CN106822552A - 一种治疗类风湿关节炎的药物及其制备方法 - Google Patents
一种治疗类风湿关节炎的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗类风湿关节炎的药物及其制备方法,其主要是由麻黄、苍术、桂枝、防风、防己、威灵仙、天南星、鸡血藤、桃仁、红花、全蝎、雷公藤、附子、川乌头、石膏、当归、白芍、伸筋草、豨莶草、忍冬藤、知母按一定重量配比制备而成,本发明药物具有祛风通络,消痰散癖,活血通经,去瘀止痛,祛风止痉,通络解毒,舒筋活血的功能,用于治疗类风湿关节炎见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗类风湿关节炎的药物及其制备方法,属中药领域。
背景技术
类风湿关节炎又称类风湿,是一种病因尚未明了的慢性全身性炎症性疾病,目前公认类风湿关节炎是一种自身免疫性疾病。可能与内分泌、代谢、营养、地理、职业、心理和社会环境的差异、细菌和病毒感染及遗传因索等方面有关系,以慢性、对称性、多滑膜关节炎和关节外病变为主要临床表现,属于自身免疫炎性疾病。该病好发于手、腕、足等小关节,反复发作,呈对称分布。早期有关节红肿热痛和功能障碍,晚期关节可出现不同程度的僵硬畸形,并伴有骨和骨骼肌的萎缩,极易致残。由于西药治疗副作用大,因此人们对有效治疗类风湿关节炎的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗类风湿关节炎的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗类风湿关节炎的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择麻黄、苍术、桂枝、防风、防己、威灵仙、天南星、鸡血藤、桃仁、红花、全蝎、雷公藤、附子、川乌头、石膏、当归、白芍、伸筋草、豨莶草、忍冬藤、知母、草乌头、枸杞子、钩藤、地骨皮、桑枝、蒲公英进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗类风湿关节炎。其中选用麻黄是因为其性味辛苦,温,入肺、膀胱经,有发汗,平喘,利水的功能,治伤寒表实,发热恶寒无汗、头痛鼻塞、骨节疼痛,咳嗽气喘,风水浮肿,小便不利,风邪顽痹,皮肤不仁,风疹瘙痒。选用苍术是因为其性味辛苦,温,入脾、胃经,有健脾,燥湿,解郁,辟秽的功能,治湿盛困脾,倦怠嗜卧,脘痞腹胀,食欲不振,呕吐,泄泻,痢疾,疟疾,痰饮,水肿,时气感冒,风寒湿痹,足痿,夜盲。选用桂枝是因为其性味辛甘,温,入膀胱、心、肺经,有发汗解肌,温经通脉的功能,治风寒表证,肩背肢节酸疼,胸痹痰饮,经闭癥瘕。选用防风是因为其性味辛甘,温,入膀胱、肺、脾经,有发表,祛风,胜湿,止痛的功能,治外感风寒,头痛,目眩,项强,风寒湿痹,骨节酸痛,四肢挛急,破伤风。选用防己是因为其性味苦,寒,入膀膛、脾、肾经,有行水,泻下焦湿热的功能,治水肿臌胀,湿热脚气,手足挛痛,癣疥疮肿。选用威灵仙是因为其性味辛咸,温,有毒,入膀胱经,有祛风湿,通经络,消痰涎,散癖积的功能,治痛风、顽痹、腰膝冷痛,脚气,疟疾,癥瘕积聚,破伤风,扁桃体炎,诸骨鲠咽。选用天南星是因为其性味苦辛,温,有毒,入肺、肝、脾经,有燥湿化痰,祛风定惊,消肿散结的功能,治中风痰壅,口眼斜,半身不遂,癫癎,惊风,破伤风,风痰眩晕,喉痹,瘰疬,痈肿,跌扑折伤,蛇虫咬伤。选用鸡血藤是因为其性味苦甘,温,入心、脾二经,有活血、舒筋的功能,治腰膝酸痛,麻木瘫痪,月经不调。选用桃仁是因为其性味苦甘,平,入心、肝、大肠经,有破血行瘀,润燥滑经的功能,治经闭,癥瘕,热病蓄血,血痹,疟疾,跌打损伤,瘀血肿痛,血燥便秘。选用红花是因为其性味辛,温,入心、肝经,有活血通经,去瘀止痛的功能,治经闭,癥瘕,难产,死胎,产后恶露不行,瘀血作痛,痈肿,跌扑损伤。选用全蝎是因为其性味咸辛,平,有毒,有祛风,止痉,通络,解毒的功能,治惊风抽搐,癫癎,中风,半身不遂,口眼斜,偏头痛,风湿痹痛,破伤风,淋巴结结核,风疹疮肿。