CN106798896A - 一种治疗病毒性心肌炎的药物及其制备方法 - Google Patents
一种治疗病毒性心肌炎的药物及其制备方法 Download PDFInfo
- Publication number
- CN106798896A CN106798896A CN201710171586.1A CN201710171586A CN106798896A CN 106798896 A CN106798896 A CN 106798896A CN 201710171586 A CN201710171586 A CN 201710171586A CN 106798896 A CN106798896 A CN 106798896A
- Authority
- CN
- China
- Prior art keywords
- grams
- radix
- impurity
- dried
- picked
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/808—Scrophularia (figwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
- A61K36/855—Clerodendrum, e.g. glorybower
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种治疗病毒性心肌炎的药物及其制备方法,其是由黄连、党参、麦冬、丹参、北沙参、玄参、五味子、郁金、降真香、苦参、瓜蒌皮、薤白、板蓝根、金银花、竹茹、陈皮、山楂、甘草、黄芪、当归、川芎、赤芍、柏子仁、墨旱莲、白芍、夜交藤、大青叶按一定重量配比制备而成,本发明药物具有泻火燥湿,解毒杀虫,活血去瘀,安神宁心,行气解随,凉血破瘀,清热解毒的功能,用于治疗病毒性心肌炎见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗病毒性心肌炎的药物及其制备方法,属中药领域。
背景技术
病毒性心肌炎是指病毒感染引起的心肌局限性或弥漫性的急性或慢性炎症病变,属于感染性心肌疾病。在病毒流行感染期约有5%患者发生心肌炎,也可散在发病。由于西药治疗副作用大,因此人们对有效治疗病毒性心肌炎的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗病毒性心肌炎的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗病毒性心肌炎的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择黄连、党参、麦冬、丹参、北沙参、玄参、五味子、郁金、降真香、苦参、瓜蒌皮、薤白、板蓝根、金银花、竹茹、陈皮、山楂、甘草、黄芪、当归、川芎、赤芍、柏子仁、墨旱莲、白芍、夜交藤、大青叶进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗病毒性心肌炎。其中选用黄连是因为其性味苦,寒,入心、肝、胃、大肠经,有泻火,燥湿,解毒,杀虫的功能,治时行热毒、伤寒,热盛心烦,痞满呕逆,菌痢,热泻腹痛,肺结核,吐、衄、下血,消渴,疳积,蛔虫病,百日咳,咽喉肿痛,火眼,口疮,痈疽疮毒,湿疹,汤火烫伤。选用党参是因为其性味甘,平,入手、足太阴经气分,有补中益气,生津的功能,治脾胃虚弱,气血两亏,体倦无力,食少,口渴,久泻,脱肛。选用麦冬是因为其性味甘微苦,寒,入肺、胃、心经,有养阴润肺,清心除烦,益胃生津的功能,治肺燥干咳,吐血,咯血,肺痿,肺痈,虚劳烦热,清渴,热病津伤,咽干口燥,便秘。选用丹参是因为其性味苦,微温,入心、肝经,有活血去瘀,安神宁心,排脓,止痛的功能,治心绞痛,月经不调,痛经,以闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠,恶疮肿毒。选用北沙参是因为其性味甘苦淡,凉,入肺、脾经,有养阴清肺,祛痰止咳的功能,治肺热燥咳,虚痨久咳,阴伤咽干、口渴。选用玄参是因为其性味苦,咸,凉,入肺、肾经,有滋阴,降火,除烦,解毒的功能,治热病烦渴,发斑,骨蒸劳热,夜寐不宁,自汗盗汗,津伤便秘,吐血衄血,咽喉肿痛,痈肿,瘰疬。选用五味子是因为其性味酸,温,入肺、肾经,有敛肺,滋肾,生津,收汗,涩精的功能,治肺虚喘咳,口干作渴,自汗,盗汗,劳伤羸瘦,梦遗滑精,久泻久痢。选用郁金是因为其性味辛苦,凉,入心、肺、肝经,有行气解随,凉血破瘀的功能,治胸腹胁肋诸痛,失心癫狂,热病神昏,吐血,衄血,尿血,血淋,妇女倒经,黄疸。