CN106421535A - 一种治疗痛风性关节炎的药物及其制备方法 - Google Patents
一种治疗痛风性关节炎的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗痛风性关节炎的药物及其制备方法,其主要是由忍冬藤、蚕沙、络石藤、车前草、防风、金钱草、秦艽、茯苓、虎杖、威灵仙、石膏、牛膝、续断、海风藤、泽泻、桂枝、赤芍、薏苡仁、菊花按一定重量配比制备而成,本发明药物具有祛风散寒,舒筋活血,渗湿泄热,补肝肾,续筋骨,调血脉,通经理气的功能,用于治疗痛风性关节炎见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗痛风性关节炎的药物及其制备方法,属中药领域。
背景技术
痛风性关节炎是由于尿酸盐沉积在关节囊、滑囊、软骨、骨质和其他组织中而引起病损及炎性反应,其多有遗传因素,好发于40岁以上男性,多见于第一跖趾关节,也可发生于其他较大关节,尤其是踝部与足部关节。中医则认为痛风性关节炎与湿热内蕴,脉络遇阻,气阴两虚有关。由于西药治疗副作用大,因此人们对有效治疗痛风性关节炎的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗痛风性关节炎的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗痛风性关节炎的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择忍冬藤、蚕沙、络石藤、车前草、防风、金钱草、秦艽、茯苓、虎杖、威灵仙、石膏、牛膝、续断、海风藤、泽泻、桂枝、赤芍、薏苡仁、伸筋草、豨莶草、丝瓜络、苍术、紫花地丁、牡丹皮、土贝母、菊花、知母、鸡血藤、蜂房、地龙、蝉蜕、甘草进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗痛风性关节炎。其中选用忍冬藤是因为其性味甘,寒,入心、肺经,有清热,解毒,通络的功能,治温病发热,热毒血痢,传染性肝炎,痈肿疮毒,筋骨疼痛。选用蚕沙是因为其性味甘、辛、温,归肝、脾经,有祛风除湿,活血定痛的功能,治风湿痹痛,关节不遂,腰脚冷痛,风疹瘙痒,头风头痛,烂弦风眼。选用络石藤是因为其性味苦,凉,入肝、肾经,有祛风,通络,止血,消瘀的功能,治风湿痹痛,筋脉拘挛,痈肿,喉痹,吐血,跌打损伤,产后恶露不行。选用车前草是因为其性味甘,寒,入肝、脾二经,有利水,清热,明目,祛痰的功能,治小便不通,淋浊,带下,尿血,黄疸,水肿,热痢,泄泻,鼻衄,目赤肿痛,喉痹乳蛾,咳嗽,皮肤溃疡。选用防风是因为其性味辛甘,温,入膀胱、肺、脾经,有发表,祛风,胜湿,止痛的功能,治外感风寒,头痛,目眩,项强,风寒湿痹,骨节酸痛,四肢挛急,破伤风。选用金钱草是因为其性味苦辛,凉,有清热,利尿,镇咳,消肿,解毒的功能,治黄疸,水肿,膀胱结石,疟疾,肺痈,咳嗽,吐血,淋浊,带下,风湿痹痛,小儿疳积,惊癎,痈肿,疮癣,湿疹。选用秦艽是因为其性味苦辛,平,入肝、胃、胆经,有祛风除湿,和血舒筋,清热利尿的功能,治风湿痹痛,筋骨拘挛,黄疸,便血,骨蒸潮热,小儿疳热,小便不利。选用土茯苓是因为其性味甘淡,平,入肝、胃经,有解毒,除湿,利关节的功能,治梅毒,淋浊,筋骨挛痛,脚气,疔疮,痈肿,瘰疬。选用虎杖是因为其性味苦,平,有祛风,利湿,破瘀,通经的功能,治风湿筋骨疼痛,湿热黄疸,淋浊带下,妇女经闭,产后恶露不下,癥瘕积聚,痔漏下血,跌扑损伤,烫伤,恶疮癣疾。选用威灵仙是因为其性味辛咸,温,有毒,入膀胱经,有祛风湿,通经络,消痰涎,散癖积的功能,治痛风、顽痹、腰膝冷痛,脚气,疟疾,癥瘕积聚,破伤风,扁桃体炎,诸骨鲠咽。选用石膏是因为其性味辛甘,寒,入肺、胃经,生用有解肌清热,除烦止渴的功能,治热病壮热不退,心烦神昏,谵语发狂,口渴咽干,肺热喘急,中暑自汗,胃火头痛、牙痛,热毒壅盛,发斑发疹,口舌生疮,煅敷生肌敛疮,外治痈疽疮疡,溃不收回,汤火烫伤。选用川牛膝是因为其性味平,味苦微苦,无毒,入肝、肾二经,有祛风,利湿,通经,活血的功能,治风湿腰膝疼痛,脚痿筋挛,血淋,尿血,妇女经闭,癥瘕。选用续断是因为其性味苦辛,微温,入肝、肾经,有补肝肾,续筋骨,调血脉的功能,治腰背酸痛,足膝无力,胎漏,崩漏,带下,遗精,跌打损伤,金疮,痔漏,痈疽疮肿。选用海风藤是因为其性味辛苦,微温,入心、肾二经,有祛风湿,通经络,理气的功能,治风寒湿痹,关节疼痛,筋脉拘挛,跌打损伤,哮喘,久咳。选用泽泻是因为其性味甘,寒,入膀胱经,有利水,渗湿,泄热的功能,治小便不利,水肿肛满,呕吐,泻痢,痰饮,脚气,淋病,尿血。选用桂枝是因为其性味辛甘,温,入膀胱、心、肺经,有发汗解肌,温经通脉的功能,治风寒表证,肩背肢节酸疼,胸痹痰饮,经闭癥瘕。选用赤芍是因为其性味苦,微寒,归肝经,有清热凉血,散瘀止痛的功能,治温毒发狂,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,癎瘕腹痛,跌扑损伤,痈肿疮疡。选用薏苡仁是因为其性味甘淡,凉,入脾、肺、肾经,有健脾,补肺,清热,利湿的功能,治泄泻,湿痹,筋脉拘挛,屈伸不利,水肿,脚气,肺痿,肺痈,肠痈,淋浊,白带。选用伸筋草是因为其性味苦辛,温,入肝、胃、肾三经,有祛风散寒,除湿消肿,舒筋活血的功能,治风寒湿痹,关节酸痛,皮肤麻木,四肢软弱,水肿,跌打损伤。选用豨莶草是因为其性味苦,寒,入肝、脾、肾经,有祛风湿,利筋骨,降血压的功能,治四肢麻痹,筋骨疼痛,腰膝无力,疟疾,急性肝炎,高血压病,疔疮肿毒,外伤出血。选用丝瓜络是因为其性味甘,平,有通经活络,清热化痰的功能,治胸胁疼痛,腹痛,腰痛,睾丸肿痛,肺热痰咳,妇女经闭,乳汁不通,痈肿,痔漏。选用苍术是因为其性味辛苦,温,入脾、胃经,有健脾,燥湿,解郁,辟秽的功能,治湿盛困脾,倦怠嗜卧,脘痞腹胀,食欲不振,呕吐,泄泻,痢疾,疟疾,痰饮,水肿,时气感冒,风寒湿痹,足痿,夜盲。选用紫花地丁是因为其性味苦、辛、寒,归心、肝经,有清热解毒,凉血消肿的功能,治疔疮肿毒,痈疽发背,丹毒,毒蛇咬伤。选用牡丹皮是因为其性味辛苦,凉,入心、肝、肾经,有清热,凉血,和血,消瘀的功能,治热入血分,发斑,惊癎,吐、衄、便血,骨蒸劳热,经闭,癥瘕,痈疡,扑损。选用土贝母是因为其性味苦,凉,有散结毒,消痈肿的功能,治乳痈,瘰疬痰核,疮疡肿毒及蛇虫毒。选用菊花是因为其性味甘苦,凉,入肺,肝经,有疏风,消热,明目,解毒的功能,治头痛,眩晕,目赤,心胸烦热,疔疮,肿毒。选用知母是因为其性味苦,寒,入肺、胃、肾经,有滋阴降火,润燥滑肠的功能,治烦热消渴,骨蒸劳热,肺热咳嗽,大便燥结,小便不利。选用鸡血藤是因为其性味苦甘,温,入心、脾二经,有活血、舒筋的功能,治腰膝酸痛,麻木瘫痪,月经不调。选用蜂房是因为其性味甘,平,归胃经,有祛风,攻毒,杀虫,止痛的功能,用于龋齿牙痛,疮疡肿毒,乳痈,瘰疬,皮肤顽癣,鹅掌风。选用蚯蚓是因为其性味咸,寒,入肝、脾、肺经,有清热,平肝,止喘,通络的功能,治高热狂躁,惊风抽搐,风热头痛,目赤,中风半身不遂,喘息,喉痹,关节疼痛,齿衄,小便不通,瘰疬,痄腮,疮疡。选用蝉蜕是因为其性味甘咸,凉,入肺、肝经,有散风热,宣肺,定痉的功能,治外感风热,咳嗽音哑,麻疹透发不畅,风疹瘙痒,小儿惊癎,目赤,翳障,疔疮肿毒,破伤风。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊痈,生用治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
忍冬藤15-25克,蚕沙10-20克,络石藤5-15克,车前草5-15克,防风10-20克,金钱草5-15克,秦艽7-12克,土茯苓10-20克,虎杖10-20克,威灵仙1-5克,石膏10-20克,牛膝10-20克,续断5-15克,海风藤10-15克,泽泻10-20克,桂枝5-15克,赤芍10-20克,薏苡仁10-20克,伸筋草15-25克,豨莶草10-20克,丝瓜络5-15克,苍术10-20克,紫花地丁15-25克,牡丹皮10-15克,土贝母10-20克,菊花10-20克,知母10-20克,鸡血藤15-25克,蜂房7-12克,地龙10-20克,蝉蜕5-15克,甘草5-15克。
优选为:
忍冬藤20克,蚕沙15克,络石藤10克,车前草10克,防风15克,金钱草10克,秦艽9克,土茯苓15克,虎杖15克,威灵仙3克,石膏15克,牛膝15克,续断10克,海风藤12克,泽泻15克,桂枝10克,赤芍15克,薏苡仁15克,伸筋草20克,豨莶草15克,丝瓜络10克,苍术15克,紫花地丁20克,牡丹皮12克,土贝母15克,菊花15克,知母15克,鸡血藤20克,蜂房9克,地龙15克,蝉蜕10克,甘草10克。
本发明药物的制备方法如下
一、备料
1、忍冬藤:拣去杂质,用水浸泡,润透,切片,晒干;
2、蚕沙:除去杂质,筛去灰屑;
3、络石藤:用水洗去泥土,拣净杂质,稍浸泡,润透,切断,晒干;
4、车前草:去尽泥土,晒干;
5、防风:除去残茎,用水浸泡,捞出,润透切片,晒干;
6、金钱草:拣净杂质,筛去灰屑,晒干;
7、秦艽:拣去杂质,除去芦头,稍浸,润透切片,晒干;
8、土茯苓:用水浸漂,夏季每日换水1次,春、秋每2日换水1次,冬季可3日换水1次,防止发臭,以泡透为止,捞出切片,及时干燥;
9、虎杖:采得后,细锉,晒干;
10、威灵仙:拣净杂质,除去残茎,用水浸泡,捞出润透,切段,晒干;
11、石膏:去净杂石,洗净泥土,打碎成小块;
12、牛膝:拣去杂质,洗净,润软,去芦,切段,晒干;
13、续断:洗净泥沙,除去残留根头,润透后切片晒干,筛去屑;
14、海风藤:原药放清水中浸30-60分钟,取出放箩内润16-24小时,切片,晒干;
15、泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
16、桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
17、赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
18、薏苡仁:取原药材,除去残留皮壳、杂质;
19、伸筋草:筛去灰屑,拣净杂质,切成小段;
20、豨莶草:拣去杂质,除去残根与老梗,先抖下叶另放,将梗洗净,用水浸泡,捞出,润透后切片,晒干,再与叶和匀;
21、丝瓜络:洗净晒干,切段;
22、苍术:拣去杂质,用水泡至七、八成透,捞出,润透后切片,晒干;
23、紫花地丁:取原药材,除去杂质,洗净,稍晾,切段,干燥;
24、牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
25、土贝母:秋季采挖,洗净,掰开,煮至无白心,取出,晒干;
26、菊花:拣净叶梗、花柄及泥屑杂质;
27、知母:拣净杂质,用水撞洗,捞出,润软,切片晒干;
28、鸡血藤:用水润透,切片,或蒸软后乘热切片,晒干;
29、蜂房:取原药材,除去杂质,切块,筛去碎屑;
30、地龙:拣去杂质,用水漂净,及时捞出,晒干,切段;
31、蝉蜕:拣去杂质,洗净晒干;
32、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,凉干。
二、制备
1、将炮制后的忍冬藤、蚕沙、络石藤、车前草、防风、金钱草、秦艽、茯苓、虎杖、威灵仙、石膏、牛膝、续断、海风藤、泽泻、桂枝、赤芍、薏苡仁、伸筋草、豨莶草、丝瓜络、苍术、紫花地丁、牡丹皮、土贝母、菊花、知母、鸡血藤、蜂房、地龙、蝉蜕、甘草放入煎药容器内,第一次加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为4剂服用。
组方中伸筋草有祛风散寒,除湿消肿,舒筋活血的功能为君药;川牛膝祛风,利湿,通经,活血;续断有补肝肾,续筋骨,调血脉的功能,二者为臣药,三味药共同发挥祛风散寒,除湿消肿,舒筋活血,补肝肾,续筋骨,调血脉的作用,治疗痛风性关节炎效力全面,且以祛风散寒,舒筋活血,补肝肾,续筋骨,调血脉为主可治本,泽泻有利水,渗湿,泄热的功能为佐药,海风藤有祛风湿,通经络,理气的功能为使药,与余下诸药是治标。
本发明药物具有祛风散寒,舒筋活血,渗湿泄热,补肝肾,续筋骨,调血脉,通经理气的功能,用于治疗痛风性关节炎,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治痛风性关节炎门诊患者共33例。
2、诊断标准
典型症状为受累关节剧痛,首发关节常累及第一跖趾关节,其次为踝、膝等。关节红、肿、热和压痛,全身无力、发热、头痛等症状。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,7天为一个疗程,连续服用3个疗程。
4、疗效评定标准
显效:痛风性关节炎症状消失,体质恢复正常,痊愈;
好转:患者关节红、肿、发热,压痛和全身无力的症状减轻,痛风性关节炎症状明显好转,体质逐步恢复;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗痛风性关节炎患者33例,结果显效26例,显效率为78.79%,好转5例,好转率为15.15%,无效2例,总有效率为93.94%。
Claims (3)
1.一种治疗痛风性关节炎的药物,其特征在于:它是由下列重量范围内的原料药制成:
忍冬藤15-25克,蚕沙10-20克,络石藤5-15克,车前草5-15克,防风10-20克,金钱草5-15克,秦艽7-12克,土茯苓10-20克,虎杖10-20克,威灵仙2-5克,石膏10-20克,牛膝10-20克,续断5-15克,海风藤10-15克,泽泻10-20克,桂枝5-15克,赤芍10-20克,薏苡仁10-20克,伸筋草15-25克,豨莶草10-20克,丝瓜络5-15克,苍术10-20克,紫花地丁15-25克,牡丹皮10-15克,土贝母10-20克,菊花10-20克,知母10-20克,鸡血藤15-25克,蜂房7-12克,地龙10-20克,蝉蜕5-15克,甘草5-15克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
忍冬藤20克,蚕沙15克,络石藤10克,车前草10克,防风15克,金钱草10克,秦艽9克,土茯苓15克,虎杖15克,威灵仙3克,石膏15克,牛膝15克,续断10克,海风藤12克,泽泻15克,桂枝10克,赤芍15克,薏苡仁15克,伸筋草20克,豨莶草15克,丝瓜络10克,苍术15克,紫花地丁20克,牡丹皮12克,土贝母15克,菊花15克,知母15克,鸡血藤20克,蜂房9克,地龙15克,蝉蜕10克,甘草10克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)忍冬藤:拣去杂质,用水浸泡,润透,切片,晒干;
(2)蚕沙:除去杂质,筛去灰屑;
(3)络石藤:用水洗去泥土,拣净杂质,稍浸泡,润透,切断,晒干;
(4)车前草:去尽泥土,晒干;
(5)防风:除去残茎,用水浸泡,捞出,润透切片,晒干;
(6)金钱草:拣净杂质,筛去灰屑,晒干;
(7)秦艽:拣去杂质,除去芦头,稍浸,润透切片,晒干;
(8)土茯苓:用水浸漂,夏季每日换水1次,春、秋每2日换水1次,冬季可3日换水1次,防止发臭,以泡透为止,捞出切片,及时干燥;
(9)虎杖:采得后,细锉,晒干;
(10)威灵仙:拣净杂质,除去残茎,用水浸泡,捞出润透,切段,晒干;
(11)石膏:去净杂石,洗净泥土,打碎成小块;
(12)牛膝:拣去杂质,洗净,润软,去芦,切段,晒干;
(13)续断:洗净泥沙,除去残留根头,润透后切片晒干,筛去屑;
(14)海风藤:原药放清水中浸30-60分钟,取出放箩内润16-24小时,切片,晒干;
(15)泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
(16)桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
(17)赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
(18)薏苡仁:取原药材,除去残留皮壳、杂质;
(19)伸筋草:筛去灰屑,拣净杂质,切成小段;
(20)豨莶草:拣去杂质,除去残根与老梗,先抖下叶另放,将梗洗净,用水浸泡,捞出,润透后切片,晒干,再与叶和匀;
(21)丝瓜络:洗净晒干,切段;
(22)苍术:拣去杂质,用水泡至七、八成透,捞出,润透后切片,晒干;
(23)紫花地丁:取原药材,除去杂质,洗净,稍晾,切段,干燥;
(24)牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
(25)土贝母:秋季采挖,洗净,掰开,煮至无白心,取出,晒干;
(26)菊花:拣净叶梗、花柄及泥屑杂质;
(27)知母:拣净杂质,用水撞洗,捞出,润软,切片晒干;
(28)鸡血藤:用水润透,切片,或蒸软后乘热切片,晒干;
(29)蜂房:取原药材,除去杂质,切块,筛去碎屑;
(30)地龙:拣去杂质,用水漂净,及时捞出,晒干,切段;
(31)蝉蜕:拣去杂质,洗净晒干;
(32)甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,凉干;
(二)制备
(1)将炮制后的忍冬藤、蚕沙、络石藤、车前草、防风、金钱草、秦艽、茯苓、虎杖、威灵仙、石膏、牛膝、续断、海风藤、泽泻、桂枝、赤芍、薏苡仁、伸筋草、豨莶草、丝瓜络、苍术、紫花地丁、牡丹皮、土贝母、菊花、知母、鸡血藤、蜂房、地龙、蝉蜕、甘草放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为4剂服用。
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CN114848746A (zh) * | 2022-04-13 | 2022-08-05 | 华中农业大学 | 具有抗高尿酸血症和痛风性关节炎作用的中药复方及其制备方法和应用 |
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CN114848746A (zh) * | 2022-04-13 | 2022-08-05 | 华中农业大学 | 具有抗高尿酸血症和痛风性关节炎作用的中药复方及其制备方法和应用 |
CN114848746B (zh) * | 2022-04-13 | 2023-06-27 | 华中农业大学 | 具有抗高尿酸血症和痛风性关节炎作用的中药复方及其制备方法和应用 |
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