CN106107997A - A kind of antioxidation hypertension and hyperlipemia SOD Semen Lini oil soft capsule and preparation method thereof - Google Patents
A kind of antioxidation hypertension and hyperlipemia SOD Semen Lini oil soft capsule and preparation method thereof Download PDFInfo
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- CN106107997A CN106107997A CN201610681781.4A CN201610681781A CN106107997A CN 106107997 A CN106107997 A CN 106107997A CN 201610681781 A CN201610681781 A CN 201610681781A CN 106107997 A CN106107997 A CN 106107997A
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- semen lini
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of antioxidation hypertension and hyperlipemia SOD Semen Lini oil soft capsule, in every 500mg soft capsule content, each constituent content is: superoxide dismutase (SOD) 3,000 6000 unit of activity, Semen Lini oil 250～420mg, trehalose 50～100 mg, green tea extract EGCG 10～100 mg, astaxanthin 5～50 mg.Its preparation method is: first the SOD of proportional quantity, green tea extract EGCG and trehalose were mixed 100 mesh sieves, after irradiation sterilization, astaxanthin, Semen Lini oil stirring with proportional quantity mix, grind with colloid mill again and make intimate mixing liquid, then intimate mixing liquid soft capsule filling process routinely is prepared SOD Semen Lini oil soft capsule.The present invention selects multiple antioxidation natural, potent, hypertension and hyperlipemia new resource food functional component, precise and appropriate compatibility and Synergistic, has significant antioxidation, hypertension and hyperlipemia function, and without any side effects, can long-term taking, safe and reliable.
Description
Technical field
The present invention relates to a kind of health food, particularly relate to a kind of antioxidation hypertension and hyperlipemia SOD Semen Lini oil soft capsule and
Its preparation method.
Background technology
Increasing scientific research display free radical is human senility and ill root, the disease of the mankind more than 90%
Relevant with free radical, such as: common cardiovascular diseases, senile dementia, arthritis, diabetes, cataract, cancer etc., these diseases
Disease is considered to relevant to free radical.The lipid peroxidation that free radical causes is the main cause causing organism oxidative damage,
If the lipid in serum is under the attack of free radical, it is susceptible to peroxidization, forms lipid peroxide, small artery can be sent out
Raw damaging action, causes the fibroid of small artery to become, thus causes arteriosclerosis, on the other hand, generate substantial amounts of fat in blood
Matter peroxide (LPO) promotes the oxidation of plasma low density lipoprotein (LDL), is to cause the cardiovascular disease such as atherosclerosis
The major reason occurred.If it is possible to eliminate too much oxygen-derived free radicals, the cardiovascular disease that some free radicals are caused
Effective preventive and therapeutic action can be played.
The defensive substance of antagonism radical reaction mainly has antioxidase and little molecular radical scavenger, and SOD is the heaviest
One of antioxidase wanted.SOD specifically acts on ultra-oxygen anion free radical (O2 -. ), the hydrogen peroxide (H of generation2O2)
It is decomposed into nontoxic water and oxygen further under catalase (CAT) or glutathione peroxidase (GSH-Px) are catalyzed
Gas, thus eliminate H2O2Murder by poisoning to body, removes blood rubbish, expands blood vessel, reduces cholesterol and triglyceride value, to reach
To lowering blood pressure and blood fat, protect cardiovascular purpose.
At present, domestic market has the interpolation antioxidation of SOD composition, the medicine of lowering blood pressure and blood fat and health product,
Some of which has declared patent of invention, and as patent No. ZL200610044379.1 discloses a kind of SOD health composition, this is special
Profit is that to utilize SOD with VC, VE, pollen and Radix Polygoni Multiflori to mix with Rhizoma Polygonati extract compounding, obtain having antioxidation, defying age,
The health composition of the functions such as resisting fatigue, enhancing immunity, blood fat reducing；Patent No. ZL201010604957.9 discloses a kind of anti-ageing
Always, blood pressure lowering, blood fat reducing SOD pharmaceutical composition and preparation method thereof, this patent mainly takes Radix Ginseng powder, Radix Notoginseng powder, Flos Carthami powder, ginkgo powder
After Cortex Pini Massonianae extract mixing drying and sterilizing, add SOD mixing, make capsule preparations, have can activate, repair cell,
Reduce effect of cholesterol and triglyceride value, comprehensively regulation total balance of the body.Product involved by these patents is essentially all
Form with Chinese medicine extract compatible combination with SOD, to alleviating and treatment cardiovascular disease has certain effect, but long-term taking meeting
Bring side effect.Therefore, prior art is in terms of product efficacy and saferry in place of Shortcomings.
