CN106668489A - 一种治疗细菌性心内膜炎的药物及其制备方法 - Google Patents
一种治疗细菌性心内膜炎的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗细菌性心内膜炎的药物及其制备方法,其是由忍冬藤、紫花地丁、蒲公英、野菊花、大青叶、板蓝根、大蓟、小蓟、连翘、黄芩、木香、生地黄、甘草、党参、麦冬、五味子、丹参、桂枝、附子、防风按一定重量配比制备而成,本发明药物具有清热解毒,凉血止血,活血去瘀,安神宁心,排脓止痛的功能,用于治疗细菌性心内膜炎见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗细菌性心内膜炎的药物及其制备方法,属中药领域。
背景技术
细菌性心内膜炎是细菌进入血液后,随血液周游全身各个器官。当瓣膜有炎症或损伤时,细菌可以停留下来,在此生长繁殖,并引起发炎。由于西药治疗副作用大,因此人们对有效治疗细菌性心内膜炎的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗细菌性心内膜炎的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗细菌性心内膜炎的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择忍冬藤、紫花地丁、蒲公英、野菊花、大青叶、板蓝根、大蓟、小蓟、连翘、黄芩、木香、生地黄、甘草、党参、麦冬、五味子、丹参、桂枝、附子、防风进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗细菌性心内膜炎。其中选用忍冬藤是因为其性味甘,寒,入心、肺经,有清热,解毒,通络的功能,治温病发热,热毒血痢,传染性肝炎,痈肿疮毒,筋骨疼痛。选用紫花地丁是因为其性味苦、辛、寒,归心、肝经,有清热解毒,凉血消肿的功能,治疔疮肿毒,痈疽发背,丹毒,毒蛇咬伤。选用蒲公英是因为其性味苦甘,寒,入肝、胃经,有清热解毒,利尿散结的功能,治急性乳腺炎,淋巴腺炎,瘰疬,疔毒疮肿,急性结膜炎,感冒发热,急性扁桃体炎,急性支气管炎,胃炎,肝炎,胆囊炎,尿路感染。选用野菊花是因为其性味苦辛,凉,入肺、肝经,有疏风清热,消肿解毒的功能,治风热感冒,肺炎,白喉,胃肠炎,高血压,疔,痈,口疮,丹毒,湿疹,天泡疮。选用大青叶是因为其性味苦,寒,入肝、心、胃经,有清热,解毒,凉血,止血的功能,治温病热盛烦渴,流行性感冒,急性传染性肝炎,菌痢,急性胃肠炎,急性肺炎,丹毒,吐血,衄血,黄疸,痢疾,喉痹,口疮,痈疽肿毒。选用板蓝根是因为其性味苦,寒,入肝、胃血分,有清热,解毒,凉血的功能,治流感,流脑,乙脑,肺炎,丹毒,热毒发斑,神昏吐衄,咽肿,痄腮,火眼,疮疹。选用大蓟是因为其性味甘,凉,入肝、脾经,有凉血,止血,祛瘀,消痈肿的功能,治吐血,衄血,尿血,血淋,血崩,带下,肠风,肠痈,痈疡肿毒,疔疮。选用小蓟是因为其性味辛,温,入脾、胃二经,有温中,下气,消谷,杀虫的功能,治吐泻,心腹胀痛,疔肿毒疮,毒虫蛟伤。选用连翘是因为其性味苦,凉,入心、肝、胆经,有清热,解毒,散结,消肿的功能,治温热,丹毒,斑疹,痈疡肿毒,瘰疬,小便淋闭。选用黄芩是因为其性味苦,寒,入心、肺、胆、大肠经,有泻实火,除湿热,止血,安胎的功能,治壮热烦渴,肺热咳嗽,湿热泻痢,黄疸,热淋,吐、衄、崩、漏,目赤肿痛,胎动不安,痈肿疔疮。选用木香是因为其性味辛苦,温,入肺、肝、脾经,有行气止痛,温中和胃的功能,治中寒气滞,胸腹胀痛,呕吐,泄泻,下痢里急后重,寒疝。选用生地黄是因为其性味甘,寒,归心、肝、肾经,有清热凉血,养阴,生津的功能,治热病烦渴,阴虚内热,骨蒸劳热,内热消渴,吐血,衄血,发斑发疹。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊痈,生用治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用党参是因为其性味甘,平,入手、足太阴经气分,有补中益气,生津的功能,治脾胃虚弱,气血两亏,体倦无力,食少,口渴,久泻,脱肛。选用麦冬是因为其性味甘微苦,寒,入肺、胃、心经,有养阴润肺,清心除烦,益胃生津的功能,治肺燥干咳,吐血,咯血,肺痿,肺痈,虚劳烦热,清渴,热病津伤,咽干口燥,便秘。选用五味子是因为其性味酸,温,入肺、肾经,有敛肺,滋肾,生津,收汗,涩精的功能,治肺虚喘咳,口干作渴,自汗,盗汗,劳伤羸瘦,梦遗滑精,久泻久痢。选用丹参是因为其性味苦,微温,入心、肝经,有活血去瘀,安神宁心,排脓,止痛的功能,治心绞痛,月经不调,痛经,以闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠,恶疮肿毒。选用桂枝是因为其性味辛甘,温,入膀胱、心、肺经,有发汗解肌,温经通脉的功能,治风寒表证,肩背肢节酸疼,胸痹痰饮,经闭癥瘕。选用附子是因为其性味辛甘,热,有毒,入心、脾、肾经,有回阳补火,散寒除湿的功能,治阴盛格阳,大汗亡阳,吐利厥逆,心腹冷痛,脾泄冷痢,脚气水肿,小儿慢惊,风寒湿痹,踒躄拘挛,阴疽疮漏及一切沉寒痼冷之疾。选用防风是因为其性味辛甘,温,入膀胱、肺、脾经,有发表,祛风,胜湿,止痛的功能,治外感风寒,头痛,目眩,项强,风寒湿痹,骨节酸痛,四肢挛急,破伤风。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
忍冬藤25-35克,紫花地丁10-20克,蒲公英10-20克,野菊花10-20克,大青叶10-20克,板蓝根10-20克,大蓟10-20克,小蓟10-20克,连翘10-20克,黄芩16-20克,木香4-8克,生地黄4-8克,甘草7-11克,党参10-14克,麦冬10-14克,五味子5-15克,丹参10-20克,桂枝5-15克,附子10-20克,防风5-15克。
优选为:
忍冬藤30克,紫花地丁15克,蒲公英15克,野菊花15克,大青叶15克,板蓝根15克,大蓟15克,小蓟15克,连翘15克,黄芩18克,木香6克,生地黄6克,甘草9克,党参12克,麦冬12克,五味子10克,丹参15克,桂枝10克,附子15克,防风10克。
本发明药物的制备方法如下
一、备料
1、忍冬藤:拣去杂质,用水浸泡,润透,切片,晒干;
2、紫花地丁:取原药材,除去杂质,洗净,稍晾,切段,干燥;
3、蒲公英:拣去杂质,洗净泥土,切段,晒干;
4、野菊花:秋季花盛开时采收,晒干;
5、大青叶:拣去杂质及枯叶,洗净,稍润,切段,晒干;
6、板蓝根:拣净杂质,洗净,润透,切片,晒干;
7、大蓟:拣去杂质,清水洗净,润透,切段,晒干;
8、小蓟:拣净杂质,去根,水洗润透,切段,晒干;
9、连翘:拣净杂质,搓开,除去枝梗;
10、黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干;
11、木香:将原生药放清水内洗净,捞出,闷润12-24小时使软,切片,晒干;
12、生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑;
13、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干;
14、党参:洗净泥沙后润透去芦,切片或切段,晒干;
15、麦冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干;
16、五味子:筛去灰屑,除去杂质,置蒸笼内蒸透,取出晒干;
17、丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
18、桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
19、附子:用水浸泡,捞出,切片,晾干;
20、防风:除去残茎,用水浸泡,捞出,润透切片,晒干。
二、制备
1、将所述重量的忍冬藤、紫花地丁、蒲公英、野菊花、大青叶、板蓝根、大蓟、小蓟、连翘、黄芩、木香、生地黄、甘草、党参、麦冬、五味子、丹参、桂枝、附子、防风放入煎药容器内,加水7倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水5倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为2剂服用。
组方中紫花地丁有清热解毒,凉血消肿的功能为君药;大青叶有清热,解毒,凉血,止血的功能;丹参有活血去瘀,安神宁心,排脓,止痛的功能,二者为臣药,三味药共同发挥清热解毒,凉血止血,活血去瘀,安神宁心,排脓止痛的作用,治疗细菌性心内膜炎效力全面,且以清热解毒,凉血止血,安神宁心为主可治本,桂枝有发汗解肌,温经通脉的功能为佐药,附子有回阳补火,散寒除湿的功能为使药,与下余诸药是治标。
本发明药物具有清热解毒,凉血止血,活血去瘀,安神宁心,排脓止痛的功能,用于治疗细菌性心内膜炎,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治细菌性心内膜炎门诊患者共24例。
2、诊断标准
细菌性心内膜炎时均有发热,而且是长期发热,多为不规则热型,中等度或高热。全身症状尚有精神不振、头痛、胸闷、气短、食欲不振等。心脏方面的表现是在原有的基础上加重,出现心功能不全症状。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,8天为一个疗程,连续服用5个疗程。
4、疗效评定标准
显效:细菌性心内膜炎症状消失,恢复正常,痊愈;
好转:细菌性心内膜炎症状明显好转,发热、头痛、胸闷症状得到有效控制,质逐步恢复正常;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗细菌性心内膜炎患者24例,结果显效20例,显效率为83.4%,好转2例,好转率为8.3%,无效2例,总有效率为91.7%。
Claims (3)
1.一种治疗细菌性心内膜炎的药物,其特征在于:它是由下列重量范围内的原料药制成:
忍冬藤25-35克,紫花地丁10-20克,蒲公英10-20克,野菊花10-20克,大青叶10-20克,板蓝根10-20克,大蓟10-20克,小蓟10-20克,连翘10-20克,黄芩16-20克,木香4-8克,生地黄4-8克,甘草7-11克,党参10-14克,麦冬10-14克,五味子5-15克,丹参10-20克,桂枝5-15克,附子10-20克,防风5-15克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
忍冬藤30克,紫花地丁15克,蒲公英15克,野菊花15克,大青叶15克,板蓝根15克,大蓟15克,小蓟15克,连翘15克,黄芩18克,木香6克,生地黄6克,甘草9克,党参12克,麦冬12克,五味子10克,丹参15克,桂枝10克,附子15克,防风10克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)忍冬藤:拣去杂质,用水浸泡,润透,切片,晒干;
(2)紫花地丁:取原药材,除去杂质,洗净,稍晾,切段,干燥;
(3)蒲公英:拣去杂质,洗净泥土,切段,晒干;
(4)野菊花:秋季花盛开时采收,晒干;
(5)大青叶:拣去杂质及枯叶,洗净,稍润,切段,晒干;
(6)板蓝根:拣净杂质,洗净,润透,切片,晒干;
(7)大蓟:拣去杂质,清水洗净,润透,切段,晒干;
(8)小蓟:拣净杂质,去根,水洗润透,切段,晒干;
(9)连翘:拣净杂质,搓开,除去枝梗;
(10)黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干;
(11)木香:将原生药放清水内洗净,捞出,闷润12-24小时使软,切片,晒干;
(12)生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑;
(13)甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干;
(14)党参:洗净泥沙后润透去芦,切片或切段,晒干;
(15)麦冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干;
(16)五味子:筛去灰屑,除去杂质,置蒸笼内蒸透,取出晒干;
(17)丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
(18)桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
(19)附子:用水浸泡,捞出,切片,晾干;
(20)防风:除去残茎,用水浸泡,捞出,润透切片,晒干;
(二)制备
(1)将所述重量的忍冬藤、紫花地丁、蒲公英、野菊花、大青叶、板蓝根、大蓟、小蓟、连翘、黄芩、木香、生地黄、甘草、党参、麦冬、五味子、丹参、桂枝、附子、防风放入煎药容器内,加水7倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水5倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为2剂服用。
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