CN107823497A - 一种治疗多发性疖肿的药物及其制备方法 - Google Patents
一种治疗多发性疖肿的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗多发性疖肿的药物及其制备方法,其主要是由当归、赤芍、熟地黄、川芎、连翘、丝瓜络、皂角刺、黄芪、大黄、木通、牡丹皮、薏苡仁、藿香、佩兰、金银花、天葵、野菊花、蒲公英、僵蚕、甘草、黄连、滑石按一定重量配比制备而成,本发明药物具有清热凉血,散瘀止痛,清热解毒,散结消肿,搜风拔毒,消肿排脓的功能,用于治疗多发性疖肿见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗多发性疖肿的药物及其制备方法,属中药领域。
背景技术
多发性疖肿是临床的常见病、多发病,其局部形态虽小,但其危害却很大,可反复发作,此愈彼起,连续缠绵而不愈,甚则迁延数年、十数年。因其最易反复,顽固难愈,不易根除,给患者带来了无限的苦恼,医治起来也甚是棘手。临床症见病变处疮小,色红,有白头,灼热疼痛,突起无根,肿势局限,脓出即愈。本病可此愈彼生,接连不断,病程绵延,长期不愈。全身症状可有发热恶寒,乏力纳呆,便于尿黄等。由于西药治疗副作用大,因此人们对有效治疗多发性疖肿的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗多发性疖肿的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗多发性疖肿的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择当归、赤芍、熟地黄、川芎、连翘、丝瓜络、皂角刺、黄芪、大黄、木通、牡丹皮、薏苡仁、藿香、佩兰、金银花、天葵、野菊花、蒲公英、僵蚕、甘草、黄连、滑石、淡竹叶、大青叶、车前草、黄芩进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗多发性疖肿。其中选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血活血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用赤芍是因为其性味苦,微寒,归肝经,有清热凉血,散瘀止痛的功能,治温毒发狂,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,癎瘕腹痛,跌扑损伤,痈肿疮疡。选用熟地黄是因为其性味甘,微温,入肝、肾经,有滋阴,补血的功能,治阴虚血少,腰膝痿弱,劳嗽骨蒸,遗精,崩漏,月经不调,消渴,溲数,耳聋,目昏。选用川芎是因为其性味辛,温,入肝、胆经,有行气开郁,祛风燥湿,活血止痛的功能,治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。选用连翘是因为其性味苦,凉,入心、肝、胆经,有清热,解毒,散结,消肿的功能,治温热,丹毒,斑疹,痈疡肿毒,瘰疬,小便淋闭。选用丝瓜络是因为其性味甘,平,有通经活络,清热化痰的功能,治胸胁疼痛,腹痛,腰痛,睾丸肿痛,肺热痰咳,妇女经闭,乳汁不通,痈肿,痔漏。选用皂角刺是因为其性味辛,温,有搜风,拔毒,消肿,排脓的功能,治痈肿,疮毒,疠风,癣疮,胎衣不下。选用黄芪是因为其性味甘,微温,入肺、脾经,生用有益卫固表,利水消肿,托毒,生肌的功能,治自汗,盗汗,血痹,浮肿,痈疽不溃或溃久敛;炙用有补中益气的功能,治内伤劳倦,脾虚泄泻,脱肛,气虚血脱,崩带及一切气衰血虚之症。选用大黄是因为其性味苦、寒,入胃、大肠、肝径,有泻热毒,破积滞,行瘀血的功能,治实热便秘,谵语发狂,食积痞满,痢疾初起,里急后重,瘀停经闭,癥瘕积聚,时行热疫,暴眼赤痛,吐血,衄血,阳黄,水肿,淋浊,溲赤,痈疡肿毒,疔疮,汤火伤。