选用雷公藤是因为其性味苦,大毒,有杀虫,消炎,解毒的功能。选用附子是因为其性味辛甘,热,有毒,入心、脾、肾经,有回阳补火,散寒除湿的功能,治阴盛络阳,大汗亡阳,吐利厥逆,心腹冷痛,脾泄冷痢,脚气水肿,小儿慢惊,风寒湿痹,踒躄拘挛,阴疽疮漏及一切沉寒痼冷之疾。选用川乌头是因为其性味辛,热,有毒,入脾、命门二经,有祛寒湿,散风邪,温经,止痛的功能,治风寒湿痹,历节风痛,四肢拘挛,半身不遂,头风头痛,心腹冷痛,阴疽肿毒。选用石膏是因为其性味辛甘,寒,入肺、胃经,生用有解肌清热,除烦止渴的功能,治热病壮热不退,心烦神昏,谵语发狂,口渴咽干,肺热喘急,中暑自汗,胃火头痛、牙痛,热毒壅盛,发斑发疹,口舌生疮,煅敷生肌敛疮,外治痈疽疮疡,溃不收回,汤火烫伤。选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用白芍是因为其性味苦酸,凉,入肝、脾经,有养血柔肝,缓中止痛,敛阴收汗的功能,治胸腹胁肋疼痛,泻痢腹痛,自汗盗汗,阴虚发热,月经不调,崩漏,带下。选用伸筋草是因为其性味苦辛,温,入肝、胃、肾三经,有祛风散寒,除湿消肿,舒筋活血的功能,治风寒湿痹,关节酸痛,皮肤麻木,四肢软弱,水肿,跌打损伤。选用豨莶草是因为其性味苦,寒,入肝、脾、肾经,有祛风湿,利筋骨,降血压的功能,治四肢麻痹,筋骨疼痛,腰膝无力,疟疾,急性肝炎,高血压病,疔疮肿毒,外伤出血。选用忍冬藤是因为其性味甘,寒,入心、肺经,有清热,解毒,通络的功能,治温病发热,热毒血痢,传染性肝炎,痈肿疮毒,筋骨疼痛。选用知母是因为其性味苦,寒,入肺、胃、肾经,有滋阴降火,润燥滑肠的功能,治烦热消渴,骨蒸劳热,肺热咳嗽,大便燥结,小便不利。选用草乌头,异名草乌,其性味辛,热,有毒,入肝、脾、肺经,有搜风胜湿,散寒止痛,开痰,消肿的功能,治风寒湿痹,中风瘫痪,破伤风,头风,脘腹冷痛,痰癖,气块,冷痢,喉痹,痈疽,疔疮,瘰疬。选用枸杞子是因为其性味甘,平,有滋肾,润肺,补肝,明目的功能,治肝肾阴亏,腰膝酸软,头晕目眩,目昏多泪,虚劳咳嗽,消渴,遗精。选用钩藤是因为其性味苦,凉,入肝、心经,有清热平肝,熄风定惊的功能,治小儿惊癎瘈瘲,大人血压偏高,头晕、目眩,妇人子癎。选用地骨皮是因为其性味甘,寒,入肺、肝、肾经,有清热,凉血的功能,治虚劳潮热盗汗,肺热咳喘,吐血,衄血,血淋,消渴,高血压,痈肿,恶疮。选用桑枝是因为其性味苦,平,入肝经,有祛风湿,利关节,行水气的功能,治风寒湿痹,四肢拘挛,脚气浮肿,肌体风痒。选用蒲公英是因为其性味苦甘,寒,入肝、胃经,有清热解毒,利尿散结的功能,治急性乳腺炎,淋巴腺炎,瘰疬,疔毒疮肿,急性结膜炎,感冒发热,急性扁桃体炎,急性支气管炎,胃炎,肝炎,胆囊炎,尿路感染。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
麻黄6-10克,苍术5-15克,桂枝6-10克,防风5-15克,防己5-15克,威灵仙5-15克,天南星5-15克,鸡血藤10-20克,桃仁5-15克,红花5-15克,全蝎2-3克,雷公藤10-20克,附子5-15克,川乌头5-10克,石膏25-35克,当归5-15克,白芍5-15克,伸筋草5-15克,豨莶草15-25克,忍冬藤15-25克,知母5-15克,草乌头6-10克,枸杞子10-20克,钩藤10-20克,地骨皮15-25克,桑枝15-25克,蒲公英25-35克。
优选为:
麻黄8克,苍术10克,桂枝8克,防风10克,防己10克,威灵仙10克,天南星10克,鸡血藤15克,桃仁10克,红花10克,全蝎3克,雷公藤15克,附子10克,川乌头10克,石膏30克,当归10克,白芍10克,伸筋草10克,豨莶草20克,忍冬藤20克,知母10克,草乌头8克,枸杞子15克,钩藤15克,地骨皮20克,桑枝20克,蒲公英30克。
本发明药物的制备方法如下
一、备料
1、麻黄:拣去杂质,去尽木质茎及残根,用水洗净,微润后切段,干燥即得;
2、苍术:拣去杂质,用水泡至七、八成透,捞出,润透后切片,晒干;
3、桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
4、防风:除去残茎,用水浸泡,捞出,润透切片,晒干;
5、防己:原药用水洗净,捞出润透,切片,晒干;
6、威灵仙:拣净杂质,除去残茎,用水浸泡,捞出润透,切段,晒干;
7、天南星:拣去杂质,洗净灰屑,晒干;
8、鸡血藤:用水润透,切片,或蒸软后趁热切片,晒干;
9、桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒干,簸净;
10、红花:拣净杂质,除去茎叶、蒂头,晒干;
11、全蝎:清水漂去盐质,晒干,或微火焙用;
12、雷公藤:除去残留的根皮,浸泡,洗净,润透,切厚片,干燥,筛去碎屑;
13、附子:用水浸泡,捞出,切片,晾干;
14、川乌头:拣去杂质,洗净灰屑,晒干;
15、石膏:去净杂石,洗净泥土,打碎成小块;
16、当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
17、白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥;
18、伸筋草:筛去灰屑,拣净杂质,切成小段;
19、豨莶草:拣去杂质,除去残根与老梗,先抖下叶另放,将梗洗净,用水浸泡,捞出,润透后切片,晒干,再与叶和匀;
20、忍冬藤:拣去杂质,用水浸泡,润透,切片,晒干;
21、知母:拣净杂质,用水撞洗,捞出,润软,切片晒干;
22、制草乌头:取净草乌,用凉水浸漂,每日换水2-3次,至口尝仅稍留麻辣感时取出,同甘草、黑豆加水共煮,以草乌熟透、内无白心为度,然后除去甘草及黑豆,晒至六成干,闷润后切片,晒干,每草乌100斤,用甘草5斤,黑豆10斤;
23、枸杞子:簸净杂质,摘去残留的梗和蒂;
24、钩藤:拣去老梗、杂质,洗净,晒干;
25、地骨皮:拣去杂质及木心,略洗,切段,晒干;
26、桑枝:拣去杂质,洗净,用水浸泡,润透后,切段,晒干;
27、蒲公英:拣去杂质,洗净泥土,切段,晒干。
二、制备
1、将所述重量的麻黄、苍术、桂枝、防风、防己、威灵仙、天南星、鸡血藤、桃仁、红花、全蝎、雷公藤、附子、川乌头、石膏、当归、白芍、伸筋草、豨莶草、忍冬藤、知母、草乌头、枸杞子、钩藤、地骨皮、桑枝、蒲公英放入煎药容器内,加水8倍量,浸泡120分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为3剂服用。
组方中威灵仙有祛风湿,通经络,消痰涎,散癖积的功能为君药;红花有活血通经,去瘀止痛的功能;全蝎有祛风,止痉,通络,解毒的功能,二者为臣药,三味药共同发挥祛风通络,消痰散癖,活血通经,去瘀止痛,祛风止痉,通络解毒的作用,治疗类风湿关节炎效力全面,且以祛风通络,消痰散癖,活血通经为主可治本,川乌头有祛寒湿,散风邪,温经,止痛的功能为佐药,伸筋草有祛风散寒,除湿消肿,舒筋活血的功能为使药,与下余诸药是治标。
本发明药物具有祛风通络,消痰散癖,活血通经,去瘀止痛,祛风止痉,通络解毒,舒筋活血的功能,用于治疗类风湿关节炎,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治类风湿关节炎门诊患者共38例。
2、诊断标准
典型症状为反复发作的、对称性的、多发性小关节炎,以手部指掌、腕、足趾等关节最常见。早期呈现红、肿、热、痛和功能障碍,晚期关节可出现不同程度的强硬和畸形,并有骨和骨骼肌萎缩,是一种致残率较高的疾病。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、中、晚各服1次,15天为一个疗程,连续服用3个疗程。
4、疗效评定标准
显效:类风湿关节炎症状消失,恢复正常,痊愈;
好转:类风湿关节炎症状明显好转,关节红、肿、热、痛症状减轻,逐步恢复正常;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗类风湿关节炎患者38例,结果显效31例,显效率为81.6%,好转5例,好转率为13.2%,无效2例,总有效率为94.8%。
Claims (3)
1.一种治疗类风湿关节炎的药物,其特征在于:它是由下列重量范围内的原料药制成:
麻黄6-10克,苍术5-15克,桂枝6-10克,防风5-15克,防己5-15克,威灵仙5-15克,天南星5-15克,鸡血藤10-20克,桃仁5-15克,红花5-15克,全蝎2-3克,雷公藤10-20克,附子5-15克,川乌头5-10克,石膏25-35克,当归5-15克,白芍5-15克,伸筋草5-15克,豨莶草15-25克,忍冬藤15-25克,知母5-15克,草乌头6-10克,枸杞子10-20克,钩藤10-20克,地骨皮15-25克,桑枝15-25克,蒲公英25-35克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
麻黄8克,苍术10克,桂枝8克,防风10克,防己10克,威灵仙10克,天南星10克,鸡血藤15克,桃仁10克,红花10克,全蝎3克,雷公藤15克,附子10克,川乌头10克,石膏30克,当归10克,白芍10克,伸筋草10克,豨莶草20克,忍冬藤20克,知母10克,草乌头8克,枸杞子15克,钩藤15克,地骨皮20克,桑枝20克,蒲公英30克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)麻黄:拣去杂质,去尽木质茎及残根,用水洗净,微润后切段,干燥即得;
(2)苍术:拣去杂质,用水泡至七、八成透,捞出,润透后切片,晒干;
(3)桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
(4)防风:除去残茎,用水浸泡,捞出,润透切片,晒干;
(5)防己:原药用水洗净,捞出润透,切片,晒干;
(6)威灵仙:拣净杂质,除去残茎,用水浸泡,捞出润透,切段,晒干;
(7)天南星:拣去杂质,洗净灰屑,晒干;
(8)鸡血藤:用水润透,切片,或蒸软后趁热切片,晒干;
(9)桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒干,簸净;
(10)红花:拣净杂质,除去茎叶、蒂头,晒干;
(11)全蝎:清水漂去盐质,晒干,或微火焙用;
(12)雷公藤:除去残留的根皮,浸泡,洗净,润透,切厚片,干燥,筛去碎屑;
(13)附子:用水浸泡,捞出,切片,晾干;
(14)川乌头:拣去杂质,洗净灰屑,晒干;
(15)石膏:去净杂石,洗净泥土,打碎成小块;
(16)当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
(17)白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥;
(18)伸筋草:筛去灰屑,拣净杂质,切成小段;
(19)豨莶草:拣去杂质,除去残根与老梗,先抖下叶另放,将梗洗净,用水浸泡,捞出,润透后切片,晒干,再与叶和匀;
(20)忍冬藤:拣去杂质,用水浸泡,润透,切片,晒干;
(21)知母:拣净杂质,用水撞洗,捞出,润软,切片晒干;
(22)制草乌头:取净草乌,用凉水浸漂,每日换水2-3次,至口尝仅稍留麻辣感时取出,同甘草、黑豆加水共煮,以草乌熟透、内无白心为度,然后除去甘草及黑豆,晒至六成干,闷润后切片,晒干,每草乌100斤,用甘草5斤,黑豆10斤;
(23)枸杞子:簸净杂质,摘去残留的梗和蒂;
(24)钩藤:拣去老梗、杂质,洗净,晒干;
(25)地骨皮:拣去杂质及木心,略洗,切段,晒干;
(26)桑枝:拣去杂质,洗净,用水浸泡,润透后,切段,晒干;
(27)蒲公英:拣去杂质,洗净泥土,切段,晒干;
(二)制备
(1)将所述重量的麻黄、苍术、桂枝、防风、防己、威灵仙、天南星、鸡血藤、桃仁、红花、全蝎、雷公藤、附子、川乌头、石膏、当归、白芍、伸筋草、豨莶草、忍冬藤、知母、草乌头、枸杞子、钩藤、地骨皮、桑枝、蒲公英放入煎药容器内,加水8倍量,浸泡120分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为3剂服用。
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