CN106860744A - 一种治疗流行性腮腺炎的药物及其制备方法 - Google Patents
一种治疗流行性腮腺炎的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗流行性腮腺炎的药物及其制备方法,其主要是由板蓝根、忍冬藤、大青叶、牛蒡子、金银花、柴胡、青黛、瓜蒌、葛根、桔梗、蒲公英、紫花地丁、乳香、没药、野菊花、独活、连翘、龙胆、牡丹皮、栀子、浮萍、防风按一定重量配比制备而成,本发明药物具有清热解毒,散结消肿,清热凉血,宽胸散结,滋阴降火的功能,用于治疗流行性腮腺炎见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗流行性腮腺炎的药物及其制备方法,属中药领域。
背景技术
流行性腮腺炎是由腮腺炎病毒引起的急性、全身性感染,以腮腺肿痛为主要特征,有时亦可累及其他唾液腺。中医则认为流行性腮腺炎与外感风邪,邪毒壅滞,热毒炽盛有关。由于西药治疗副作用大,因此人们对有效治疗流行性腮腺炎的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗流行性腮腺炎的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗流行性腮腺炎的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择板蓝根、忍冬藤、大青叶、牛蒡子、金银花、柴胡、青黛、瓜蒌、葛根、桔梗、蒲公英、紫花地丁、乳香、没药、野菊花、独活、连翘、龙胆、牡丹皮、栀子、浮萍、防风、甘草、浙贝母、玄参进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗流行性腮腺炎。其中选用板蓝根是因为其性味苦,寒,入肝、胃血分,有清热,解毒,凉血的功能,治流感,流脑,乙脑,肺炎,丹毒,热毒发斑,神昏吐衄,咽肿,痄腮,火眼,疮疹。选用忍冬藤是因为其性味甘,寒,入心、肺经,有清热,解毒,通络的功能,治温病发热,热毒血痢,传染性肝炎,痈肿疮毒,筋骨疼痛。选用大青叶是因为其性味苦,寒,入肝、心、胃经,有清热,解毒,凉血,止血的功能,治温病热盛烦渴,流行性感冒,急性传染性肝炎,菌痢,急性胃肠炎,急性肺炎,丹毒,吐血,衄血,黄疸,痢疾,喉痹,口疮,痈疽肿毒。选用牛蒡子是因为其性味辛苦,凉,入肺、胃经,有疏散风热,宣肺透疹,消肿解毒的功能,治风热咳嗽,咽喉肿痛,斑疹不透,风疹作痒,痈肿疮毒。选用金银花是因为其性味甘,寒,入肺、胃经,有清热,解毒的功能,治温病发热,热毒血痢,痈疡,肿毒,瘰疬,痔漏。选用柴胡是因为其性味苦,凉,入肝、胆经,有和解表里,疏肝,升阳的功能,治寒热往来,胸满胁痛,口苦耳聋,头痛目眩,疟疾,下利脱肛,月经不调,子宫下垂。选用青黛是因为其性味咸,寒,入肝、肺、胃经,有清热,凉血,解毒的功能,治温病热盛,斑疹,吐血、咯血,小儿惊癎,疮肿,丹毒,蛇虫咬伤。选用瓜蒌是因为其性味甘、微苦,寒,归肺、胃、大肠经,有清热涤痰,宽胸散结,润燥滑肠的功能,治肺热咳嗽,痰浊黄稠,胸痹心痛,结胸痞满,乳痈,肠痈,大便秘结。选用葛根是因为其性味甘辛,平,入脾、胃经,有升阳解肌,透疹止泻,除烦止渴的功能,治伤寒,温热,头痛,项强,烦热消喝,泄泻,痢疾,癍诊不透,高血压,心绞痛,耳聋。选用桔梗是因为其性味苦辛,平,入肺、胃经,有开宣肺气,祛痰排脓的功能,治外感咳嗽,咽喉肿痛,肺痈吐脓,胸满胁痛,痢疾腹痛。