选用木通是因为其性味苦,凉,入心、小肠、膀胱经,有泻火行水,通利血脉的功能,治小便赤涩,淋浊,水肿,胸中烦热,喉痹咽痛,遍身拘痛,妇女经闭,乳汁不通。选用牡丹皮是因为其性味辛苦,凉,入心、肝、肾经,有清热,凉血,和血,消瘀的功能,治热入血分,发斑,惊癎,吐、衄、便血,骨蒸劳热,经闭,癥瘕,痈疡,扑损。选用薏苡仁是因为其性味甘淡,凉,入脾、肺、肾经,有健脾,补肺,清热,利湿的功能,治泄泻,湿痹,筋脉拘挛,屈伸不利,水肿,脚气,肺痿,肺痈,肠痈,淋浊,白带。选用藿香是因为其性味辛,微温,入肺、脾、胃经,有快气,和中,辟秽,祛湿的功能,治感冒暑湿,寒热,头痛,胸脘痞闷,呕吐泄泻,疟疾,痢疾,口臭。选用佩兰是因为其性味辛,平,入脾、胃经,有清暑,辟秽,化湿,调经的功能,治感受暑湿,寒热头痛,湿邪内蕴,脘痞不饥,口甘苔腻,月经不调。选用金银花是因为其性味甘,寒,入肺、胃经,有清热,解毒的功能,治温病发热,热毒血痢,痈疡,肿毒,瘰疬,痔漏。选用天葵是因为其性味甘,寒,有消肿,解毒,利水的功能,治瘰疬,疝气,小便不利。选用野菊花是因为其性味苦辛,凉,入肺、肝经,有疏风清热,消肿解毒的功能,治风热感冒,肺炎,白喉,胃肠炎,高血压,疔,痈,口疮,丹毒,湿疹,天泡疮。选用蒲公英是因为其性味苦甘,寒,入肝、胃经,有清热解毒,利尿散结的功能,治急性乳腺炎,淋巴腺炎,瘰疬,疔毒疮肿,急性结膜炎,感冒发热,急性扁桃体炎,急性支气管炎,胃炎,肝炎,胆囊炎,尿路感染。选用僵蚕是因为其性味辛、咸,平,归肝,肺经。祛风解痉,化痰散结。用于中风口眼歪斜,惊痫抽搐,头赐,喉痹,瘰疠结核,风疹丹毒。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊痈,生用治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用黄连是因为其性味苦,寒,入心、肝、胃、大肠经,有泻火,燥湿,解毒,杀虫的功能,治时行热毒、伤寒,热盛心烦,痞满呕逆,菌痢,热泻腹痛,肺结核,吐、衄、下血,消渴,疳积,蛔虫病,百日咳,咽喉肿痛,火眼,口疮,痈疽疮毒,湿疹,汤火烫伤。选用滑石是因为其性味甘、淡,寒,归膀胱、肺、胃经,有利尿通淋,清热解毒,祛湿解暑的功能,治热淋、石淋,尿热涩痛,暑湿烦渴,湿热水泻,外治湿疹,湿疮,痱子。选用淡竹叶是因为其性味甘淡,寒,入心肾二经,有清心火,除烦热,利小便的功能,治热病口渴,心烦,小便赤涩,淋浊,口糜舌疮,牙龈肿痛。选用大青叶是因为其性味苦,寒,入肝、心、胃经,有清热,解毒,凉血,止血的功能,治温病热盛烦渴,流行性感冒,急性传染性肝炎,菌痢,急性胃肠炎,急性肺炎,丹毒,吐血,衄血,黄疸,痢疾,喉痹,口疮,痈疽肿毒。选用车前草是因为其性味甘,寒,入肝、脾二经,有利水,清热,明目,祛痰的功能,治小便不通,淋浊,带下,尿血,黄疸,水肿,热痢,泄泻,鼻衄,目赤肿痛,喉痹乳蛾,咳嗽,皮肤溃疡。选用黄芩是因为其性味苦寒,入心肺、胆、大肠经,有泻实火,除湿热,止血安胎的功能,治壮热烦渴,肺热咳嗽。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
当归10-20克,赤芍10-14克,熟地黄15-25克,川芎10-14克,连翘10-14克,丝瓜络25-35克,皂角刺10-14克,黄芪25-35克,大黄7-11克,木通10-20克,牡丹皮5-15克,薏苡仁25-35克,藿香4-8克,佩兰4-8克,金银花5-15克,天葵5-15克,野菊花5-15克,蒲公英5-15克,僵蚕4-8克,甘草4-8克,黄连5-15克,滑石4-8克,淡竹叶4-8克,大青叶15-25克,车前草5-15克,黄芩4-8克。
优选为:
当归15克,赤芍12克,熟地黄20克,川芎12克,连翘12克,丝瓜络30克,皂角刺12克,黄芪30克,大黄9克,木通15克,牡丹皮10克,薏苡仁30克,藿香6克,佩兰6克,金银花10克,天葵10克,野菊花10克,蒲公英10克,僵蚕6克,甘草6克,黄连10克,滑石6克,淡竹叶6克,大青叶20克,车前草10克,黄芩6克。
