CN106211782B - 抗体-fynomer缀合物 - Google Patents

抗体-fynomer缀合物 Download PDF

Info

Publication number
CN106211782B
CN106211782B CN201580014271.5A CN201580014271A CN106211782B CN 106211782 B CN106211782 B CN 106211782B CN 201580014271 A CN201580014271 A CN 201580014271A CN 106211782 B CN106211782 B CN 106211782B
Authority
CN
China
Prior art keywords
sequence
antibody
fynomer
fusion polypeptide
light chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201580014271.5A
Other languages
English (en)
Chinese (zh)
Other versions
CN106211782A (zh
Inventor
罗兰·纽曼
史蒂夫·格兰杰
迈克尔·莱曼
德拉甘·格拉布洛夫斯基
理查德·伍兹
米赫拉·西拉基
査文娟
伊沙贝拉·阿廷杰-托勒
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corp filed Critical Mitsubishi Tanabe Pharma Corp
Publication of CN106211782A publication Critical patent/CN106211782A/zh
Application granted granted Critical
Publication of CN106211782B publication Critical patent/CN106211782B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01112—Protein-tyrosine kinase (2.7.1.112)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/10—Protein-tyrosine kinases (2.7.10)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201580014271.5A 2014-03-17 2015-03-16 抗体-fynomer缀合物 Active CN106211782B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461954437P 2014-03-17 2014-03-17
US61/954,437 2014-03-17
PCT/JP2015/058645 WO2015141862A1 (fr) 2014-03-17 2015-03-16 Conjugués anticorps-fynomer

Publications (2)

Publication Number Publication Date
CN106211782A CN106211782A (zh) 2016-12-07
CN106211782B true CN106211782B (zh) 2021-01-15

Family

ID=54144822

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580014271.5A Active CN106211782B (zh) 2014-03-17 2015-03-16 抗体-fynomer缀合物

Country Status (18)

Country Link
US (1) US10323095B2 (fr)
EP (1) EP3119885B1 (fr)
JP (1) JP6345800B2 (fr)
KR (1) KR102473544B1 (fr)
CN (1) CN106211782B (fr)
AU (1) AU2015232352B2 (fr)
BR (1) BR112016021083A2 (fr)
CA (1) CA2942546C (fr)
DK (1) DK3119885T3 (fr)
ES (1) ES2881602T3 (fr)
HU (1) HUE055424T2 (fr)
MX (1) MX2016012010A (fr)
PH (1) PH12016501816B1 (fr)
PL (1) PL3119885T3 (fr)
PT (1) PT3119885T (fr)
RU (1) RU2732226C2 (fr)
TW (1) TWI674274B (fr)
WO (1) WO2015141862A1 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11566082B2 (en) 2014-11-17 2023-01-31 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
US10654887B2 (en) 2016-05-11 2020-05-19 Ge Healthcare Bio-Process R&D Ab Separation matrix
EP3455241B1 (fr) 2016-05-11 2022-02-23 Cytiva BioProcess R&D AB Procédé de nettoyage et/ou de désinfection d'une matrice de séparation
US10703774B2 (en) 2016-09-30 2020-07-07 Ge Healthcare Bioprocess R&D Ab Separation method
CN109311949B (zh) 2016-05-11 2022-09-16 思拓凡生物工艺研发有限公司 储存分离基质的方法
US10730908B2 (en) 2016-05-11 2020-08-04 Ge Healthcare Bioprocess R&D Ab Separation method
WO2017194597A1 (fr) 2016-05-11 2017-11-16 Ge Healthcare Bioprocess R&D Ab Matrice de séparation
US10889615B2 (en) 2016-05-11 2021-01-12 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
US10722589B2 (en) 2017-04-03 2020-07-28 Covagen Ag FGFR3 binding molecules
US20190100587A1 (en) 2017-10-02 2019-04-04 Covagen Ag IgG1 Fc MUTANTS WITH ABLATED EFFECTOR FUNCTIONS
US20190153096A1 (en) 2017-10-02 2019-05-23 Covagen Ag Cd3/cd33 bispecific binding molecules
EP3861117A4 (fr) * 2018-10-02 2023-01-11 Mitsubishi Tanabe Pharma Corporation Agents de liaison bispécifiques ciblant le syndécan-1 et le récepteur du facteur de croissance des fibroblastes
WO2020135201A1 (fr) 2018-12-28 2020-07-02 四川科伦博泰生物医药股份有限公司 Anticorps et son utilisation
JP2022528595A (ja) 2019-04-16 2022-06-15 シチュアン ケルン－バイオテック バイオファーマシューティカル カンパニー リミテッド 抗ＦＸＩ／ＦＸＩａ抗体及びその使用
JP2022550243A (ja) 2019-09-30 2022-12-01 シチュアン ケルン－バイオテック バイオファーマシューティカル カンパニー リミテッド 抗ｐｄ－１抗体及びその使用
JP2023505408A (ja) 2019-12-13 2023-02-09 シチュアン ケルン－バイオテック バイオファーマシューティカル カンパニー リミテッド 抗ｔｓｌｐ抗体及びその使用
WO2021228141A1 (fr) 2020-05-15 2021-11-18 四川科伦博泰生物医药股份有限公司 Conjugué anticorps-médicament, son procédé de préparation et son utilisation
CA3194641A1 (fr) 2020-10-26 2022-05-05 Akeso Biopharma, Inc. Anticorps anti-tigit, composition pharmaceutique et utilisation correspondante
CN117043189A (zh) 2020-12-31 2023-11-10 诺纳生物（苏州）有限公司 人lifr抗原结合蛋白及其制备方法和应用
WO2022157493A1 (fr) 2021-01-21 2022-07-28 Eusa Pharma (Uk) Limited Méthode de traitement de troubles histiocytaires et lymphoprolifératifs associés à il-6
JP2024508597A (ja) 2021-03-09 2024-02-28 四川科倫博泰生物医薬股▲フン▼有限公司 Ｒｏｒ１結合タンパク質及びその用途
EP4375300A1 (fr) 2021-07-23 2024-05-29 Akeso Biopharma, Inc. Composition pharmaceutique et son utilisation
WO2023044483A2 (fr) 2021-09-20 2023-03-23 Voyager Therapeutics, Inc. Compositions et procédés pour le traitement du cancer positif her2
WO2023092004A1 (fr) 2021-11-17 2023-05-25 Voyager Therapeutics, Inc. Compositions et méthodes pour le traitement de troubles liés à tau
CN114181310B (zh) 2022-02-14 2022-07-05 中山康方生物医药有限公司 抗tigit抗体、其药物组合物及用途
WO2023220695A2 (fr) 2022-05-13 2023-11-16 Voyager Therapeutics, Inc. Compositions et procédés pour le traitement du cancer her2 positif

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102112495A (zh) * 2008-06-03 2011-06-29 雅培制药有限公司 双重可变结构域免疫球蛋白及其用途
CN102858366A (zh) * 2010-01-20 2013-01-02 中外制药株式会社 含稳定化抗体的溶液制剂
CN102869678A (zh) * 2009-08-27 2013-01-09 科瓦根股份公司 Il-17结合化合物及其医药用途
WO2013135588A1 (fr) * 2012-03-16 2013-09-19 Covagen Ag Nouvelles molécules de liaison à activité antinéoplasique

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859205A (en) * 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
SI2202245T1 (sl) * 2007-09-26 2016-10-28 Chugai Seiyaku Kabushiki Kaisha Postopek modificiranja izoelektrične točke protitelesa preko aminokislinske substitucije v CDR
CA2724279C (fr) 2008-05-13 2017-03-07 Novimmune S.A. Anticorps anti-il-6/il-6r et procedes d'utilisation
TWI440469B (zh) * 2008-09-26 2014-06-11 Chugai Pharmaceutical Co Ltd Improved antibody molecules
US8524217B2 (en) * 2010-05-11 2013-09-03 Merck Sharp & Dohme Corp. MCP1-Ig fusion variants
EP2597102A1 (fr) * 2011-11-25 2013-05-29 Covagen AG Nouvelle protéine de fusion comprenant une chaîne légère d'anticorps et un polypeptide se liant à IL-17
US9580501B2 (en) 2011-12-16 2017-02-28 Synthon Biopharmaceuticals B.V. Anti-TNF alpha monoclonal secretory IgA antibodies and methods for treating inflammatory diseases
EP2638916A1 (fr) * 2012-03-16 2013-09-18 Covagen AG Nouvelles molécules de liaison ayant une activité antitumorale
EP2711016A1 (fr) 2012-09-21 2014-03-26 Covagen AG Nouvelles molécules de liaison IL-17A et leurs utilisations médicales

