CN107343931A - 一种治疗乳腺炎伴有乳腺小叶增生的药物及其制备方法 - Google Patents
一种治疗乳腺炎伴有乳腺小叶增生的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗乳腺炎伴有乳腺小叶增生的药物及其制备方法,它主要是由枸橘、咸虾花、柳叶、挂金灯、挖耳草、钩藤、香茅、鬼灯笼、胆木、迷迭香、桔梗、莲须、莳萝子、夏天无、铁马豆、铁包金、狼把草、凉粉藤、小通草、路路通、青皮、柴胡、石椒草、王不留行、石蟹、白花丹、竹节香附、牡丹皮、牡蒿、青葙花、昆布、海藻、伸筋草、胡颓子、狗舌草按一定重量配比制备而成,本发明具有疏肝、和胃、理气、清热解毒、清肝泻热、凉血的功能,用于治疗乳腺炎伴有乳腺小叶增生见效快,疗效好。
Description
技术领域
本发明涉及一种治疗乳腺炎伴有乳腺小叶增生的药物及其制备方法,属中药领域。
技术背景
乳腺炎伴有乳腺小叶增生是女性常见的疾病,引起乳腺小叶增生的原因很多,但主要与内分泌失调或精神情志有密切关系,严重者可发生脓毒败血症急性感染。中医则认为乳腺炎伴有乳腺小叶增生与肝郁胃热、热毒壅滞、气血两虚有关。由于西药治疗副作用大,因此人们对有效治疗乳腺炎伴有乳腺小叶增生的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于研究出有效治疗乳腺炎伴有乳腺小叶增生的药物,从而完成了本发明。
本发明的目的就是提供一种更有效的治疗乳腺炎伴有乳腺小叶增生的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择枸橘、咸虾花、柳叶、挂金灯、挖耳草、钩藤、香茅、鬼灯笼、胆木、迷迭香、桔梗、莲须、莳萝子、夏天无、铁马豆、铁包金、狼把草、凉粉藤、小通草、路路通、青皮、柴胡、石椒草、王不留行、石蟹、白花丹、竹节香附、牡丹皮、牡蒿、青葙花、昆布、海藻、伸筋草、胡颓子、狗舌草、蛴螬、蜈蚣、水蛭、虻虫进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗乳腺炎伴有乳腺小叶增生。其中选用枸橘是因为其性味辛苦,温,有疏肝,和胃,理气,止痛的功能,治胸腹胀满,胃痛,疝气,睾丸肿胀,乳房结核,子宫下垂,跌打损伤,解酒毒。选用咸虾花是因为其性味苦,平,无毒,治风热感冒,疟疾,热泻,肝阳头痛。选用柳叶是因为其性味苦,寒,无毒,入心、脾二经,有清热,透疹,利尿,解毒的功能,治痧疹透发不畅,白浊,疔疮疖肿,乳腺炎,甲状腺肿,丹毒,烫伤,牙痛。选用挂金灯是因为其性味酸,寒,入肝、脾二经,有清热,解毒,利尿的功能,治骨蒸劳热,咳嗽,咽喉肿痛,黄疸,水肿,天泡湿疮。选用挖耳草是因为其性味苦辛,寒,有清热,解毒,消肿的功能,治咽喉肿痛,乳蛾,痄腮,风火牙痛,痈肿疮毒。选用钩藤是因为其性味苦,凉,入肝、心经,有清热平肝,熄风定惊的功能,治小儿惊癎瘈瘲,大人血压偏高,头晕、目眩,妇人子癎。选用香茅是因为其性味辛,温,有疏风解表,祛瘀通络的功能,治感冒头痛,胃痛,泄泻,风湿痹痛,跌打损伤。选用鬼灯笼是因为其性性,味苦,无毒,有清热,利尿,解毒的功能,治感冒,肺热咳嗽,咽喉肿痛,龈肿,湿热黄疸,痢疾,水肿,热淋,天疱疮,疔疮。选用胆木是因为其性味苦,寒,有清热解毒,消肿止痛的功能,治急性扁桃体炎,咽喉炎,乳腺炎,肠炎,菌痢,尿路感染,胆囊炎,下肢溃疡,脚癣感染,疖肿脓疡,皮炎湿疹。选用迷迭香是因为其性味辛、温,有发汗,健脾,安神,止痛作用,治疗消化不良和胃痛。选用桔梗是因为其性味苦辛,平,入肺、胃经,有开宣肺气,祛痰排脓的功能,治外感咳嗽,咽喉肿痛,肺痈吐脓,胸满胁痛,痢疾腹痛。选用莲须是因为其性味甘涩,平,入心、肾经,有清心,益肾,涩精,止血的功能,治梦遗滑泄,吐、衄、崩、带,泻痢。选用莳萝子是因为其性味辛,温,入脾、肾经,有温脾肾,开胃,散寒,行气,解鱼肉毒的功能,治痧秽呕逆,腹中冷痛,寒疝,痞满少食。选用夏天无是因为其有除压镇痉,行气止痛,活血去瘀的功能,治高血压,偏瘫,风湿性关节炎,坐骨神经痛,小儿麻痹后遗症。选用铁马豆是因为其性味苦,凉,入肝、胆二经,有清肝泄热,除蒸宁咳的功能,治阴虚潮热,午后骨蒸,虚痨咳嗽,乳腺炎,腮腺炎。选用铁包金是因为其性味苦,平,有化瘀血,祛风湿,消肿毒的功能,治肺痨久咳,喀血,吐血,跌打损伤,风湿疼痛,痈肿,荨麻疹。选用狼把草是因为其性味苦甘,平,治气管炎,肺结核,咽喉炎,扁桃体炎,痢疾,丹毒,癣疮。选用凉粉藤是因为其性味苦,寒,根有泻肝火,解热毒,消炎的功能,治一般喉痛,白喉,小儿胎毒,风火牙痛。选用小通草是因为其性平,味淡,无毒,入肺、胃二经,有利尿渗湿的功能,治热病小便赤黄或尿闭,湿热癃、淋等症。选用路路通是因为其性味苦平,通行十二经,有祛风通络,利尿除湿的功能,治水肿,胀满,经闭,乳少,手足拘挛。选用青皮是因为其性味苦辛,微温,入肝、胆经,有疏肝破气,散结消痰的功能,治胸胁胃脘疼痛,疝气,食积,乳肿,乳核,久疟癖块。选用柴胡是因为其性味苦,凉,入肝、胆经,有和解表里,疏肝,升阳的功能,治寒热往来,胸满胁痛,口苦耳聋,头痛目眩,疟疾,下利脱肛,月经不调,子宫下垂。选用石椒草是因为其性温,味苦辣,有小毒,走经络,止胸膈气痛,冷寒攻心,胃气疼痛,腹胀,发散疮毒。选用王不留行是因为其性味苦平,入肝、胃经,有行血通经,催生下乳,消肿敛疮的功能,治妇女经闭,乳汁不通,难产,血淋,痈肿,金疮出血。选用蛴螬是因为其性味咸,微温,入足厥阴肝经,有破血,行瘀,散结,通乳的功能,治折损瘀痛,痛风,破伤风,喉痹,目翳,丹毒,痈疽,痔漏。选用蜈蚣是因为其性味辛,温,有毒,入肝经,有祛风,定惊,攻毒,散结的功能,治中风,惊癎,破伤风,百日咳,冀疬,结核,癥积瘤块,疮疡肿毒,风癣,白秃,痔漏,烫伤。选用石蟹是因为其性味咸,寒,入肝、胆经,有清肝明目,消肿解毒的功能,治目赤,翳膜遮睛,喉痹,痈肿,漆疮。选用白花丹是因为其性味辛苦涩,温,有毒,有祛风,散瘀,解毒,杀虫的功能,治风湿关节疼痛,血瘀经闭,跌打损伤,肿毒恶疮,疮癣。选用竹节香附是因为其味辛,性热,有毒,有祛风湿,消痈肿的功能,治风寒湿痹,痈肿,金疮。选用牡丹皮是因为其性味辛苦,凉,入心、肝、肾经,有清热,凉血,和血,消瘀的功能,治热入血分,发斑,惊癎,吐、衄、便血,骨蒸劳热,经闭,癥瘕,痈疡,扑损。选用牡蒿是因为其性味苦微甘,寒,有解表,清热,杀虫的功能,治感冒身热,劳伤咳嗽,潮热,小儿疳热,疟疾,口疮,疥癣,湿疹。选用青葙花是因为其性微寒,味苦,有清肝凉血,明目去翳的功能,治吐血,头风,目赤,血淋,月经不调,白带,血崩。选用昆布是因为其性味咸,寒,入胃经,有软坚,行水的功能,治瘰疬,瘿瘤,噎膈,水肿,睾丸肿痛,带下。选用海藻是因为其性味苦咸,寒,入肺、脾、肾经,有软坚,消痰,利水,泄热的功能,治瘰疬,瘿瘤,积聚,水肿,脚气,睾丸肿痛。选用伸筋草是因为其性味苦辛,温,入肝、胃、肾三经,有祛风散寒,除湿消肿,舒筋活血的功能,治风寒湿痹,关节酸痛,皮肤麻木,四肢软弱,水肿,跌打损伤。选用胡颓子是因为其性味酸涩,平,治泻痢,消渴,喘咳的功能。选用狗舌草是因为其性味苦,寒,有小毒,有清热,利水,杀虫的功能,治肺脓疡,肾炎水肿,疖肿,疥疮。选用水蛭是因为其性味咸苦,平,有毒,入肝、膀胱经,有破血,逐瘀,通经的功能,治蓄血,癥瘕,积聚,妇女经闭,干血成痨,跌扑损伤,目赤痛,云翳。选用虻虫是因为其性味苦,凉,有毒,入肝经,有逐瘀,破积,通经的功能,治癥瘕,积聚,少腹蓄血,血滞经闭,扑损瘀血。
具体实施方式
本发明组方的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
枸橘10-20克、咸虾花30-40克、柳叶10-20克、挂金灯7-12克、挖耳草10-15克、钩藤10-20克、香茅10-20克、鬼灯笼10-20克、胆木30-40克、迷迭香7-12克、桔梗10-20克、莲须3-9克、莳萝子3-9克、夏天无7-12克、铁马豆10-20克、铁包金30-40克、狼把草10-20克、凉粉藤10-20克、小通草3-9克、路路通10-20克、青皮10-20克、柴胡10-20克、石椒草10-20克、王不留行10-20克、蛴螬5-10克、蜈蚣1-5克、石蟹3-7克、白花丹10-15克、竹节香附3-5克、牡丹皮15-25克、牡蒿3-9克、青葙花30-40克、昆布10-20克、海藻10-20克、伸筋草7-12克、胡颓子10-20克、狗舌草10-15克、水蛭3-5克、虻虫2-6克。
优选为:
枸橘15克、咸虾花35克、柳叶15克、挂金灯9克、挖耳草12克、钩藤15克、香茅15克、鬼灯笼15克、胆木35克、迷迭香9克、桔梗15克、莲须6克、莳萝子6克、夏天无9克、铁马豆15克、铁包金35克、狼把草15克、凉粉藤15克、小通草6克、路路通15克、青皮15克、柴胡15克、石椒草15克、王不留行15克、蛴螬8克、蜈蚣3克、石蟹5克、白花丹12克、竹节香附3克、牡丹皮20克、牡蒿6克、青葙花35克、昆布15克、海藻15克、伸筋草9克、胡颓子15克、狗舌草12克、水蛭3克、虻虫4克。
本发明药物的制备方法如下:
一、备料
1、枸橘:8-9月果实未成熟时采摘,日晒夜露,至全部干燥;
2、咸虾花:秋季采收,晒干;
3、柳叶:取原药材,拣去杂质;
4、挂金灯:秋季果实成熟,宿萼呈红色或红黄色时摘下,去掉果实或连同果实一起晒干;
5、挖耳草:夏季初开花时拔取全株,除去老茎及根,切成小段,晒干;
6、钩藤:拣去老梗、杂质,洗净,晒干;
7、香茅:全年可采,采得后洗净,晒干;
8、鬼灯笼:夏季采收,拣净杂质,晒干;
9、胆木:全年可采,洗净切片,晒干;
10、迷迭香:5-6月采收,洗净,切段,晒干;
11、桔梗:拣净杂质,除去芦头,洗净捞出,润透后切片,晒干;
12、莲须:取原药材,除去杂质;
13、莳萝子:果实成熟后采收果枝,晒干,打落果实,去净杂质,晒至干透为止;
14、夏天无:采取块茎,去泥洗净,切片,晒干;
15、铁马豆:夏、秋采集,晒干;
16、铁包金:全年可采;
17、狼把草:夏、秋间割取地上部分,晒干;
18、凉粉藤:秋后采,拣净杂质,晒干;
19、小通草:夏、秋采收,割取地上茎,趁鲜时取出茎髓,理直,晒干;
20、路路通:除去杂质,洗净,晒干;
21、青皮:拣净杂质,用水浸泡,捞出,润透,切片,晒干;
22、柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,随即晒干;
23、石椒草:夏季采收,除去泥沙,晒干;
24、王不留行:簸净杂质,置锅内,用文火炒至爆开白花六、七成时取出,放凉;
25、蛴螬:筛去泥土,洗净晒干;
26、蜈蚣:拭净,除去头足,剪断用;
27、石蟹:洗净泥土,捣碎;
28、白花丹:全年可采,拣净杂质;
29、竹节香附:除去残茎及须根,晒干;
30、牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
31、牡蒿:夏、秋间,采取全草,晒干;
32、青葙花:拣净杂质,晒干;
33、昆布:拣去杂质,用水漂净,切成宽丝,晾干;
34、海藻:拣去杂质,用水略漂,稍晾,切段,晒干;
35、伸筋草:筛去灰屑,拣净杂质,切成小段;
36、胡颓子:拣净杂质,晒干;
37、狗舌草:拣净杂质,晒干;
38、水蛭:洗净,闷软,切段,晒干;
39、虻虫:拣净杂质,除去翅、足,或用文火微炒用。
二、制备
1、取蛴螬、蜈蚣、水蛭、虻虫分别与2克黄酒置于铁锅中炒干,取出捣碎;
2、将枸橘、咸虾花、柳叶、挂金灯、挖耳草、钩藤、香茅、鬼灯笼、胆木、迷迭香、桔梗、莲须、莳萝子、夏天无、铁马豆、铁包金、狼把草、凉粉藤、小通草、路路通、青皮、柴胡、石椒草、王不留行、石蟹、白花丹、竹节香附、牡丹皮、牡蒿、青葙花、昆布、海藻、伸筋草、胡颓子、狗舌草磨成碎药粉;
3、丸剂的制备:另取炼蜜300克置于煎药容器内煎煮20分钟,加入上述捣碎的药粉和磨碎的药粉,共同煎煮6分钟,待温后,制成丸剂,每丸0.6克;
4、膏剂的制备:取麻油500克置煎药容器内,煎至水分蒸尽后,加入上述捣碎和磨碎的药粉,武火煎至药粉全黑时,滤除药渣,改用文火煎煮15分钟取出,于夜间放至空旷之处露一夜即得药膏,用时将药膏摊在生白布上外贴患处。
组方中枸橘疏肝,和胃,理气,止痛,胆木有清热解毒,消肿止痛的功能与咸虾花三者为君药;挂金灯清热,解毒,利尿,香茅有疏风解表,祛瘀通络的功能,与柳叶、挖耳草、钩藤、鬼灯笼六味为臣药,与君药共同发挥疏肝、和胃、理气、清热解毒、祛瘀通络的作用,治疗乳腺炎伴有乳腺小叶增生效力全面,且以疏肝、和胃、理气、清热解毒为主,可治本;铁马豆有清肝泄热,除蒸宁咳的功能与迷迭香、桔梗、莲须、莳萝子、夏天无、铁包金、狼把草、凉粉藤为佐药;青葙花有清肝凉血,明目去翳的功能与余下诸药为使药,可治标。
本发明药物具有疏肝、和胃、理气、清热解毒、清肝泻热、凉血的功能,用于治疗乳腺炎伴有乳腺小叶增生见效快,疗效好,无副作用。
以下通过试验例来进一步阐述本发明药物的有益效果,这些试验包括本发明药物的动物毒性试验和临床疗效观察试验。
