CN106794211A - 多聚半乳糖醛酸‑鼠李聚糖半乳糖醛酸(pgrg1)组合物 - Google Patents

多聚半乳糖醛酸‑鼠李聚糖半乳糖醛酸(pgrg1)组合物 Download PDF

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Publication number
CN106794211A
CN106794211A CN201580048061.8A CN201580048061A CN106794211A CN 106794211 A CN106794211 A CN 106794211A CN 201580048061 A CN201580048061 A CN 201580048061A CN 106794211 A CN106794211 A CN 106794211A
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CN
China
Prior art keywords
pgrg1
compositions
composition
astragalus
radix astragali
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Pending
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CN201580048061.8A
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English (en)
Chinese (zh)
Inventor
约翰·H·马瑟
安金华
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Pharmagenesis Inc
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Pharmagenesis Inc
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Publication of CN106794211A publication Critical patent/CN106794211A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/732—Pectin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0045—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Galacturonans, e.g. methyl ester of (alpha-1,4)-linked D-galacturonic acid units, i.e. pectin, or hydrolysis product of methyl ester of alpha-1,4-linked D-galacturonic acid units, i.e. pectinic acid; Derivatives thereof
    • C08B37/0048—Processes of extraction from organic materials
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Polymers & Plastics (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Materials Engineering (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201580048061.8A 2014-08-18 2015-08-17 多聚半乳糖醛酸‑鼠李聚糖半乳糖醛酸(pgrg1)组合物 Pending CN106794211A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462038583P 2014-08-18 2014-08-18
US62/038,583 2014-08-18
PCT/US2015/045574 WO2016028714A1 (en) 2014-08-18 2015-08-17 Polygalacturonan rhamnogalacturonan1 (pgrg1) composition

Publications (1)

Publication Number Publication Date
CN106794211A true CN106794211A (zh) 2017-05-31

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580048061.8A Pending CN106794211A (zh) 2014-08-18 2015-08-17 多聚半乳糖醛酸‑鼠李聚糖半乳糖醛酸(pgrg1)组合物

Country Status (5)

Country Link
US (1) US20170232035A1 (enExample)
EP (1) EP3191110A4 (enExample)
JP (1) JP2017525702A (enExample)
CN (1) CN106794211A (enExample)
WO (1) WO2016028714A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108084290A (zh) * 2018-01-09 2018-05-29 东北农业大学 一种微波辅助提取薇菜中多糖的方法
CN112961258A (zh) * 2021-02-26 2021-06-15 重庆医科大学附属第二医院 一种红参均一性多糖及其提取方法与应用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105866318A (zh) * 2016-03-16 2016-08-17 保定冀中药业有限公司 一种麻杏石甘口服液中麻黄的薄层色谱检测方法
CN110128562B (zh) * 2019-05-29 2021-05-25 黄河科技学院 一种抗肿瘤补骨脂多糖及其提取分离方法和在制备抗肿瘤药物方面的应用
CN111999425A (zh) * 2020-08-21 2020-11-27 广东容大生物股份有限公司 一种银黄甘颗粒中甘草成分的定性鉴别方法
CN115078581B (zh) * 2022-06-21 2024-08-27 上海长征医院 基于uhplc-q-tof/ms识别柴胡桂枝干姜免煎剂成分的方法

Citations (1)

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Publication number Priority date Publication date Assignee Title
US20120141412A1 (en) * 2008-12-15 2012-06-07 Jinhua An Methods of treating idiopathic thrombocytopenic purpura with compositions comprising extracts of astragalus membranaceus

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TWI240629B (en) * 1999-06-30 2005-10-01 Pharmagenesis Inc Hematopoietic arabinogalactan composition
AU2001271675A1 (en) * 2000-06-29 2002-01-14 Pharmagenesis, Inc. Acid-modified arabinogalactan protein composition
JP2004107295A (ja) * 2002-09-20 2004-04-08 National Agriculture & Bio-Oriented Research Organization ヒスタミン遊離抑制剤
WO2005095463A1 (en) * 2004-03-26 2005-10-13 Glycogenesys, Inc. Modified pectins, compositions and methods related thereto
PL3287471T3 (pl) * 2009-12-11 2021-08-02 Nutrileads B.V. Polisacharyd odpowiedni do modulacji odpowiedzi immunologicznej
WO2012148277A1 (en) * 2011-04-29 2012-11-01 Unilever N.V. Method for isolation of polysaccharides
WO2013040324A1 (en) * 2011-09-16 2013-03-21 Galectin Therapeutics, Inc. Galacto-rhamnogalacturonate compositions for the treatment of non-alcoholic steatohepatitis and non-alcoholic fatty liver disease
TWI554277B (zh) * 2012-03-28 2016-10-21 泰宗生物科技股份有限公司 預防及治療非酒精性脂肪肝之醫藥組成物
ES2848538T3 (es) * 2012-06-06 2021-08-10 Galectin Therapeutics Inc Composiciones de galacto-ramnogalacturonato para el tratamiento de enfermedades asociadas con elevada óxido nítrico sintasa inducible

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
US20120141412A1 (en) * 2008-12-15 2012-06-07 Jinhua An Methods of treating idiopathic thrombocytopenic purpura with compositions comprising extracts of astragalus membranaceus

Non-Patent Citations (1)

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Title
戴芹等: "黄芪多糖对5/6肾切除大鼠的肾保护作用研究", 《江苏中医药》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108084290A (zh) * 2018-01-09 2018-05-29 东北农业大学 一种微波辅助提取薇菜中多糖的方法
CN112961258A (zh) * 2021-02-26 2021-06-15 重庆医科大学附属第二医院 一种红参均一性多糖及其提取方法与应用

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WO2016028714A1 (en) 2016-02-25
US20170232035A1 (en) 2017-08-17
EP3191110A1 (en) 2017-07-19
EP3191110A4 (en) 2018-04-18
JP2017525702A (ja) 2017-09-07

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Application publication date: 20170531