CN106458866B - 氨基羰基氨基甲酸酯化合物 - Google Patents

氨基羰基氨基甲酸酯化合物 Download PDF

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Publication number
CN106458866B
CN106458866B CN201580010772.6A CN201580010772A CN106458866B CN 106458866 B CN106458866 B CN 106458866B CN 201580010772 A CN201580010772 A CN 201580010772A CN 106458866 B CN106458866 B CN 106458866B
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Prior art keywords
amino
ester
propyl
aminocarbonyl
compound
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CN201580010772.6A
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Chinese (zh)
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CN106458866A (zh
Inventor
康永順
郑镇龙
孟哲永
李翰柱
李基好
许晙
蔡银熙
申惟轸
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SK Biopharmaceuticals Co Ltd
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SK Biopharmaceuticals Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
    • C07C275/58—Y being a hetero atom
    • C07C275/60—Y being an oxygen atom, e.g. allophanic acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201580010772.6A 2014-02-28 2015-02-27 氨基羰基氨基甲酸酯化合物 Active CN106458866B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811495363.1A CN109627186B (zh) 2014-02-28 2015-02-27 氨基羰基氨基甲酸酯化合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461946142P 2014-02-28 2014-02-28
US61/946142 2014-02-28
PCT/KR2015/001915 WO2015130121A1 (en) 2014-02-28 2015-02-27 Aminocarbonylcarbamate compounds

Related Child Applications (1)

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CN201811495363.1A Division CN109627186B (zh) 2014-02-28 2015-02-27 氨基羰基氨基甲酸酯化合物

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CN106458866A CN106458866A (zh) 2017-02-22
CN106458866B true CN106458866B (zh) 2018-12-07

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CN201811495363.1A Active CN109627186B (zh) 2014-02-28 2015-02-27 氨基羰基氨基甲酸酯化合物

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Country Status (15)

Country Link
US (4) US9403761B2 (enExample)
EP (2) EP3110792B1 (enExample)
JP (2) JP6452731B2 (enExample)
KR (2) KR102487051B1 (enExample)
CN (2) CN106458866B (enExample)
AR (1) AR099581A1 (enExample)
AU (2) AU2015223579B2 (enExample)
CA (1) CA2939835C (enExample)
CL (1) CL2016002165A1 (enExample)
ES (2) ES2968840T3 (enExample)
MX (2) MX387796B (enExample)
PL (1) PL3110792T3 (enExample)
RU (1) RU2688673C2 (enExample)
TW (2) TWI698415B (enExample)
WO (1) WO2015130121A1 (enExample)

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Publication number Priority date Publication date Assignee Title
TWI698415B (zh) * 2014-02-28 2020-07-11 南韓商愛思開生物製藥股份有限公司 胺基羰基胺基甲酸酯化合物
US10888542B2 (en) * 2014-02-28 2021-01-12 Sk Biopharmaceuticals Co., Ltd. Aminocarbonylcarbamate compounds
CA3036071A1 (en) 2016-09-06 2018-03-15 Jazz Pharmaceuticals International Iii Limited Solvate form of (r)-2-amino-3-phenylpropyl carbamate
US10195151B2 (en) 2016-09-06 2019-02-05 Jazz Pharmaceuticals International Iii Limited Formulations of (R)-2-amino-3-phenylpropyl carbamate
CN110049966A (zh) 2016-10-06 2019-07-23 杰资制药国际三期有限公司 氨基甲酰基苯丙氨醇化合物及其用途
JP2020528075A (ja) 2017-06-02 2020-09-17 ジャズ ファーマシューティカルズ アイルランド リミテッド 過度の眠気を処置するための方法および組成物
CN111153863A (zh) * 2019-12-13 2020-05-15 浙江工业大学 一种合成动物用抗球虫药物妥曲珠利的方法
US10940133B1 (en) 2020-03-19 2021-03-09 Jazz Pharmaceuticals Ireland Limited Methods of providing solriamfetol therapy to subjects with impaired renal function
KR102390194B1 (ko) 2020-08-03 2022-04-25 셀라이온바이오메드 주식회사 페닐알킬 카바메이트 화합물을 포함하는 Kca3.1채널 매개질환 치료용 조성물

Citations (12)

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EP0430201A2 (en) * 1989-11-30 1991-06-05 Hoechst-Roussel Pharmaceuticals Incorporated Aminocarbonylcarbamates related to physostigmine, a process for their preparation and their use as medicaments
EP0665226A1 (en) * 1992-10-28 1995-08-02 Toyama Chemical Co., Ltd. Novel 1,2-benzisoxazole derivative or salt thereof, and brain protective agent comprising the same
CN1173863A (zh) * 1995-02-11 1998-02-18 株式会社油公 邻氨基甲酰基－(d)－苯基丙氨醇化合物及其制备方法
WO2004111006A1 (en) * 2003-06-12 2004-12-23 Novo Nordisk A/S Para-subtituted phenyl carbamates as inhibitors of hormone sensitive lipase
CN1898201A (zh) * 2003-10-21 2007-01-17 森蒂有限公司 可抑制胆碱酯酶和释放药理学活性试剂的氨基甲酸酯
WO2008013860A2 (en) * 2006-07-28 2008-01-31 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of alpha-amino acids, methods of synthesis and use
CN101217949A (zh) * 2005-06-08 2008-07-09 Sk株式会社 治疗睡眠-清醒病症
CN101228138A (zh) * 2005-04-22 2008-07-23 Sk株式会社 神经治疗吡咯化合物
CN101631770A (zh) * 2007-02-02 2010-01-20 科露西德医药品公司 抑制胆碱酯酶的化合物
CN102695502A (zh) * 2009-06-26 2012-09-26 爱思开生物制药株式会社 用于治疗药瘾和改善药瘾相关行为的组合物
CN102762201A (zh) * 2009-11-06 2012-10-31 爱思开生物制药株式会社 注意力缺陷/多动症的治疗方法
CN102985085A (zh) * 2010-06-30 2013-03-20 爱思开生物制药株式会社 治疗双相型障碍的方法

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KR100197892B1 (ko) * 1994-09-09 1999-06-15 남창우 신규한 페닐알킬아미노 카바메이트 화합물과 그의 제조방법
US5756817C1 (en) 1995-02-11 2001-04-17 Sk Corp O-carbamoyl-phenylananinol compounds their pharmaceutically useful salts and process for preparing the same
KR0173863B1 (ko) 1995-04-10 1999-04-01 조규향 페닐에 치환체가 있는 o-카바모일-페닐알라닌올 화합물과 그의 약제학적으로 유용한 염 및 이들의 제조방법
US20050080268A1 (en) 2003-10-08 2005-04-14 Yong-Moon Choi Process of preparing O-carbamoyl compounds in the presence of active amine group
CA2587481A1 (en) 2004-10-28 2006-05-11 Sk Corporation Phenylalkylamino carbamates adjunctive therapy for depression
CA2612672C (en) 2005-06-22 2014-10-14 Janssen Pharmaceutica, N.V. Treatment for sexual dysfunction
KR20120098578A (ko) 2009-06-22 2012-09-05 에스케이바이오팜 주식회사 피로의 치료 또는 예방 방법
ES2743153T3 (es) 2009-11-06 2020-02-18 Sk Biopharmaceuticals Co Ltd Métodos para tratar el síndrome de fibromialgia
US8623913B2 (en) * 2010-06-30 2014-01-07 Sk Biopharmaceuticals Co., Ltd. Methods for treating restless legs syndrome
CN110638804A (zh) * 2013-07-18 2020-01-03 爵士制药国际Iii有限公司 治疗肥胖
TWI698415B (zh) * 2014-02-28 2020-07-11 南韓商愛思開生物製藥股份有限公司 胺基羰基胺基甲酸酯化合物