选用降真香是因为其性味辛,温,入肝、脾经,有理气,止血,行瘀,定痛的功能,治吐血,咯血,金疮出血,跌打损伤,痈疽疮肿,风湿腰腿痛,心胃气痛。选用苦参是因为其性味苦,寒,入肝、肾、大肠、小肠经,有清热,燥湿,杀虫的功能,治热毒血痢,肠风下血,黄疸,赤白带下,小儿肺炎,疳积,急性扁桃体炎,痔漏,脱肛,皮肤瘙痒,阴疮湿痒,瘰疬,烫伤。选用瓜蒌皮是因为其性味甘,寒,归肺、胃经,有清热化痰,利气宽胸的功能,治痰热咳嗽,胸闷胁痛。选用薤白是因为其性味辛苦,温,入手阳明经,有理气,宽胸,通阳,散结的功能,治胸痹心痛彻背,脘痞不舒,干呕,泻痢后重,疮疖。选用板蓝根是因为其性味苦,寒,入肝、胃血分,有清热,解毒,凉血的功能,治流感,流脑,乙脑,肺炎,丹毒,热毒发斑,神昏吐衄,咽肿,痄腮,火眼,疮疹。选用金银花是因为其性味甘,寒,入肺、胃经,有清热,解毒的功能,治温病发热,热毒血痢,痈疡,肿毒,瘰疬,痔漏。选用竹茹是因为其性味甘,凉,入胃、胆经,有清热,凉血,化痰,止吐的功能,治烦热呕吐、呃逆,痰热咳喘,吐血,衄血,崩漏,恶阻,胎动,惊癎。选用陈皮是因为其性味苦、辛,温,归肺、脾经,有理气健脾,燥湿化痰的功能,治胸脘胀满,食少吐泻,咳嗽痰多。选用山楂是因为其性味酸甘,微温,入脾、胃、肝经,有消食积,散瘀血,驱绦虫的功能,治肉积,癥瘕,痰饮,痞满,吞酸,泻痢,肠风,腰痛,疝气,产后儿枕痛,恶露不尽,小儿乳食停滞。选用甘草是因为其性味甘,平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能;炙用,治脾胃食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊癎;生用,治咽喉肿痛,消化性溃疡,痈疸疮疡,解药毒及食物中毒。选用黄芪是因为其性味甘,微温,入肺、脾经,生用有益卫固表,利水消肿,托毒,生肌的功能,治自汗,盗汗,血痹,浮肿,痈疽不溃或溃久敛;炙用有补中益的功能,治内伤劳倦,脾虚泄泻,脱肛,气虚血脱,崩带及一切气衰血虚之症。选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用川芎是因为其性味辛,温,入肝、胆经,有行气开郁,祛风燥湿,活血止痛的功能,治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。选用赤芍是因为其性味苦,微寒,归肝经,有清热凉血,散瘀止痛的功能,治温毒发狂,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,癎瘕腹痛,跌扑损伤,痈肿疮疡。选用柏子仁是因为其性味甘,平,入心、肝、脾经,有养心安神,润肠通便的功能,治惊悸,失眠,遗精,盗汗,便秘的功能。选用墨旱莲是因为其性味苦酸,凉,入肝、肾经,有凉血,止血,补肾,益阴的功能,治吐血,咳血,衄血,尿血,便血,血痢,刀伤出血,须发早白,白喉,淋浊,滞下,阴部湿痒。选用白芍是因为其性味苦酸,凉,入肝、脾经,有养血柔肝,缓中止痛,敛阴收汗的功能,治胸腹胁肋疼痛,泻痢腹痛,自汗盗汗,阴虚发热,月经不调,崩漏,带下。选用夜交藤是因为其性味甘微苦,平,入心、肝经,有养心,安神,通络,祛风的功能,治失眠,劳伤,多汗,血虚身痛,痈疽,瘰疬,风疮疥癣。选用大青叶是因为其性味苦,寒,入肝、心、胃经,有清热,解毒,凉血,止血的功能,治温病热盛烦渴,流行性感冒,急性传染性肝炎,菌痢,急性胃肠炎,急性肺炎,丹毒,吐血,衄血,黄疸,痢疾,喉痹,口疮,痈疽肿毒。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
黄连3-5克,党参15-25克,麦冬10-14克,丹参5-15克,北沙参15-25克,玄参5-15克,五味子2-6克,郁金10-14克,降真香4-8克,苦参5-15克,瓜蒌皮5-9克,薤白5-9克,板蓝根10-20克,金银花10-20克,竹茹5-15克,陈皮5-15克,山楂5-15克,甘草4-8克,黄芪10-20克,当归5-15克,川芎5-15克,赤芍5-15克,柏子仁5-15克,墨旱莲5-15克,白芍5-15克,夜交藤10-20克,大青叶10-20克。
优选为:
黄连5克,党参20克,麦冬12克,丹参10克,北沙参20克,玄参10克,五味子4克,郁金12克,降真香6克,苦参10克,瓜蒌皮7克,薤白7克,板蓝根15克,金银花15克,竹茹10克,陈皮10克,山楂10克,甘草6克,黄芪15克,当归10克,川芎10克,赤芍10克,柏子仁10克,墨旱莲10克,白芍10克,夜交藤15克,大青叶15克。
