CN106798857A - 一种治疗骨肿瘤的药物及其制备方法 - Google Patents
一种治疗骨肿瘤的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗骨肿瘤的药物及其制备方法,其主要是由桑寄生、牡蛎、徐长卿、天麻、续断、透骨草、重楼、薏苡仁、骨碎补、菟丝子、藁本、延胡索、红花、全蝎、葛根、紫河车、杜仲、刘寄奴、山豆根等按一定重量配比制备而成,本发明药物具有祛风除湿、舒筋活血、止痛、强筋骨,通经络、补气养血、益精的功能,用于治疗骨肿瘤见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗骨肿瘤的药物及其制备方法,属中药领域。
技术背景
骨肿瘤是发生于骨骼或其附属组织的肿瘤。有良性,恶性之分,良性骨肿瘤易根治,预后良好,恶性骨肿瘤发展迅速,预后不佳,死亡率高。中医则认为骨肿瘤与寒湿侵袭,热毒炽盛,正气虚弱,痰浊凝聚有关。由于西药治疗副作用大,因此人们对有效治疗骨肿瘤的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗骨肿瘤的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗骨肿瘤的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择桑寄生、牡蛎、徐长卿、天麻、续断、透骨草、重楼、薏苡仁、骨碎补、菟丝子、藁本、延胡索、红花、全蝎、葛根、紫河车、杜仲、刘寄奴、山豆根、牛膝、血竭进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗骨肿瘤。其中选用桑寄生是因为其性味苦甘,平,入肝、肾经,有补肝肾,强筋骨,除风湿,通经络,益血,安胎的功能,治腰膝酸痛,筋骨痿弱,偏枯,脚气,风寒湿痹,胎漏血崩,产后乳汁不下。选用牡蛎是因为其性味咸涩,凉,入肝、肾经,有敛阴,潜阳,止汗,涩精,化痰,软坚的功能,治惊癎,眩晕,自汗,盗汗,遗精,淋浊,崩漏,带下,瘰疬,瘿瘤。选用徐长卿是因为其性味辛,温,有镇痛,止咳,利水消肿,活血解毒的功能,治胃痛,牙痛,风湿疼痛,经期腹痛,慢性气管炎,腹水,水肿,痢疾,肠炎,跌打损伤,湿疹,荨麻疹,毒蛇咬伤。选用天麻是因为其性味甘,平,入肝经,有息风,定惊的功能,治眩晕眼黑,头风头痛,肢体麻木,半身不遂,语言蹇涩,小儿惊癎动风。选用续断是因为其性味苦辛,微温,入肝、肾经,有补肝肾,续筋骨,调血脉的功能,治腰背酸痛,足膝无力,胎漏,崩漏,带下,遗精,跌打损伤,金疮,痔漏,痈疽疮肿。选用透骨草是因为其性味辛温,有祛风,除湿,舒筋,活血,止痛的功能,治风湿痹痛,筋骨挛缩,疮癣肿毒。选用重楼是因为其性味苦,微寒,有小毒,归肝经,有清热解毒,消肿止痛,凉肝定惊的功能,治疔疮痈肿,咽喉肿痛,毒蛇咬伤,跌扑伤痛,惊风抽搐。选用薏苡仁是因为其性味甘淡,凉,入脾、肺、肾经,有健脾,补肺,清热,利湿的功能,治泄泻,湿痹,筋脉拘挛,屈伸不利,水肿,脚气,肺痿,肺痈,肠痈,淋浊,白带。选用骨碎补是因为其性味苦,温,入肝、肾经,有补肾,活血,止血的功能,治肾虚久泻及腰痛,风湿痹痛,齿痛,耳鸣,跌打闪挫、骨伤,阑尾炎,斑秃,鸡眼。选用菟丝子是因为其性味辛甘,平,入肝、肾经,有补肝肾,益精髓,明目的功能,治腰膝酸痛,遗精,消渴,尿有余沥,目暗。选用藁本是因为其性味辛,温,归膀胱经,有散寒祛风,除湿止痛的功能,用于风寒感冒,巅顶疼痛。选用延胡索是因为其性味辛苦,温,入肝、胃经,有活血,散瘀,理气,止痛的功能,治心腹腰膝诸痛,月经不调,癥瘕,崩中,产后血晕,恶露不尽,跌打损伤。选用红花是因为其性味辛,温,入心、肝经,有活血通经,去瘀止痛的功能,治经闭,癥瘕,难产,死胎,产后恶露不行,瘀血作痛,痈肿,跌扑损伤。选用全蝎是因为其性味咸辛,平,有毒,有祛风,止痉,通络,解毒的功能,治惊风抽搐,癫癎,中风,半身不遂,口眼斜,偏头痛,风湿痹痛,破伤风,淋巴结结核,风疹疮肿。选用葛根是因为其性味甘辛,平,入脾、胃经,有升阳解肌,透疹止泻,除烦止渴的功能,治伤寒,温热,头痛,项强,烦热消喝,泄泻,痢疾,癍诊不透,高血压,心绞痛,耳聋。选用紫河车是因为其性味甘咸,温,入肺、肝、肾经,有补气,养血,益精的功能,治虚损,羸瘦,劳热骨蒸,咳喘,咯血,盗汗,遗精,阳痿,妇女血气不足,不孕或乳少。选用杜仲是因为其性味甘微辛,温,入肝、肾经,有补肝肾,强筋骨,安胎的功能,治腰脊酸疼,足膝痿弱,小便余沥,阴下湿痒,胎漏欲堕,高血压。选用刘寄奴是因为其性味苦,温,入心、脾经,有破血通经,敛疮消肿的功能,治经闭癥瘕,胸腹胀痛,产后血瘀,跌打损伤,金疮出血,痈毒焮肿。选用山豆根是因为其性味苦,寒,入心、肺、大肠三经,有清火,解毒,消肿,止痛的功能,治喉痈,喉风,喉痹,牙龈肿痛,喘满热咳,黄疸,下痢,痔疾,热肿,秃疮,疥癣,蛇、虫、犬咬伤。选用牛膝是因为其性味甘苦酸,平,入肝、肾经,生用散瘀血,消痈肿的功能,治淋病,尿血,经闭,癥瘕,难产,胞衣不下,产后瘀血腹痛,喉痹,痈肿,跌打损伤,熟用补肝肾,强筋骨,治腰膝骨痛,四肢拘挛,痿痹。选用血竭是因为其性味甘咸,平,入心、肝经,有散瘀定痛,止血生肌的功能,治跌打折损,内伤瘀痛,外伤出血不止,瘰疬,臁疮溃久不合。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
桑寄生10-20克,牡蛎15-25克,徐长卿5-15克,天麻10-15克,续断10-20克,透骨草15-25克,重楼10-20克,薏苡仁15-25克,骨碎补10-20克,菟丝子15-25克,藁本15-25克,延胡索10-15克,红花5-15克,全蝎5-8克,葛根10-20克,紫河车5-15克,杜仲10-20克,刘寄奴5-15克,山豆根15-25克,牛膝5-15克,血竭1-2克。
优选为:
桑寄生15克,牡蛎20克,徐长卿10克,天麻12克,续断15克,透骨草20克,重楼15克,薏苡仁20克,骨碎补15克,菟丝子20克,藁本20克,延胡索12克,红花10克,全蝎8克,葛根15克,紫河车10克,杜仲15克,刘寄奴10克,山豆根20克,牛膝10克,血竭2克。
本发明药物的制备方法如下
一、备料
1、桑寄生:用水洗净,润透,切段,晒干;;
2、牡蛎:洗净,晒干,碾碎用;
3、徐长卿:拣净杂质,洗净,润透,切成1.5厘米段,晒干;
4、天麻:拣去杂质,大小分档,用水浸泡至七成透,捞出,稍晾,再润至内外温度均匀,切片,晒干;
5、续断:洗净泥沙,除去残留根头,润透后切片晒干,筛去屑;
6、透骨草:拣净杂质,切段;
7、重楼:除去须根,洗净,干燥;
8、薏苡仁:取原药材,除去残留皮壳、杂质;
9、骨碎补:去净泥砂杂质,洗净,稍浸泡,润透,切片,晒干;
10、菟丝子:过箩去净杂质,洗净,晒干;
11、藁本:取原药材,除去杂质,大小分档,抢水洗净,润透,切片,晒干;
12、延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎;
13、红花:拣净杂质,除去茎叶、蒂头,晒干;
14、全蝎:清水漂去盐质,晒干,或微火焙用;
15、葛根:拣去杂质,洗净,用水浸泡,捞出,润透,及时切片,晒干;
16、紫河车:用新鲜的紫河车,横直割开血管,用水反复洗漂干净;
17、杜仲:除去粗皮,洗净,润透,切成方块或丝条,晒干;
18、刘寄奴:拣净杂质,去根,用水冼净,稍浸,切段,晒干;
19、山豆根:拣净杂质,粗细分档,用水浸泡,捞出,润透后切片,晒干;
20、牛膝:拣去杂质,洗净,润软,去芦,切段,晒干;
21、血竭:拭去灰尘,敲成小块,于冬季干燥天气,放在石灰坛内使燥,然后乘脆研末。
二、制备
1、将所述重量的桑寄生、牡蛎、徐长卿、天麻、续断、透骨草、重楼、薏苡仁、骨碎补、菟丝子、藁本、延胡索、红花、全蝎、葛根、紫河车、杜仲、刘寄奴、山豆根、牛膝放入煎药容器内,第一次加水6倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水4倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为3剂,再分别加入血竭冲服。
组方中透骨草有祛风,除湿,舒筋,活血,止痛的功能为君药;桑寄生补肝肾,强筋骨,除风湿,通经络,益血,安胎;徐长卿镇痛,止咳,利水消肿,活血解毒二者为臣药,三味药共同发挥祛风除湿、舒筋活血、止痛、强筋骨,通经络,补肝肾的作用,治疗骨肿瘤效力全面,且以祛风除湿、舒筋活血、止痛、强筋骨,通经络为主可治本,薏苡仁有健脾,补肺,清热,利湿的功能为佐药,紫河车有补气,养血,益精的功能为使药,与下余诸药是治标。
