CN106421536A - 一种治疗坐骨神经痛的药物及其制备方法 - Google Patents
一种治疗坐骨神经痛的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗坐骨神经痛的药物及其制备方法,其主要是由黄芪、天南星、川牛膝、秦艽、续断、威灵仙、羌活、黄柏、伸筋草、淫羊藿、花椒、牛蒡子、地龙、虎杖、全蝎、防风、鸡血藤、路路通、千年健、甘草、延胡索、白芥子按一定重量配比制备而成,本发明药物具有祛风散寒,除湿消肿,舒筋活血,补肝肾,利关节,通络止痛的功能,用于治疗坐骨神经痛见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗坐骨神经痛的药物及其制备方法,属中药领域。
背景技术
坐骨神经痛是以坐骨神经径路及分布区域疼痛为主的综合征。坐骨神经痛的绝大多数病例是继发于坐骨神经局部及周围结构的病变对坐骨神经的刺激压迫与损害,称为继发坐骨神经痛;少数系原发性,即坐骨神经炎。中医则认为坐骨神经痛与风寒湿邪,肝肾不足,气滞血瘀,有关。由于西药治疗副作用大,因此人们对有效治疗坐骨神经痛的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗坐骨神经痛的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗坐骨神经痛的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择黄芪、天南星、川牛膝、秦艽、续断、威灵仙、羌活、黄柏、伸筋草、淫羊藿、花椒、牛蒡子、地龙、虎杖、全蝎、防风、鸡血藤、路路通、千年健、甘草、没药、络石藤、皂角刺、薏苡仁、苍术、狗脊、川芎、延胡索、白芥子、五灵脂、乳香、独活进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗坐骨神经痛。其中选用黄芪是因为其性味甘,微温,入肺、脾经,生用有益卫固表,利水消肿,托毒,生肌的功能,治自汗,盗汗,血痹,浮肿,痈疽不溃或溃久敛;炙用有补中益的功能,治内伤劳倦,脾虚泄泻,脱肛,气虚血脱,崩带及一切气衰血虚之症。选用天南星是因为其性味苦辛,温,有毒,入肺、肝、脾经,有燥湿化痰,祛风定惊,消肿散结的功能,治中风痰壅,口眼斜,半身不遂,癫癎,惊风,破伤风,风痰眩晕,喉痹,瘰疬,痈肿,跌扑折伤,蛇虫咬伤。选用川牛膝是因为其性味平,味苦微苦,无毒,入肝、肾二经,有祛风,利湿,通经,活血的功能,治风湿腰膝疼痛,脚痿筋挛,血淋,尿血,妇女经闭,癥瘕。选用秦艽是因为其性味苦辛,平,入肝、胃、胆经,有祛风除湿,和血舒筋,清热利尿的功能,治风湿痹痛,筋骨拘挛,黄疸,便血,骨蒸潮热,小儿疳热,小便不利。选用续断是因为其性味苦辛,微温,入肝、肾经,有补肝肾,续筋骨,调血脉的功能,治腰背酸痛,足膝无力,胎漏,崩漏,带下,遗精,跌打损伤,金疮,痔漏,痈疽疮肿。选用威灵仙是因为其性味辛咸,温,有毒,入膀胱经,有祛风湿,通经络,消痰涎,散癖积的功能,治痛风、顽痹、腰膝冷痛,脚气,疟疾,癥瘕积聚,破伤风,扁桃体炎,诸骨鲠咽。选用羌活是因为其性味辛苦,温,入膀胱、肾经,有散表寒,祛风湿,利关节的功能,治感冒风寒,头痛无汗,风寒湿痹,项强筋急,骨节酸疼,风水浮肿,痈疽疮毒。选用黄柏是因为其性味苦,寒,入肺、胃、肾经,有滋阴降火,润燥滑肠的功能,治烦热消渴,骨蒸劳热,肺热咳嗽,大便燥结,小便不利。选用伸筋草是因为其性味苦辛,温,入肝、胃、肾三经,有祛风散寒,除湿消肿,舒筋活血的功能,治风寒湿痹,关节酸痛,皮肤麻木,四肢软弱,水肿,跌打损伤。选用淫羊藿是因为其性味辛甘,温,入肝、肾经,有补肾壮阳,祛风除湿的功能,治阳痿不举,小便淋沥,筋骨挛急,半身不遂,腰膝无力,风湿痹痛,四脚不仁。选用花椒是因为其性味辛,温,有毒,入脾、肺、肾经,有温中散寒,除湿,止痛,杀虫,解鱼腥毒,治积食停饮,心腹冷痛,呕吐,噫呃,咳嗽气逆,风寒湿痹,泄泻,痢疾,疝痛,齿痛,蛔虫病,蛲虫病,阴痒,疮疥。选用牛蒡子是因为其性味辛苦,凉,入肺、胃经,有疏散风热,宣肺透疹,消肿解毒的功能,治风热咳嗽,咽喉肿痛,斑疹不透,风疹作痒,痈肿疮毒。选用蚯蚓是因为其性味咸,寒,入肝、脾、肺经,有清热,平肝,止喘,通络的功能,治高热狂躁,惊风抽搐,风热头痛,目赤,中风半身不遂,喘息,喉痹,关节疼痛,齿衄,小便不通,瘰疬,痄腮,疮疡。选用虎杖是因为其性味苦,平,有祛风,利湿,破瘀,通经的功能,治风湿筋骨疼痛,湿热黄疸,淋浊带下,妇女经闭,产后恶露不下,癥瘕积聚,痔漏下血,跌扑损伤,烫伤,恶疮癣疾。选用全蝎是因为其性味咸辛,平,有毒,入足厥阴经,有祛风,止痉,通络,解毒的功能,治惊风抽搐,癫癎,中风、半身不遂、口眼喎斜,偏头痛,风湿痹痛,破伤风,淋巴结结核,风疹疮肿。选用防风是因为其性味辛甘,温,入膀胱、肺、脾经,有发表,祛风,胜湿,止痛的功能,治外感风寒,头痛,目眩,项强,风寒湿痹,骨节酸痛,四肢挛急,破伤风。选用鸡血藤是因为其性味苦甘,温,入心、脾二经,有活血、舒筋的功能,治腰膝酸痛,麻木瘫痪,月经不调。选用路路通是因为其性味苦平,通行十二经,有祛风通络,利尿除湿的功能,治水肿,胀满,经闭,乳少,手足拘挛。选用千年健是因为其性味苦、辛,温,归肝、肾经,有祛风湿,健筋骨的功能,治风寒湿痹,腰膝冷痛,下肢拘挛麻木。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊痈,生用治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用没药是因为其性味苦,平,入肝经,有散血去瘀,消肿定痛的功能,治跌损,金疮,筋骨,心腹诸痛,癥瘕,经闭,痈疽肿痛,痔漏,目障。选用络石藤是因为其性味苦,凉,入肝、肾经,有祛风,通络,止血,消瘀的功能,治风湿痹痛,筋脉拘挛,痈肿,喉痹,吐血,跌打损伤,产后恶露不行。选用皂角刺是因为其性味辛,温,有搜风,拔毒,消肿,排脓的功能,治痈肿,疮毒,疠风,癣疮,胎衣不下。选用薏苡仁是因为其性味甘淡,凉,入脾、肺、肾经,有健脾,补肺,清热,利湿的功能,治泄泻,湿痹,筋脉拘挛,屈伸不利,水肿,脚气,肺痿,肺痈,肠痈,淋浊,白带。选用苍术是因为其性味辛苦,温,入脾、胃经,有健脾,燥湿,解郁,辟秽的功能,治湿盛困脾,倦怠嗜卧,脘痞腹胀,食欲不振,呕吐,泄泻,痢疾,疟疾,痰饮,水肿,时气感冒,风寒湿痹,足痿,夜盲。选用狗脊是因为其性味苦甘,温,入肝、肾经,有补肝肾,除风湿,健腰脚,利关节的功能,治腰背酸疼,膝痛脚弱,寒湿周痹,失溺,尿频,遗精,白带。选用川芎是因为其性味辛,温,入肝、胆经,有行气开郁,祛风燥湿,活血止痛的功能,治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。选用延胡索是因为其性味辛苦,温,入肝、胃经,有活血,散瘀,理气,止痛的功能,治心腹腰膝诸痛,月经不调,癥瘕,崩中,产后血晕,恶露不尽,跌打损伤。选用白芥子是因为其性味辛,温,入肺、胃经,有利气豁痰,温中散寒,通络止痛的功能,治痰饮咳喘,胸胁胀满疼痛,反胃呕吐,中风不语,肢体痹痛麻木,脚气,阴疽,肿毒,跌打肿痛。选用五灵脂是因为其性味苦甘,温,入肝、脾经,生用有行血止痛的功能,治心腹血气诸痛,妇女经闭,产后瘀血作痛;外治蛇、蝎、蜈蚣咬伤,炒用止血,治妇女血崩,经水过多,赤带不绝。选用乳香是因为其性味辛苦,温,入心、肝、脾经,有调气活血,定痛,追毒的功能,治气血凝滞,心腹疼痛,痈疮肿毒,跌打损伤,痛经,产后瘀血刺痛。选用独活是因为其性味辛苦,温,入肾、膀胱经,有祛风,胜湿,散寒,止痛的功能,治风寒湿痹,腰漆酸痛,手脚挛痛,慢性气管炎,头痛,齿痛。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
黄芪15-25克,天南星5-15克,川牛膝15-25克,秦艽10-20克,续断10-15克,威灵仙5-15克,羌活5-15克,黄柏5-15克,伸筋草15-25克,淫羊藿10-20克,花椒5-15克,牛蒡子10-20克,地龙10-20克,虎杖10-20克,全蝎5-10克,防风10-20克,鸡血藤10-20克,路路通10-20克,千年健10-20克,甘草5-15克,没药5-15克,络石藤5-15克,皂角刺10-20克,薏苡仁10-20克,苍术10-20克,狗脊10-20克,川芎5-15克,延胡索10-20克,白芥子10-20克,五灵脂5-15克,乳香5-15克,独活10-20克。
优选为:
黄芪20克,天南星10克,川牛膝20克,秦艽15克,续断12克,威灵仙10克,羌活10克,黄柏10克,伸筋草20克,淫羊藿15克,花椒10克,牛蒡子15克,地龙15克,虎杖15克,全蝎8克,防风15克,鸡血藤15克,路路通15克,千年健15克,甘草10克,没药10克,络石藤10克,皂角刺15克,薏苡仁15克,苍术15克,狗脊15克,川芎10克,延胡索15克,白芥子15克,五灵脂10克,乳香10克,独活15克。
本发明药物的制备方法如下
一、备料
1、黄芪:拣净杂质,除去残留的根头和空心较大者,用水浸泡,捞出,润透后及时切片,晒干;
2、天南星:拣去杂质,洗净灰屑,晒干;
3、川牛膝:拣去杂质,晾干;
4、秦艽:拣去杂质,除去芦头,稍浸,润透切片,晒干;
5、续断:洗净泥沙,除去残留根头,润透后切片晒干,筛去屑;
6、威灵仙:拣净杂质,除去残茎,用水浸泡,捞出润透,切段,晒干;
7、羌活:拣去杂质,洗净,润透,切片,晾干;
8、黄柏:拣去杂质,用水洗净,捞出,润透,切片或切丝,晒干;
9、伸筋草:筛去灰屑,拣净杂质,切成小段;
10、淫羊藿:拣净杂质,去梗,切丝,筛去碎屑;
11、花椒:除去果柄及种子、椒目,置锅内炒至发响、油出,取出,放凉;
12、牛蒡子:拣去杂质,筛去泥屑;
13、地龙:拣去杂质,用水漂净,及时捞出,晒干,切段;
14、虎杖:采得后,细锉,晒干;
15、全蝎:清水漂去盐质,晒干,或微火焙用;
16、防风:除去残茎,用水浸泡,捞出,润透切片,晒干;
17、鸡血藤:用水润透,切片,或蒸软后乘热切片,晒干;
18、路路通:除去杂质,洗净,晒干;
19、千年健:除去杂质,洗净,润透,切薄片,干燥,筛去碎屑;
20、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,凉干;
21、没药:拣去杂质,打成碎块;
22、络石藤:用水洗去泥土,拣净杂质,稍浸泡,润透,切断,晒干;
23、皂角刺:拣去杂质,用水浸泡,润透后切片,晒干;
24、薏苡仁:取原药材,除去残留皮壳、杂质;
25、苍术:拣去杂质,用水泡至七、八成透,捞出,润透后切片,晒干;
26、狗脊:取沙子置锅内炒热,加入拣净的狗脊,用武火炒至鼓起并显深黄色,取出,筛除沙子,风晾后,撞去或刮净黄绒毛;
27、川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
28、延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎;
29、白芥子:原药簸尽杂质,炒至深黄色,微有香气即得;
30、五灵脂:拣净杂质,打碎或筛去灰屑;
31、乳香:拣去砂子杂质;
32、独活:拣去杂质,分开大小个,洗净,润透后切片,干燥。
二、制备
1、将炮制后的黄芪、天南星、川牛膝、秦艽、续断、威灵仙、羌活、黄柏、伸筋草、淫羊藿、花椒、牛蒡子、地龙、虎杖、全蝎、防风、鸡血藤、路路通、千年健、甘草、没药、络石藤、皂角刺、薏苡仁、苍术、狗脊、川芎、延胡索、白芥子、五灵脂、乳香、独活放入煎药容器内,第一次加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为4剂服用。
组方中伸筋草有祛风散寒,除湿消肿,舒筋活血,治风寒湿痹,关节酸痛,皮肤麻木,四肢软弱的功能为君药;狗脊补肝肾,除风湿,健腰脚,利关节;千年健有祛风湿,健筋骨的功能,二者为臣药,三味药共同发挥祛风散寒,除湿消肿,舒筋活血,补肝肾,除风湿,健腰脚,利关节的作用,治疗坐骨神经痛效力全面,且以祛风散寒,舒筋活血,补肝肾,通络止痛为主可治本,独活有祛风,胜湿,散寒,止痛的功能为佐药,白芥子有利气豁痰,温中散寒,通络止痛的功能为使药,与余下诸药是治标。
本发明药物具有祛风散寒,除湿消肿,舒筋活血,补肝肾,利关节,通络止痛的功能,用于治疗坐骨神经痛,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治坐骨神经痛门诊患者共27例。
2、诊断标准
典型症状为坐骨神经疼痛呈持续性钝痛,并有发作性加剧且向下窜行。发作性疼痛可为烧灼和刀刺样,常在夜间加剧;疼痛在腰部、臀部并向股后、小腿后外侧、足外侧放射;踝反射减低或消失,可有神经根型的感觉障碍,拇趾背屈力差;弯腰或活动下肢、咳嗽、排便时疼痛加重等症状。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,10天为一个疗程,连续服用3个疗程。
4、疗效评定标准
显效:坐骨神经痛症状消失,体质恢复正常,痊愈;
好转:患者腰部,臀部疼痛,弯腰,活动下肢或咳嗽排便时疼痛的症状减轻,坐骨神经痛症状明显好转,体质逐步恢复;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗坐骨神经痛患者27例,结果显效22例,显效率为81.48%,好转3例,好转率为14.81%,无效1例,总有效率为96.29%。
Claims (3)
1.一种治疗坐骨神经痛的药物,其特征在于:它是由下列重量范围内的原料药制成:
黄芪15-25克,天南星5-15克,川牛膝15-25克,秦艽10-20克,续断10-15克,威灵仙5-15克,羌活5-15克,黄柏5-15克,伸筋草15-25克,淫羊藿10-20克,花椒5-15克,牛蒡子10-20克,地龙10-20克,虎杖10-20克,全蝎5-10克,防风10-20克,鸡血藤10-20克,路路通10-20克,千年健10-20克,甘草5-15克,没药5-15克,络石藤5-15克,皂角刺10-20克,薏苡仁10-20克,苍术10-20克,狗脊10-20克,川芎5-15克,延胡索10-20克,白芥子10-20克,五灵脂5-15克,乳香5-15克,独活10-20克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
黄芪20克,天南星10克,川牛膝20克,秦艽15克,续断12克,威灵仙10克,羌活10克,黄柏10克,伸筋草20克,淫羊藿15克,花椒10克,牛蒡子15克,地龙15克,虎杖15克,全蝎8克,防风15克,鸡血藤15克,路路通15克,千年健15克,甘草10克,没药10克,络石藤10克,皂角刺15克,薏苡仁15克,苍术15克,狗脊15克,川芎10克,延胡索15克,白芥子15克,五灵脂10克,乳香10克,独活15克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)黄芪:拣净杂质,除去残留的根头和空心较大者,用水浸泡,捞出,润透后及时切片,晒干;
(2)天南星:拣去杂质,洗净灰屑,晒干;
(3)川牛膝:拣去杂质,晾干;
(4)秦艽:拣去杂质,除去芦头,稍浸,润透切片,晒干;
(5)续断:洗净泥沙,除去残留根头,润透后切片晒干,筛去屑;
(6)威灵仙:拣净杂质,除去残茎,用水浸泡,捞出润透,切段,晒干;
(7)羌活:拣去杂质,洗净,润透,切片,晾干;
(8)黄柏:拣去杂质,用水洗净,捞出,润透,切片或切丝,晒干;
(9)伸筋草:筛去灰屑,拣净杂质,切成小段;
(10)淫羊藿:拣净杂质,去梗,切丝,筛去碎屑;
(11)花椒:除去果柄及种子、椒目,置锅内炒至发响、油出,取出,放凉;
(12)牛蒡子:拣去杂质,筛去泥屑;
(13)地龙:拣去杂质,用水漂净,及时捞出,晒干,切段;
(14)虎杖:采得后,细锉,晒干;
(15)全蝎:清水漂去盐质,晒干,或微火焙用;
(16)防风:除去残茎,用水浸泡,捞出,润透切片,晒干;
(17)鸡血藤:用水润透,切片,或蒸软后乘热切片,晒干;
(18)路路通:除去杂质,洗净,晒干;
(19)千年健:除去杂质,洗净,润透,切薄片,干燥,筛去碎屑;
(20)甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,凉干;
(21)没药:拣去杂质,打成碎块;
(22)络石藤:用水洗去泥土,拣净杂质,稍浸泡,润透,切断,晒干;
(23)皂角刺:拣去杂质,用水浸泡,润透后切片,晒干;
(24)薏苡仁:取原药材,除去残留皮壳、杂质;
(25)苍术:拣去杂质,用水泡至七、八成透,捞出,润透后切片,晒干;
(26)狗脊:取沙子置锅内炒热,加入拣净的狗脊,用武火炒至鼓起并显深黄色,取出,筛除沙子,风晾后,撞去或刮净黄绒毛;
(27)川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
(28)延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎;
(29)白芥子:原药簸尽杂质,炒至深黄色,微有香气即得;
(30)五灵脂:拣净杂质,打碎或筛去灰屑;
(31)乳香:拣去砂子杂质;
(32)独活:拣去杂质,分开大小个,洗净,润透后切片,干燥;
(二)制备
(1)将炮制后的黄芪、天南星、川牛膝、秦艽、续断、威灵仙、羌活、黄柏、伸筋草、淫羊藿、花椒、牛蒡子、地龙、虎杖、全蝎、防风、鸡血藤、路路通、千年健、甘草、没药、络石藤、皂角刺、薏苡仁、苍术、狗脊、川芎、延胡索、白芥子、五灵脂、乳香、独活放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为4剂服用。
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