CN1068597C - 制备4-芳基-哌啶衍生物的方法 - Google Patents
制备4-芳基-哌啶衍生物的方法 Download PDFInfo
- Publication number
- CN1068597C CN1068597C CN96193942A CN96193942A CN1068597C CN 1068597 C CN1068597 C CN 1068597C CN 96193942 A CN96193942 A CN 96193942A CN 96193942 A CN96193942 A CN 96193942A CN 1068597 C CN1068597 C CN 1068597C
- Authority
- CN
- China
- Prior art keywords
- compound
- formula
- limits
- alkyl
- above group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK0563/1995 | 1995-05-17 | ||
DK56395 | 1995-05-17 | ||
DK0563/95 | 1995-05-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1184476A CN1184476A (zh) | 1998-06-10 |
CN1068597C true CN1068597C (zh) | 2001-07-18 |
Family
ID=8094959
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN96193942A Expired - Fee Related CN1068597C (zh) | 1995-05-17 | 1996-04-25 | 制备4-芳基-哌啶衍生物的方法 |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0828735A1 (fr) |
JP (1) | JPH11505229A (fr) |
CN (1) | CN1068597C (fr) |
AU (1) | AU721257B2 (fr) |
BR (1) | BR9608471A (fr) |
CA (1) | CA2220963A1 (fr) |
HU (1) | HUP9900318A3 (fr) |
IL (1) | IL118294A0 (fr) |
NZ (1) | NZ307479A (fr) |
WO (1) | WO1996036636A1 (fr) |
ZA (1) | ZA963951B (fr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9526645D0 (en) * | 1995-12-28 | 1996-02-28 | Chiroscience Ltd | Stereoselective synthesis |
ES2117557B1 (es) * | 1996-02-29 | 1999-07-01 | Ferrer Int | Nuevo procedimiento de obtencion de (-)-trans -n-p-fluorobenzoilmetil-4-(p-fluorofenil)-3- ((3,4-(metilendioxi)fenoxi ) metil)-piperidina. |
EP0812827B1 (fr) * | 1996-06-13 | 2009-09-02 | Sumitomo Chemical Company, Limited | Dérivés de pipéridine comme intermédiaire pour la production de paroxétine et procédé pour leur préparation |
HU221921B1 (hu) * | 1996-07-08 | 2003-02-28 | Richter Gedeon Vegyészeti Gyár Rt. | N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására |
GB9623359D0 (en) * | 1996-11-09 | 1997-01-08 | Smithkline Beecham Plc | Novel process |
GB9700690D0 (en) | 1997-01-15 | 1997-03-05 | Smithkline Beecham Plc | Novel process |
GB9710004D0 (en) * | 1997-05-17 | 1997-07-09 | Knoll Ag | Chemical process |
ID24383A (id) | 1997-05-29 | 2000-07-13 | Smithkline Beecham Corp | Proses baru |
EE03970B1 (et) | 1997-06-10 | 2003-02-17 | Synthon B.V. | 4-fenüülpiperidiinühend, selle valmistamine ja kasutamine ning seda sisaldav ravim |
CH689805A8 (fr) * | 1998-07-02 | 2000-02-29 | Smithkline Beecham Plc | Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant. |
GB9826175D0 (en) * | 1998-11-28 | 1999-01-20 | Smithkline Beecham Plc | Novel process |
GB9828767D0 (en) * | 1998-12-29 | 1999-02-17 | Smithkline Beecham Plc | Novel process |
IT1308629B1 (it) * | 1999-02-23 | 2002-01-09 | Recordati Chem Pharm | Processo per la produzione di paroxetina. |
IT1313702B1 (it) | 1999-08-02 | 2002-09-09 | Chemi Spa | Processo per la preparazione di derivati 3-sostituiti di 4-fenil-piperidine. |
AU1018801A (en) * | 1999-10-29 | 2001-05-14 | Novo Nordisk A/S | Use of 3,4-substituted piperidines |