Summary of the invention
The purpose of the present invention is contemplated to overcome the deficiencies in the prior art, it is provided that a kind of safe and reliable, without chemicals and in
Herb ingredients energy high-efficiency antioxidant, the antioxidation hypertension and hyperlipemia SOD Semen Lini oil soft capsule of quick lowering blood pressure and blood fat, institute
The soft capsule stated contains superoxide dismutase (SOD), Semen Lini oil, green tea extract EGCG, astaxanthin and trehalose.
It is an object of the invention to be achieved through the following technical solutions:
This antioxidation hypertension and hyperlipemia SOD Semen Lini oil soft capsule, it is characterised in that: containing superoxides in described soft capsule
Dismutase (SOD), Semen Lini oil, green tea extract EGCG, astaxanthin and trehalose, in every 500mg soft capsule content each group
Point content is:
Superoxide dismutase (SOD) 3000-6000 unit of activity,
Semen Lini oil 250～420mg,
Trehalose 50～100 mg,
Green tea extract EGCG 10～100 mg,
Astaxanthin 5～50 mg.
Described superoxide dismutase (SOD) is pig erythrocyte extract, its unit enzyme activity be 3000～
8000U/mg。
Described Semen Lini oil is the Semen Lini oil using physical squeezing method to extract from Semen Lini, and its alpha-linolenic acid contains
Amount >=50%.
Described astaxanthin is natural algae extract, its astaxanthin mass content >=0.4wt%.
It is a further object to provide the preparation side of a kind of antioxidation hypertension and hyperlipemia SOD Semen Lini oil soft capsule
Method, it is characterised in that: in described soft capsule containing superoxide dismutase (SOD), Semen Lini oil, green tea extract EGCG,
Astaxanthin and trehalose, in every 500mg soft capsule content, each constituent content is: superoxide dismutase (SOD) 3000-6000
Unit of activity, Semen Lini oil 250～420mg, trehalose 50～100 mg, green tea extract EGCG 10～100 mg, shrimp
Blue or green element 5～50 mg, including following preparation process:
(1) SOD of proportional quantity, green tea extract EGCG and trehalose were mixed 100 mesh sieves, must mix after using irradiation sterilization
Material；
(2) compound is mixed with astaxanthin, the Semen Lini oil stirring of proportional quantity, grind with colloid mill and make intimate mixing liquid；
(3) intimate mixing liquid soft capsule filling process routinely is prepared SOD Semen Lini oil soft capsule.
This antioxidation hypertension and hyperlipemia SOD Semen Lini oil soft capsule proposed according to above technical scheme, has following excellent
Point:
(1) present invention is based on old and feeble free radical theory, starts with from human senility and ill root, by multiple potent antioxygen
Change, the precise and appropriate compatibility of hypertension and hyperlipemia material and synergy, make product of the present invention have significant antioxidation, blood pressure lowering, fall blood
Effect of fat；
(2) product of the present invention mutually protected between various components, mutually work in coordination with, complement each other, improve product on the whole
Stability.As: SOD, EGCG and astaxanthin itself are high-efficiency antioxidant agent, can strengthen the oxidation of Semen Lini oil in the product
Stability, prevents to EGCG efficiency SOD and the astaxanthin destruction during longer-term storage, and trehalose is the activity guarantor of SOD
Protect agent, the stability of EGCG and astaxanthin can be improved again simultaneously, moreover it is possible to the layering preventing soft capsule from producing after long-term placement is existing
As；
(3) present invention is with SOD and functional edible vegetable oil Semen Lini oil as primary raw material, and supplements up-to-date biological purification technique
The natural new resource food functional component EGCG of extraction and astaxanthin, without Chinese herbal medicine, western medicine composition, without any secondary work
With, can long-term taking, safe and reliable.
Below in conjunction with the performance of main composition, the present invention will be further described:
(1) SOD:SOD is the antioxidase of direct scavenging activated oxygen, can block free radical and cause polyunsaturated fatty acid peroxide
Change and produce the chain reaction of lipid peroxide (LPO), thus protect the lipid in human body cell and blood to exempt from free radical
Infringement, therefore, SOD can be used for treating aging, the cardiovascular disease chronic diseases that lipid peroxidation causes.
(2) Semen Lini oil: the unsaturated fatty acid content in Semen Lini oil is up to more than 90%, especially belongs to ω-3 series many
The alpha-linolenic acid content of alkene unsaturated fatty acid reaches 53%.Alpha-linolenic acid is needed by human and the fat that can not synthesize
Acid, the metabolite of alpha-linolenic acid has good regulation effect to blood fat, and plasma low density lipoprotein (LDL) can be promoted to highly dense
The conversion of degree lipoprotein (HDL), makes low density lipoprotein, LDL (LDL) reduce, and high density lipoprotein (HDL) raises, thus plays fall
Hypolipemia, the effect of atherosclerosis.The metabolite of alpha-linolenic acid can expand blood vessel, strengthens blood vessel elasticity, from
And reach the purpose of blood pressure lowering.Additionally, containing abundant VE in Semen Lini oil, in every 100ml Semen Lini oil, VE content reaches
80mg, VE are a kind of strong effective free radical scavengers, have slow down aging and antioxidative effect.In Semen Lini oil possibly together with
Flavonoid, flavonoids has blood fat reducing, antiatherogenic good action.Alpha-linolenic acid can not be autonomous in human body
Synthesis, it is necessary to supply from food (oily), and in food, pole lacks, therefore Semen Lini oil is to supplement the required α-Caulis et Folium Lini of human body institute
The important sources of acid.
(3) trehalose: trehalose is a kind of safe and reliable natural saccharide, has non-spy to various bioactivators
Opposite sex protective effect, also can be some little molecule antioxidation as the excellent activity protective agent of pharmaceutical grade protein, enzyme and vaccine
The good stabilizer of agent (such as EGCG, astaxanthin etc.).
(4) astaxanthin: have another name called astaxanthin, Astaxanthin, is a Carotenoids, be also carotenogenesis
High-level product, chemical constitution is similar to beta-carotene.Therefore at nature, astaxanthin has the strongest non-oxidizability.Natural
On Anti-oxidation Actity of Astaxanthin exceedes existing antioxidant, and its ability removing free radical is 6000 times of ascorbic effect,
It is 1000 times of vitamin E, is 800 times of coenzyme Q10, be 3100 times of natto, be 700 times of anthocyanidin, be beta-carotene
100 times of effect, are 10 times of lycopene effect, are 200 times of phylloxanthin effect, are 320 times of tea polyphenols effect.Natural
Astaxanthin is uniquely can be by a Carotenoids of blood brain barrier.Astaxanthin in vivo can with protein bound and in blue or green, blue
Color, has antioxidation, defying age, antitumor, the effect of prevention cardiovascular and cerebrovascular disease.External and clinical trial proves that everyone is administered orally 3.
6mg/d astaxanthin, continuous 2 weeks, can prevent the oxidation of LDL.It addition, there is zooscopy to show, astaxanthin has significantly in vivo
Raise HDL and effect of fall LDL.Therefore speculate that astaxanthin can alleviate the oxidation of apolipoprotein, can be used to prevention of arterial hardening, hat
Cardiopathia and ischemic brain injury.Astaxanthin mainly passes through: 1. increase high density lipoprotein HDL-C；2. low density lipoprotein, LDL is reduced
LDL is oxidized to Ox-LDL；3. the inflammatory reaction of macrophage is alleviated；4. the formation of atherosclerotic plaque is reduced；5. medicated porridge is increased
The stability of sample plaque；6. reduce plaque rupture, improve the modes such as blood flow and carry out prevention and cure of cardiovascular disease.Natural algae source shrimp is blue or green
Extract is approved as new resource food (Ministry of Public Health No. 17 bulletin in 2010) by China, use that can be quantity-unlimiting.
(5) green tea extract EGCG:EGCG is a kind of antioxidation polyphenol compound extracted from natural green tea
Epigallocatechin gallate (EGCG), it is the topmost activity of green tea and water-soluble components, is that in catechin, content is high
Component, because having special stereochemical structure, EGCG has the strongest antioxidant activity, in anticancer and cardiovascular disease
Aspect act as important role.Its antioxidant activity is at least ascorbic more than 100 times, is 25 times of vitamin E, it is possible to
Protecting cell and DNA from the infringement of free radical, this infringement is relevant with cancer, heart disease and other major diseases, EGCG
These effects be attributed to its removing (antioxidation) ability to oxygen-derived free radicals.EGCG is approved as new resource food by China
(Ministry of Public Health No. 17 bulletin in 2010), use that can be quantity-unlimiting.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further detailed explanation, but embodiments of the present invention not office
It is limited to the scope that this embodiment represents.
This antioxidation hypertension and hyperlipemia SOD Semen Lini oil soft capsule that the present invention relates to, it is characterised in that: described flexible glue
Containing superoxide dismutase (SOD), Semen Lini oil, green tea extract EGCG, astaxanthin and trehalose in capsule, every 500mg is soft
In capsule 's content, each constituent content is: superoxide dismutase (SOD) 3000-6000 unit of activity, Semen Lini oil 250～
420mg, trehalose 50～100 mg, green tea extract EGCG 10～100 mg, astaxanthin 5～50 mg.
Described superoxide dismutase (SOD) is pig erythrocyte extract, its unit enzyme activity be 3000～
8000U/mg。
Described Semen Lini oil is the Semen Lini oil using physical squeezing method to extract from Semen Lini, and its alpha-linolenic acid contains
Amount >=50%.
Described astaxanthin is natural algae extract, its astaxanthin mass content >=0.4wt%.
It is a further object to provide the preparation side of a kind of antioxidation hypertension and hyperlipemia SOD Semen Lini oil soft capsule
Method, it is characterised in that: in described soft capsule containing superoxide dismutase (SOD), Semen Lini oil, green tea extract EGCG,
Astaxanthin and trehalose, in every 500mg soft capsule content, each constituent content is: superoxide dismutase (SOD) 3000-6000
Unit of activity, Semen Lini oil 250～420mg, trehalose 50～100 mg, green tea extract EGCG 10～100 mg, shrimp
Blue or green element 5～50 mg, including following preparation process:
(1) SOD of proportional quantity, green tea extract EGCG and trehalose were mixed 100 mesh sieves, must mix after using irradiation sterilization
Close material；
(2) compound is mixed with astaxanthin, the Semen Lini oil stirring of proportional quantity, grind with colloid mill and make intimate mixing liquid；
(3) intimate mixing liquid soft capsule filling process routinely is prepared SOD Semen Lini oil soft capsule.
Embodiments of the invention given below, and the present invention is expanded on further in conjunction with the embodiments.
Embodiment 1:
The preparation method of this antioxidation hypertension and hyperlipemia SOD Semen Lini oil soft capsule, it is characterised in that: described soft capsule contains
There are superoxide dismutase (SOD), Semen Lini oil, green tea extract EGCG, astaxanthin and trehalose, 500g soft capsule content
In each constituent content be: superoxide dismutase (SOD) 3,000,000 unit of activity, Semen Lini oil 420g, trehalose 55 g, green
Tea extract EGCG 15g, astaxanthin 10 g.
The concrete preparation process of this antioxidation hypertension and hyperlipemia SOD Semen Lini oil soft capsule is as follows:
(1), after the SOD of proportional quantity, green tea extract EGCG and trehalose being mixed 100 mesh sieves, use irradiation sterilization, obtain mixed
Close material；
(2) astaxanthin, the Semen Lini oil of compound with proportional quantity are uniformly mixed, grind with colloid mill and make intimate mixing
Liquid；
(3) intimate mixing liquid soft capsule filling process routinely is prepared SOD Semen Lini oil soft capsule, average every net weight
500mg。
Instructions of taking and consumption: oral, adult daily 3 times, each 2-3 grain.
Embodiment 2:
The preparation method of this antioxidation hypertension and hyperlipemia SOD Semen Lini oil soft capsule, it is characterised in that: described soft capsule contains
There are superoxide dismutase (SOD), Semen Lini oil, green tea extract EGCG, astaxanthin and trehalose, 500g soft capsule content
In each constituent content be: superoxide dismutase (SOD) 3,500,000 unit of activity, Semen Lini oil 270g, trehalose 90g, green
Tea extract EGCG 95g, astaxanthin 45g.
The concrete preparation process of this antioxidation hypertension and hyperlipemia SOD Semen Lini oil soft capsule is as follows:
(1), after the SOD of proportional quantity, green tea extract EGCG and trehalose being mixed 100 mesh sieves, use irradiation sterilization, obtain mixed
Close material；
(2) astaxanthin, the Semen Lini oil of compound with proportional quantity are uniformly mixed, grind with colloid mill and make intimate mixing
Liquid；
(3) intimate mixing liquid soft capsule filling process routinely is prepared SOD Semen Lini oil soft capsule, average every net weight
500mg。
Instructions of taking and consumption: oral, adult daily 3 times, each 2-3 grain.
Embodiment 3:
The preparation method of this antioxidation hypertension and hyperlipemia SOD Semen Lini oil soft capsule, it is characterised in that: described soft capsule contains
There are superoxide dismutase (SOD), Semen Lini oil, green tea extract EGCG, astaxanthin and trehalose, 500g soft capsule content
In each constituent content be: superoxide dismutase (SOD) 4,000,000 unit of activity, Semen Lini oil 350g, trehalose 70g, green
Tea extract EGCG 50g, astaxanthin 30g.
The concrete preparation process of this antioxidation hypertension and hyperlipemia SOD Semen Lini oil soft capsule is as follows:
(1), after the SOD of proportional quantity, green tea extract EGCG and trehalose being mixed 100 mesh sieves, use irradiation sterilization, obtain mixed
Close material；
(2) astaxanthin, the Semen Lini oil of compound with proportional quantity are uniformly mixed, grind with colloid mill and make intimate mixing
Liquid；
(3) intimate mixing liquid soft capsule filling process routinely is prepared SOD Semen Lini oil soft capsule, average every net weight
500mg。
Instructions of taking and consumption: oral, adult daily 3 times, each 2-3 grain.
Embodiment 4:
The preparation method of this antioxidation hypertension and hyperlipemia SOD Semen Lini oil soft capsule, it is characterised in that: described soft capsule contains
There are superoxide dismutase (SOD), Semen Lini oil, green tea extract EGCG, astaxanthin and trehalose, 500g soft capsule content
In each constituent content be: superoxide dismutase (SOD) 5,000,000 unit of activity, Semen Lini oil 305g, trehalose 95g, green tea
Extract EGCG 90g, astaxanthin 10g.
The concrete preparation process of this antioxidation hypertension and hyperlipemia SOD Semen Lini oil soft capsule is as follows:
(1), after the SOD of proportional quantity, green tea extract EGCG and trehalose being mixed 100 mesh sieves, use irradiation sterilization, obtain mixed
Close material；
(2) astaxanthin, the Semen Lini oil of compound with proportional quantity are uniformly mixed, grind with colloid mill and make intimate mixing
Liquid；
(3) intimate mixing liquid soft capsule filling process routinely is prepared SOD Semen Lini oil soft capsule, average every net weight
500mg。
Instructions of taking and consumption: oral, adult daily 3 times, each 2-3 grain.
Embodiment 5:
The preparation method of this antioxidation hypertension and hyperlipemia SOD Semen Lini oil soft capsule, it is characterised in that: described soft capsule contains
There are superoxide dismutase (SOD), Semen Lini oil, green tea extract EGCG, astaxanthin and trehalose, 500g soft capsule content
In each constituent content be: superoxide dismutase (SOD) 5,500,000 unit of activity, Semen Lini oil 390g, trehalose 50g, green tea
Extract EGCG 15g, astaxanthin 45g.
The concrete preparation process of this antioxidation hypertension and hyperlipemia SOD Semen Lini oil soft capsule is as follows:
(1), by the SOD of proportional quantity, green tea extract EGCG and trehalose mix homogeneously, after crossing 100 mesh sieves, irradiation sterilization is used,
Obtain compound；
(2) astaxanthin, the Semen Lini oil of compound with proportional quantity are uniformly mixed, grind with colloid mill and make intimate mixing
Liquid；
(3) intimate mixing liquid soft capsule filling process routinely is prepared SOD Semen Lini oil soft capsule, average every net weight
500mg。
Instructions of taking and consumption: oral, adult daily 3 times, each 2-3 grain.
The raw material that the present invention uses is common commercially available product, all can buy in market.Wherein, SOD is purchased from Hubei red biology difficult to understand
Sanguis sus domestica source superoxide dismutase (SOD) lyophilized powder that goods Science and Technology Ltd. produces, Semen Lini oil is glad very purchased from Hebei
Allusion quotation bio tech ltd, astaxanthin is purchased from natural astaxanthin company limited of Jingzhou City.
For confirming that product of the present invention has effective therapeutic effect, carry out series of experimental research.
The animal experiment effect of anti-oxidation function of the present invention is as follows:
1. materials and methods
Animal modeling and packet: select female KM mice 60, body weight 18-22 gram, be randomly divided into Normal group, old and feeble mould
Type group, Semen Lini line of oils, reagent A group, reagent B group and reagent C group, often group 10.Mice subcutaneous injection every day D-galactose 1
Secondary, dosage 120mg/kg.bw, continuous 8 weeks, builds mice aging model.
It is administered: injection of d-galactose starts to give test medicine, successive administration 6 weeks after 2 weeks, once a day, reagent A group is every
The capsule 's content 250mg/kg.bw of day gavage embodiment 1 gained, the capsule contents of reagent B group gavage every day embodiment 3 gained
Thing 250mg/kg.bw, the capsule 's content 250mg/kg.bw of reagent C group gavage every day embodiment 5 gained, Semen Lini line of oils is every
Day gavage Semen Lini oil 250mg/kg.bw, Normal group gavage every day such as gives at weight distilled water, aging model group note every day
Penetrate D-galactose 120mg/kg.bw.
2. Antioxidant Indexes detection
After drug withdrawal the 2nd day, femoral artery took blood, separated serum.Nanjing is used to build up the test kit that Bioengineering Research Institute provides
Detection serum total number born (SOD) vigor (hydroxylamine assay) and malonaldehyde (MDA) content (TBA method) respectively.
3. efficacy result
The results are shown in Table 1, table 2:
From table 1 it follows that each reagent set mice serum total SOD enzyme activity level is significantly higher than aging model group, this is described
Invention SOD Semen Lini oil soft capsule can significantly improve modeling mice serum total SOD enzyme activity (P ＜ 0.01.), and it is evident in efficacy
It is better than Normal group and Semen Lini line of oils.
Have significantly from Table 2, it can be seen that each reagent set mice serum malonaldehyde (MDA) content compares with aging model group
Reduction ((P ＜ 0.05, or P ＜ 0.01.) shows that SOD Semen Lini oil soft capsule of the present invention can significantly reduce mice serum the third two
Aldehyde (MDA) content, has good removing free radical, antioxidation, and its curative effect and is better than Semen Lini line of oils.
4. conclusion
SOD Semen Lini oil soft capsule of the present invention can be obviously enhanced exhausted mining areas serum activity of SOD, significantly reduces aging model
Mice serum malonaldehyde (MDA) content, animal test results shows that product of the present invention has good antioxidation.