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102112495A (zh) * 2008-06-03 2011-06-29 雅培制药有限公司 双重可变结构域免疫球蛋白及其用途
CN102869678A (zh) * 2009-08-27 2013-01-09 科瓦根股份公司 Il-17结合化合物及其医药用途
CN102858366A (zh) * 2010-01-20 2013-01-02 中外制药株式会社 含稳定化抗体的溶液制剂
WO2013135588A1 (fr) * 2012-03-16 2013-09-19 Covagen Ag Nouvelles molécules de liaison à activité antinéoplasique

Also Published As

Publication number Publication date
JP2017510575A (ja) 2017-04-13
BR112016021083A2 (pt) 2017-10-03
CA2942546C (fr) 2022-11-22
US20170081412A1 (en) 2017-03-23
CN106211782A (zh) 2016-12-07
KR102473544B1 (ko) 2022-12-01
ES2881602T3 (es) 2021-11-30
RU2732226C2 (ru) 2020-09-14
PT3119885T (pt) 2021-08-02
DK3119885T3 (da) 2021-09-13
AU2015232352A1 (en) 2016-10-20
TW201620933A (zh) 2016-06-16
KR20160132112A (ko) 2016-11-16
PH12016501816A1 (en) 2016-11-07
HUE055424T2 (hu) 2021-11-29
MX2016012010A (es) 2016-12-07
PH12016501816B1 (en) 2016-11-07
EP3119885B1 (fr) 2021-06-02
JP6345800B2 (ja) 2018-06-20
AU2015232352B2 (en) 2021-02-18
EP3119885A1 (fr) 2017-01-25
EP3119885A4 (fr) 2017-08-23
US10323095B2 (en) 2019-06-18
RU2016140572A (ru) 2018-04-20
TWI674274B (zh) 2019-10-11
PL3119885T3 (pl) 2021-12-13
RU2016140572A3 (fr) 2018-11-12
CA2942546A1 (fr) 2015-09-24
WO2015141862A1 (fr) 2015-09-24

Similar Documents

Publication Publication Date Title
CN106211782B (zh) 抗体-fynomer缀合物
JP6527643B2 (ja) Ｉｌ−８関連疾患の治療用又は予防用組成物
EP2744822B1 (fr) Protéines et peptides modifiés
CN110099924B (zh) Gremlin-1晶体结构和抑制性抗体
CN106232626B (zh) 结合人大麻素1(cb1)受体的抗体
US20170152313A1 (en) Lectin-like oxidized ldl receptor 1 antibodies and methods of use
US20230120270A1 (en) New polypeptide complex
WO2022095926A1 (fr) Anticorps ciblant l'interleukine 36r, son procédé de préparation et son utilisation
CA3205037A1 (fr) Domaines variables d'anticorps se liant a il-31
TW201922798A (zh) 靶向rankl的治療性抗體
JP2023139243A (ja) 抗ペリオスチン抗体及びその使用
WO2021009267A1 (fr) Anticorps anti-pd-l1
JP2024512267A (ja) 抗ｔｓｌｐ抗体を含む医薬組成物
TW202229337A (zh) 犬抗體變異體
KR20220079561A (ko) 항-줄기세포 인자 항체 및 이의 사용 방법
CN114502583A (zh) 补体c2结合蛋白及其用途
JP2017057201A (ja) 抗体−フィノマー複合体を含む医薬組成物
US20230212281A1 (en) Compositions and methods for anti-pacap antibodies
WO2023025217A1 (fr) Composition pharmaceutique d'anticorps anti-il4r et utilisation associée
CN117222429A (zh) 包括针对tnf样配体1a（tl1a）的人源化抗体的组合物以及其用途

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant