CN106421535A - 一种治疗痛风性关节炎的药物及其制备方法 - Google Patents
一种治疗痛风性关节炎的药物及其制备方法 Download PDFInfo
- Publication number
- CN106421535A CN106421535A CN201611122824.1A CN201611122824A CN106421535A CN 106421535 A CN106421535 A CN 106421535A CN 201611122824 A CN201611122824 A CN 201611122824A CN 106421535 A CN106421535 A CN 106421535A
- Authority
- CN
- China
- Prior art keywords
- grams
- gram
- radix
- dry
- impurity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003814 drug Substances 0.000 title claims abstract description 46
- 201000005569 Gout Diseases 0.000 title claims abstract description 19
- 206010018634 Gouty Arthritis Diseases 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 229940079593 drug Drugs 0.000 title claims description 25
- 241000255789 Bombyx mori Species 0.000 claims abstract description 11
- 241000903946 Clematidis Species 0.000 claims abstract description 11
- 230000008901 benefit Effects 0.000 claims abstract description 3
- 239000012535 impurity Substances 0.000 claims description 42
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 35
- 241000628997 Flos Species 0.000 claims description 10
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 10
- 210000000582 semen Anatomy 0.000 claims description 10
- 241000237636 Pheretima Species 0.000 claims description 9
- 206010044565 Tremor Diseases 0.000 claims description 9
- 239000002689 soil Substances 0.000 claims description 8
- 210000002216 heart Anatomy 0.000 claims description 7
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 5
- 241000196324 Embryophyta Species 0.000 claims description 4
- 238000009835 boiling Methods 0.000 claims description 4
- 230000008859 change Effects 0.000 claims description 4
- 238000009738 saturating Methods 0.000 claims description 4
- 238000002791 soaking Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims description 2
- 235000017491 Bambusa tulda Nutrition 0.000 claims description 2
- 235000019082 Osmanthus Nutrition 0.000 claims description 2
- 241000333181 Osmanthus Species 0.000 claims description 2
- 235000014676 Phragmites communis Nutrition 0.000 claims description 2
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims description 2
- 239000011425 bamboo Substances 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 238000002386 leaching Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- 230000000717 retained effect Effects 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 239000004575 stone Substances 0.000 claims description 2
- 241001330002 Bambuseae Species 0.000 claims 1
- 230000006870 function Effects 0.000 abstract description 37
- 210000004185 liver Anatomy 0.000 abstract description 22
- 210000003205 muscle Anatomy 0.000 abstract description 21
- 230000017531 blood circulation Effects 0.000 abstract description 16
- 210000003734 kidney Anatomy 0.000 abstract description 15
- 210000000988 bone and bone Anatomy 0.000 abstract description 12
- 210000002435 tendon Anatomy 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 10
- 230000001737 promoting effect Effects 0.000 abstract description 8
- 230000001105 regulatory effect Effects 0.000 abstract description 7
- 230000002040 relaxant effect Effects 0.000 abstract description 7
- 230000002175 menstrual effect Effects 0.000 abstract description 5
- 244000170916 Paeonia officinalis Species 0.000 abstract description 2
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract description 2
- 240000000031 Achyranthes bidentata Species 0.000 abstract 1
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 235000007516 Chrysanthemum Nutrition 0.000 abstract 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 abstract 1
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 1
- 244000077995 Coix lacryma jobi Species 0.000 abstract 1
- 241000123589 Dipsacus Species 0.000 abstract 1
- 241000501743 Gentiana macrophylla Species 0.000 abstract 1
- 244000248825 Peltandra virginica Species 0.000 abstract 1
- 235000001188 Peltandra virginica Nutrition 0.000 abstract 1
- 241001499733 Plantago asiatica Species 0.000 abstract 1
- 235000008599 Poria cocos Nutrition 0.000 abstract 1
- 244000153955 Reynoutria sachalinensis Species 0.000 abstract 1
- 235000003202 Reynoutria sachalinensis Nutrition 0.000 abstract 1
- 241000983344 Trachelospermum jasminoides Species 0.000 abstract 1
- 210000004204 blood vessel Anatomy 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 229910052602 gypsum Inorganic materials 0.000 abstract 1
- 239000010440 gypsum Substances 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 description 31
- 235000019634 flavors Nutrition 0.000 description 31
- 208000002193 Pain Diseases 0.000 description 18
- 210000004072 lung Anatomy 0.000 description 13
- 231100000614 poison Toxicity 0.000 description 13
- 210000000952 spleen Anatomy 0.000 description 13
- 208000006820 Arthralgia Diseases 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 12
- 239000008280 blood Substances 0.000 description 12
- 206010007247 Carbuncle Diseases 0.000 description 11
- 210000002784 stomach Anatomy 0.000 description 10
- 235000009508 confectionery Nutrition 0.000 description 9
- 230000008961 swelling Effects 0.000 description 8
- 244000052769 pathogen Species 0.000 description 7
- 239000003440 toxic substance Substances 0.000 description 7
- 206010000077 Abdominal mass Diseases 0.000 description 6
- 206010030113 Oedema Diseases 0.000 description 6
- 206010037660 Pyrexia Diseases 0.000 description 6
- 208000014674 injury Diseases 0.000 description 6
- 230000001717 pathogenic effect Effects 0.000 description 6
- 201000000736 Amenorrhea Diseases 0.000 description 5
- 206010001928 Amenorrhoea Diseases 0.000 description 5
- 206010011224 Cough Diseases 0.000 description 5
- 206010017553 Furuncle Diseases 0.000 description 5
- 206010019233 Headaches Diseases 0.000 description 5
- 206010062717 Increased upper airway secretion Diseases 0.000 description 5
- 208000004880 Polyuria Diseases 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 231100000540 amenorrhea Toxicity 0.000 description 5
- 230000035619 diuresis Effects 0.000 description 5
- 231100000869 headache Toxicity 0.000 description 5
- 201000007227 lymph node tuberculosis Diseases 0.000 description 5
- 208000026435 phlegm Diseases 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 4
- 206010012735 Diarrhoea Diseases 0.000 description 4
- 206010023126 Jaundice Diseases 0.000 description 4
- 208000025865 Ulcer Diseases 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 210000002683 foot Anatomy 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 230000014759 maintenance of location Effects 0.000 description 4
- 201000004792 malaria Diseases 0.000 description 4
- 239000002574 poison Substances 0.000 description 4
- 201000004647 tinea pedis Diseases 0.000 description 4
- 239000003053 toxin Substances 0.000 description 4
- 231100000765 toxin Toxicity 0.000 description 4
- 230000008736 traumatic injury Effects 0.000 description 4
- 231100000397 ulcer Toxicity 0.000 description 4
- 206010068319 Oropharyngeal pain Diseases 0.000 description 3
- 201000007100 Pharyngitis Diseases 0.000 description 3
- 208000004680 Rectal Fistula Diseases 0.000 description 3
- 206010043376 Tetanus Diseases 0.000 description 3
- 206010052428 Wound Diseases 0.000 description 3
- 206010002156 anal fistula Diseases 0.000 description 3
- 210000001367 artery Anatomy 0.000 description 3
- 230000008602 contraction Effects 0.000 description 3
- 238000007791 dehumidification Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000002934 diuretic Substances 0.000 description 3
- 230000001882 diuretic effect Effects 0.000 description 3
- 206010013990 dysuria Diseases 0.000 description 3
- 208000001780 epistaxis Diseases 0.000 description 3
- 208000006750 hematuria Diseases 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 210000003462 vein Anatomy 0.000 description 3
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- 206010021118 Hypotonia Diseases 0.000 description 2
- 208000015817 Infant Nutrition disease Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 208000019693 Lung disease Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 206010062575 Muscle contracture Diseases 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 206010040943 Skin Ulcer Diseases 0.000 description 2
- 208000005392 Spasm Diseases 0.000 description 2
- 208000002474 Tinea Diseases 0.000 description 2
- 241000130764 Tinea Species 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 208000031971 Yin Deficiency Diseases 0.000 description 2
- 208000006111 contracture Diseases 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 230000036461 convulsion Effects 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 208000001848 dysentery Diseases 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 208000017561 flaccidity Diseases 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 208000035861 hematochezia Diseases 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 210000001503 joint Anatomy 0.000 description 2
- 210000003127 knee Anatomy 0.000 description 2
- 210000000629 knee joint Anatomy 0.000 description 2
- 201000003453 lung abscess Diseases 0.000 description 2
- 208000004396 mastitis Diseases 0.000 description 2
- 210000000878 metatarsophalangeal joint Anatomy 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 231100000862 numbness Toxicity 0.000 description 2
- 210000003800 pharynx Anatomy 0.000 description 2
- 230000007096 poisonous effect Effects 0.000 description 2
- 201000005404 rubella Diseases 0.000 description 2
- 231100000019 skin ulcer Toxicity 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 206010044008 tonsillitis Diseases 0.000 description 2
- 208000004371 toothache Diseases 0.000 description 2
- 231100000820 toxicity test Toxicity 0.000 description 2
- 201000002327 urinary tract obstruction Diseases 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 241000208365 Celastraceae Species 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 206010009346 Clonus Diseases 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 206010010726 Conjunctival oedema Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010012218 Delirium Diseases 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 206010013952 Dysphonia Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- 208000015220 Febrile disease Diseases 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 206010060710 Galactostasis Diseases 0.000 description 1
- 206010018612 Gonorrhoea Diseases 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 206010019345 Heat stroke Diseases 0.000 description 1
- 206010019468 Hemiplegia Diseases 0.000 description 1
- 208000037319 Hepatitis infectious Diseases 0.000 description 1
- 208000010473 Hoarseness Diseases 0.000 description 1
- 206010020741 Hyperpyrexia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000004044 Hypesthesia Diseases 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 241000243684 Lumbricus Species 0.000 description 1
- 206010026749 Mania Diseases 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 208000005647 Mumps Diseases 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 206010052904 Musculoskeletal stiffness Diseases 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000001140 Night Blindness Diseases 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 240000005373 Panax quinquefolius Species 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 208000008469 Peptic Ulcer Diseases 0.000 description 1
- 244000082204 Phyllostachys viridis Species 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010037714 Quadriplegia Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 241000270295 Serpentes Species 0.000 description 1
- 238000003457 Shi epoxidation reaction Methods 0.000 description 1
- 206010067868 Skin mass Diseases 0.000 description 1
- 235000000336 Solanum dulcamara Nutrition 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- 208000006568 Urinary Bladder Calculi Diseases 0.000 description 1
- 206010046788 Uterine haemorrhage Diseases 0.000 description 1
- 206010046910 Vaginal haemorrhage Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 231100000354 acute hepatitis Toxicity 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 210000003423 ankle Anatomy 0.000 description 1
- 229940124584 antitussives Drugs 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000002917 arthritic effect Effects 0.000 description 1
- 210000000544 articulatio talocruralis Anatomy 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 208000010217 blepharitis Diseases 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 210000003108 foot joint Anatomy 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 208000001786 gonorrhea Diseases 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 208000005252 hepatitis A Diseases 0.000 description 1
- 208000021760 high fever Diseases 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 208000034783 hypoesthesia Diseases 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 210000000281 joint capsule Anatomy 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 208000010805 mumps infectious disease Diseases 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 208000011906 peptic ulcer disease Diseases 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 208000010540 rapid respiration Diseases 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 108010048734 sclerotin Proteins 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 210000001171 synovial bursa Anatomy 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 230000008359 toxicosis Effects 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/716—Clematis (leather flower)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/86—Violaceae (Violet family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Insects & Arthropods (AREA)
- Tropical Medicine & Parasitology (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种治疗痛风性关节炎的药物及其制备方法,其主要是由忍冬藤、蚕沙、络石藤、车前草、防风、金钱草、秦艽、茯苓、虎杖、威灵仙、石膏、牛膝、续断、海风藤、泽泻、桂枝、赤芍、薏苡仁、菊花按一定重量配比制备而成,本发明药物具有祛风散寒,舒筋活血,渗湿泄热,补肝肾,续筋骨,调血脉,通经理气的功能,用于治疗痛风性关节炎见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗痛风性关节炎的药物及其制备方法,属中药领域。
背景技术
痛风性关节炎是由于尿酸盐沉积在关节囊、滑囊、软骨、骨质和其他组织中而引起病损及炎性反应,其多有遗传因素,好发于40岁以上男性,多见于第一跖趾关节,也可发生于其他较大关节,尤其是踝部与足部关节。中医则认为痛风性关节炎与湿热内蕴,脉络遇阻,气阴两虚有关。由于西药治疗副作用大,因此人们对有效治疗痛风性关节炎的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗痛风性关节炎的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗痛风性关节炎的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择忍冬藤、蚕沙、络石藤、车前草、防风、金钱草、秦艽、茯苓、虎杖、威灵仙、石膏、牛膝、续断、海风藤、泽泻、桂枝、赤芍、薏苡仁、伸筋草、豨莶草、丝瓜络、苍术、紫花地丁、牡丹皮、土贝母、菊花、知母、鸡血藤、蜂房、地龙、蝉蜕、甘草进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗痛风性关节炎。其中选用忍冬藤是因为其性味甘,寒,入心、肺经,有清热,解毒,通络的功能,治温病发热,热毒血痢,传染性肝炎,痈肿疮毒,筋骨疼痛。选用蚕沙是因为其性味甘、辛、温,归肝、脾经,有祛风除湿,活血定痛的功能,治风湿痹痛,关节不遂,腰脚冷痛,风疹瘙痒,头风头痛,烂弦风眼。选用络石藤是因为其性味苦,凉,入肝、肾经,有祛风,通络,止血,消瘀的功能,治风湿痹痛,筋脉拘挛,痈肿,喉痹,吐血,跌打损伤,产后恶露不行。选用车前草是因为其性味甘,寒,入肝、脾二经,有利水,清热,明目,祛痰的功能,治小便不通,淋浊,带下,尿血,黄疸,水肿,热痢,泄泻,鼻衄,目赤肿痛,喉痹乳蛾,咳嗽,皮肤溃疡。选用防风是因为其性味辛甘,温,入膀胱、肺、脾经,有发表,祛风,胜湿,止痛的功能,治外感风寒,头痛,目眩,项强,风寒湿痹,骨节酸痛,四肢挛急,破伤风。选用金钱草是因为其性味苦辛,凉,有清热,利尿,镇咳,消肿,解毒的功能,治黄疸,水肿,膀胱结石,疟疾,肺痈,咳嗽,吐血,淋浊,带下,风湿痹痛,小儿疳积,惊癎,痈肿,疮癣,湿疹。选用秦艽是因为其性味苦辛,平,入肝、胃、胆经,有祛风除湿,和血舒筋,清热利尿的功能,治风湿痹痛,筋骨拘挛,黄疸,便血,骨蒸潮热,小儿疳热,小便不利。选用土茯苓是因为其性味甘淡,平,入肝、胃经,有解毒,除湿,利关节的功能,治梅毒,淋浊,筋骨挛痛,脚气,疔疮,痈肿,瘰疬。选用虎杖是因为其性味苦,平,有祛风,利湿,破瘀,通经的功能,治风湿筋骨疼痛,湿热黄疸,淋浊带下,妇女经闭,产后恶露不下,癥瘕积聚,痔漏下血,跌扑损伤,烫伤,恶疮癣疾。选用威灵仙是因为其性味辛咸,温,有毒,入膀胱经,有祛风湿,通经络,消痰涎,散癖积的功能,治痛风、顽痹、腰膝冷痛,脚气,疟疾,癥瘕积聚,破伤风,扁桃体炎,诸骨鲠咽。选用石膏是因为其性味辛甘,寒,入肺、胃经,生用有解肌清热,除烦止渴的功能,治热病壮热不退,心烦神昏,谵语发狂,口渴咽干,肺热喘急,中暑自汗,胃火头痛、牙痛,热毒壅盛,发斑发疹,口舌生疮,煅敷生肌敛疮,外治痈疽疮疡,溃不收回,汤火烫伤。选用川牛膝是因为其性味平,味苦微苦,无毒,入肝、肾二经,有祛风,利湿,通经,活血的功能,治风湿腰膝疼痛,脚痿筋挛,血淋,尿血,妇女经闭,癥瘕。选用续断是因为其性味苦辛,微温,入肝、肾经,有补肝肾,续筋骨,调血脉的功能,治腰背酸痛,足膝无力,胎漏,崩漏,带下,遗精,跌打损伤,金疮,痔漏,痈疽疮肿。选用海风藤是因为其性味辛苦,微温,入心、肾二经,有祛风湿,通经络,理气的功能,治风寒湿痹,关节疼痛,筋脉拘挛,跌打损伤,哮喘,久咳。选用泽泻是因为其性味甘,寒,入膀胱经,有利水,渗湿,泄热的功能,治小便不利,水肿肛满,呕吐,泻痢,痰饮,脚气,淋病,尿血。选用桂枝是因为其性味辛甘,温,入膀胱、心、肺经,有发汗解肌,温经通脉的功能,治风寒表证,肩背肢节酸疼,胸痹痰饮,经闭癥瘕。选用赤芍是因为其性味苦,微寒,归肝经,有清热凉血,散瘀止痛的功能,治温毒发狂,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,癎瘕腹痛,跌扑损伤,痈肿疮疡。选用薏苡仁是因为其性味甘淡,凉,入脾、肺、肾经,有健脾,补肺,清热,利湿的功能,治泄泻,湿痹,筋脉拘挛,屈伸不利,水肿,脚气,肺痿,肺痈,肠痈,淋浊,白带。选用伸筋草是因为其性味苦辛,温,入肝、胃、肾三经,有祛风散寒,除湿消肿,舒筋活血的功能,治风寒湿痹,关节酸痛,皮肤麻木,四肢软弱,水肿,跌打损伤。选用豨莶草是因为其性味苦,寒,入肝、脾、肾经,有祛风湿,利筋骨,降血压的功能,治四肢麻痹,筋骨疼痛,腰膝无力,疟疾,急性肝炎,高血压病,疔疮肿毒,外伤出血。选用丝瓜络是因为其性味甘,平,有通经活络,清热化痰的功能,治胸胁疼痛,腹痛,腰痛,睾丸肿痛,肺热痰咳,妇女经闭,乳汁不通,痈肿,痔漏。选用苍术是因为其性味辛苦,温,入脾、胃经,有健脾,燥湿,解郁,辟秽的功能,治湿盛困脾,倦怠嗜卧,脘痞腹胀,食欲不振,呕吐,泄泻,痢疾,疟疾,痰饮,水肿,时气感冒,风寒湿痹,足痿,夜盲。选用紫花地丁是因为其性味苦、辛、寒,归心、肝经,有清热解毒,凉血消肿的功能,治疔疮肿毒,痈疽发背,丹毒,毒蛇咬伤。选用牡丹皮是因为其性味辛苦,凉,入心、肝、肾经,有清热,凉血,和血,消瘀的功能,治热入血分,发斑,惊癎,吐、衄、便血,骨蒸劳热,经闭,癥瘕,痈疡,扑损。选用土贝母是因为其性味苦,凉,有散结毒,消痈肿的功能,治乳痈,瘰疬痰核,疮疡肿毒及蛇虫毒。选用菊花是因为其性味甘苦,凉,入肺,肝经,有疏风,消热,明目,解毒的功能,治头痛,眩晕,目赤,心胸烦热,疔疮,肿毒。选用知母是因为其性味苦,寒,入肺、胃、肾经,有滋阴降火,润燥滑肠的功能,治烦热消渴,骨蒸劳热,肺热咳嗽,大便燥结,小便不利。选用鸡血藤是因为其性味苦甘,温,入心、脾二经,有活血、舒筋的功能,治腰膝酸痛,麻木瘫痪,月经不调。选用蜂房是因为其性味甘,平,归胃经,有祛风,攻毒,杀虫,止痛的功能,用于龋齿牙痛,疮疡肿毒,乳痈,瘰疬,皮肤顽癣,鹅掌风。选用蚯蚓是因为其性味咸,寒,入肝、脾、肺经,有清热,平肝,止喘,通络的功能,治高热狂躁,惊风抽搐,风热头痛,目赤,中风半身不遂,喘息,喉痹,关节疼痛,齿衄,小便不通,瘰疬,痄腮,疮疡。选用蝉蜕是因为其性味甘咸,凉,入肺、肝经,有散风热,宣肺,定痉的功能,治外感风热,咳嗽音哑,麻疹透发不畅,风疹瘙痒,小儿惊癎,目赤,翳障,疔疮肿毒,破伤风。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊痈,生用治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
忍冬藤15-25克,蚕沙10-20克,络石藤5-15克,车前草5-15克,防风10-20克,金钱草5-15克,秦艽7-12克,土茯苓10-20克,虎杖10-20克,威灵仙1-5克,石膏10-20克,牛膝10-20克,续断5-15克,海风藤10-15克,泽泻10-20克,桂枝5-15克,赤芍10-20克,薏苡仁10-20克,伸筋草15-25克,豨莶草10-20克,丝瓜络5-15克,苍术10-20克,紫花地丁15-25克,牡丹皮10-15克,土贝母10-20克,菊花10-20克,知母10-20克,鸡血藤15-25克,蜂房7-12克,地龙10-20克,蝉蜕5-15克,甘草5-15克。
优选为:
忍冬藤20克,蚕沙15克,络石藤10克,车前草10克,防风15克,金钱草10克,秦艽9克,土茯苓15克,虎杖15克,威灵仙3克,石膏15克,牛膝15克,续断10克,海风藤12克,泽泻15克,桂枝10克,赤芍15克,薏苡仁15克,伸筋草20克,豨莶草15克,丝瓜络10克,苍术15克,紫花地丁20克,牡丹皮12克,土贝母15克,菊花15克,知母15克,鸡血藤20克,蜂房9克,地龙15克,蝉蜕10克,甘草10克。
本发明药物的制备方法如下
一、备料
1、忍冬藤:拣去杂质,用水浸泡,润透,切片,晒干;
2、蚕沙:除去杂质,筛去灰屑;
3、络石藤:用水洗去泥土,拣净杂质,稍浸泡,润透,切断,晒干;
4、车前草:去尽泥土,晒干;
5、防风:除去残茎,用水浸泡,捞出,润透切片,晒干;
6、金钱草:拣净杂质,筛去灰屑,晒干;
7、秦艽:拣去杂质,除去芦头,稍浸,润透切片,晒干;
8、土茯苓:用水浸漂,夏季每日换水1次,春、秋每2日换水1次,冬季可3日换水1次,防止发臭,以泡透为止,捞出切片,及时干燥;
9、虎杖:采得后,细锉,晒干;
10、威灵仙:拣净杂质,除去残茎,用水浸泡,捞出润透,切段,晒干;
11、石膏:去净杂石,洗净泥土,打碎成小块;
12、牛膝:拣去杂质,洗净,润软,去芦,切段,晒干;
13、续断:洗净泥沙,除去残留根头,润透后切片晒干,筛去屑;
14、海风藤:原药放清水中浸30-60分钟,取出放箩内润16-24小时,切片,晒干;
15、泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
16、桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
17、赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
18、薏苡仁:取原药材,除去残留皮壳、杂质;
19、伸筋草:筛去灰屑,拣净杂质,切成小段;
20、豨莶草:拣去杂质,除去残根与老梗,先抖下叶另放,将梗洗净,用水浸泡,捞出,润透后切片,晒干,再与叶和匀;
21、丝瓜络:洗净晒干,切段;
22、苍术:拣去杂质,用水泡至七、八成透,捞出,润透后切片,晒干;
23、紫花地丁:取原药材,除去杂质,洗净,稍晾,切段,干燥;
24、牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
25、土贝母:秋季采挖,洗净,掰开,煮至无白心,取出,晒干;
26、菊花:拣净叶梗、花柄及泥屑杂质;
27、知母:拣净杂质,用水撞洗,捞出,润软,切片晒干;
28、鸡血藤:用水润透,切片,或蒸软后乘热切片,晒干;
29、蜂房:取原药材,除去杂质,切块,筛去碎屑;
30、地龙:拣去杂质,用水漂净,及时捞出,晒干,切段;
31、蝉蜕:拣去杂质,洗净晒干;
32、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,凉干。
二、制备
1、将炮制后的忍冬藤、蚕沙、络石藤、车前草、防风、金钱草、秦艽、茯苓、虎杖、威灵仙、石膏、牛膝、续断、海风藤、泽泻、桂枝、赤芍、薏苡仁、伸筋草、豨莶草、丝瓜络、苍术、紫花地丁、牡丹皮、土贝母、菊花、知母、鸡血藤、蜂房、地龙、蝉蜕、甘草放入煎药容器内,第一次加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为4剂服用。
组方中伸筋草有祛风散寒,除湿消肿,舒筋活血的功能为君药;川牛膝祛风,利湿,通经,活血;续断有补肝肾,续筋骨,调血脉的功能,二者为臣药,三味药共同发挥祛风散寒,除湿消肿,舒筋活血,补肝肾,续筋骨,调血脉的作用,治疗痛风性关节炎效力全面,且以祛风散寒,舒筋活血,补肝肾,续筋骨,调血脉为主可治本,泽泻有利水,渗湿,泄热的功能为佐药,海风藤有祛风湿,通经络,理气的功能为使药,与余下诸药是治标。
本发明药物具有祛风散寒,舒筋活血,渗湿泄热,补肝肾,续筋骨,调血脉,通经理气的功能,用于治疗痛风性关节炎,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治痛风性关节炎门诊患者共33例。
2、诊断标准
典型症状为受累关节剧痛,首发关节常累及第一跖趾关节,其次为踝、膝等。关节红、肿、热和压痛,全身无力、发热、头痛等症状。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,7天为一个疗程,连续服用3个疗程。
4、疗效评定标准
显效:痛风性关节炎症状消失,体质恢复正常,痊愈;
好转:患者关节红、肿、发热,压痛和全身无力的症状减轻,痛风性关节炎症状明显好转,体质逐步恢复;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗痛风性关节炎患者33例,结果显效26例,显效率为78.79%,好转5例,好转率为15.15%,无效2例,总有效率为93.94%。
Claims (3)
1.一种治疗痛风性关节炎的药物,其特征在于:它是由下列重量范围内的原料药制成:
忍冬藤15-25克,蚕沙10-20克,络石藤5-15克,车前草5-15克,防风10-20克,金钱草5-15克,秦艽7-12克,土茯苓10-20克,虎杖10-20克,威灵仙2-5克,石膏10-20克,牛膝10-20克,续断5-15克,海风藤10-15克,泽泻10-20克,桂枝5-15克,赤芍10-20克,薏苡仁10-20克,伸筋草15-25克,豨莶草10-20克,丝瓜络5-15克,苍术10-20克,紫花地丁15-25克,牡丹皮10-15克,土贝母10-20克,菊花10-20克,知母10-20克,鸡血藤15-25克,蜂房7-12克,地龙10-20克,蝉蜕5-15克,甘草5-15克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
忍冬藤20克,蚕沙15克,络石藤10克,车前草10克,防风15克,金钱草10克,秦艽9克,土茯苓15克,虎杖15克,威灵仙3克,石膏15克,牛膝15克,续断10克,海风藤12克,泽泻15克,桂枝10克,赤芍15克,薏苡仁15克,伸筋草20克,豨莶草15克,丝瓜络10克,苍术15克,紫花地丁20克,牡丹皮12克,土贝母15克,菊花15克,知母15克,鸡血藤20克,蜂房9克,地龙15克,蝉蜕10克,甘草10克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)忍冬藤:拣去杂质,用水浸泡,润透,切片,晒干;
(2)蚕沙:除去杂质,筛去灰屑;
(3)络石藤:用水洗去泥土,拣净杂质,稍浸泡,润透,切断,晒干;
(4)车前草:去尽泥土,晒干;
(5)防风:除去残茎,用水浸泡,捞出,润透切片,晒干;
(6)金钱草:拣净杂质,筛去灰屑,晒干;
(7)秦艽:拣去杂质,除去芦头,稍浸,润透切片,晒干;
(8)土茯苓:用水浸漂,夏季每日换水1次,春、秋每2日换水1次,冬季可3日换水1次,防止发臭,以泡透为止,捞出切片,及时干燥;
(9)虎杖:采得后,细锉,晒干;
(10)威灵仙:拣净杂质,除去残茎,用水浸泡,捞出润透,切段,晒干;
(11)石膏:去净杂石,洗净泥土,打碎成小块;
(12)牛膝:拣去杂质,洗净,润软,去芦,切段,晒干;
(13)续断:洗净泥沙,除去残留根头,润透后切片晒干,筛去屑;
(14)海风藤:原药放清水中浸30-60分钟,取出放箩内润16-24小时,切片,晒干;
(15)泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
(16)桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
(17)赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
(18)薏苡仁:取原药材,除去残留皮壳、杂质;
(19)伸筋草:筛去灰屑,拣净杂质,切成小段;
(20)豨莶草:拣去杂质,除去残根与老梗,先抖下叶另放,将梗洗净,用水浸泡,捞出,润透后切片,晒干,再与叶和匀;
(21)丝瓜络:洗净晒干,切段;
(22)苍术:拣去杂质,用水泡至七、八成透,捞出,润透后切片,晒干;
(23)紫花地丁:取原药材,除去杂质,洗净,稍晾,切段,干燥;
(24)牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
(25)土贝母:秋季采挖,洗净,掰开,煮至无白心,取出,晒干;
(26)菊花:拣净叶梗、花柄及泥屑杂质;
(27)知母:拣净杂质,用水撞洗,捞出,润软,切片晒干;
(28)鸡血藤:用水润透,切片,或蒸软后乘热切片,晒干;
(29)蜂房:取原药材,除去杂质,切块,筛去碎屑;
(30)地龙:拣去杂质,用水漂净,及时捞出,晒干,切段;
(31)蝉蜕:拣去杂质,洗净晒干;
(32)甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,凉干;
(二)制备
(1)将炮制后的忍冬藤、蚕沙、络石藤、车前草、防风、金钱草、秦艽、茯苓、虎杖、威灵仙、石膏、牛膝、续断、海风藤、泽泻、桂枝、赤芍、薏苡仁、伸筋草、豨莶草、丝瓜络、苍术、紫花地丁、牡丹皮、土贝母、菊花、知母、鸡血藤、蜂房、地龙、蝉蜕、甘草放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为4剂服用。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201611122824.1A CN106421535A (zh) | 2016-12-08 | 2016-12-08 | 一种治疗痛风性关节炎的药物及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201611122824.1A CN106421535A (zh) | 2016-12-08 | 2016-12-08 | 一种治疗痛风性关节炎的药物及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN106421535A true CN106421535A (zh) | 2017-02-22 |
Family
ID=58217887
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201611122824.1A Withdrawn CN106421535A (zh) | 2016-12-08 | 2016-12-08 | 一种治疗痛风性关节炎的药物及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN106421535A (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107213379A (zh) * | 2017-06-13 | 2017-09-29 | 安徽恒海生态农业观光园有限公司 | 一种治疗痛风的保健药粉及其制备方法 |
CN114848746A (zh) * | 2022-04-13 | 2022-08-05 | 华中农业大学 | 具有抗高尿酸血症和痛风性关节炎作用的中药复方及其制备方法和应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103611085A (zh) * | 2013-12-05 | 2014-03-05 | 侯青兰 | 一种治疗痛风性关节炎的药物及其制备方法 |
-
2016
- 2016-12-08 CN CN201611122824.1A patent/CN106421535A/zh not_active Withdrawn
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103611085A (zh) * | 2013-12-05 | 2014-03-05 | 侯青兰 | 一种治疗痛风性关节炎的药物及其制备方法 |
Non-Patent Citations (1)
Title |
---|
李含文: "《实用软组织伤病学》", 30 September 2014, 人民体育出版社 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107213379A (zh) * | 2017-06-13 | 2017-09-29 | 安徽恒海生态农业观光园有限公司 | 一种治疗痛风的保健药粉及其制备方法 |
CN114848746A (zh) * | 2022-04-13 | 2022-08-05 | 华中农业大学 | 具有抗高尿酸血症和痛风性关节炎作用的中药复方及其制备方法和应用 |
CN114848746B (zh) * | 2022-04-13 | 2023-06-27 | 华中农业大学 | 具有抗高尿酸血症和痛风性关节炎作用的中药复方及其制备方法和应用 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN105327296A (zh) | 一种治疗消化性溃疡的药物及其制备方法 | |
CN103611085B (zh) | 一种治疗痛风性关节炎的药物及其制备方法 | |
CN103610947B (zh) | 一种治疗面肌痉挛的药物及其制备方法 | |
CN105477487A (zh) | 一种治疗慢性咽炎的药物及其制备方法 | |
CN106421535A (zh) | 一种治疗痛风性关节炎的药物及其制备方法 | |
CN105031357A (zh) | 一种治疗口腔溃疡的药物及其制备方法 | |
CN104398925A (zh) | 一种治疗皮肤病的药物及其制备方法 | |
CN103830619A (zh) | 一种治疗疔疮的药物及其制备方法 | |
CN103830604B (zh) | 一种治疗痈疽的药物及其制备方法 | |
CN106421672A (zh) | 一种治疗流行性腮腺炎的药物及其制备方法 | |
CN106620519A (zh) | 一种治疗乳腺炎的药物及其制备方法 | |
CN103386066B (zh) | 一种治疗疝气的药物及其制备方法 | |
CN105412665A (zh) | 一种治疗麻疹的药物及其制备方法 | |
CN103768465B (zh) | 一种治疗胁痛的药物及其制备方法 | |
CN103830630B (zh) | 一种治疗血栓闭塞性脉管炎的药物及其制备方法 | |
CN103356803B (zh) | 一种治疗荨麻疹的药物及其制备方法 | |
CN105963586A (zh) | 一种治疗肺脓肿的药物及其制备方法 | |
CN106474448A (zh) | 一种治疗时行感冒的药物及其制备方法 | |
CN106421536A (zh) | 一种治疗坐骨神经痛的药物及其制备方法 | |
CN106822552A (zh) | 一种治疗类风湿关节炎的药物及其制备方法 | |
CN106729118A (zh) | 一种治疗肾盂肾炎的药物及其制备方法 | |
CN106110056A (zh) | 一种治疗睑腺炎的药物及其制备方法 | |
CN106214858A (zh) | 一种治疗过敏性鼻炎的药物及其制备方法 | |
CN106492029A (zh) | 一种治疗丹痧的药物及其制备方法 | |
CN105381064A (zh) | 一种治疗脑出血的中药组合物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170222 |
|
WW01 | Invention patent application withdrawn after publication |