CN106214858A - 一种治疗过敏性鼻炎的药物及其制备方法 - Google Patents

一种治疗过敏性鼻炎的药物及其制备方法 Download PDF

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CN106214858A
CN106214858A CN201610724028.9A CN201610724028A CN106214858A CN 106214858 A CN106214858 A CN 106214858A CN 201610724028 A CN201610724028 A CN 201610724028A CN 106214858 A CN106214858 A CN 106214858A
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李洪芳
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Abstract

本发明公开了一种治疗过敏性鼻炎的药物及其制备方法,其主要是由黄芪、白术、苍耳子、防风、辛夷、牡丹皮、甘草、白芷按一定重量配比制备而成,本发明药物具有益卫固表,补中益气,通窍,补脾益胃,和血消淤,清利头目的功能,用于治疗过敏性鼻炎见效快,疗效好,不复发。

Description

一种治疗过敏性鼻炎的药物及其制备方法
技术领域
本发明涉及一种治疗过敏性鼻炎的药物及其制备方法,属中药领域。
技术背景
过敏性鼻炎是指机体对某些物质敏感性增高,而出现的发病部位以鼻黏膜为主的变态反应性炎症,多数呈阵发性发作。中医则认为过敏性鼻炎与肺气虚寒,脾气虚弱,肾阳亏虚,气虚血瘀,外寒内热有关。由于西药治疗副作用大,因此人们对有效治疗过敏性鼻炎的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据祖传的单方和临床试验的反复验证,终于确定了有效治疗过敏性鼻炎的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗过敏性鼻炎的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择黄芪、白术、苍耳子、防风、辛夷、牡丹皮、甘草、白芷、蔓荆子进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗过敏性鼻炎。其中选用黄芪是因为其性味甘,微温,入肺、脾经,生用有益卫固表,利水消肿,托毒,生肌的功能,治自汗,盗汗,血痹,浮肿,痈疽不溃或溃久敛;炙用有补中益气的功能,治内伤劳倦,脾虚泄泻,脱肛,气虚血脱,崩带及一切气衰血虚之症。选用白术是因为其性味苦甘,温,入脾、胃经,有补脾,益胃,燥湿,和中的功能,治脾胃气弱,不思饮食,倦怠少气,虚胀,泄泻,痰饮,水肿,黄疸,湿痹,小便不利,头晕,自汗,胎气不安。选用苍耳子是因为其性味甘,温,有毒,入肺、肝经,有散风,止痛,祛湿,杀虫的功能,治风寒头痛,鼻渊,齿痛,风寒湿痹,四脚挛痛,疥癞,瘙痒。选用防风是因为其性味辛甘,温,入膀胱、肺、脾经,有发表,祛风,胜湿,止痛的功能,治外感风寒,头痛,目眩,项强,风寒湿痹,骨节酸痛,四肢挛急,破伤风。选用辛夷是因为其性味辛,温,入肺、胃经,有祛风,通窍的功能,治头痛,鼻渊,鼻塞不通,齿痛。选用牡丹皮是因为其性味辛苦,凉,入心、肝、肾经,有清热,凉血,和血,消瘀的功能,治热入血分,发斑,惊癎,吐、衄、便血,骨蒸劳热,经闭,癥瘕,痈疡,扑损。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊痈,生用治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用白芷是因为其性味辛,温,入肺、脾、胃经,有祛风,燥湿,消肿,止痛的功能,治头痛,眉棱骨痛,齿痛,鼻渊,寒湿腹痛,肠风痔漏,赤白带下,痈疽疮疡,皮肤燥痒,疥癣。选用蔓荆子是因为其性味苦辛,凉,入肝、胃,膀胱经,有疏散风热,清利头目的功能,治风热感冒,正、偏头痛,齿痛,目睛内痛。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
黄芪15-25克,白术5-15克,苍耳子5-15克,防风4-8克,辛夷4-8克,牡丹皮5-15克,甘草3-7克,白芷3-7克,蔓荆子5-15克。
优选为:
黄芪20克,白术10克,苍耳子10克,防风6克,辛夷6克,牡丹皮10克,甘草5克,白芷5克,蔓荆子10克。
本发明药物的制备方法如下
一、备料
1、黄芪:拣净杂质,除去残留的根头和空心较大的根,用水浸泡,捞出,润透后及时切片,晒干;
2、白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干;
3、苍耳子:拣尽杂质,去刺,筛去灰屑,微炒至黄色,取出放凉;
4、防风:除去残茎,用水浸泡,捞出,润透切片,晒干;
5、辛夷:拣净枝梗杂质,捣碎用;
6、牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
7、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干;
8、白芷:拣净杂质,用水洗净,浸泡,捞出润透,略晒至外皮无滑腻感时,再闷润后,切片干燥;
9、蔓荆子:筛净灰屑,除去残存萼片,置锅内用武火炒至焦黄色,略喷清水,放凉。
二、制备
1、将炮制后的黄芪、白术、苍耳子、防风、辛夷、牡丹皮、甘草、白芷、蔓荆子放入煎药容器内,第一次加水6倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内。
2、将过滤的药渣加4倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液。
3、将两次煎煮液混合搅拌均匀,分为2剂服用。
组方中黄芪有益卫固表,利水消肿,补中益气的功能为君药;辛夷祛风,通窍;白术有补脾,益胃,燥湿,和中的功能,二者为臣药,三味药共同发挥益卫固表,利水消肿,补中益气,通窍,补脾,益胃,燥湿的作用,治疗过敏性鼻炎效力全面,且以益卫固表,补中益气,通窍,补脾益胃为主可治本,牡丹皮有清热,凉血,和血,消瘀的功能为佐药,蔓荆子有疏散风热,清利头目的功能为使药,与余下诸药是治标。
本发明药物具有益卫固表,补中益气,通窍,补脾益胃,和血消淤,清利头目的功能,用于治疗过敏性鼻炎,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治过敏性鼻炎门诊患者共23例。
2、诊断标准
典型症状为阵发性喷嚏、清水样鼻涕、鼻塞和鼻痒,部分伴有嗅觉减退。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天2次,7天为一个疗程,连续服用2个疗程。
4、疗效评定标准
显效:过敏性鼻炎症状消失,恢复正常,痊愈;
好转:患者阵发性喷嚏、清水样鼻涕、鼻塞和鼻痒现象减轻,过敏性鼻炎症状明显好转,逐步恢复;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗过敏性鼻炎患者23例,结果显效20例,显效率为86.95%,好转2例,好转率为8.7%,无效1例,总有效率为95.65%。

Claims (3)

1.一种治疗过敏性鼻炎的药物,其特征在于:它是由下列重量范围内的原料药制成:
黄芪15-25克,白术5-15克,苍耳子5-15克,防风4-8克,辛夷4-8克,牡丹皮5-15克,甘草3-7克,白芷3-7克,蔓荆子5-15克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
黄芪20克,白术10克,苍耳子10克,防风6克,辛夷6克,牡丹皮10克,甘草5克,白芷5克,蔓荆子10克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)黄芪:拣净杂质,除去残留的根头和空心较大的根,用水浸泡,捞出,润透后及时切片,晒干;
(2)白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干;
(3)苍耳子:拣尽杂质,去刺,筛去灰屑,微炒至黄色,取出放凉;
(4)防风:除去残茎,用水浸泡,捞出,润透切片,晒干;
(5)辛夷:拣净枝梗杂质,捣碎用;
(6)牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
(7)甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干;
(8)白芷:拣净杂质,用水洗净,浸泡,捞出润透,略晒至外皮无滑腻感时,再闷润后,切片干燥;
(9)蔓荆子:筛净灰屑,除去残存萼片,置锅内用武火炒至焦黄色,略喷清水,放凉;
(二)制备
(1)将炮制后的黄芪、白术、苍耳子、防风、辛夷、牡丹皮、甘草、白芷、蔓荆子放入煎药容器内,加水6倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水4倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为2剂服用。
CN201610724028.9A 2016-08-26 2016-08-26 一种治疗过敏性鼻炎的药物及其制备方法 Withdrawn CN106214858A (zh)

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