CN106798897A - 一种治疗功能性痛经的药物及其制备方法 - Google Patents
一种治疗功能性痛经的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗功能性痛经的药物及其制备方法,其主要是由山药、巴戟天、香附、当归、熟地黄、柴胡、白芍、郁金、丹参、桃仁、红花、阿胶、肉桂、木通、葛根、川芎、乌药、赤芍、泽泻、茯苓、延胡索、桂枝、枸杞子按一定重量配比制备而成,本发明药物具有理气解郁,止痛调经,补血和血,养血柔肝,缓中止痛,敛阴收汗的功能,用于治疗功能性痛经见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗功能性痛经的药物及其制备方法,属中药领域。
背景技术
功能性痛经是是在月经来临时,经前、经期、经后发生周期性下腹疼痛或痛引腰骶,以致影响工作及日常生活,称痛经。可分为功能性痛经和器质性痛经两种,前者常始于月经初潮或初潮不久,又称原发性痛经,后者可由子宫内膜异位症、盆腔炎、子宫肌瘤或宫内节育器等引起又称继发性痛经。由于西药治疗副作用大,因此人们对有效治疗功能性痛经的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗功能性痛经的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗功能性痛经的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择山药、巴戟天、香附、当归、熟地黄、柴胡、白芍、郁金、丹参、桃仁、红花、阿胶、肉桂、木通、葛根、川芎、乌药、赤芍、泽泻、茯苓、延胡索、桂枝、枸杞子、甘草、山楂、五灵脂、蒲公英、砂仁进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗功能性痛经。其中选用山药是因为其性味甘,平,入肺、脾、肾经,有健脾,补肺,固肾,益精的功能,治脾虚泄泻,久痢,虚劳咳嗽,消渴,遗精、带下,小便频数。选用巴戟天是因为其性味辛甘,温,入肝、肾经,有补肾阳,壮筋骨,祛风湿的功能,治阳痿,少腹冷痛,小便不禁,子宫虚冷,风寒湿痹,腰膝酸痛。选用香附是因为其性味辛微苦干,平,入肝、三焦经,有理气解郁,止痛调经的功能,治肝胃不和,气郁不舒,胸腹胁肋胀痛,痰饮痞满,月经不调,崩漏带下。选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用熟地黄是因为其性味甘,微温,入肝、肾经,有滋阴,补血的功能,治阴虚血少,腰膝痿弱,劳嗽骨蒸,遗精,崩漏,月经不调,消渴,溲数,耳聋,目昏。选用柴胡是因为其性味苦,凉,入肝、胆经,有和解表里,疏肝,升阳的功能,治寒热往来,胸满胁痛,口苦耳聋,头痛目眩,疟疾,下利脱肛,月经不调,子宫下垂。选用白芍是因为其性味苦酸,凉,入肝、脾经,有养血柔肝,缓中止痛,敛阴收汗的功能,治胸腹胁肋疼痛,泻痢腹痛,自汗盗汗,阴虚发热,月经不调,崩漏,带下。选用郁金是因为其性味辛苦,凉,入心、肺、肝经,有行气解随,凉血破瘀的功能,治胸腹胁肋诸痛,失心癫狂,热病神昏,吐血,衄血,尿血,血淋,妇女倒经,黄疸。选用丹参是因为其性味苦,微温,入心、肝经,有活血去瘀,安神宁心,排脓,止痛的功能,治心绞痛,月经不调,痛经,以闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠,恶疮肿毒。选用桃仁是因为其性味苦甘,平,入心、肝、大肠经,有破血行瘀,润燥滑经的功能,治经闭,癥瘕,热病蓄血,血痹,疟疾,跌打损伤,瘀血肿痛,血燥便秘。选用红花是因为其性味辛,温,入心、肝经,有活血通经,去瘀止痛的功能,治经闭,癥瘕,难产,死胎,产后恶露不行,瘀血作痛,痈肿,跌扑损伤。选用阿胶是因为其性味甘平,入肺、肝、肾经,有滋阴补血,安胎的功能,治血虚,虚劳咳嗽,吐血、衄血、便血,妇女月经不调,崩中,治漏。选用肉桂是因为其性味辛甘,热,入肾、脾、膀胱经,有补元阳,暖脾胃,除积冷,通血脉的功能,治命门火衰,肢冷脉微,亡阳虚脱,腹痛泄泻,寒疝奔豚,腰膝冷痛,经闭癥瘕,阴疽,流注,及虚阳浮越,上热下寒。选用木通是因为其性味苦,凉,入心、小肠、膀胱经,有泻火行水,通利血脉的功能,治小便赤涩,淋浊,水肿,胸中烦热,喉痹咽痛,遍身拘痛,妇女经闭,乳汁不通。选用葛根是因为其性味甘辛,平,入脾、胃经,有升阳解肌,透疹止泻,除烦止喝的功能,治伤寒,治伤寒,温热头痛项强,烦热消渴,泄泻,痢疾,癍疹不透,高血压,心绞痛,耳聋。选用川芎是因为其性味辛,温,入肝、胆经,有行气开郁,祛风燥湿,活血止痛的功能,治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。选用乌药是因为其性味辛,温,入脾、肺、肾、膀胱经,有顺气,开郁,散寒,止痛的功能,治气逆胸腹胀痛,宿食不满,反胃吐食,寒疝,脚气,小便频数。选用赤芍是因为其性味苦,微寒,归肝经,有清热凉血,散瘀止痛的功能,治温毒发狂,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,癎瘕腹痛,跌扑损伤,痈肿疮疡。选用泽泻是因为其性味甘,寒,入膀胱经,有利水,渗湿,泄热的功能,治小便不利,水肿肛满,呕吐,泻痢,痰饮,脚气,淋病,尿血。选用茯苓是因为其性味甘淡,平,入心、脾、肺经,有渗湿利水,益脾和胃,宁心安神的功能,治小便不利,水肿胀满,痰饮咳逆,呕哕,泄泻,遗精,淋浊,惊悸,健忘。选用延胡索是因为其性味辛苦,温,入肝、胃经,有活血,散瘀,理气,止痛的功能,治心腹腰膝诸痛,月经不调,癥瘕,崩中,产后血晕,恶露不尽,跌打损伤。选用桂枝是因为其性味辛甘,温,入膀胱、心、肺经,有发汗解肌,温经通脉的功能,治风寒表证,肩背肢节酸疼,胸痹痰饮,经闭癥瘕。选用枸杞子是因为其性味甘,平,有滋肾,润肺,补肝,明目的功能,治肝肾阴亏,腰膝酸软,头晕目眩,目昏多泪,虚劳咳嗽,消渴,遗精。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊痈,生用治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用山楂是因为其性味酸甘,微温,入脾、胃、肝经,有消食积,散瘀血,驱绦虫的功能,治肉积,癥瘕,痰饮,痞满,吞酸,泻痢,肠风,腰痛,疝气,产后儿枕痛,恶露不尽,小儿乳食停滞。选用五灵脂是因为其性味苦甘,温,入肝、脾经,生用有行血止痛的功能,治心腹血气诸痛,妇女经闭,产后瘀血作痛;外治蛇、蝎、蜈蚣咬伤,炒用止血,治妇女血崩,经水过多,赤带不绝。选用蒲公英是因为其性味苦甘,寒,入肝、胃经,有清热解毒,利尿散结的功能,治急性乳腺炎,淋巴腺炎,瘰疬,疔毒疮肿,急性结膜炎,感冒发热,急性扁桃体炎,急性支气管炎,胃炎,肝炎,胆囊炎,尿路感染。选用砂仁是因为其性味辛,温,入脾、胃经,有行气调中,和胃、醒脾的功能,治腹痛痞胀,胃呆食滞,噎隔呕吐,寒泻冷痢,妊娠胎动。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
山药20-30克,巴戟天10-14克,香附10-14克,当归10-14克,熟地黄10-14克,柴胡10-14克,白芍10-20克,郁金5-15克,丹参16-20克,桃仁10-14克,红花10-14克,阿胶4-8克,肉桂5-15克,木通5-15克,葛根5-15克,川芎5-15克,乌药5-15克,赤芍5-15克,泽泻5-15克,茯苓5-15克,延胡索5-15克,桂枝5-15克,枸杞子10-14克,甘草6-10克,山楂15-25克,五灵脂5-15克,蒲公英15-25克,砂仁5-15克。
优选为:
山药25克,巴戟天12克,香附12克,当归12克,熟地黄12克,柴胡12克,白芍15克,郁金10克,丹参18克,桃仁12克,红花12克,阿胶6克,肉桂10克,木通10克,葛根10克,川芎10克,乌药10克,赤芍10克,泽泻10克,茯苓10克,延胡索10克,桂枝10克,枸杞子12克,甘草8克,山楂20克,五灵脂10克,蒲公英20克,砂仁10克。
本发明药物的制备方法如下
一、备料
1、山药:拣净杂质,用水浸泡至山药中心部软化为止,捞出稍晾,切片晒干或烘干;
2、巴戟天:拣去杂质,用热水泡透后,趁热抽去木心,切段,晒干;
3、香附:拣去杂质,碾成碎粒,簸去细毛及细末;
4、当归:拣去杂质,洗净,闷润,稍晾至内外湿度适宜时,切片晒干;
5、熟地黄:取原药材,蒸至表面乌黑色,取出,晒至八成干时,切片,干燥;
6、柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,晒干;
7、白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥;
8、郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干;
9、丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
10、桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒干,簸净;
11、红花:拣净杂质,除去茎叶、蒂头,晒干;
12、阿胶:捣碎;
13、肉桂:拣净杂质,刮去粗皮,用时打碎,或刮去粗皮,用温开水浸润片刻,切片,晾干;
14、木通:用水稍浸泡,闷润至透,切片,晒干;
15、葛根:拣去杂质,洗净,用水浸泡,捞出,润透,及时切片,晒干;
16、川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
17、乌药:拣去杂质,分开大小条,用水泡透,根据季节注意换水,防止发臭,及时捞出切片,筛去灰屑;
18、赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
19、泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
20、茯苓:用水浸泡,洗净,捞出,闷透后,切片,晒干;
21、延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎;
22、桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
23、枸杞子:簸净杂质,摘去残留的梗和蒂;
24、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干;
25、山楂:拣净杂质,筛去核;
26、五灵脂:拣净杂质,打碎或筛去灰屑;
27、蒲公英:拣去杂质,洗净泥土,切段,晒干;
28、砂仁:拣去杂质及果壳,捣碎。
二、制备
1、将所述重量的山药、巴戟天、香附、当归、熟地黄、柴胡、白芍、郁金、丹参、桃仁、红花、阿胶、肉桂、木通、葛根、川芎、乌药、赤芍、泽泻、茯苓、延胡索、桂枝、枸杞子、甘草、山楂、五灵脂、蒲公英、砂仁放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为3剂服用。
组方中香附有理气解郁,止痛调经的功能为君药;当归有补血和血,调经止痛,润燥滑肠的功能;熟地黄有滋阴,补血的功能,二者为臣药,三味药共同发挥理气解郁,止痛调经,补血和血,润燥滑肠的作用,治疗功能性痛经效力全面,且以理气解郁,止痛调经,补血和血为主可治本,白芍有养血柔肝,缓中止痛,敛阴收汗的功能为佐药,郁金有行气解随,凉血破瘀的功能为使药,与下余诸药是治标。
本发明药物具有理气解郁,止痛调经,补血和血,养血柔肝,缓中止痛,敛阴收汗的功能,用于治疗功能性痛经,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治功能性痛经门诊患者共46例。
2、诊断标准
典型症状为月经来临时在经前、经期、经后发生周期性下腹疼痛或痛引腰骶,以致影响工作及日常生活,称痛经。可分为功能性痛经和器质性痛经两种,前者常始于月经初潮或初潮不久,又称原发性痛经,后者可由子宫内膜异位症、盆腔炎、子宫肌瘤或宫内节育器等引起又称继发性痛经。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,7天为一个疗程,连续服用4个疗程。
4、疗效评定标准
显效:功能性痛经症状消失,恢复正常,痊愈;
好转:功能性痛经症状明显好转,周期性下腹痛疼减轻,痛经逐步恢复正常;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗功能性痛经患者46例,结果显效37例,显效率为80.4%,好转6例,好转率为13.1%,无效3例,总有效率为93.5%。
Claims (3)
1.一种治疗功能性痛经的药物,其特征在于:它是由下列重量范围内的原料药制成:
山药20-30克,巴戟天10-14克,香附10-14克,当归10-14克,熟地黄10-14克,柴胡10-14克,白芍10-20克,郁金5-15克,丹参16-20克,桃仁10-14克,红花10-14克,阿胶4-8克,肉桂5-15克,木通5-15克,葛根5-15克,川芎5-15克,乌药5-15克,赤芍5-15克,泽泻5-15克,茯苓5-15克,延胡索5-15克,桂枝5-15克,枸杞子10-14克,甘草6-10克,山楂15-25克,五灵脂5-15克,蒲公英15-25克,砂仁5-15克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
山药25克,巴戟天12克,香附12克,当归12克,熟地黄12克,柴胡12克,白芍15克,郁金10克,丹参18克,桃仁12克,红花12克,阿胶6克,肉桂10克,木通10克,葛根10克,川芎10克,乌药10克,赤芍10克,泽泻10克,茯苓10克,延胡索10克,桂枝10克,枸杞子12克,甘草8克,山楂20克,五灵脂10克,蒲公英20克,砂仁10克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)山药:拣净杂质,用水浸泡至山药中心部软化为止,捞出稍晾,切片晒干或烘干;
(2)巴戟天:拣去杂质,用热水泡透后,趁热抽去木心,切段,晒干;
(3)香附:拣去杂质,碾成碎粒,簸去细毛及细末;
(4)当归:拣去杂质,洗净,闷润,稍晾至内外湿度适宜时,切片晒干;
(5)熟地黄:取原药材,蒸至表面乌黑色,取出,晒至八成干时,切片,干燥;
(6)柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,晒干;
(7)白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥;
(8)郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干;
(9)丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
(10)桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒干,簸净;
(11)红花:拣净杂质,除去茎叶、蒂头,晒干;
(12)阿胶:捣碎;
(13)肉桂:拣净杂质,刮去粗皮,用时打碎,或刮去粗皮,用温开水浸润片刻,切片,晾干;
(14)木通:用水稍浸泡,闷润至透,切片,晒干;
(15)葛根:拣去杂质,洗净,用水浸泡,捞出,润透,及时切片,晒干;
(16)川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
(17)乌药:拣去杂质,分开大小条,用水泡透,根据季节注意换水,防止发臭,及时捞出切片,筛去灰屑;
(18)赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
(19)泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
(20)茯苓:用水浸泡,洗净,捞出,闷透后,切片,晒干;
(21)延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎;
(22)桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
(23)枸杞子:簸净杂质,摘去残留的梗和蒂;
(24)甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干;
(25)山楂:拣净杂质,筛去核;
(26)五灵脂:拣净杂质,打碎或筛去灰屑;
(27)蒲公英:拣去杂质,洗净泥土,切段,晒干;
(28)砂仁:拣去杂质及果壳,捣碎;
(二)制备
(1)将所述重量的山药、巴戟天、香附、当归、熟地黄、柴胡、白芍、郁金、丹参、桃仁、红花、阿胶、肉桂、木通、葛根、川芎、乌药、赤芍、泽泻、茯苓、延胡索、桂枝、枸杞子、甘草、山楂、五灵脂、蒲公英、砂仁放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为3剂服用。
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