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0430201A2 (en) * 1989-11-30 1991-06-05 Hoechst-Roussel Pharmaceuticals Incorporated Aminocarbonylcarbamates related to physostigmine, a process for their preparation and their use as medicaments
EP0665226A1 (en) * 1992-10-28 1995-08-02 Toyama Chemical Co., Ltd. Novel 1,2-benzisoxazole derivative or salt thereof, and brain protective agent comprising the same
CN1173863A (zh) * 1995-02-11 1998-02-18 株式会社油公 邻氨基甲酰基－(d)－苯基丙氨醇化合物及其制备方法
WO2004111006A1 (en) * 2003-06-12 2004-12-23 Novo Nordisk A/S Para-subtituted phenyl carbamates as inhibitors of hormone sensitive lipase
CN1898201A (zh) * 2003-10-21 2007-01-17 森蒂有限公司 可抑制胆碱酯酶和释放药理学活性试剂的氨基甲酸酯
CN101228138A (zh) * 2005-04-22 2008-07-23 Sk株式会社 神经治疗吡咯化合物
CN101217949A (zh) * 2005-06-08 2008-07-09 Sk株式会社 治疗睡眠-清醒病症
WO2008013860A2 (en) * 2006-07-28 2008-01-31 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of alpha-amino acids, methods of synthesis and use
CN101631770A (zh) * 2007-02-02 2010-01-20 科露西德医药品公司 抑制胆碱酯酶的化合物
CN102695502A (zh) * 2009-06-26 2012-09-26 爱思开生物制药株式会社 用于治疗药瘾和改善药瘾相关行为的组合物
CN102762201A (zh) * 2009-11-06 2012-10-31 爱思开生物制药株式会社 注意力缺陷/多动症的治疗方法
CN102985085A (zh) * 2010-06-30 2013-03-20 爱思开生物制药株式会社 治疗双相型障碍的方法

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Publication number Publication date
US20150246874A1 (en) 2015-09-03
EP3110792A1 (en) 2017-01-04
ES2968840T3 (es) 2024-05-14
KR20160126988A (ko) 2016-11-02
TWI655179B (zh) 2019-04-01
RU2688673C2 (ru) 2019-05-22
KR20210124520A (ko) 2021-10-14
PL3110792T3 (pl) 2020-02-28
EP3587394A1 (en) 2020-01-01
US10314808B2 (en) 2019-06-11
ES2759312T3 (es) 2020-05-08
US10485781B2 (en) 2019-11-26
JP2019059764A (ja) 2019-04-18
AU2019236666B2 (en) 2021-03-25
KR102487051B1 (ko) 2023-01-09
AU2015223579B2 (en) 2019-06-27
AU2019236666A1 (en) 2019-10-17
CN106458866A (zh) 2017-02-22
CA2939835C (en) 2022-11-01
EP3110792A4 (en) 2017-09-27
RU2016136193A (ru) 2018-03-30
RU2016136193A3 (enExample) 2018-10-29
US20190247356A1 (en) 2019-08-15
AU2015223579A1 (en) 2016-08-25
US9403761B2 (en) 2016-08-02
MX2020003020A (es) 2021-11-11
CN109627186B (zh) 2021-10-29
KR102309903B1 (ko) 2021-10-06
AR099581A1 (es) 2016-08-03
CL2016002165A1 (es) 2017-06-09
US9833432B2 (en) 2017-12-05
CA2939835A1 (en) 2015-09-03
TWI698415B (zh) 2020-07-11
TW201920086A (zh) 2019-06-01
RU2019113158A (ru) 2019-06-25
JP6452731B2 (ja) 2019-01-16
US20160303067A1 (en) 2016-10-20
JP6595078B2 (ja) 2019-10-23
WO2015130121A1 (en) 2015-09-03
JP2017512211A (ja) 2017-05-18
MX2016010973A (es) 2016-11-29
TW201623224A (zh) 2016-07-01
MX387796B (es) 2025-03-19
CN109627186A (zh) 2019-04-16
US20180085337A1 (en) 2018-03-29
EP3587394B1 (en) 2023-11-01
EP3110792B1 (en) 2019-09-04

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