本发明药物具有祛风除湿、舒筋活血、止痛、强筋骨,通经络、补气养血、益精的功能,用于治疗骨肿瘤,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治骨肿瘤门诊患者共20例。
2、诊断标准
典型症状为患处疼痛、肿胀或肿块、功能障碍、畸形、病理性骨折等全身症状。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、中、晚各服1次,15天为一个疗程,连续服用3个疗程。
4、疗效评定标准
显效:骨肿瘤症状消失,体质恢复正常,痊愈;
好转:患者患处疼痛、肿胀或肿块、功能障碍减轻、畸形的症状明显好转,体质逐步恢复;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗骨肿瘤患者20例,结果显效17例,显效率为85%,好转2例,好转率为10%,无效1例,总有效率为95%。
Claims (3)
1.一种治疗骨肿瘤的药物,其特征在于:它是由下列重量范围内的原料药制成:
桑寄生10-20克,牡蛎15-25克,徐长卿5-15克,天麻10-15克,续断10-20克,透骨草15-25克,重楼10-20克,薏苡仁15-25克,骨碎补10-20克,菟丝子15-25克,藁本15-25克,延胡索10-15克,红花5-15克,全蝎5-8克,葛根10-20克,紫河车5-15克,杜仲10-20克,刘寄奴5-15克,山豆根15-25克,牛膝5-15克,血竭1-2克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
桑寄生15克,牡蛎20克,徐长卿10克,天麻12克,续断15克,透骨草20克,重楼15克,薏苡仁20克,骨碎补15克,菟丝子20克,藁本20克,延胡索12克,红花10克,全蝎8克,葛根15克,紫河车10克,杜仲15克,刘寄奴10克,山豆根20克,牛膝10克,血竭2克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)桑寄生:用水洗净,润透,切段,晒干;
(2)牡蛎:洗净,晒干,碾碎用;
(3)徐长卿:拣净杂质,洗净,润透,切成1.5厘米段,晒干;
(4)天麻:拣去杂质,大小分档,用水浸泡至七成透,捞出,稍晾,再润至内外温度均匀,切片,晒干;
(5)续断:洗净泥沙,除去残留根头,润透后切片晒干,筛去屑;
(6)透骨草:拣净杂质,切段;
(7)重楼:除去须根,洗净,干燥;
(8)薏苡仁:取原药材,除去残留皮壳、杂质;
(9)骨碎补:去净泥砂杂质,洗净,稍浸泡,润透,切片,晒干;
(10)菟丝子:过箩去净杂质,洗净,晒干;
(11)藁本:取原药材,除去杂质,大小分档,抢水洗净,润透,切片,晒干;
(12)延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎;
(13)红花:拣净杂质,除去茎叶、蒂头,晒干;
(14)全蝎:清水漂去盐质,晒干,或微火焙用;
(15)葛根:拣去杂质,洗净,用水浸泡,捞出,润透,及时切片,晒干;
(16)紫河车:用新鲜的紫河车,横直割开血管,用水反复洗漂干净;
(17)杜仲:除去粗皮,洗净,润透,切成方块或丝条,晒干;
(18)刘寄奴:拣净杂质,去根,用水冼净,稍浸,切段,晒干;
(19)山豆根:拣净杂质,粗细分档,用水浸泡,捞出,润透后切片,晒干;
(20)牛膝:拣去杂质,洗净,润软,去芦,切段,晒干;
(21)血竭:拭去灰尘,敲成小块,于冬季干燥天气,放在石灰坛内使燥,然后乘脆研末;
(二)制备
(1)将所述重量的桑寄生、牡蛎、徐长卿、天麻、续断、透骨草、重楼、薏苡仁、骨碎补、菟丝子、藁本、延胡索、红花、全蝎、葛根、紫河车、杜仲、刘寄奴、山豆根、牛膝放入煎药容器内,加水6倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水4倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为3剂,再分别加入血竭冲服。
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CN107823371A (zh) * | 2017-12-13 | 2018-03-23 | 董继功 | 一种治疗恶性骨肿瘤(骨癌)骨病疼痛的外用中药 |
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