[试验例1]本发明药物的动物毒性试验
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为0.4g/kg,正常量为0.2g/kg,给药方式为稀释灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治门诊患者共45例。
2、诊断标准
乳腺炎伴有乳腺小叶增生的症状包括:皮肤红、肿、热、痛,这种哺乳期乳腺炎症状出现较明显的硬结,触痛更加,同时病人可出现寒战、高热、头痛、无力、脉快等全身症状;月经来潮前5-7天,乳房胀满疼痛,月经来潮乳房胀痛缓解,乃至消失,待下次月经来潮前又出现周期性的变化。
3、治疗方法
选用上述药物,给患者服用,每次服用12克,每天早、晚各一次,15天为一疗程,连续使用3个疗程。外用膏剂,每3天换贴1次。
4、疗效评定标准
显效:乳腺炎伴有乳腺小叶增生症状消失,恢复正常,痊愈;
好转:患者皮肤红、肿、热、痛,寒战、高热等全身症状和乳房胀满疼痛的现象减轻,乳腺炎伴有乳腺小叶增生症状明显好转,逐步恢复正常;
无效:达不到好转标准者。
5、治疗结果(见下表):
在上述治疗中,用本发明药物治疗乳腺炎伴有乳腺小叶增生患者45例,结果显效36例,显效率为80%,好转4例,好转率为13.33%,无效3例,总有效率为93.33%。
Claims (3)
1.一种治疗乳腺炎伴有乳腺小叶增生的药物,其特征在于:它是由下列重量范围内的原料药制成:
枸橘10-20克、咸虾花30-40克、柳叶10-20克、挂金灯7-12克、挖耳草10-15克、钩藤10-20克、香茅10-20克、鬼灯笼10-20克、胆木30-40克、迷迭香7-12克、桔梗10-20克、莲须3-9克、莳萝子3-9克、夏天无7-12克、铁马豆10-20克、铁包金30-40克、狼把草10-20克、凉粉藤10-20克、小通草3-9克、路路通10-20克、青皮10-20克、柴胡10-20克、石椒草10-20克、王不留行10-20克、蛴螬5-10克、蜈蚣1-5克、石蟹3-7克、白花丹10-15克、竹节香附3-5克、牡丹皮15-25克、牡蒿3-9克、青葙花30-40克、昆布10-20克、海藻10-20克、伸筋草7-12克、胡颓子10-20克、狗舌草10-15克、水蛭3-5克、虻虫2-6克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
枸橘15克、咸虾花35克、柳叶15克、挂金灯9克、挖耳草12克、钩藤15克、香茅15克、鬼灯笼15克、胆木35克、迷迭香9克、桔梗15克、莲须6克、莳萝子6克、夏天无9克、铁马豆15克、铁包金35克、狼把草15克、凉粉藤15克、小通草6克、路路通15克、青皮15克、柴胡15克、石椒草15克、王不留行15克、蛴螬8克、蜈蚣3克、石蟹5克、白花丹12克、竹节香附3克、牡丹皮20克、牡蒿6克、青葙花35克、昆布15克、海藻15克、伸筋草9克、胡颓子15克、狗舌草12克、水蛭3克、虻虫4克。
3.根据权利要求1或2所述药物的制备方法,其特征在于:它包括下列步骤:
(一)备料
(1)枸橘:8-9月果实未成熟时采摘,日晒夜露,至全部干燥;
