-03-25 2002-02-15 Adir Nouveaux derives dimeriques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
RU2183126C2 (ru) * 2000-06-26 2002-06-10 Государственное унитарное предприятие "Иммунопрепарат" Средство, нормализующее функциональную активность спинного мозга, и способ его получения
RU2224528C2 (ru) * 2001-07-24 2004-02-27 Брянский государственный университет им. акад. И.Г. Петровского Способ получения биологически активных пептидов каудальной нейросекреторной системы (кнсс) позвоночных
PL206100B1 (pl) * 2001-11-16 2010-06-30 Toyama Chemical Co Ltd Nowe pochodne benzofenonu lub ich sole oraz środek leczniczy
ATE468851T1 (de) * 2002-07-30 2010-06-15 Merck Sharp & Dohme Ppar alpha selektive verbindungen zur behandlung von dyslipidämie und anderen lipidstörungen
JP4475406B2 (ja) * 2002-07-30 2010-06-09 メルク・シャープ・エンド・ドーム・コーポレイション 異常脂血症および他の脂質障害の治療用のＰＰＡＲα選択的化合物
US8093253B2 (en) * 2008-03-06 2012-01-10 Hoffmann-La Roche Inc. Leukotriene B4 inhibitors
EP2943756A4 (en) * 2010-01-13 2016-02-24 Qsc Llc OPTICALLY CONTROLLED MOTORIZED CONTROL DEVICE

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3776944A (en) * 1971-09-16 1973-12-04 Warner Lambert Co Tetraloneoxy acetic acids and esters thereof
DE3275295D1 (en) * 1981-11-12 1987-03-05 Fisons Plc Anti-srs-a carboxylic acid derivatives, processes for their production, and pharmaceutical formulation containing them
ZA844519B (en) * 1983-06-24 1985-02-27 Hoffmann La Roche Dihydrobenzopyran derivatives
US4801616A (en) * 1986-03-25 1989-01-31 Eli Lilly And Company Diphenylmethanone compounds and anti-inflammatory use thereof
US4992576A (en) * 1987-01-12 1991-02-12 Eli Lilly And Company Intermediates for leukotriene antagonists
FR2615515B1 (fr) * 1987-05-22 1989-06-30 Adir Nouveaux derives du spiro 4, 5 decane, leur procede de preparation et les compositions pharmaceutiques les renfermant
US4889871A (en) * 1987-05-29 1989-12-26 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives
CA2019335C (en) * 1989-06-27 2000-08-01 Mitoshi Konno Phenylalkan (en)oic acids
US5124350A (en) * 1990-06-28 1992-06-23 G. D. Searle & Co. Leukotriene b4 antagonists

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105431405A (zh) * 2013-03-14 2016-03-23 澳门大学 分离自益智仁的新抗神经变性天然化合物及其全合成
US9475749B2 (en) 2013-03-14 2016-10-25 University Of Macau Anti-neurodegenerative natural compound isolated from alpiniae oxyphyllae fructose and their total synthesis
CN105431405B (zh) * 2013-03-14 2018-06-01 澳门大学 分离自益智仁的新抗神经变性天然化合物及其全合成
US10011555B2 (en) 2013-03-14 2018-07-03 University Of Macau Methods of treating Parkinson's disease
CN105418576A (zh) * 2015-11-16 2016-03-23 黄林海 一种伪麻黄碱类衍生物及其抗过敏应用
CN105418576B (zh) * 2015-11-16 2018-03-13 北京新沿线医药科技发展有限公司 一种伪麻黄碱类衍生物及其抗过敏应用

Also Published As

Publication number Publication date
NO923508L (no) 1993-03-11
US5434186A (en) 1995-07-18
KR930005998A (ko) 1993-04-20
HU9202817D0 (en) 1992-11-30
FI924048A7 (fi) 1993-03-11
TW218013B (enExample) 1993-12-21
RU2067973C1 (ru) 1996-10-20
EP0531823A1 (en) 1993-03-17
AU655057B2 (en) 1994-12-01
CA2077213A1 (en) 1993-03-11
FI924048L (fi) 1993-03-11
NO923508D0 (no) 1992-09-09
AU2219192A (en) 1993-03-11
NZ244218A (en) 1995-07-26
FI924048A0 (fi) 1992-09-10
CZ265492A3 (en) 1993-03-17
IL103058A0 (en) 1993-02-21
HUT66238A (en) 1994-10-28
JPH05201915A (ja) 1993-08-10
US5273999A (en) 1993-12-28

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication