CN106853187A - 一种治疗血小板减少性紫癜的药物及其制备方法 - Google Patents
一种治疗血小板减少性紫癜的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗血小板减少性紫癜的药物及其制备方法,其是由藕节、紫草、三七、连翘、栀子、白茅根、木通、夜交藤、鸡血藤、大枣、大青叶、青黛、茜草、虎杖、太子参、赤芍、白芍、刺蒺藜等按一定重量配比制备而成,本发明药物具有凉血,活血,清热解毒,散瘀的功能,用于治疗血小板减少性紫癜见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗血小板减少性紫癜的药物及其制备方法,属中药领域。
背景技术
血小板减少性紫癜是指角膜疾患痊愈后结成厚薄不一的瘢痕翳障。中医则认为血小板减少性紫癜与血热伤络,气不摄血,阴虚火旺,气滞血瘀有关。由于西药治疗副作用大,因此人们对有效治疗血小板减少性紫癜的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗血小板减少性紫癜的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗血小板减少性紫癜的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择藕节、紫草、三七、连翘、栀子、白茅根、木通、夜交藤、鸡血藤、大枣、大青叶、青黛、茜草、虎杖、太子参、赤芍、白芍、刺蒺藜、牡丹皮、甘草、枳壳进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗血小板减少性紫癜。其中选用藕节是因为其性味甘涩,平,入手少阴,足阳明,厥阴经,有止血,散瘀的功能,治咳血,吐血,衄血,尿血,便血,血痢,血崩。选用紫草是因为其性味苦苦,寒,入心包络、肝经,有凉血,活血,清热解毒的功能,治温热斑疹,湿热黄疸,紫癜,吐、衄、尿血,淋浊,血痢,热结便秘,烧伤,湿疹,丹毒,痈疡。选用三七是因为其性味甘微苦,温,入肝、胃、大肠经,有止血,散瘀,消肿,定痛的功能,治吐血,咳血,衄血,便血,血痢,崩漏,癥瘕,产后血晕,恶露不下,跌扑瘀血,外伤出血,痈肿疼痛。选用连翘是因为其性味苦,凉,入心、肝、胆经,有清热,解毒,散结,消肿的功能,治温热,丹毒,斑疹,痈疡肿毒,瘰疬,小便淋闭。选用栀子是因为其性味苦,寒,入心、肝、肺、胃经,有清热,泻火,凉血的功能,治热病虚烦不眠,黄疸,淋病,消渴,目赤,咽痛,吐血,衄血,血痢,尿血,热毒疮疡,扭伤肿痛。选用白茅根是因为其性味甘、寒,入肺、胃、小肠经,有凉血,止血,清热,利尿的功能,治热病烦渴,吐血,衄血,肺热喘急,胃热哕逆,淋病,小便不利,水肿,黄疸。选用木通是因为其性味苦,凉,入心、小肠、膀胱经,有泻火行水,通利血脉的功能,治小便赤涩,淋浊,水肿,胸中烦热,喉痹咽痛,遍身拘痛,妇女经闭,乳汁不通。选用夜交藤是因为其性味甘微苦,平,入心、肝经,有养心,安神,通络,祛风的功能,治失眠,劳伤,多汗,血虚身痛,痈疽,瘰疬,风疮疥癣。选用鸡血藤是因为其性味苦甘,温,入心、脾二经,有活血、舒筋的功能,治腰膝酸痛,麻木瘫痪,月经不调。选用大枣是因为其性味甘,温,入脾、胃经,有补脾和胃,益气生津,调营卫,解药毒的功能,治胃虚食少,脾弱便溏,气血津液不足,营卫不和,心悸怔忡,妇人脏躁。选用大青叶是因为其性味苦,寒,入肝、心、胃经,有清热,解毒,凉血,止血的功能,治温病热盛烦渴,流行性感冒,急性传染性肝炎,菌痢,急性胃肠炎,急性肺炎,丹毒,吐血,衄血,黄疸,痢疾,喉痹,口疮,痈疽肿毒。选用青黛是因为其性味咸,寒,入肝、肺、胃经,有清热,凉血,解毒的功能,治温病热盛,斑疹,吐血、咯血,小儿惊癎,疮肿,丹毒,蛇虫咬伤。选用茜草是因为其性味苦,寒,有凉血止血,祛瘀通经的功能,治吐血,衄血,崩漏,外伤出血,瘀阻经闭,关节痹痛,跌扑肿痛。选用虎杖是因为其性味苦,平,有祛风,利湿,破瘀,通经的功能,治风湿筋骨疼痛,湿热黄疸,淋浊带下,妇女经闭,产后恶露不下,癥瘕积聚,痔漏下血,跌扑损伤,烫伤,恶疮癣疾。选用太子参是因为其性味甘苦,微温,入心、脾、肺三经,有补肺、健脾的功能,治肺虚咳嗽,脾虚食少,心悸目汗,精神疲乏。选用赤芍是因为其性味苦,微寒,归肝经,有清热凉血,散瘀止痛的功能,治温毒发狂,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,癎瘕腹痛,跌扑损伤,痈肿疮疡。选用白芍是因为其性味苦酸,凉,入肝、脾经,有养血柔肝,缓中止痛,敛阴收汗的功能,治胸腹胁肋疼痛,泻痢腹痛,自汗盗汗,阴虚发热,月经不调,崩漏,带下。选用刺蒺藜是因为其性味苦辛,温,入肝、肺经,有散风,明目,下气,行血的功能,治头痛,身痒,目赤肿翳,胸满,咳逆,癥瘕,乳难,痈疽,瘰疬。选用牡丹皮是因为其性味辛苦,凉,入心、肝、肾经,有清热,凉血,和血,消瘀的功能,治热入血分,发斑,惊癎,吐、衄、便血,骨蒸劳热,经闭,癥瘕,痈疡,扑损。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊痈,生用治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用枳壳是因为其性味苦辛,凉,入肺、脾、大肠经,有破气,行痰,消积的功能,治胸膈痰滞,胸痞,胁胀,食积,噫气,呕逆,下痢后重,脱肛,子宫脱垂。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
藕节10-15克,紫草5-15克,三七5-15克,连翘10-20克,栀子5-15克,白茅根10-20克,木通7-12克,夜交藤15-25克,鸡血藤15-20克,大枣10-15克,大青叶10-20克,青黛5-10克,茜草5-15克,虎杖10-15克,太子参10-20克,赤芍10-15克,白芍5-15克,刺蒺藜15-20克,牡丹皮5-15克,甘草5-15克,枳壳10-20克。
优选为:
藕节12克,紫草10克,三七10克,连翘15克,栀子10克,白茅根15克,木通9克,夜交藤20克,鸡血藤18克,大枣12克,大青叶15克,青黛8克,茜草10克,虎杖12克,太子参15克,赤芍12克,白芍10克,刺蒺藜18克,牡丹皮10克,甘草10克,枳壳15克。
本发明药物的制备方法如下
一、备料
1、藕节:取净藕节置锅内炒至外面呈黑色,内部呈老黄色,稍洒清水,取出,干燥;
2、紫草:洗净,润透,切片,晒干;
3、三七:拣净杂质,捣碎,研末或润透后切片晒干;
4、连翘:拣净杂质,搓开,除去枝梗;
5、栀子:筛去灰屑,拣去杂质,碾碎过筛或剪去两端;
6、白茅根:拣净杂质,洗净,微润,切段,晒干,簸净碎屑;
7、木通:用水稍浸泡,闷润至透,切片,晒干;
8、夜交藤:清水洗净,稍浸泡,捞出,润透后,切段,晒干;
9、鸡血藤:用水润透,切片,或蒸软后乘热切片,晒干;
10、大枣:拣净杂质,晒干;
11、大青叶:拣去杂质及枯叶,洗净,稍润,切段,晒干;
12、青黛:拣去杂质,过箩;
13、茜草:除去杂质,洗净,润透,切厚片或段,干燥,筛去碎屑;
14、虎杖:采得后,细锉,晒干;
15、太子参:摘除须根,晒干;
16、赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
17、白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥;
18、刺蒺藜:漂去泥沙,除净残留的硬刺;
19、牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
20、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,凉干;
21、枳壳:除去瓤、核,冼净,稍浸,捞出,润软,切片,晾干。
二、制备
1、将所述重量的藕节、紫草、三七、连翘、栀子、白茅根、木通、夜交藤、鸡血藤、大枣、大青叶、青黛、茜草、虎杖、太子参、赤芍、白芍、刺蒺藜、牡丹皮、甘草、枳壳放入煎药容器内,第一次加水6倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水4倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为2剂服用。
组方中紫草有凉血,活血,清热解毒的功能为君药;鸡血藤活血、舒筋;牡丹皮清热,凉血,和血,消瘀,二者为臣药,三味药共同发挥凉血,活血,清热解毒,舒筋的作用,治疗血小板减少性紫癜效力全面,且以凉血,活血,清热解毒,活血为主可治本,甘草有和中缓急,润肺,解毒,调和诸药的功能为佐药,赤芍有清热凉血,散瘀止痛的功能为使药,与下余诸药是治标。
本发明药物具有凉血,活血,清热解毒,散瘀的功能,用于治疗血小板减少性紫癜,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治血小板减少性紫癜门诊患者共38例。
2、诊断标准
典型症状为皮肤呈现大小不等的青紫斑点或斑块,常伴有鼻衄、齿衄,甚至咳血、吐血、尿血、便血等症状;女性常伴崩漏,严重者出现中风。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,10天为一个疗程,连续服用3个疗程。
4、疗效评定标准
显效:血小板减少性紫癜症状消失,皮肤恢复正常,痊愈;
好转:患者皮肤紫斑,咳血、吐血、尿血、鼻衄、齿衄,便血的症状明显好转,皮肤逐步恢复;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗血小板减少性紫癜患者38例,结果显效32例,显效率为84.21%,好转4例,好转率为10.52%,无效1例,总有效率为94.73%。
Claims (3)
1.一种治疗血小板减少性紫癜的药物,其特征在于:它是由下列重量范围内的原料药制成:
藕节10-15克,紫草5-15克,三七5-15克,连翘10-20克,栀子5-15克,白茅根10-20克,木通7-12克,夜交藤15-25克,鸡血藤15-20克,大枣10-15克,大青叶10-20克,青黛5-10克,茜草5-15克,虎杖10-15克,太子参10-20克,赤芍10-15克,白芍5-15克,刺蒺藜15-20克,牡丹皮5-15克,甘草5-15克,枳壳10-20克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
藕节12克,紫草10克,三七10克,连翘15克,栀子10克,白茅根15克,木通9克,夜交藤20克,鸡血藤18克,大枣12克,大青叶15克,青黛8克,茜草10克,虎杖12克,太子参15克,赤芍12克,白芍10克,刺蒺藜18克,牡丹皮10克,甘草10克,枳壳15克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)藕节:取净藕节置锅内炒至外面呈黑色,内部呈老黄色,稍洒清水,取出,干燥;
(2)紫草:洗净,润透,切片,晒干;
(3)三七:拣净杂质,捣碎,研末或润透后切片晒干;
(4)连翘:拣净杂质,搓开,除去枝梗;
(5)栀子:筛去灰屑,拣去杂质,碾碎过筛或剪去两端;
(6)白茅根:拣净杂质,洗净,微润,切段,晒干,簸净碎屑;
(7)木通:用水稍浸泡,闷润至透,切片,晒干;
(8)夜交藤:清水洗净,稍浸泡,捞出,润透后,切段,晒干;
(9)鸡血藤:用水润透,切片,或蒸软后乘热切片,晒干;
(10)大枣:拣净杂质,晒干;
(11)大青叶:拣去杂质及枯叶,洗净,稍润,切段,晒干;
(12)青黛:拣去杂质,过箩;
(13)茜草:除去杂质,洗净,润透,切厚片或段,干燥,筛去碎屑;
(14)虎杖:采得后,细锉,晒干;
(15)太子参:摘除须根,晒干;
(16)赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
(17)白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥;
(18)刺蒺藜:漂去泥沙,除净残留的硬刺;
(19)牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
(20)甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,凉干;
(21)枳壳:除去瓤、核,冼净,稍浸,捞出,润软,切片,晾干;
(二)制备
(1)将所述重量的藕节、紫草、三七、连翘、栀子、白茅根、木通、夜交藤、鸡血藤、大枣、大青叶、青黛、茜草、虎杖、太子参、赤芍、白芍、刺蒺藜、牡丹皮、甘草、枳壳放入煎药容器内,加水6倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水4倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为2剂服用。
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CN107375738A (zh) * | 2017-07-27 | 2017-11-24 | 四川聚豪生物科技有限公司 | 一种治疗特发性血小板减少性紫癜血热病的中药组合物 |
CN107551201A (zh) * | 2017-10-26 | 2018-01-09 | 刘萍 | 一种治疗过敏性紫癜的药物及其制备方法 |
CN107648504A (zh) * | 2017-11-23 | 2018-02-02 | 杨小丽 | 一种治疗血小板减少症的药物及其制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1319403A (zh) * | 2000-11-01 | 2001-10-31 | 王志好 | 一种治疗过敏性紫癜病的药 |
CN106074837A (zh) * | 2016-07-29 | 2016-11-09 | 山东省立医院 | 一种抑制和清除血小板抗体、治疗原发性血小板减少性紫癜的中药组合物 |
-
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1319403A (zh) * | 2000-11-01 | 2001-10-31 | 王志好 | 一种治疗过敏性紫癜病的药 |
CN106074837A (zh) * | 2016-07-29 | 2016-11-09 | 山东省立医院 | 一种抑制和清除血小板抗体、治疗原发性血小板减少性紫癜的中药组合物 |
Cited By (3)
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---|---|---|---|---|
CN107375738A (zh) * | 2017-07-27 | 2017-11-24 | 四川聚豪生物科技有限公司 | 一种治疗特发性血小板减少性紫癜血热病的中药组合物 |
CN107551201A (zh) * | 2017-10-26 | 2018-01-09 | 刘萍 | 一种治疗过敏性紫癜的药物及其制备方法 |
CN107648504A (zh) * | 2017-11-23 | 2018-02-02 | 杨小丽 | 一种治疗血小板减少症的药物及其制备方法 |
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