GB9930577D0 (en) * | 1999-12-23 | 2000-02-16 | Smithkline Beecham Plc | Novel process |
EP1280775A1 (fr) | 2000-05-12 | 2003-02-05 | Synthon B.V. | Tosylates de 4-(p-fluorophenyl)-piperidine-3-carbinols |
US20040087795A1 (en) * | 2000-07-17 | 2004-05-06 | Borrett Gary Thomas | Novel processes for the preparation of 4-phenylpiperidine derivatives |
GB0021147D0 (en) | 2000-08-30 | 2000-10-11 | Knoll Ag | Chemical process |
GB0021145D0 (en) * | 2000-08-30 | 2000-10-11 | Knoll Ag | Chemical process |
AU2001211337A1 (en) * | 2000-10-06 | 2002-04-15 | Smithkline Beecham Plc | Process for the preparation of aryl-piperidine carbinols and intermediates thereof |
BR0116721A (pt) | 2001-01-04 | 2003-12-23 | Ferrer Int | Processo para a preparação de (±)-trans-4-p-fluorofenil-3-hidroximetil-1-metilpiperi dina |
WO2015071831A1 (fr) * | 2013-11-18 | 2015-05-21 | Piramal Enterprises Limited | Procédé amélioré permettant de réduire au minimum la formation de sous-produits déshalogénés |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1422263A (en) * | 1973-01-30 | 1976-01-21 | Ferrosan As | 4-phenyl-piperidine compounds |
US4593036A (en) * | 1984-02-07 | 1986-06-03 | A/S Ferrosan | (-)-Trans-4-(4-fluorophenyl)-3-[(4-methoxyphenoxy)methyl]-1-methylpiperidine useful as 5-HT potentiator |
IE66332B1 (en) * | 1986-11-03 | 1995-12-27 | Novo Nordisk As | Piperidine compounds and their preparation and use |
DK715988D0 (da) * | 1988-12-22 | 1988-12-22 | Ferrosan As | Etherifikation og dealkylering af piperidin-derivater samt intermediater |
-
1996
- 1996-04-25 HU HU9900318A patent/HUP9900318A3/hu unknown
- 1996-04-25 NZ NZ307479A patent/NZ307479A/xx unknown
- 1996-04-25 JP JP8534464A patent/JPH11505229A/ja active Pending
- 1996-04-25 CN CN96193942A patent/CN1068597C/zh not_active Expired - Fee Related
- 1996-04-25 AU AU56845/96A patent/AU721257B2/en not_active Ceased
- 1996-04-25 EP EP96914861A patent/EP0828735A1/fr not_active Ceased
- 1996-04-25 WO PCT/DK1996/000185 patent/WO1996036636A1/fr not_active Application Discontinuation
- 1996-04-25 CA CA002220963A patent/CA2220963A1/fr not_active Abandoned
- 1996-04-25 BR BR9608471A patent/BR9608471A/pt not_active Application Discontinuation
- 1996-05-16 IL IL11829496A patent/IL118294A0/xx unknown
- 1996-05-17 ZA ZA963951A patent/ZA963951B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
WO1996036636A1 (fr) | 1996-11-21 |
HUP9900318A3 (en) | 2001-09-28 |
IL118294A0 (en) | 1996-09-12 |
BR9608471A (pt) | 1998-12-29 |
HUP9900318A2 (hu) | 1999-09-28 |
AU5684596A (en) | 1996-11-29 |
JPH11505229A (ja) | 1999-05-18 |
NZ307479A (en) | 1999-08-30 |
EP0828735A1 (fr) | 1998-03-18 |
AU721257B2 (en) | 2000-06-29 |
ZA963951B (en) | 1997-01-21 |
CA2220963A1 (fr) | 1996-11-21 |
CN1184476A (zh) | 1998-06-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C19 | Lapse of patent right due to non-payment of the annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |