CN106692764A - 一种治疗猩红热的药物及其制备方法 - Google Patents

一种治疗猩红热的药物及其制备方法 Download PDF

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CN106692764A
CN106692764A CN201710187824.8A CN201710187824A CN106692764A CN 106692764 A CN106692764 A CN 106692764A CN 201710187824 A CN201710187824 A CN 201710187824A CN 106692764 A CN106692764 A CN 106692764A
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李少伦
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李少伦
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Abstract

本发明公开了一种治疗猩红热的药物及其制备方法,其主要是由石斛、麦冬、金银花、芦根、生地黄、大青叶、菊花、金果榄、板蓝根、牡丹皮、紫草、丹参、牛蒡子、地骨皮、紫花地丁、重楼、黄芩、浮萍、竹茹、山楂、钩藤、知母、浙贝母、甘草、连翘按一定重量配比制备而成,本发明药物具有清热养阴,清热解毒,凉血,宣肺透疹,滋阴降火的功能,用于治疗猩红热见效快、疗效好,不复发。

Description

一种治疗猩红热的药物及其制备方法
技术领域
[0001] 本发明涉及一种治疗猩红热的药物及其制备方法,属中药领域。 技术背景
[0002] 猩红热为A组溶血性链球菌感染引起的急性呼吸道传染病。中医则认为猩红热与 邪侵肺卫,毒在气营,疹后阴伤有关。由于西药治疗副作用大,因此人们对有效治疗猩红热 的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
[0003] 本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗猩红 热的药物,从而完成了本发明。
[0004] 本发明的目的就是提供一种有效治疗猩红热的中药组合药物。
[0005] 本发明的另一目的就是提供了该中药组合药物的制备方法。
[0006] 本发明药物是选择石斛、麦冬、金银花、芦根、生地黄、大青叶、菊花、金果榄、板蓝 根、牡丹皮、紫草、丹参、牛蒡子、地骨皮、紫花地丁、重楼、黄芩、浮萍、竹茹、山楂、钩藤、知 母、浙贝母、甘草、连翘、玄参、桔梗、赤芍进行组合制备的,将这些药物组合使得各药物功效 产生协同作用,从而能够有效治疗猩红热。其中选用石斛是因为其性味甘淡微咸,寒,入有、 肺、肾经,有生津益胃,清热养阴的功能,治热病伤津,口干烦喝,病后虚热,阴伤目暗。选用 麦冬是因为其性味甘微苦,寒,入肺、胃、心经,有养阴润肺,清心除烦,益胃生津的功能,治 肺燥干咳,吐血,咯血,肺痿,肺痈,虚劳烦热,清渴,热病津伤,咽干口燥,便秘。选用金银花 是因为其性味甘,寒,入肺、胃经,有清热,解毒的功能,治温病发热,热毒血痢,痈疡,肿毒, 瘰疬,痔漏。选用芦根是因为其性味甘,寒,入肺,胃经,有清热,生津,除烦,止呕的功能,治 热病烦渴,胃热呕吐,噎膈,反胃,肺痿,肺痈,并解河豚鱼毒。选用生地黄是因为其性味甘, 寒,归心、肝、肾经,有清热凉血,养阴,生津的功能,治热病烦渴,阴虚内热,骨蒸劳热,内热 消渴,吐血,衄血,发斑发疹。选用大青叶是因为其性味苦,寒,入肝、心、胃经,有清热,解毒, 凉血,止血的功能,治温病热盛烦渴,流行性感冒,急性传染性肝炎,菌痢,急性胃肠炎,急性 肺炎,丹毒,吐血,紐血,黄疸,痢疾,喉痹,口疮,痈疽肿毒。选用菊花是因为其性味甘苦,凉, 入肺,肝经,有疏风,消热,明目,解毒的功能,治头痛,眩晕,目赤,心胸烦热,疔疮,肿毒。选 用金果榄是因为其性味苦,寒,入脾、肾二经,有清热解毒的功能,治急慢性扁桃体炎,急性 咽喉炎,口腔炎,腮腺炎,乳腺炎,阑尾炎,痈疽疔疮,急慢性肠炎,菌痢,胃痛,热嗽失音。选 用板蓝根是因为其性味苦,寒,入肝、胃血分,有清热,解毒,凉血的功能,治流感,流脑,乙 脑,肺炎,丹毒,热毒发斑,神昏吐衄,咽肿,痄腮,火眼,疮疹。选用牡丹皮是因为其性味辛 苦,凉,入心、肝、肾经,有清热,凉血,和血,消瘀的功能,治热入血分,发斑,惊癎,吐、衄、便 血,骨蒸劳热,经闭,癥瘕,痈疡,扑损。选用紫草是因为其性味苦苦,寒,入心包络、肝经,有 凉血,活血,清热解毒的功能,治温热斑疹,湿热黄疸,紫癜,吐、衄、尿血,淋浊,血痢,热结便 秘,烧伤,湿疹,丹毒,痈疡。选用丹参是因为其性味苦,微温,入心、肝经,有活血去瘀,安神 宁心,排脓,止痛的功能,治心绞痛,月经不调,痛经,以闭,血崩带下,癥瘕,积聚,瘀血腹痛, 骨节疼痛,惊悸不眠,恶疮肿毒。选用牛蒡子是因为其性味辛苦,凉,入肺、胃经,有疏散风 热,宣肺透疹,消肿解毒的功能,治风热咳嗽,咽喉肿痛,斑疹不透,风疹作痒,痈肿疮毒。选 用地骨皮是因为其性味甘,寒,入肺、肝、肾经,有清热,凉血的功能,治虚劳潮热盗汗,肺热 咳喘,吐血,衄血,血淋,消渴,高血压,痈肿,恶疮。选用紫花地丁是因为其性味苦、辛、寒,归 心、肝经,有清热解毒,凉血消肿的功能,治疔疮肿毒,痈疽发背,丹毒,毒蛇咬伤。选用重楼 是因为其性味苦,微寒,有小毒,归肝经,有清热解毒,消肿止痛,凉肝定惊的功能,治疔疮痈 月中,咽喉肿痛,毒蛇咬伤,跌扑伤痛,惊风抽搐。选用黄芩是因为其性味苦寒,入心肺、胆、大 肠经,有泻实火,除湿热,止血安胎的功能,治壮热烦渴,肺热咳嗽。选用浮萍是因为其性味 辛,寒,入肺经,有发汗,祛风,行水,清热,解毒的功能,治时行热病,斑疹不透,风热瘾疹,皮 肤瘙痒,水肿,癃闭,疮癣,丹毒,烫伤。选用竹茹是因为其性味甘,凉,入胃、胆经,有清热,凉 血,化痰,止吐的功能,治烦热呕吐、呃逆,痰热咳喘,吐血,衄血,崩漏,恶阻,胎动,惊癎。选 用山楂是因为其性味酸甘,微温,入脾、胃、肝经,有消食积,散瘀血,驱绦虫的功能,治肉积, 癥瘕,痰饮,痞满,吞酸,泻痢,肠风,腰痛,疝气,产后儿枕痛,恶露不尽,小儿乳食停滞。选用 钩藤是因为其性味苦,凉,入肝、心经,有清热平肝,熄风定惊的功能,治小儿惊癎瘈痕,大人 血压偏高,头晕、目眩,妇人子癎。选用知母是因为其性味苦,寒,入肺、胃、肾经,有滋阴降 火,润燥滑肠的功能,治烦热消渴,骨蒸劳热,肺热咳嗽,大便燥结,小便不利。选用浙贝母是 因为其性味苦,微寒,归肺、心、经,有清热散结,化痰止咳的功能,治风热犯肺,痰火咳嗽,肺 痈,乳痈,瘰疬,疮毒,心胸郁闷。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急, 润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸, 惊痈,生用治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用连翘是因为其性味 苦,凉,入心、肝、胆经,有清热,解毒,散结,消肿的功能,治温热,丹毒,斑疹,痈疡肿毒,瘰 疬,小便淋闭。选用玄参是因为其性味苦,咸,凉,入肺、肾经,有滋阴,降火,除烦,解毒的功 能,治热病烦渴,发斑,骨蒸劳热,夜寐不宁,自汗盗汗,津伤便秘,吐血衄血,咽喉肿痛,痈 月中,瘰疬。选用桔梗是因为其性味苦辛,平,入肺、胃经,有开宣肺气,祛痰排脓的功能,治外 感咳嗽,咽喉肿痛,肺痈吐脓,胸满胁痛,痢疾腹痛。选用赤芍是因为其性味苦,微寒,归肝 经,有清热凉血,散瘀止痛的功能,治温毒发狂,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经, 癎瘕腹痛,跌扑损伤,痈肿疮疡。
具体实施方式
[0007] 本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重 量范围内都具有较好的疗效: 石斛5-15克,麦冬10-15克,金银花5-15克,芦根10-20克,生地黄10-15克,大青叶15-20 克,菊花10-20克,金果榄5-10克,板蓝根15-25克,牡丹皮5-15克,紫草15-25克,丹参10-20 克,牛蒡子15-20克,地骨皮5-15克,紫花地丁10-20克,重楼10-15克,黄芩10-20克,浮萍5-15克,竹茹10-15克,山楂5-15克,钩藤10-15克,知母5-15克,浙贝母10-15克,甘草10-20克, 连翘10-20克,玄参5-15克,桔梗10-20克,赤芍10-15克。
[0008] 优选为: 石斛10克,麦冬12克,金银花10克,芦根15克,生地黄12克,大青叶18克,菊花15克,金果 榄8克,板蓝根20克,牡丹皮10克,紫草20克,丹参15克,牛蒡子18克,地骨皮10克,紫花地丁 15克,重楼12克,黄芩15克,浮萍10克,竹茹12克,山楂10克,钩藤12克,知母10克,浙贝母12 克,甘草15克,连翘15克,玄参10克,桔梗15克,赤芍12克。
[0009] 本发明药物的制备方法如下 一、备料 1、 石斛:取干燥的石斛,用水泡约至八成透,闷润,除去残根及黑枝,切段,撞去薄膜,晒 干; 2、 麦冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干; 3、 金银花:筛去泥沙,拣净杂质; 4、 芦根:拣去杂质及根,切段,晒干; 5、 生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎肩; 6、 大青叶:拣去杂质及枯叶,洗净,稍润,切段,晒干; 7、 菊花:拣净叶梗、花柄及泥肩杂质; 8、 金果榄:去净杂质,用水浸泡,约七成透,取出,待润至内外湿度均匀,切片或切成小 块,晒干; 9、 板蓝根:拣净杂质,洗净,润透,切片,晒干; 10、 牡丹皮:拣去杂质,除去木心,洗净,润透,切片,瞭干; 11、 紫草:洗净,润透,切片,晒干; 12、 丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干; 13、 牛蒡子:拣去杂质,筛去泥肩; 14、 地骨皮:拣去杂质及木心,略洗,切段,晒干; 15、 紫花地丁:取原药材,除去杂质,洗净,稍晾,切段,干燥; 16、 重楼:除去须根,洗净,干燥; 17、 黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干; 18、 浮萍:6-9月间捞取,晒士; 19、 竹茹:除去硬竹签、杂质,抖掉灰肩,揉成小团或切段; 20、 山楂:拣净杂质,筛去核; 21、 钩藤:拣去老梗、杂质,洗净,晒干; 22、 知母:拣净杂质,用水撞洗,捞出,润软,切片晒干; 23、 浙贝母:除去杂质,大小分档,洗净,润透,切厚片,干燥,街去碎肩,或打碎; 24、 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,凉干; 25、 连翘:拣净杂质,搓开,除去枝梗; 26、 玄参:拣净杂质,除去芦头,洗净润透,切片,晾干; 27、 桔梗:拣净杂质,除去芦头,洗净捞出,润透后切片,晒干; 28、 赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎肩。
[0010] 二、制备 1、将所述重量的石斛、麦冬、金银花、芦根、生地黄、大青叶、菊花、金果榄、板蓝根、牡丹 皮、紫草、丹参、牛蒡子、地骨皮、紫花地丁、重楼、黄芩、浮萍、竹茹、山楂、钩藤、知母、浙贝 母、甘草、连翘、玄参、桔梗、赤芍放入煎药容器内,第一次加水8倍量,浸泡100分钟后,武火 煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内; 2、 将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液; 3、 将两次煎煮液混合搅拌均匀,分为3剂服用。
[0011] 组方中石斛有生津益胃,清热养阴的功能为君药;大青叶清热,解毒,凉血,止血; 生地黄有清热凉血,养阴,生津的功能,二者为臣药,三味药共同发挥清热养阴,清热解毒, 凉血,生津益胃的作用,治疗猩红热效力全面,且以清热养阴,清热解毒,凉血为主可治本, 牛蒡子有疏散风热,宣肺透疹,消肿解毒的功能为佐药,玄参有滋阴,降火,除烦,解毒的功 能为使药,与下余诸药是治标。
[0012] 本发明药物具有清热养阴,清热解毒,凉血,宣肺透疹,滋阴降火的功能,用于治疗 猩红热,疗程短、见效快、治愈后不复发。
[0013] 以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发 明药物的动物毒性试验报告和临床疗效观察资料。
[0014] [试验例1]本发明药物的动物毒性试验报告: 取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验 组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给 药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良 毒副作用。
[0015] [试验例2]本发明药物的临床疗效观察 1、一般资料 收治猩红热门诊患者共19例。
[0016] 2、诊断标准 典型症状为发热、咽峡炎、全身弥漫性鲜红色皮疹和疹退后明显的脱肩。少数患者患病 后由于变态反应而出现心、肾、关节的损害。
[0017] 3、治疗方法 选用上述药剂,给患者服用,每次服用1剂,每天早、中、晚各服1次,7天为一个疗程,连 续服用3个疗程。
[0018] 4、疗效评定标准 显效:猩红热症状消失,恢复正常,痊愈; 好转:患者发热、咽峡炎、全身弥漫性鲜红色皮疹,心、肾、关节损害的现象减轻,猩红热 症状明显好转,逐步恢复正常; 无效:达不到好转标准者。
[0019] 5、治疗结果(见下表)
Figure CN106692764AD00071
在上述治疗中,用本发明药物治疗猩红热患者19例,结果显效16例,显效率为84.22%, 好转2例,好转率为10.52%,无效1例,总有效率为94.74%。

