HUP9900318A2 - Eljárás 4-aril-piperidin-származékok előállítására - Google Patents
Eljárás 4-aril-piperidin-származékok előállításáraInfo
- Publication number
- HUP9900318A2 HUP9900318A2 HU9900318A HUP9900318A HUP9900318A2 HU P9900318 A2 HUP9900318 A2 HU P9900318A2 HU 9900318 A HU9900318 A HU 9900318A HU P9900318 A HUP9900318 A HU P9900318A HU P9900318 A2 HUP9900318 A2 HU P9900318A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- pure
- phenyl
- viii
- trans
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 239000000843 powder Substances 0.000 abstract 2
- AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical class C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 abstract 1
- VSWICNJIUPRZIK-UHFFFAOYSA-N 2-piperideine Chemical class C1CNC=CC1 VSWICNJIUPRZIK-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000012280 lithium aluminium hydride Substances 0.000 abstract 1
- -1 lithium aluminum hydride Chemical compound 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány tárgya a (VIII) általánős képletű vegyület - ahől R1 jelentése 2-5 szénatőmős alkilcsőpőrt vagy adőtt esetbenhelyettesített fenil-(1-5 szénatőmős)-alkil-csőpőrt, X jelentésehalőgén - előállítására szőlgáló új eljárás. A találmány szerint aracém tetrahidrőpiridinszármazékőt (III) tiszta enantiőmerekreválasztják szét, melyeket katalitikűsan vagy lítiűm-alűmíniűm-hidriddel redűkálnak a tiszta (+)-cisz-(VII) és (-)-transz-1-alkil-4-fenil-3-hidrőxi-metil-piperidin (VI) származékká. Mindkettőtátalakítják a tiszta (-)-transz-1-alkil-4-fenil-3-(3,4-metilén-diőxi-fenőxi-metil)-piperidinné (VIII), a (IX) általánős képletűparőxetinanalógők szintézisének gazdaságős, mindkét lehetségesenantiőmert felhasználó eljárásáhőz jűtva. ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK56395 | 1995-05-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9900318A2 true HUP9900318A2 (hu) | 1999-09-28 |
| HUP9900318A3 HUP9900318A3 (en) | 2001-09-28 |
Family
ID=8094959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9900318A HUP9900318A3 (en) | 1995-05-17 | 1996-04-25 | Process for preparing 4-aryl-piperidine derivatives |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0828735A1 (hu) |
| JP (1) | JPH11505229A (hu) |
| CN (1) | CN1068597C (hu) |
| AU (1) | AU721257B2 (hu) |
| BR (1) | BR9608471A (hu) |
| CA (1) | CA2220963A1 (hu) |
| HU (1) | HUP9900318A3 (hu) |
| IL (1) | IL118294A0 (hu) |
| NZ (1) | NZ307479A (hu) |
| WO (1) | WO1996036636A1 (hu) |
| ZA (1) | ZA963951B (hu) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9526645D0 (en) * | 1995-12-28 | 1996-02-28 | Chiroscience Ltd | Stereoselective synthesis |
| ES2117557B1 (es) * | 1996-02-29 | 1999-07-01 | Ferrer Int | Nuevo procedimiento de obtencion de (-)-trans -n-p-fluorobenzoilmetil-4-(p-fluorofenil)-3- ((3,4-(metilendioxi)fenoxi ) metil)-piperidina. |
| EP1384720A1 (en) | 1996-06-13 | 2004-01-28 | SUMIKA FINE CHEMICALS Co., Ltd. | Process for drying paroxetine hydrochloride |
| HU221921B1 (hu) * | 1996-07-08 | 2003-02-28 | Richter Gedeon Vegyészeti Gyár Rt. | N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására |
| GB9623359D0 (en) * | 1996-11-09 | 1997-01-08 | Smithkline Beecham Plc | Novel process |
| GB9700690D0 (en) | 1997-01-15 | 1997-03-05 | Smithkline Beecham Plc | Novel process |
| GB9710004D0 (en) | 1997-05-17 | 1997-07-09 | Knoll Ag | Chemical process |
| JP2002514222A (ja) | 1997-05-29 | 2002-05-14 | スミスクライン・ビーチャム・コーポレイション | 新規方法 |
| ES2155995T3 (es) | 1997-06-10 | 2001-06-01 | Synthon Bv | Compuestos de 4-fenilpiperidina. |
| CH689805A8 (fr) * | 1998-07-02 | 2000-02-29 | Smithkline Beecham Plc | Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant. |
| GB9826175D0 (en) * | 1998-11-28 | 1999-01-20 | Smithkline Beecham Plc | Novel process |
| GB9828767D0 (en) * | 1998-12-29 | 1999-02-17 | Smithkline Beecham Plc | Novel process |
| IT1308629B1 (it) * | 1999-02-23 | 2002-01-09 | Recordati Chem Pharm | Processo per la produzione di paroxetina. |
| IT1313702B1 (it) * | 1999-08-02 | 2002-09-09 | Chemi Spa | Processo per la preparazione di derivati 3-sostituiti di 4-fenil-piperidine. |
| WO2001032178A1 (en) * | 1999-10-29 | 2001-05-10 | Novo Nordisk A/S | Use of 3,4-substituted piperidines |
| GB9930577D0 (en) * | 1999-12-23 | 2000-02-16 | Smithkline Beecham Plc | Novel process |
| WO2001085688A1 (en) | 2000-05-12 | 2001-11-15 | Synthon B.V. | TOSYLATE SALTS OF 4-(p-FLUOROPHENYL)-PIPERIDINE-3-CARBINOLS |
| EP1301508A1 (en) * | 2000-07-17 | 2003-04-16 | Smithkline Beecham Plc | Novel processes for the preparation of 4-phenylpiperidine derivatives |
| GB0021147D0 (en) | 2000-08-30 | 2000-10-11 | Knoll Ag | Chemical process |
| GB0021145D0 (en) * | 2000-08-30 | 2000-10-11 | Knoll Ag | Chemical process |
| AU2001211337A1 (en) * | 2000-10-06 | 2002-04-15 | Smithkline Beecham Plc | Process for the preparation of aryl-piperidine carbinols and intermediates thereof |
| EP1347960B1 (en) * | 2001-01-04 | 2004-11-17 | Ferrer Internacional, S.A. | Process for preparing (+) trans-4-p-fluorophenyl-3-hydroxymethyl-1 |
| WO2015071831A1 (en) * | 2013-11-18 | 2015-05-21 | Piramal Enterprises Limited | An improved process for minimising the formation of dehalogenated byproducts |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1422263A (en) * | 1973-01-30 | 1976-01-21 | Ferrosan As | 4-phenyl-piperidine compounds |
| US4593036A (en) * | 1984-02-07 | 1986-06-03 | A/S Ferrosan | (-)-Trans-4-(4-fluorophenyl)-3-[(4-methoxyphenoxy)methyl]-1-methylpiperidine useful as 5-HT potentiator |
| IE66332B1 (en) * | 1986-11-03 | 1995-12-27 | Novo Nordisk As | Piperidine compounds and their preparation and use |
| DK715988D0 (da) * | 1988-12-22 | 1988-12-22 | Ferrosan As | Etherifikation og dealkylering af piperidin-derivater samt intermediater |
-
1996
- 1996-04-25 BR BR9608471A patent/BR9608471A/pt not_active Application Discontinuation
- 1996-04-25 AU AU56845/96A patent/AU721257B2/en not_active Ceased
- 1996-04-25 CN CN96193942A patent/CN1068597C/zh not_active Expired - Fee Related
- 1996-04-25 JP JP8534464A patent/JPH11505229A/ja active Pending
- 1996-04-25 EP EP96914861A patent/EP0828735A1/en not_active Ceased
- 1996-04-25 NZ NZ307479A patent/NZ307479A/xx unknown
- 1996-04-25 HU HU9900318A patent/HUP9900318A3/hu unknown
- 1996-04-25 CA CA002220963A patent/CA2220963A1/en not_active Abandoned
- 1996-04-25 WO PCT/DK1996/000185 patent/WO1996036636A1/en not_active Application Discontinuation
- 1996-05-16 IL IL11829496A patent/IL118294A0/xx unknown
- 1996-05-17 ZA ZA963951A patent/ZA963951B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL118294A0 (en) | 1996-09-12 |
| WO1996036636A1 (en) | 1996-11-21 |
| HUP9900318A3 (en) | 2001-09-28 |
| NZ307479A (en) | 1999-08-30 |
| ZA963951B (en) | 1997-01-21 |
| CN1184476A (zh) | 1998-06-10 |
| BR9608471A (pt) | 1998-12-29 |
| CN1068597C (zh) | 2001-07-18 |
| EP0828735A1 (en) | 1998-03-18 |
| AU5684596A (en) | 1996-11-29 |
| AU721257B2 (en) | 2000-06-29 |
| JPH11505229A (ja) | 1999-05-18 |
| CA2220963A1 (en) | 1996-11-21 |
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