(2)咸虾花:秋季采收,晒干;
(3)柳叶:取原药材,拣去杂质;
(4)挂金灯:秋季果实成熟,宿萼呈红色或红黄色时摘下,去掉果实或连同果实一起晒干;
(5)挖耳草:夏季初开花时拔取全株,除去老茎及根,切成小段,晒干;
(6)钩藤:拣去老梗、杂质,洗净,晒干;
(7)香茅:全年可采,采得后洗净,晒干;
(8)鬼灯笼:夏季采收,拣净杂质,晒干;
(9)胆木:全年可采,洗净切片,晒干;
(10)迷迭香:5-6月采收,洗净,切段,晒干;
(11)桔梗:拣净杂质,除去芦头,洗净捞出,润透后切片,晒干;
(12)莲须:取原药材,除去杂质;
(13)莳萝子:果实成熟后采收果枝,晒干,打落果实,去净杂质,晒至干透为止;
(14)夏天无:采取块茎,去泥洗净,切片,晒干;
(15)铁马豆:夏、秋采集,晒干;
(16)铁包金:全年可采;
(17)狼把草:夏、秋间割取地上部分,晒干;
(18)凉粉藤:秋后采,拣净杂质,晒干;
(19)小通草:夏、秋采收,割取地上茎,趁鲜时取出茎髓,理直,晒干;
(20)路路通:除去杂质,洗净,晒干;
(21)青皮:拣净杂质,用水浸泡,捞出,润透,切片,晒干;
(22)柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,随即晒干;
(23)石椒草:夏季采收,除去泥沙,晒干;
(24)王不留行:簸净杂质,置锅内,用文火炒至爆开白花六、七成时取出,放凉;
(25)蛴螬:筛去泥土,洗净晒干;
(26)蜈蚣:拭净,除去头足,剪断用;
(27)石蟹:洗净泥土,捣碎;
(28)白花丹:全年可采,拣净杂质;
(29)竹节香附:除去残茎及须根,晒干;
(30)牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
(31)牡蒿:夏、秋间,采取全草,晒干;
(32)青葙花:拣净杂质,晒干;
(33)昆布:拣去杂质,用水漂净,切成宽丝,晾干;
(34)海藻:拣去杂质,用水略漂,稍晾,切段,晒干;
(35)伸筋草:筛去灰屑,拣净杂质,切成小段;
(36)胡颓子:拣净杂质,晒干;
(37)狗舌草:拣净杂质,晒干;
(38)水蛭:洗净,闷软,切段,晒干;
(39)虻虫:拣净杂质,除去翅、足,或用文火微炒用;
(二)制备
(1)取蛴螬、蜈蚣、水蛭、虻虫分别与2克黄酒置于铁锅中炒干,取出捣碎;
(2)将枸橘、咸虾花、柳叶、挂金灯、挖耳草、钩藤、香茅、鬼灯笼、胆木、迷迭香、桔梗、莲须、莳萝子、夏天无、铁马豆、铁包金、狼把草、凉粉藤、小通草、路路通、青皮、柴胡、石椒草、王不留行、石蟹、白花丹、竹节香附、牡丹皮、牡蒿、青葙花、昆布、海藻、伸筋草、胡颓子、狗舌草磨成碎药粉;
(3)丸剂的制备:另取炼蜜300克置于煎药容器内煎煮20分钟,加入上述捣碎的药粉和磨碎的药粉,共同煎煮6分钟,待温后,制成丸剂,每丸0.6克;
(4)膏剂的制备:取麻油500克置煎药容器内,煎至水分蒸尽后,加入上述捣碎和磨碎的药粉,武火煎至药粉全黑时,滤除药渣,改用文火煎煮15分钟取出,于夜间放至空旷之处露一夜即得药膏,用时将药膏摊在生白布上外贴患处。
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