本发明药物的制备方法如下
一、备料
1、当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
2、赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
3、熟地黄:取原药材,蒸至表面乌黑色,取出,晒至八成干时,切片,干燥;
4、川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
5、连翘:拣净杂质,搓开,除去枝梗;
6、丝瓜络:洗净晒干,切段;
7、皂角刺:拣去杂质,用水浸泡,润透后切片,晒干;
8、黄芪:拣净杂质,除去残留的根头和空心较大的根,用水浸泡,捞出,润透后及时切片,晒干;
9、大黄:拣净杂质,大小分档,闷润至内外湿度均匀,切片或切成小块、晒干;
10、木通:用水稍浸泡,闷润至透,切片,晒干;
11、牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
12、薏苡仁:取原药材,除去残留皮壳、杂质;
13、藿香:拣去杂质,除去残根及老茎,先将叶摘下另放,茎用水润透,切段,晒干,然后与叶和匀;
14、佩兰:拣净杂质,用水洗净,捞出,稍润后,除去残根,切段,晒干;
15、金银花:筛去泥沙,拣净杂质;
16、天葵:取原药材,洗净,晒干;
17、野菊花:秋季花盛开时采收,晒干;
18、蒲公英:拣去杂质,洗净泥土,切段,晒干;
19、僵蚕:取原药材,除去残丝,杂质;
20、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干;
21、黄连:拣去杂质,洗净泥砂,润透,切片,阴干;
22、滑石:取原药材,除去杂质,洗净,干燥;
23、淡竹叶:拣去杂质及根,切段,晒干;
24、大青叶:拣去杂质及枯叶,洗净,稍润,切段,晒干;
25、车前草:去尽泥土,晒干;
26、黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干。
二、制备
1、将所述重量的当归、赤芍、熟地黄、川芎、连翘、丝瓜络、皂角刺、黄芪、大黄、木通、牡丹皮、薏苡仁、藿香、佩兰、金银花、天葵、野菊花、蒲公英、僵蚕、甘草、黄连、滑石、淡竹叶、大青叶、车前草、黄芩放入煎药容器内,加水6倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水5倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为2剂服用。
组方中赤芍有清热凉血,散瘀止痛的功能为君药;连翘有清热解毒,散结消肿的功能;皂角刺有搜风拔毒,消肿排脓的功能,二者为臣药,三味药共同发挥清热凉血,散瘀止痛,清热解毒,散结消肿,搜风拔毒,消肿排脓的作用,治疗多发性疖肿效力全面,且以清热解毒,散结消肿,搜风拔毒,消肿排脓为主可治本,野菊花有疏风清热,消肿解毒的功能为佐药,黄连有泻火,燥湿,解毒,杀虫的功能为使药,与下余诸药是治标。
本发明药物具有清热凉血,散瘀止痛,清热解毒,散结消肿,搜风拔毒,消肿排脓的功能,用于治疗多发性疖肿,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治多发性疖肿门诊患者共39例。
2、诊断标准
多发性疖肿临床症见病变处疮小,色红,有白头,灼热疼痛,突起无根,肿势局限,脓出即愈。本病可此愈彼生,接连不断,病程绵延,长期不愈。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、中、晚各服1次,5天为一个疗程,连续服用4个疗程。
4、疗效评定标准
显效:多发性疖肿症状消失,恢复正常,痊愈;
好转:多发性疖肿症状明显好转,愈后不生逐步恢复正常;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗多发性疖肿患者39例,结果显效34例,显效率为87.2%,好转3例,好转率为7.7%,无效2例,总有效率为94.9%。