Claims (3)

1. 一种治疗猩红热的药物,其特征在于:它是由下列重量范围内的原料药制成: 石斛5-15克,麦冬10-15克,金银花5-15克,芦根10-20克,生地黄10-15克,大青叶15-20 克,菊花10-20克,金果榄5-10克,板蓝根15-25克,牡丹皮5-15克,紫草15-25克,丹参10-20 克,牛蒡子15-20克,地骨皮5-15克,紫花地丁10-20克,重楼10-15克,黄芩10-20克,浮萍5-15克,竹茹10-15克,山楂5-15克,钩藤10-15克,知母5-15克,浙贝母10-15克,甘草10-20克, 连翘10-20克,玄参5-15克,桔梗10-20克,赤芍10-15克。
2. 根据权利要求1所述的药物,其中各原料药的用量为: 石斛10克,麦冬12克,金银花10克,芦根15克,生地黄12克,大青叶18克,菊花15克,金果 榄8克,板蓝根20克,牡丹皮10克,紫草20克,丹参15克,牛蒡子18克,地骨皮10克,紫花地丁 15克,重楼12克,黄芩15克,浮萍10克,竹茹12克,山楂10克,钩藤12克,知母10克,浙贝母12 克,甘草15克,连翘15克,玄参10克,桔梗15克,赤芍12克。
3. 根据权利要求1或2所述药物的制备方法,它包括下列步骤: (一)备料 (1) 石斛:取干燥的石斛,用水泡约至八成透,闷润,除去残根及黑枝,切段,撞去薄膜, 晒干; (2) 麦冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干; (3) 金银花:筛去泥沙,拣净杂质; (4) 芦根:拣去杂质及根,切段,晒干; (5) 生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎肩; (6) 大青叶:拣去杂质及枯叶,洗净,稍润,切段,晒干; (7) 菊花:拣净叶梗、花柄及泥肩杂质; (8) 金果榄:去净杂质,用水浸泡,约七成透,取出,待润至内外湿度均匀,切片或切成小 块,晒干; (9) 板蓝根:拣净杂质,洗净,润透,切片,晒干; (10) 牡丹皮:拣去杂质,除去木心,洗净,润透,切片,瞭干; (11) 紫草:洗净,润透,切片,晒干; (12) 丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,瞭干; (13) 牛蒡子:拣去杂质,筛去泥肩; (14) 地骨皮:拣去杂质及木心,略洗,切段,晒干; (15) 紫花地丁:取原药材,除去杂质,洗净,稍晾,切段,干燥; (16) 重楼:除去须根,洗净,干燥; (17) 黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干; (18) 浮萍:6-9月间捞取,晒士; (19) 竹茹:除去硬竹签、杂质,抖掉灰肩,揉成小团或切段; (20) 山楂:拣净杂质,筛去核; (21) 钩藤:拣去老梗、杂质,洗净,晒干; (22) 知母:拣净杂质,用水撞洗,捞出,润软,切片晒干; (23) 浙贝母:除去杂质,大小分档,洗净,润透,切厚片,干燥,街去碎肩,或打碎; (24) 甘草:拣去杂质,洗净,用水浸泡至Λ成透时,捞出,润透,切片,凉干; (25) 连翘:拣净杂质,搓开,除去枝梗; (26) 玄参:拣净杂质,除去芦头,洗净润透,切片,晾干; (27) 桔梗:拣净杂质,除去芦头,洗净捞出,润透后切片,晒干; (28) 赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎肩; (二)制备 (1) 将所述重量的石斛、麦冬、金银花、芦根、生地黄、大青叶、菊花、金果榄、板蓝根、牡 丹皮、紫草、丹参、牛蒡子、地骨皮、紫花地丁、重楼、黄芩、浮萍、竹茹、山楂、钩藤、知母、浙贝 母、甘草、连翘、玄参、桔梗、赤芍放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸 腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内; (2) 将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液; (3) 将两次煎煮液混合搅拌均匀,分为3剂服用。
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