CN106692571A - 一种治疗大骨节病的药物及其制备方法 - Google Patents
一种治疗大骨节病的药物及其制备方法 Download PDFInfo
- Publication number
- CN106692571A CN106692571A CN201710121978.7A CN201710121978A CN106692571A CN 106692571 A CN106692571 A CN 106692571A CN 201710121978 A CN201710121978 A CN 201710121978A CN 106692571 A CN106692571 A CN 106692571A
- Authority
- CN
- China
- Prior art keywords
- grams
- medicine
- dried
- impurity
- picked
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003814 drug Substances 0.000 title claims abstract description 44
- 201000008482 osteoarthritis Diseases 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 229940079593 drug Drugs 0.000 title claims description 17
- 241001166194 Geranium wilfordii Species 0.000 claims abstract description 12
- 241000132171 Phryma leptostachya Species 0.000 claims abstract description 12
- 210000001320 hippocampus Anatomy 0.000 claims abstract description 12
- 235000003717 Boswellia sacra Nutrition 0.000 claims abstract description 11
- 240000007551 Boswellia serrata Species 0.000 claims abstract description 11
- 235000012035 Boswellia serrata Nutrition 0.000 claims abstract description 11
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims abstract description 11
- 244000020518 Carthamus tinctorius Species 0.000 claims abstract description 11
- 239000004863 Frankincense Substances 0.000 claims abstract description 11
- 241000112528 Ligusticum striatum Species 0.000 claims abstract description 11
- 239000009136 dragon's blood Substances 0.000 claims abstract description 11
- 239000012535 impurity Substances 0.000 claims description 26
- 244000037364 Cinnamomum aromaticum Species 0.000 claims description 11
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims description 11
- 241000427159 Achyranthes Species 0.000 claims description 10
- 244000189799 Asimina triloba Species 0.000 claims description 10
- 235000006264 Asimina triloba Nutrition 0.000 claims description 10
- 235000009467 Carica papaya Nutrition 0.000 claims description 10
- 241000195947 Lycopodium Species 0.000 claims description 10
- 240000004824 Trimezia steyermarkii Species 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 238000009738 saturating Methods 0.000 claims description 4
- 241000196324 Embryophyta Species 0.000 claims description 2
- 235000014676 Phragmites communis Nutrition 0.000 claims description 2
- 239000000428 dust Substances 0.000 claims description 2
- 235000013399 edible fruits Nutrition 0.000 claims description 2
- 210000000981 epithelium Anatomy 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 235000013305 food Nutrition 0.000 claims description 2
- 238000007654 immersion Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- 239000004576 sand Substances 0.000 claims description 2
- 239000002689 soil Substances 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 210000001835 viscera Anatomy 0.000 claims description 2
- 210000003205 muscle Anatomy 0.000 abstract description 20
- 230000017531 blood circulation Effects 0.000 abstract description 19
- 239000008280 blood Substances 0.000 abstract description 16
- 210000004369 blood Anatomy 0.000 abstract description 16
- 230000001737 promoting effect Effects 0.000 abstract description 13
- 230000000694 effects Effects 0.000 abstract description 11
- 230000002040 relaxant effect Effects 0.000 abstract description 7
- 230000008961 swelling Effects 0.000 abstract description 7
- 241000132012 Atractylodes Species 0.000 abstract 1
- 241001043298 Croton draco Species 0.000 abstract 1
- 241000501743 Gentiana macrophylla Species 0.000 abstract 1
- 241000195954 Lycopodium clavatum Species 0.000 abstract 1
- 241001050737 Sambucus williamsii Species 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 235000008216 herbs Nutrition 0.000 abstract 1
- 235000021018 plums Nutrition 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 description 20
- 210000004185 liver Anatomy 0.000 description 17
- 239000000796 flavoring agent Substances 0.000 description 15
- 235000019634 flavors Nutrition 0.000 description 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 11
- 208000014674 injury Diseases 0.000 description 8
- 210000000952 spleen Anatomy 0.000 description 8
- 208000006820 Arthralgia Diseases 0.000 description 7
- 206010030113 Oedema Diseases 0.000 description 7
- 210000000988 bone and bone Anatomy 0.000 description 7
- 208000025865 Ulcer Diseases 0.000 description 6
- 210000001015 abdomen Anatomy 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000001848 dysentery Diseases 0.000 description 6
- 210000002216 heart Anatomy 0.000 description 6
- 210000003734 kidney Anatomy 0.000 description 6
- 230000000202 analgesic effect Effects 0.000 description 5
- 230000008602 contraction Effects 0.000 description 5
- 230000001105 regulatory effect Effects 0.000 description 5
- 210000002435 tendon Anatomy 0.000 description 5
- 230000008736 traumatic injury Effects 0.000 description 5
- 231100000397 ulcer Toxicity 0.000 description 5
- 206010062717 Increased upper airway secretion Diseases 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 230000004087 circulation Effects 0.000 description 4
- 238000007791 dehumidification Methods 0.000 description 4
- 208000035475 disorder Diseases 0.000 description 4
- 201000001881 impotence Diseases 0.000 description 4
- 231100000862 numbness Toxicity 0.000 description 4
- 208000026435 phlegm Diseases 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 230000035900 sweating Effects 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 201000000736 Amenorrhea Diseases 0.000 description 3
- 206010001928 Amenorrhoea Diseases 0.000 description 3
- 206010007247 Carbuncle Diseases 0.000 description 3
- 206010047700 Vomiting Diseases 0.000 description 3
- 231100000540 amenorrhea Toxicity 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 208000035861 hematochezia Diseases 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 230000000717 retained effect Effects 0.000 description 3
- 201000004647 tinea pedis Diseases 0.000 description 3
- 230000008673 vomiting Effects 0.000 description 3
- 206010000087 Abdominal pain upper Diseases 0.000 description 2
- 208000034656 Contusions Diseases 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 241000521257 Hydrops Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 206010046788 Uterine haemorrhage Diseases 0.000 description 2
- 206010003246 arthritis Diseases 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 208000034526 bruise Diseases 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 230000036461 convulsion Effects 0.000 description 2
- 210000000232 gallbladder Anatomy 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 208000006750 hematuria Diseases 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- 201000004792 malaria Diseases 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 231100000820 toxicity test Toxicity 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 241001465677 Ancylostomatoidea Species 0.000 description 1
- 241000244186 Ascaris Species 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 206010018612 Gonorrhoea Diseases 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 208000004044 Hypesthesia Diseases 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 208000015817 Infant Nutrition disease Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 208000005102 Kashin-Beck Disease Diseases 0.000 description 1
- 208000037093 Menstruation Disturbances Diseases 0.000 description 1
- 206010027339 Menstruation irregular Diseases 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 206010059013 Nocturnal emission Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000012287 Prolapse Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 201000009361 ascariasis Diseases 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000003445 biliary tract Anatomy 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 208000013116 chronic cough Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 208000017561 flaccidity Diseases 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000034783 hypoesthesia Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 244000000053 intestinal parasite Species 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 230000001114 myogenic effect Effects 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/60—Fish, e.g. seahorses; Fish eggs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/732—Chaenomeles, e.g. flowering quince
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Marine Sciences & Fisheries (AREA)
- Molecular Biology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种治疗大骨节病的药物及其制备方法,其是由当归、苍术、五加皮、红花、血竭、老鹳草、透骨草、乌梅、伸筋草、秦艽、牛膝、龙骨、乳香、川芎、海马、接骨木等按一定重量配比制备而成,本发明药物具有祛风散寒,除湿消肿,舒筋活血,活血祛瘀的功能,用于治疗大骨节病见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗大骨节病的药物及其制备方法,属中药领域。
技术背景
大骨节病是指一种地方性、变形性骨关节病,国内又叫矮人病、算盘珠病等,国际医学界称为Kaschin-Beck病。中医则认为大骨节病与气滞血瘀,寒湿阻络,痰瘀互结有关。由于西药治疗副作用大,因此人们对有效治疗大骨节病的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗大骨节病的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗大骨节病的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择当归、苍术、五加皮、红花、血竭、老鹳草、透骨草、乌梅、伸筋草、秦艽、牛膝、龙骨、乳香、川芎、海马、接骨木、木瓜、红糖、桂枝进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗大骨节病。其中选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用苍术是因为其性味辛苦,温,入脾、胃经,有健脾,燥湿,解郁,辟秽的功能,治湿盛困脾,倦怠嗜卧,脘痞腹胀,食欲不振,呕吐,泄泻,痢疾,疟疾,痰饮,水肿,时气感冒,风寒湿痹,足痿,夜盲。选用五加皮是因为其性味辛,温,入肝、肾经,有祛风湿,壮筋骨,活血去瘀的功能,治风寒湿痹,筋骨挛急,腰痛,阳痿,脚弱,小儿行迟、水肿,脚气,疮疽肿毒,跌打劳伤。选用红花是因为其性味辛,温,入心、肝经,有活血通经,去瘀止痛的功能,治经闭,癥瘕,难产,死胎,产后恶露不行,瘀血作痛,痈肿,跌扑损伤。选用血竭是因为其性味甘咸,平,入心、肝经,有散瘀定痛,止血生肌的功能,治跌打折损,内伤瘀痛,外伤出血不止。选用老鹳草是因为其性味苦辛,有祛风,活血,清热解毒的功能,治风湿疼痛,拘挛麻木,痈疽,跌打,肠炎,痢疾。选用透骨草是因为其性味辛温,有祛风,除湿,舒筋,活血,止痛的功能,治风湿痹痛,筋骨挛缩,疮癣肿毒。选用乌梅是因为其性味酸,温,入肝,脾,肺,大肠经,有收敛生津,安蛔驱虫的功能,治久咳,虚热烦渴,久疟,痢疾,便血,尿血,血崩,蛔厥腹痛,呕吐,钩虫病,牛皮癣,胬肉。选用伸筋草是因为其性味苦辛,温,入肝、胃、肾三经,有祛风散寒,除湿消肿,舒筋活血的功能,治风寒湿痹,关节酸痛,皮肤麻木,四肢软弱,水肿,跌打损伤。选用秦艽是因为其性味苦辛,平,入肝、胃、胆经,有祛风除湿,和血舒筋,清热利尿的功能,治风湿痹痛,筋骨拘挛,黄疸,便血,骨蒸潮热,小儿疳热,小便不利。选用牛膝是因为其性味甘苦酸,平,入肝、肾经,生用散瘀血,消痈肿,治淋病,尿血,经闭,癥瘕,难产,胞衣不下,产后瘀血腹痛,喉痹,痈肿,跌打损伤,熟用补肝肾,强筋骨,治腰膝骨痛,四肥拘挛,痿痹。选用龙骨是因为其性味甘涩,平,入心、肝、肾、大肠经,有镇惊安神,敛汗固精,止血涩肠,生肌敛疮的功能,治惊癎癫狂,怔忡健忘,失眠多梦,自汗盗汗,遗精淋浊,吐衄便血,崩漏带下,泻痢脱肛,溃疡久不收口。选用乳香是因为其性味辛苦,温,入心、肝、脾经,有调气活血,定痛,追毒的功能,治气血凝滞,心腹疼痛,痈疮肿毒,跌打损伤,痛经,产后瘀血刺痛。选用川芎是因为其性味辛,温,入肝、胆经,有行气开郁,祛风燥湿,活血止痛的功能,治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。选用海马是因为其味甘咸、性慢、入肝、肾二经,有补肝益肾、壮阳安神、调气、活血祛瘀、舒筋活络、止喘平喘等功用。选用接骨木是因为其味甘、苦,性平,归肝经。有祛风除湿,活血接骨,消肿止痛。主治风湿痹痛,腰痛,骨节痛,水肿,脚气,风痒瘾疹,产后血晕,跌打肿痛,筋伤骨折,创伤出血。选用木瓜是因为其性味酸,温,入肝、脾经,有平肝和胃,去湿舒筋的功能,治吐泻转筋,湿痹,脚气,水肿,痢疾。选用红糖是因为其性味甘甜,温润,入肝、脾经,有和中助脾,补血破瘀的功能,治咽喉肿痛,肺热咳嗽,心腹热胀。选用桂枝是因为其性味辛甘,温,入膀胱、心、肺经,有发汗解肌,温经通脉的功能,治风寒表证,肩背肢节酸疼,胸痹痰饮,经闭癥瘕。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
当归5-15克,苍术5-15克,五加皮10-20克,红花10-20克,血竭5-15克,老鹳草10-20克,透骨草15-25克,乌梅10-15克,伸筋草20-30克,秦艽10-15克,牛膝10-20克,龙骨10-20克,乳香10-20克,川芎10-15克,海马5-10克,接骨木10-15克,木瓜10-15克,红糖10-20克,桂枝15-25克。
优选为:
当归10克,苍术10克,五加皮15克,红花15克,血竭10克,老鹳草15克,透骨草20克,乌梅12克,伸筋草25克,秦艽12克,牛膝15克,龙骨15克,乳香15克,川芎12克,海马8克,接骨木12克,木瓜12克,红糖15克,桂枝20克。
本发明药物的制备方法如下
一、备料
1、当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
2、苍术:拣去杂质,用水泡至七、八成透,捞出,润透后切片,晒干;
3、五加皮:拣净杂质,用水洗净,稍润后切片,干燥;
4、红花:拣净杂质,除去茎叶、蒂头,晒干;
5、血竭:拭去灰尘,敲成小块;
6、老鹳草:拣去杂质,除去残根,用水洗净,捞出,切段,晒干;
7、透骨草:拣净杂质,切段;
8、乌梅:拣净杂质,筛去灰屑,洗净,晒干;
9、伸筋草:筛去灰屑,拣净杂质,切成小段;
10、秦艽:拣去杂质,除去芦头,稍浸,润透切片,晒干;
11、牛膝:拣去杂质,洗净,润软,去芦,切段,晒干;
12、龙骨:刷净泥土,打碎;
13、乳香:拣去砂子杂质;
14、川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
15、海马:夏,秋两季捕捞,洗干净,然后再晒干,或者除掉皮膜和内脏,然后再晒干;
16、接骨木:取原药材,除去杂质,洗净,润透,切斜薄片,干燥;
17、木瓜:清水洗净,稍浸泡,闷润至透,置蒸笼内蒸熟,乘热切片,日晒夜露,以由红转紫黑色为度;
18、红糖:原品入药
19、桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑。
二、制备
1、将所述重量的当归、苍术、五加皮、红花、血竭、老鹳草、透骨草、乌梅、伸筋草、秦艽、牛膝、龙骨、乳香、川芎、海马、接骨木、木瓜、红糖、桂枝放入煎药容器内,第一次加水6倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水4倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为2剂服用。
组方中伸筋有祛风散寒,除湿消肿,舒筋活血的功能为君药;老鹳草祛风,活血,清热解毒;透骨草祛风,除湿,舒筋,活血,止痛,二者为臣药,三味药共同发挥祛风散寒,除湿消肿,清热解毒,舒筋活血,止痛的作用,治疗大骨节病效力全面,且以祛风散寒,除湿消肿,舒筋活血为主可治本,桂枝有发汗解肌,温经通脉的功能,治风寒表证,肩背肢节酸疼,胸痹痰饮的功能为佐药,海马有补肝益肾、壮阳安神、调气、活血祛瘀、舒筋活络、止喘平喘的功能为使药,与下余诸药是治标。
本发明药物具有祛风散寒,除湿消肿,舒筋活血,活血祛瘀的功能,用于治疗大骨节病,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治大骨节病门诊患者共17例。
2、诊断标准
典型症状为关节粗大,并有疼痛与活动受限,一般青春后期发病的畸形看不明显,主要是骨关节炎症状,如关节肿胀,有少量积液,活动时有磨擦感,并时有交锁等症状。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,30天为一个疗程,连续服用2个疗程。
4、疗效评定标准
显效:大骨节病症状消失,体质恢复正常,痊愈;
好转:患者关节粗大、疼痛,关节肿胀、积液、活动时有摩擦感的现象减轻,大骨节病症状明显好转,体质逐步恢复;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗大骨节病患者17例,结果显效14例,显效率为82.35%,好转2例,好转率为11.77%,无效1例,总有效率为94.12%。
Claims (3)
1.一种治疗大骨节病的药物,其特征在于:它是由下列重量范围内的原料药制成:
当归5-15克,苍术5-15克,五加皮10-20克,红花10-20克,血竭5-15克,老鹳草10-20克,透骨草15-25克,乌梅10-15克,伸筋草20-30克,秦艽10-15克,牛膝10-20克,龙骨10-20克,乳香10-20克,川芎10-15克,海马5-10克,接骨木10-15克,木瓜10-15克,红糖10-20克,桂枝15-25克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
当归10克,苍术10克,五加皮15克,红花15克,血竭10克,老鹳草15克,透骨草20克,乌梅12克,伸筋草25克,秦艽12克,牛膝15克,龙骨15克,乳香15克,川芎12克,海马8克,接骨木12克,木瓜12克,红糖15克,桂枝20克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
(2)苍术:拣去杂质,用水泡至七、八成透,捞出,润透后切片,晒干;
(3)五加皮:拣净杂质,用水洗净,稍润后切片,干燥;
(4)红花:拣净杂质,除去茎叶、蒂头,晒干;
(5)血竭:拭去灰尘,敲成小块;
(6)老鹳草:拣去杂质,除去残根,用水洗净,捞出,切段,晒干;
(7)透骨草:拣净杂质,切段;
(8)乌梅:拣净杂质,筛去灰屑,洗净,晒干;
(9)伸筋草:筛去灰屑,拣净杂质,切成小段;
(10)秦艽:拣去杂质,除去芦头,稍浸,润透切片,晒干;
(11)牛膝:拣去杂质,洗净,润软,去芦,切段,晒干;
(12)龙骨:刷净泥土,打碎;
(13)乳香:拣去砂子杂质;
(14)川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
(15)海马:夏,秋两季捕捞,洗干净,然后再晒干,
或者除掉皮膜和内脏,然后再晒干;
(16)接骨木:取原药材,除去杂质,洗净,润透,切斜薄片,干燥;
(17)木瓜:清水洗净,稍浸泡,闷润至透,置蒸笼内蒸熟,乘热切片,日晒夜露,以由红转紫黑色为度;
(18)红糖:原品入药;
(19)桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
(二)制备
(1)将所述重量的当归、苍术、五加皮、红花、血竭、老鹳草、透骨草、乌梅、伸筋草、秦艽、牛膝、龙骨、乳香、川芎、海马、接骨木、木瓜、红糖、桂枝放入煎药容器内,加水6倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水4倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为2剂服用。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710121978.7A CN106692571A (zh) | 2017-03-03 | 2017-03-03 | 一种治疗大骨节病的药物及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710121978.7A CN106692571A (zh) | 2017-03-03 | 2017-03-03 | 一种治疗大骨节病的药物及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN106692571A true CN106692571A (zh) | 2017-05-24 |
Family
ID=58911998
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710121978.7A Withdrawn CN106692571A (zh) | 2017-03-03 | 2017-03-03 | 一种治疗大骨节病的药物及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN106692571A (zh) |
-
2017
- 2017-03-03 CN CN201710121978.7A patent/CN106692571A/zh not_active Withdrawn
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN105031013A (zh) | 一种治疗腰椎骨质增生的药物及其制备方法 | |
CN106728705A (zh) | 一种治疗视网膜色素变性的药物及其制备方法 | |
CN105521473A (zh) | 一种治疗小儿麻痹后遗症的药物及其制备方法 | |
CN106692571A (zh) | 一种治疗大骨节病的药物及其制备方法 | |
CN106798857A (zh) | 一种治疗骨肿瘤的药物及其制备方法 | |
CN108743901A (zh) | 一种治疗颈椎病的药物及其制备方法 | |
CN106902343A (zh) | 一种治疗坐骨神经痛的药物及其制备方法 | |
CN106822552A (zh) | 一种治疗类风湿关节炎的药物及其制备方法 | |
CN106692858A (zh) | 一种治疗胎动不安的药物及其制备方法 | |
CN106728880A (zh) | 一种治疗再生障碍性贫血的药物及其制备方法 | |
CN106822651A (zh) | 一种治疗过敏性紫癜的药物及其制备方法 | |
CN106822534A (zh) | 一种治疗宫颈炎的药物及其制备方法 | |
CN106692832A (zh) | 一种治疗咳嗽的药物及其制备方法 | |
CN106511489A (zh) | 一种治疗风湿的药物及其制备方法 | |
CN105056093A (zh) | 一种治疗慢性胃及十二指肠溃疡的药物及其制备方法 | |
CN103356800B (zh) | 一种治疗腰痛的药物及其制备方法 | |
CN108283710A (zh) | 一种治疗强直性脊柱炎的药物及其制备方法 | |
CN108273013A (zh) | 一种治疗系统性硬化病的药物及其制备方法 | |
CN106729162A (zh) | 一种治疗肩周炎的药物及其制备方法 | |
CN106692793A (zh) | 一种治疗多发性末梢神经炎的药物及其制备方法 | |
CN108283693A (zh) | 一种治疗慢性肠炎的药物及其制备方法 | |
CN106692794A (zh) | 一种治疗下肢溃疡的药物及其制备方法 | |
CN106822840A (zh) | 一种治疗克山病的药物及其制备方法 | |
CN107648347A (zh) | 一种治疗肩周炎的药物及其制备方法 | |
CN106798860A (zh) | 一种治疗脊髓灰质炎的药物及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170524 |
|
WW01 | Invention patent application withdrawn after publication |