选用蒲公英是因为其性味苦甘,寒,入肝、胃经,有清热解毒,利尿散结的功能,治急性乳腺炎,淋巴腺炎,瘰疬,疔毒疮肿,急性结膜炎,感冒发热,急性扁桃体炎,急性支气管炎,胃炎,肝炎,胆囊炎,尿路感染。选用紫花地丁是因为其性味苦、辛、寒,归心、肝经,有清热解毒,凉血消肿的功能,治疔疮肿毒,痈疽发背,丹毒,毒蛇咬伤。选用乳香是因为其性味辛苦,温,入心、肝、脾经,有调气活血,定痛,追毒的功能,治气血凝滞,心腹疼痛,痈疮肿毒,跌打损伤,痛经,产后瘀血刺痛。选用没药是因为其性味苦,平,入肝经,有散血去瘀,消肿定痛的功能,治跌损,金疮,筋骨,心腹诸痛,癥瘕,经闭,痈疽肿痛,痔漏,目障。选用野菊花是因为其性味苦辛,凉,入肺、肝经,有疏风清热,消肿解毒的功能,治风热感冒,肺炎,白喉,胃肠炎,高血压,疔,痈,口疮,丹毒,湿疹,天泡疮。选用独活是因为其性味辛苦,温,入肾、膀胱经,有祛风,胜湿,散寒,止痛的功能,治风寒湿痹,腰漆酸痛,手脚挛痛,慢性气管炎,头痛,齿痛。选用连翘是因为其性味苦,凉,入心、肝、胆经,有清热,解毒,散结,消肿的功能,治温热,丹毒,斑疹,痈疡肿毒,瘰疬,小便淋闭。选用龙胆是因为其性味苦,寒,入肝、胆经,有泻肝实火,除下焦湿热的功能,治肝经热盛,惊癎狂躁,乙型脑炎,头痛,目赤,咽痛,黄疸,热痢,痈肿疮疡,阴囊肿痛,阴部湿痒。选用牡丹皮是因为其性味辛苦,凉,入心、肝、肾经,有清热,凉血,和血,消瘀的功能,治热入血分,发斑,惊癎,吐、衄、便血,骨蒸劳热,经闭,癥瘕,痈疡,扑损。选用栀子是因为其性味苦,寒,入心、肝、肺、胃经,有清热,泻火,凉血的功能,治热病虚烦不眠,黄疸,淋病,消渴,目赤,咽痛,吐血,衄血,血痢,尿血,热毒疮疡,扭伤肿痛。选用浮萍是因为其性味辛,寒,入肺经,有发汗,祛风,行水,清热,解毒的功能,治时行热病,斑疹不透,风热瘾疹,皮肤瘙痒,水肿,癃闭,疮癣,丹毒,烫伤。选用防风是因为其性味辛甘,温,入膀胱、肺、脾经,有发表,祛风,胜湿,止痛的功能,治外感风寒,头痛,目眩,项强,风寒湿痹,骨节酸痛,四肢挛急,破伤风。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊痈,生用治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用浙贝母是因为其性味苦,微寒,归肺、心经,有清热散结,化痰止咳的功能,治风热犯肺,痰火咳嗽,肺痈,乳痈,瘰疬,疮毒,心胸郁闷。选用玄参是因为其性味苦,咸,凉,入肺、肾经,有滋阴,降火,除烦,解毒的功能,治热病烦渴,发斑,骨蒸劳热,夜寐不宁,自汗盗汗,津伤便秘,吐血衄血,咽喉肿痛,痈肿,瘰疬。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
板蓝根10-15克,忍冬藤10-20克,大青叶15-25克,牛蒡子5-15克,金银花10-20克,柴胡5-10克,青黛5-15克,瓜蒌5-10克,葛根10-20克,桔梗10-15克,蒲公英10-20克,紫花地丁10-15克,乳香5-10克,没药5-10克,野菊花10-20克,独活5-15克,连翘5-15克,龙胆5-15克,牡丹皮5-15克,栀子10-15克,浮萍5-15克,防风10-15克,甘草5-15克,浙贝母5-10克,玄参5-15克。
优选为:
板蓝根12克,忍冬藤15克,大青叶20克,牛蒡子10克,金银花15克,柴胡8克,青黛10克,瓜蒌8克,葛根15克,桔梗12克,蒲公英15克,紫花地丁12克,乳香8克,没药8克,野菊花15克,独活10克,连翘10克,龙胆10克,牡丹皮10克,栀子12克,浮萍10克,防风12克,甘草10克,浙贝母8克,玄参10克。
本发明药物的制备方法如下
一、备料
1、板蓝根:拣净杂质,洗净,润透,切片,晒干;
2、忍冬藤:拣去杂质,用水浸泡,润透,切片,晒干;
3、大青叶:拣去杂质及枯叶,洗净,稍润,切段,晒干;
4、牛蒡子:拣去杂质,筛去泥屑;
5、金银花:筛去泥沙,拣净杂质;
6、柴胡:取原药材,除去残茎,杂质,洗净,润软,切厚片,干燥,筛去碎屑;
7、青黛:拣去杂质,过箩;
8、瓜蒌:取原药材,除去杂质及果柄,洗净,压扁,切丝或小块,干燥;
9、葛根:拣去杂质,洗净,用水浸泡,捞出,润透,及时切片,晒干;
10、桔梗:拣净杂质,除去芦头,洗净捞出,润透后切片,晒干;
11、蒲公英:拣去杂质,洗净泥土,切段,晒干;
12、紫花地丁:取原药材,除去杂质,洗净,稍晾,切段,干燥;
13、乳香:拣去砂子杂质;
14、没药:拣去杂质,打成碎块;
15、野菊花:去净杂质,除去残根,洗净切段,晒干;
16、独活:拣去杂质,分开大小个,洗净,润透后切片,干燥;
17、连翘:拣净杂质,搓开,除去枝梗;
18、龙胆:拣去杂质,除去残茎,洗净,润透后切段,晒干;
19、牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
20、栀子:筛去灰屑,拣去杂质,碾碎过筛或剪去两端;
21、浮萍:6-9月间捞取,晒干;
22、防风:除去残茎,用水浸泡,捞出,润透切片,晒干;
23、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,凉干;
24、浙贝母:除去杂质,大小分档,洗净,润透,切厚片,干燥,街去碎屑,或打碎;
25、玄参:拣净杂质,除去芦头,洗净润透,切片,晾干。
二、制备
1、将所述重量的板蓝根、忍冬藤、大青叶、牛蒡子、金银花、柴胡、青黛、瓜蒌、葛根、桔梗、蒲公英、紫花地丁、乳香、没药、野菊花、独活、连翘、龙胆、牡丹皮、栀子、浮萍、防风、甘草、浙贝母、玄参放入煎药容器内,第一次加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为3剂服用。
组方中连翘有清热,解毒,散结,消肿的功能为君药;板蓝根清热,解毒,凉血;瓜蒌有清热涤痰,宽胸散结,润燥滑肠的功能,二者为臣药,三味药共同发挥清热解毒,散结消肿,凉血,清热涤痰,宽胸散结,润燥滑肠的作用,治疗流行性腮腺炎效力全面,且以清热解毒,散结消肿,凉血,清热涤痰,宽胸散结为主可治本,栀子有清热,泻火,凉血的功能为佐药,玄参有滋阴,降火,除烦,解毒的功能为使药,二者是治标。
本发明药物具有清热解毒,散结消肿,清热凉血,宽胸散结,滋阴降火的功能,用于治疗流行性腮腺炎,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治流行性腮腺炎门诊患者共23例。
2、诊断标准
典型症状为发热、畏寒、头痛、肌痛、咽痛、食欲不佳、恶心、呕吐、全身不适等。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,7天为一个疗程,连续服用2个疗程。
4、疗效评定标准
显效:流行性腮腺炎症状消失,痊愈;
好转:患者发热、畏寒、头痛、肌痛、咽痛、食欲不佳、恶心、呕吐、全身不适的现象减轻,流行性腮腺炎症状明显好转,逐步恢复正常;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗流行性腮腺炎患者23例,结果显效20例,显效率为86.96%,好转2例,好转率为8.7%,无效1例,总有效率为95.66%。
Claims (3)
1.一种治疗流行性腮腺炎的药物,其特征在于:它是由下列重量范围内的原料药制成:
板蓝根10-15克,忍冬藤10-20克,大青叶15-25克,牛蒡子5-15克,金银花10-20克,柴胡5-10克,青黛5-15克,瓜蒌5-10克,葛根10-20克,桔梗10-15克,蒲公英10-20克,紫花地丁10-15克,乳香5-10克,没药5-10克,野菊花10-20克,独活5-15克,连翘5-15克,龙胆5-15克,牡丹皮5-15克,栀子10-15克,浮萍5-15克,防风10-15克,甘草5-15克,浙贝母5-10克,玄参5-15克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
板蓝根12克,忍冬藤15克,大青叶20克,牛蒡子10克,金银花15克,柴胡8克,青黛10克,瓜蒌8克,葛根15克,桔梗12克,蒲公英15克,紫花地丁12克,乳香8克,没药8克,野菊花15克,独活10克,连翘10克,龙胆10克,牡丹皮10克,栀子12克,浮萍10克,防风12克,甘草10克,浙贝母8克,玄参10克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)板蓝根:拣净杂质,洗净,润透,切片,晒干;
(2)忍冬藤:拣去杂质,用水浸泡,润透,切片,晒干;
(3)大青叶:拣去杂质及枯叶,洗净,稍润,切段,晒干;
(4)牛蒡子:拣去杂质,筛去泥屑;
(5)金银花:筛去泥沙,拣净杂质;
(6)柴胡:取原药材,除去残茎,杂质,洗净,润软,切厚片,干燥,筛去碎屑;
(7)青黛:拣去杂质,过箩;
(8)瓜蒌:取原药材,除去杂质及果柄,洗净,压扁,切丝或小块,干燥;
(9)葛根:拣去杂质,洗净,用水浸泡,捞出,润透,及时切片,晒干;
(10)桔梗:拣净杂质,除去芦头,洗净捞出,润透后切片,晒干;
(11)蒲公英:拣去杂质,洗净泥土,切段,晒干;
(12)紫花地丁:取原药材,除去杂质,洗净,稍晾,切段,干燥;
(13)乳香:拣去砂子杂质;
(14)没药:拣去杂质,打成碎块;
(15)野菊花:去净杂质,除去残根,洗净切段,晒干;
(16)独活:拣去杂质,分开大小个,洗净,润透后切片,干燥;
(17)连翘:拣净杂质,搓开,除去枝梗;
(18)龙胆:拣去杂质,除去残茎,洗净,润透后切段,晒干;
(19)牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
(20)栀子:筛去灰屑,拣去杂质,碾碎过筛或剪去两端;
(21)浮萍:6-9月间捞取,晒干;
(22)防风:除去残茎,用水浸泡,捞出,润透切片,晒干;
(23)甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,凉干;
(24)浙贝母:除去杂质,大小分档,洗净,润透,切厚片,干燥,街去碎屑,或打碎;
(25)玄参:拣净杂质,除去芦头,洗净润透,切片,晾干;
(二)制备
(1)将所述重量的板蓝根、忍冬藤、大青叶、牛蒡子、金银花、柴胡、青黛、瓜蒌、葛根、桔梗、蒲公英、紫花地丁、乳香、没药、野菊花、独活、连翘、龙胆、牡丹皮、栀子、浮萍、防风、甘草、浙贝母、玄参放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为3剂服用。
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