CN101212963A - 绿原酸在制备具有增加骨髓细胞功效的药物中的用途 - Google Patents

绿原酸在制备具有增加骨髓细胞功效的药物中的用途 Download PDF

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CN101212963A
CN101212963A CNA200680024175XA CN200680024175A CN101212963A CN 101212963 A CN101212963 A CN 101212963A CN A200680024175X A CNA200680024175X A CN A200680024175XA CN 200680024175 A CN200680024175 A CN 200680024175A CN 101212963 A CN101212963 A CN 101212963A
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medicine
chlorogenic acid
group
acid
bone marrow
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CN101212963B (zh
Inventor
张洁
张舒
张亮
徐小平
雍智全
包旭
易大朝
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Sichuan Jiuzhang Biotechnology Co Ltd
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Sichuan Jiuzhang Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

本发明提供了绿原酸Chlorogenic acid在制备增加骨髓细胞功效的药物中的用途。本发明还提供了含有绿原酸为活性成分的药物组合物。绿原酸可治疗各种原因引起的贫血，且不仅仅限于失血性贫血、溶血性贫血，造血不良性贫血包括巨细胞性贫血、再生障碍性贫血和脾功能亢进，对各种原因引起的白细胞减少状态、粒细胞减少症、粒细胞缺乏症有治疗作用，对各种原因引起的巨核系统改变如特发性血小板减少性紫癜等有治疗作用；对各种原因引起的骨髓纤维化，骨髓感染有一定治疗作用。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN200680024175XA 2005-07-22 2006-07-21 绿原酸在制备具有增加骨髓细胞功效的药物中的用途 Active CN101212963B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNA2005100880248A CN1899280A (zh) 2005-07-22 2005-07-22 绿原酸在制备增加骨髓细胞功效药物的用途
CN200510088024.8 2005-07-22
PCT/CN2006/001795 WO2007009393A1 (fr) 2005-07-22 2006-07-21 Utilisation d'acide chlorogene dans la fabrication de medicaments pour l'accroissement de l'effet de cellules de moelle osseuse

Related Child Applications (4)

Application Number Title Priority Date Filing Date
CN200910246133A Division CN101695484A (zh) 2005-07-22 2006-07-21 绿原酸在制备治疗骨髓感染的药物中的用途
CN2009102461340A Division CN101703497B (zh) 2005-07-22 2006-07-21 绿原酸在制备对脾脏造血干细胞损伤有保护、修复作用的药物中的用途
CN2009102466274A Division CN101695485B (zh) 2005-07-22 2006-07-21 绿原酸在制备治疗血小板减少症、贫血的药物中的用途
CN2009102466306A Division CN101695486B (zh) 2005-07-22 2006-07-21 绿原酸在制备治疗骨髓纤维化的药物中的用途

Publications (2)

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CN101212963A true CN101212963A (zh) 2008-07-02
CN101212963B CN101212963B (zh) 2010-08-25

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CNA2005100880248A Pending CN1899280A (zh) 2005-07-22 2005-07-22 绿原酸在制备增加骨髓细胞功效药物的用途
CN200680024175XA Active CN101212963B (zh) 2005-07-22 2006-07-21 绿原酸在制备具有增加骨髓细胞功效的药物中的用途

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CNA2005100880248A Pending CN1899280A (zh) 2005-07-22 2005-07-22 绿原酸在制备增加骨髓细胞功效药物的用途

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CN (2) CN1899280A (zh)
WO (1) WO2007009393A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117205225A (zh) * 2023-09-12 2023-12-12 湖南普瑞玛药物研究中心有限公司 栀子苷在制备治疗骨髓增殖性肿瘤药物中的应用

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104726399B (zh) 2015-01-26 2018-05-29 东北师范大学 对甲氧基桂皮酸乙酯及其衍生物在维持干细胞自我更新和多潜能性中的应用
CN115058389B (zh) * 2022-07-01 2023-07-25 济南大学 一种绿原酸-钙纳米缓释剂及在促进干细胞成骨分化中的应用
CN116712568B (zh) * 2023-08-04 2023-10-03 山东第一医科大学附属省立医院(山东省立医院) 一种利塞膦酸钠包合物、制剂及用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100515416C (zh) * 2002-05-31 2009-07-22 科学及工业研究委员会 能作为抗白血病药物的草药分子
CN1225262C (zh) * 2002-12-11 2005-11-02 万广灿 治疗血液病的中药胶囊及其制作方法
CN1568960A (zh) * 2004-05-08 2005-01-26 四川九章生物化工科技发展有限公司 高纯度绿原酸制剂

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117205225A (zh) * 2023-09-12 2023-12-12 湖南普瑞玛药物研究中心有限公司 栀子苷在制备治疗骨髓增殖性肿瘤药物中的应用
CN117205225B (zh) * 2023-09-12 2024-05-31 湖南普瑞玛药物研究中心有限公司 栀子苷在制备治疗骨髓增殖性肿瘤药物中的应用

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Publication number Publication date
CN1899280A (zh) 2007-01-24
WO2007009393A1 (fr) 2007-01-25
CN101212963B (zh) 2010-08-25

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Owner name: SICHUAN JIUZHANG BIOLOGICAL TECHNOLOGY CO., LTD.

Free format text: FORMER NAME: JIUZHANG BIO-CHEMICAL ENGINEERING TECH. + SCIENCE DEVELOPMENT CO., LTD., SICHUAN

CP01 Change in the name or title of a patent holder

Address after: 610041 Sichuan high tech Zone, Chengdu Province Park, No. two South Road, No. 10

Patentee after: SICHUAN JIUZHANG BIOTECHNOLOGY CO., LTD.

Address before: 610041 Sichuan high tech Zone, Chengdu Province Park, No. two South Road, No. 10

Patentee before: Jiuzhang Bio-Chemical Engineering Tech. & Science Development Co., Ltd., Sichuan