Claims (3)
1.一种治疗多发性疖肿的药物,其特征在于:它是由下列重量范围内的原料药制成:
当归10-20克,赤芍10-14克,熟地黄15-25克,川芎10-14克,连翘10-14克,丝瓜络25-35克,皂角刺10-14克,黄芪25-35克,大黄7-11克,木通10-20克,牡丹皮5-15克,薏苡仁25-35克,藿香4-8克,佩兰4-8克,金银花5-15克,天葵5-15克,野菊花5-15克,蒲公英5-15克,僵蚕4-8克,甘草4-8克,黄连5-15克,滑石4-8克,淡竹叶4-8克,大青叶15-25克,车前草5-15克,黄芩4-8克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
当归15克,赤芍12克,熟地黄20克,川芎12克,连翘12克,丝瓜络30克,皂角刺12克,黄芪30克,大黄9克,木通15克,牡丹皮10克,薏苡仁30克,藿香6克,佩兰6克,金银花10克,天葵10克,野菊花10克,蒲公英10克,僵蚕6克,甘草6克,黄连10克,滑石6克,淡竹叶6克,大青叶20克,车前草10克,黄芩6克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
(2)赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
(3)熟地黄:取原药材,蒸至表面乌黑色,取出,晒至八成干时,切片,干燥;
(4)川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
(5)连翘:拣净杂质,搓开,除去枝梗;
(6)丝瓜络:洗净晒干,切段;
(7)皂角刺:拣去杂质,用水浸泡,润透后切片,晒干;
(8)黄芪:拣净杂质,除去残留的根头和空心较大的根,用水浸泡,捞出,润透后及时切片,晒干;
(9)大黄:拣净杂质,大小分档,闷润至内外湿度均匀,切片或切成小块、晒干;
(10)木通:用水稍浸泡,闷润至透,切片,晒干;
(11)牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
(12)薏苡仁:取原药材,除去残留皮壳、杂质;
(13)藿香:拣去杂质,除去残根及老茎,先将叶摘下另放,茎用水润透,切段,晒干,然后与叶和匀;
(14)佩兰:拣净杂质,用水洗净,捞出,稍润后,除去残根,切段,晒干;
(15)金银花:筛去泥沙,拣净杂质;
(16)天葵:取原药材,洗净,晒干;
(17)野菊花:秋季花盛开时采收,晒干;
(18)蒲公英:拣去杂质,洗净泥土,切段,晒干;
(19)僵蚕:取原药材,除去残丝,杂质;
(20)甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干;
(21)黄连:拣去杂质,洗净泥砂,润透,切片,阴干;
(22)滑石:取原药材,除去杂质,洗净,干燥;
(23)淡竹叶:拣去杂质及根,切段,晒干;
(24)大青叶:拣去杂质及枯叶,洗净,稍润,切段,晒干;
(25)车前草:去尽泥土,晒干;
(26)黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干;
(二)制备
(1)将所述重量的当归、赤芍、熟地黄、川芎、连翘、丝瓜络、皂角刺、黄芪、大黄、木通、牡丹皮、薏苡仁、藿香、佩兰、金银花、天葵、野菊花、蒲公英、僵蚕、甘草、黄连、滑石、淡竹叶、大青叶、车前草、黄芩放入煎药容器内,加水6倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水5倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为2剂服用。
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