CN106668251A - 一种治疗类风湿性关节炎的药物及其制备方法 - Google Patents
一种治疗类风湿性关节炎的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗类风湿性关节炎的药物及其制备方法,其主要是由黄芪、秦艽、防己、红花、桃仁、蚯蚓、青风藤、海风藤、桂枝、白芷、白鲜皮、附子、当归、伸筋草、独活、羌活、土鳖虫、白术、威灵仙、淫羊藿按一定重量配比制备而成,本发明药物具有祛风通络,温经通脉,祛风散寒,除湿消肿,舒筋活血,消痰散癖的功能,用于治疗类风湿性关节炎见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗类风湿性关节炎的药物及其制备方法,属中药领域。
背景技术
类风湿性关节炎是一种病因未明的慢性、以炎性滑膜炎为主的系统性疾病。其特征是手、足小关节的多关节、对称性、侵袭性关节炎症,经常伴有关节外器官受累及血清类风湿因子阳性,可以导致关节畸形及功能丧失。由于西药治疗副作用大,因此人们对有效治疗类风湿性关节炎的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗类风湿性关节炎的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗类风湿性关节炎的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择黄芪、秦艽、防己、红花、桃仁、蚯蚓、青风藤、海风藤、桂枝、白芷、白鲜皮、附子、当归、伸筋草、独活、羌活、土鳖虫、白术、威灵仙、淫羊藿、苍耳子、葛根、川牛膝、桑寄生、防己进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗类风湿性关节炎。其中选用黄芪是因为其性味甘,微温,入肺、脾经,生用有益卫固表,利水消肿,托毒,生肌的功能,治自汗,盗汗,血痹,浮肿,痈疽不溃或溃久敛;炙用有补中益的功能,治内伤劳倦,脾虚泄泻,脱肛,气虚血脱,崩带及一切气衰血虚之症。选用秦艽是因为其性味苦辛,平,入肝、胃、胆经,有祛风除湿,和血舒筋,清热利尿的功能,治风湿痹痛,筋骨拘挛,黄疸,便血,骨蒸潮热,小儿疳热,小便不利。选用防己是因为其性味苦,寒,入膀膛、脾、肾经,有行水,泻下焦湿热的功能,治水肿臌胀,湿热脚气,手足挛痛,癣疥疮肿。选用红花是因为其性味辛,温,入心、肝经,有活血通经,去瘀止痛的功能,治经闭,癥瘕,难产,死胎,产后恶露不行,瘀血作痛,痈肿,跌扑损伤。选用桃仁是因为其性味苦甘,平,入心、肝、大肠经,有破血行瘀,润燥滑经的功能,治经闭,癥瘕,热病蓄血,血痹,疟疾,跌打损伤,瘀血肿痛,血燥便秘。选用蚯蚓是因为其性味咸,寒,入肝、脾、肺经,有清热,平肝,止喘,通络的功能,治高热狂躁,惊风抽搐,风热头痛,目赤,中风半身不遂,喘息,喉痹,关节疼痛,齿衄,小便不通,瘰疬,痄腮,疮疡。选用青风藤是因为其性味苦平,有祛风湿,利不便的功能,治风湿痹痛,鹤膝风,水肿,脚气。选用海风藤是因为其性味辛苦,微温,入心、肾二经,有祛风湿,通经络,理气的功能,治风寒湿痹,关节疼痛,筋脉拘挛,跌打损伤,哮喘,久咳。选用桂枝是因为其性味辛甘,温,入膀胱、心、肺经,有发汗解肌,温经通脉的功能,治风寒表证,肩背肢节酸疼,胸痹痰饮,经闭癥瘕。选用白芷是因为其性味辛,温,入肺、脾、胃经,有祛风,燥湿,消肿,止痛的功能,治头痛,眉棱骨痛,齿痛,鼻渊,寒湿腹痛,肠风痔漏,赤白带下,痈疽疮疡,皮肤燥痒,疥癣。选用白鲜皮是因为其性味苦,咸,寒,入脾、胃经,有祛风,燥湿,清热,解毒的功能,治风热疮毒,疥癣,皮肤痒疹,风湿痹痛,黄疸。选用附子是因为其性味辛甘,热,有毒,入心、脾、肾经,有回阳补火,散寒除湿的功能,治阴盛络阳,大汗亡阳,吐利厥逆,心腹冷痛,脾泄冷痢,脚气水肿,小儿慢惊,风寒湿痹,踒躄拘挛,阴疽疮漏及一切沉寒痼冷之疾。选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用伸筋草是因为其性味苦辛,温,入肝、胃、肾三经,有祛风散寒,除湿消肿,舒筋活血的功能,治风寒湿痹,关节酸痛,皮肤麻木,四肢软弱,水肿,跌打损伤。选用独活是因为其性味辛苦,温,入肾、膀胱经,有祛风,胜湿,散寒,止痛的功能,治风寒湿痹,腰漆酸痛,手脚挛痛,慢性气管炎,头痛,齿痛。选用羌活是因为其性味辛苦,温,入膀胱、肾经,有散表寒,祛风湿,利关节的功能,治感冒风寒,头痛无汗,风寒湿痹,项强筋急,骨节酸疼,风水浮肿,痈疽疮毒。选用土鳖虫是因为其性味咸、寒,有小毒,归肝经,有破瘀血,续筋骨的功能,用于筋骨折伤,瘀血经闭,癥瘕痞块。选用白术是因为其性味苦甘,温,入脾、胃经,有补脾,益胃,燥湿,和中的功能,治脾胃气弱,不思饮食,倦怠少气,虚胀,泄泻,痰饮,水肿,黄疸,湿痹,小便不利,头晕,自汗,胎气不安。选用威灵仙是因为其性味辛咸,温,有毒,入膀胱经,有祛风湿,通经络,消痰涎,散癖积的功能,治痛风、顽痹、腰膝冷痛,脚气,疟疾,癥瘕积聚,破伤风,扁桃体炎,诸骨鲠咽。选用淫羊藿是因为其性味辛甘,温,入肝、肾经,有补肾壮阳,祛风除湿的功能,治阳痿不举,小便淋沥,筋骨挛急,半身不遂,腰膝无力,风湿痹痛,四脚不仁。选用苍耳子是因为其性味甘,温,有毒,入肺、肝经,有散风,止痛,祛湿,杀虫的功能,治风寒头痛,鼻渊,齿痛,风寒湿痹,四脚挛痛,疥癞,瘙痒。选用葛根是因为其性味甘辛,平,入脾、胃经,有升阳解肌,透疹止泻,除烦止渴的功能,治伤寒,温热,头痛,项强,烦热消喝,泄泻,痢疾,癍诊不透,高血压,心绞痛,耳聋。选用川牛膝是因为其性味平,味苦微苦,无毒,入肝、肾二经,有祛风,利湿,通经,活血的功能,治风湿腰膝疼痛,脚痿筋挛,血淋,尿血,妇女经闭,癥瘕。选用桑寄生是因为其性味苦甘,平,入肝、肾经,有补肝肾,强筋骨,除风湿,通经络,益血,安胎的功能,治腰膝酸痛,筋骨痿弱,偏枯,脚气,风寒湿痹,胎漏血崩,产后乳汁不下。选用防己是因为其性味苦,寒,入膀膛、脾、肾经,有行水,泻下焦湿热的功能,治水肿臌胀,湿热脚气,手足挛痛,癣疥疮肿。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
黄芪15-25克,秦艽15-25克,防己10-20克,红花10-20克,桃仁10-20克,蚯蚓10-20克,青风藤15-25克,海风藤15-25克,桂枝10-20克,白芷10-20克,白鲜皮10-20克,附子5-15克,当归5-15克,伸筋草10-20克,独活5-15克,羌活5-15克,土鳖虫5-10克,白术5-15克,威灵仙10-14克,淫羊藿10-20克,苍耳子5-15克,葛根5-15克,川牛膝10-14克,桑寄生5-15克,防己5-15克。
优选为:
黄芪20克,秦艽20克,防己15克,红花15克,桃仁15克,蚯蚓15克,青风藤20克,海风藤20克,桂枝15克,白芷15克,白鲜皮15克,附子10克,当归10克,伸筋草15克,独活10克,羌活10克,土鳖虫10克,白术10克,威灵仙12克,淫羊藿15克,苍耳子10克,葛根10克,川牛膝12克,桑寄生10克,防己10克。
本发明药物的制备方法如下
一、备料
1、黄芪:拣净杂质,除去残留的根头和空心较大的根,用水浸泡,捞出,润透后及时切片,晒干;
2、秦艽:拣去杂质,除去芦头,稍浸,润透切片,晒干;
3、防己:原药用水洗净,捞出润透,切片,晒干;
4、红花:拣净杂质,除去茎叶、蒂头,晒干;
5、桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒干,簸净;
6、蚯蚓:拣去杂质,用水漂净,及时捞出,晒干,切段;
7、青风藤:秋冬采老藤,切段,晒干;
8、海风藤:原药放清水中浸30-60分钟,取出放箩内润16-24小时,切片,晒干;
9、桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
10、白芷:拣净杂质,用水洗净,浸泡,捞出润透,略晒至外皮无滑腻感时,再闷润后,切片干燥;
11、白鲜皮:拣净杂质,除去粗皮,洗净,稍润,切片,晒干;
12、附子:用水浸泡,捞出,切片,晾干;
13、当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
14、伸筋草:筛去灰屑,拣净杂质,切成小段;
15、独活:拣去杂质,分开大小个,洗净,润透后切片,干燥;
16、羌活:拣去杂质,洗净,润透,切片,晾干;
17、土鳖虫:取原药材,洗净,干燥;
18、白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干;
19、威灵仙:拣净杂质,除去残茎,用水浸泡,捞出润透,切段,晒干;
20、淫羊藿:拣净杂质,去梗,切丝,筛去碎屑;
21、苍耳子:拣尽杂质,去刺,筛去灰屑,微炒至黄色,取出放凉;
22、葛根:拣去杂质,洗净,用水浸泡,捞出,润透,及时切片,晒干;
23、川牛膝:拣去杂质,晾干;
24、桑寄生:用水洗净,润透,切段,晒干;
25、防己:原药用水洗净,捞出润透,切片,晒干。
二、制备
1、将所述重量的黄芪、秦艽、防己、红花、桃仁、蚯蚓、青风藤、海风藤、桂枝、白芷、白鲜皮、附子、当归、伸筋草、独活、羌活、土鳖虫、白术、威灵仙、淫羊藿、苍耳子、葛根、川牛膝、桑寄生、防己放入煎药容器内,加水8倍量,浸泡120分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为3剂服用。
组方中海风藤有祛风湿,通经络,理气的功能为君药;桂枝有发汗解肌,温经通脉的功能;伸筋草有祛风散寒,除湿消肿,舒筋活血的功能,二者为臣药,三味药共同发挥祛风通络,温经通脉,祛风散寒,除湿消肿,舒筋活血的作用,治疗类风湿性关节炎效力全面,且以祛风通络,祛风散寒,除湿消肿为主可治本,羌活有散表寒,祛风湿,利关节的功能为佐药,威灵仙有祛风湿,通经络,消痰涎,散癖积的功能为使药,与下余诸药是治标。
本发明药物具有祛风通络,温经通脉,祛风散寒,除湿消肿,舒筋活血,消痰散癖的功能,用于治疗类风湿性关节炎,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治类风湿性关节炎门诊患者共45例。
2、诊断标准
典型症状为手、膝、髋及脊柱关节易受累,而掌指、腕及其他关节较少受累。关节受累的表现:多关节受累呈对称性多关节炎,易受累的关节有手、足、腕、踝及颞颌关节等,其他还可有肘、肩、颈椎、髋、膝关节等。关节畸形手的畸形有梭形肿胀、尺侧偏斜、天鹅颈样畸形、钮扣花样畸形等。足的畸形有跖骨头向下半脱位引起的仰趾畸形、外翻畸形、跖趾关节半脱位、弯曲呈锤状趾及足外翻畸形。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,15天为一个疗程,连续服用3个疗程。
4、疗效评定标准
显效:类风湿性关节炎症状消失,恢复正常,痊愈;
好转:类风湿性关节炎症状明显好转,关节疼痛、红肿现象减轻,逐步恢复正常;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗类风湿性关节炎患者45例,结果显效36例,显效率为80%,好转6例,好转率为13.3%,无效3例,总有效率为93.3%。
Claims (3)
1.一种治疗类风湿性关节炎的药物,其特征在于:它是由下列重量范围内的原料药制成:
黄芪15-25克,秦艽15-25克,防己10-20克,红花10-20克,桃仁10-20克,蚯蚓10-20克,青风藤15-25克,海风藤15-25克,桂枝10-20克,白芷10-20克,白鲜皮10-20克,附子5-15克,当归5-15克,伸筋草10-20克,独活5-15克,羌活5-15克,土鳖虫5-10克,白术5-15克,威灵仙10-14克,淫羊藿10-20克,苍耳子5-15克,葛根5-15克,川牛膝10-14克,桑寄生5-15克,防己5-15克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
黄芪20克,秦艽20克,防己15克,红花15克,桃仁15克,蚯蚓15克,青风藤20克,海风藤20克,桂枝15克,白芷15克,白鲜皮15克,附子10克,当归10克,伸筋草15克,独活10克,羌活10克,土鳖虫10克,白术10克,威灵仙12克,淫羊藿15克,苍耳子10克,葛根10克,川牛膝12克,桑寄生10克,防己10克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)黄芪:拣净杂质,除去残留的根头和空心较大的根,用水浸泡,捞出,润透后及时切片,晒干;
(2)秦艽:拣去杂质,除去芦头,稍浸,润透切片,晒干;
(3)防己:原药用水洗净,捞出润透,切片,晒干;
(4)红花:拣净杂质,除去茎叶、蒂头,晒干;
(5)桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒干,簸净;
(6)蚯蚓:拣去杂质,用水漂净,及时捞出,晒干,切段;
(7)青风藤:秋冬采老藤,切段,晒干;
(8)海风藤:原药放清水中浸30-60分钟,取出放箩内润16-24小时,切片,晒干;
(9)桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
(10)白芷:拣净杂质,用水洗净,浸泡,捞出润透,略晒至外皮无滑腻感时,再闷润后,切片干燥;
(11)白鲜皮:拣净杂质,除去粗皮,洗净,稍润,切片,晒干;
(12)附子:用水浸泡,捞出,切片,晾干;
(13)当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
(14)伸筋草:筛去灰屑,拣净杂质,切成小段;
(15)独活:拣去杂质,分开大小个,洗净,润透后切片,干燥;
(16)羌活:拣去杂质,洗净,润透,切片,晾干;
(17)土鳖虫:取原药材,洗净,干燥;
(18)白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干;
(19)威灵仙:拣净杂质,除去残茎,用水浸泡,捞出润透,切段,晒干;
(20)淫羊藿:拣净杂质,去梗,切丝,筛去碎屑;
(21)苍耳子:拣尽杂质,去刺,筛去灰屑,微炒至黄色,取出放凉;
(22)葛根:拣去杂质,洗净,用水浸泡,捞出,润透,及时切片,晒干;
(23)川牛膝:拣去杂质,晾干;
(24)桑寄生:用水洗净,润透,切段,晒干;
(25)防己:原药用水洗净,捞出润透,切片,晒干;
(二)制备
(1)将所述重量的黄芪、秦艽、防己、红花、桃仁、蚯蚓、青风藤、海风藤、桂枝、白芷、白鲜皮、附子、当归、伸筋草、独活、羌活、土鳖虫、白术、威灵仙、淫羊藿、苍耳子、葛根、川牛膝、桑寄生、防己放入煎药容器内,加水8倍量,浸泡120分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为3剂服用。
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