本发明药物的制备方法如下
一、备料
1、黄连:拣去杂质,洗净泥砂,润透,切片,阴干;
2、党参:洗净泥沙后润透去芦,切片或切段,晒干;
3、麦冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干;
4、丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
5、北沙参:拣去杂质,除去茎基,用水略洗,捞出,稍润,切段,晒干;
6、玄参:拣净杂质,除去芦头,洗净润透,切片,晾干;
7、五味子:筛去灰屑,除去杂质,置蒸笼内蒸透,取出晒干;
8、郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干;
9、降真香:水浸后,蒸至适度,镑片或刨片,晒干;
10、苦参:拣净杂质,除去残茎,洗净泥土,用水浸泡,捞出,润透,切片,晒干;
11、瓜蒌皮:取原药材,除去果柄及杂质,抢水洗净,润透,切丝,干燥,筛去碎屑;
12、薤白:拣去杂质,簸筛去须毛;
13、板蓝根:拣净杂质,洗净,润透,切片,晒干;
14、金银花:筛去泥沙,拣净杂质;
15、竹茹:除去硬竹签、杂质,抖掉灰屑,揉成小团或切段;
16、陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥,筛去灰屑;
17、山楂:拣净杂质,筛去核;
18、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透切片,晒干;
19、黄芪:拣净杂质,除去残留的根头和空心较大的根,用水浸泡;
20、当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
21、川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
22、赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
23、柏子仁:拣净杂质,除去残留的外壳和种皮;
24、墨旱莲:拣净杂质,除去残根,洗净闷透,切段晒干;
25、白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥;
26、夜交藤:清水洗净,稍浸泡,捞出,润透后,切段,晒干;
27、大青叶:拣去杂质及枯叶,洗净,稍润,切段,晒干。
二、制备
1、将所述重量的黄连、党参、麦冬、丹参、北沙参、玄参、五味子、郁金、降真香、苦参、瓜蒌皮、薤白、板蓝根、金银花、竹茹、陈皮、山楂、甘草、黄芪、当归、川芎、赤芍、柏子仁、墨旱莲、白芍、夜交藤、大青叶放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为3剂服用。
组方中黄连有泻火燥湿,解毒杀虫的功能为君药;丹参有活血去瘀,安神宁心,排脓止痛的功能;郁金有行气解随,凉血破瘀的功能,二者为臣药,三味药共同发挥泻火燥湿,解毒杀虫,活血去瘀,安神宁心,行气解随,凉血破瘀的作用,治疗病毒性心肌炎效力全面,且以解毒杀虫,活血去瘀,行气解随为主可治本,瓜蒌皮有清热化痰,利气宽胸的功能为佐药,板蓝根有清热,解毒,凉血的功能为使药,与下余诸药是治标。
本发明药物具有泻火燥湿,解毒杀虫,活血去瘀,安神宁心,行气解随,凉血破瘀,清热解毒的功能,用于治疗病毒性心肌炎,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治病毒性心肌炎门诊患者共33例。
2、诊断标准
典型症状为患者常在发病前1~3周多有急性病毒感染史,表现为发热、全身酸痛、咽痛、咳嗽、倦怠、恶心、呕吐、腹泻等症状,然后出现心悸、胸闷、胸痛或心前区隐痛、头晕、呼吸困难、水肿,极少数患者出现心力衰竭或心源性休克。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,10天为一个疗程,连续服用3个疗程。
4、疗效评定标准
显效:病毒性心肌炎症状消失,恢复正常,痊愈;
好转:病毒性心肌炎症状明显好转,咽痛、咳嗽、腹泻、胸闷得到有效控制,体质逐步恢复正常;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗病毒性心肌炎患者33例,结果显效27例,显效率为81.8%,好转4例,好转率为12.1%,无效2例,总有效率为93.9%。
Claims (3)
1.一种治疗病毒性心肌炎的药物,其特征在于:它是由下列重量范围内的原料药制成:
黄连3-5克,党参15-25克,麦冬10-14克,丹参5-15克,北沙参15-25克,玄参5-15克,五味子2-6克,郁金10-14克,降真香4-8克,苦参5-15克,瓜蒌皮5-9克,薤白5-9克,板蓝根10-20克,金银花10-20克,竹茹5-15克,陈皮5-15克,山楂5-15克,甘草4-8克,黄芪10-20克,当归5-15克,川芎5-15克,赤芍5-15克,柏子仁5-15克,墨旱莲5-15克,白芍5-15克,夜交藤10-20克,大青叶10-20克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
黄连5克,党参20克,麦冬12克,丹参10克,北沙参20克,玄参10克,五味子4克,郁金12克,降真香6克,苦参10克,瓜蒌皮7克,薤白7克,板蓝根15克,金银花15克,竹茹10克,陈皮10克,山楂10克,甘草6克,黄芪15克,当归10克,川芎10克,赤芍10克,柏子仁10克,墨旱莲10克,白芍10克,夜交藤15克,大青叶15克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)黄连:拣去杂质,洗净泥砂,润透,切片,阴干;
(2)党参:洗净泥沙后润透去芦,切片或切段,晒干;
(3)麦冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干;
(4)丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
(5)北沙参:拣去杂质,除去茎基,用水略洗,捞出,稍润,切段,晒干;
(6)玄参:拣净杂质,除去芦头,洗净润透,切片,晾干;
(7)五味子:筛去灰屑,除去杂质,置蒸笼内蒸透,取出晒干;
(8)郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干;
(9)降真香:水浸后,蒸至适度,镑片或刨片,晒干;
(10)苦参:拣净杂质,除去残茎,洗净泥土,用水浸泡,捞出,润透,切片,晒干;
(11)瓜蒌皮:取原药材,除去果柄及杂质,抢水洗净,润透,切丝,干燥,筛去碎屑;
(12)薤白:拣去杂质,簸筛去须毛;
(13)板蓝根:拣净杂质,洗净,润透,切片,晒干;
(14)金银花:筛去泥沙,拣净杂质;
(15)竹茹:除去硬竹签、杂质,抖掉灰屑,揉成小团或切段;
(16)陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥,筛去灰屑;
(17)山楂:拣净杂质,筛去核;
(18)甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透切片,晒干;
(19)黄芪:拣净杂质,除去残留的根头和空心较大的根,用水浸泡;
(20)当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
(21)川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
(22)赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
(23)柏子仁:拣净杂质,除去残留的外壳和种皮;
(24)墨旱莲:拣净杂质,除去残根,洗净闷透,切段晒干;
(25)白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥;
(26)夜交藤:清水洗净,稍浸泡,捞出,润透后,切段,晒干;
27、大青叶:拣去杂质及枯叶,洗净,稍润,切段,晒干;
(二)制备
(1)将所述重量的黄连、党参、麦冬、丹参、北沙参、玄参、五味子、郁金、降真香、苦参、瓜蒌皮、薤白、板蓝根、金银花、竹茹、陈皮、山楂、甘草、黄芪、当归、川芎、赤芍、柏子仁、墨旱莲、白芍、夜交藤、大青叶放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为3剂服用。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710171586.1A CN106798896A (zh) | 2017-03-22 | 2017-03-22 | 一种治疗病毒性心肌炎的药物及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710171586.1A CN106798896A (zh) | 2017-03-22 | 2017-03-22 | 一种治疗病毒性心肌炎的药物及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN106798896A true CN106798896A (zh) | 2017-06-06 |
Family
ID=58988319
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710171586.1A Withdrawn CN106798896A (zh) | 2017-03-22 | 2017-03-22 | 一种治疗病毒性心肌炎的药物及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN106798896A (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108310142A (zh) * | 2018-05-04 | 2018-07-24 | 李智龙 | 一种治疗病毒性心肌炎的中药 |
-
2017
- 2017-03-22 CN CN201710171586.1A patent/CN106798896A/zh not_active Withdrawn
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108310142A (zh) * | 2018-05-04 | 2018-07-24 | 李智龙 | 一种治疗病毒性心肌炎的中药 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102973822B (zh) | 一种治疗口臭的药物及其制备方法 | |
CN103751682B (zh) | 一种治疗肺热咳嗽的药物及其制备方法 | |
CN106853187A (zh) | 一种治疗血小板减少性紫癜的药物及其制备方法 | |
CN106798896A (zh) | 一种治疗病毒性心肌炎的药物及其制备方法 | |
CN106692792A (zh) | 一种治疗急性肺脓肿的药物及其制备方法 | |
CN106692832A (zh) | 一种治疗咳嗽的药物及其制备方法 | |
CN108310281A (zh) | 一种治疗鼻咽癌的药物及其制备方法 | |
CN107638557A (zh) | 一种治疗上呼吸道感染的药物及其制备方法 | |
CN106924694A (zh) | 一种治疗习惯性便秘的药物及其制备方法 | |
CN106692889A (zh) | 一种治疗甲状腺肿瘤的药物及其制备方法 | |
CN106692764A (zh) | 一种治疗猩红热的药物及其制备方法 | |
CN106822651A (zh) | 一种治疗过敏性紫癜的药物及其制备方法 | |
CN107080829A (zh) | 一种治疗哮喘的药物及其制备方法 | |
CN106798907A (zh) | 一种治疗肾病综合症的药物及其制备方法 | |
CN106692858A (zh) | 一种治疗胎动不安的药物及其制备方法 | |
CN105963586A (zh) | 一种治疗肺脓肿的药物及其制备方法 | |
CN106620361A (zh) | 一种治疗流行性出血热的药物及其制备方法 | |
CN108743877A (zh) | 一种治疗心律失常的药物及其制备方法 | |
CN106924667A (zh) | 一种治疗流行性脑脊髓膜炎的药物及其制备方法 | |
CN107496710A (zh) | 一种治疗子宫脱垂的药物及其制备方法 | |
CN108273014A (zh) | 一种治疗鼻咽癌的药物及其制备方法 | |
CN107029102A (zh) | 一种治疗支气管哮喘的药物及其制备方法 | |
CN106692887A (zh) | 一种治疗急性黄疸性肝炎的药物及其制备方法 | |
CN108310194A (zh) | 一种治疗毛囊炎的药物及其制备方法 | |
CN106692574A (zh) | 一种治疗皮下脂肪瘤的药物及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WW01 | Invention patent application withdrawn after publication | ||
WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170606 |