Antioxidation of the present invention, lowering blood pressure and blood fat function human feeding trial effect as follows:
Antioxidant effect:
1. principle
Malonaldehyde (MDA) is oxygen-derived free radicals (O2 -.) attack cells plasma membrane, generate lipid peroxide and decompose further final
Metabolite, malonaldehyde (MDA) has the strongest bio-toxicity, is the leading indicator of human senility, and the content of MDA is with oxygen freely
Base (O2 -.) relation that is proportionate of concentration.By lipid peroxide (MDA) in urine before detection experimenter's test-meal, after test-meal
Content just can substantially judge test-meal product (medicine) scavenging activated oxygen, antioxidative effect in body.
2. testing program
With the age 80 people more than 45 years old for test-meal subjects (man, female half and half), it is divided into test A group, test B group, test C
Group and matched group, often organize each 20 people.With SOD Semen Lini oil soft capsule of the present invention and Semen Lini oil for test-meal product (medicine), wherein
Test A group takes the soft capsule that embodiment 1 obtains, and test B group takes the soft capsule that embodiment 3 obtains, and test C group takes enforcement
The soft capsule that example 5 obtains, matched group takes Semen Lini oil.
Instructions of taking and dosage: within 1 hour after the meal, warm water takes, each 2g.
3. detection method
Use Japan's LPO Kit oxidation number speed to survey liquid to be used for quickly detecting, take urine 1ml that human oral's test-meal product (medicine) is front
Instilling equipped with in the ampulla of test agent, observe the color of urine reactant liquor after 5min, same method takes human body and takes test-meal product (medicine
Thing) urine 1ml after 2h instills equipped with in the ampulla of test agent, observes the color of urine reactant liquor, the most oral examination after 5min
The difference of food (medicine) forward and backward urine reactant liquor color.The color of urine reactant liquor is the deepest, illustrates that mda content is the most,
Free-radical contents in indication body is the highest.
4. judgment criteria
Pass judgment on according to effective, effective and invalid three standards.Effective is that the color taking front urine reactant liquor is for red or deep
Redness, taking rear urine reactant liquor is colourless or shallow white；Effectively slightly shoal than the color before taking for the color after taking
Thin out, the two has the recognizable difference of naked eyes；Invalid for take the color of forward and backward urine reactant liquor without the recognizable difference of naked eyes
Or the color after taking becomes deeper than the color before taking.
5. efficacy result
All experimenters urine reactant liquor color before taking test-meal product all presents red to peony, shows that these are subject to
In examination person's body, malonaldehyde (MDA) content is high, and free-radical contents is many.When taking product SOD Semen Lini oil soft capsule 2 of the present invention and being little
Afterwards, the urine reactant liquor color of most study subjects becomes shallow white or colourless, shows that internal malonaldehyde (MDA) content drops
Low, interior free yl is eliminated the most in large quantities, and this test-meal test total effective rate reaches more than 90%, the results are shown in Table 3.
6. conclusion
Being proved by human feeding trial, SOD Semen Lini oil soft capsule of the present invention can reduce internal malonaldehyde (MDA) content, has
Well anti-oxidation efficacy.
Lowering blood pressure and blood fat effect:
The soft capsule embodiment of the present invention 3 prepared is through 85 hypertension, hyperlipemic patients Clinical practice, three times a day, each 2
Grain, early, middle and late each 1 time, detects experimenter's blood pressure, the change of blood fat after taking 30 days.As a result, 82% patient is had to present substantially
Blood pressure lowering, the effect of blood fat reducing, have 88% hyperlipemic patients can recover blood fat normal value after taking 90 days, have 86% hyperpietic
Can be down to blood pressure normal range, the restorative success rate of health reaches more than 85%.SOD Semen Lini oil of the present invention is soft
The typical clinical case of capsule is following (be and take the soft gel products that the embodiment of the present invention 3 obtains):
Chen, man, 51 years old, hyperpietic, often there are paroxysmal vertigo, shortness of breath and palpitation symptom, on July 13rd, 2015 measures blood
Pressure: shrinking pressure is 165mmHg, and diastolic pressure is 98mmHg, on July 15th, 2015 starts to take soft capsule of the present invention, after 3 months,
Measure blood pressure on October 20th, 2015: shrinking pressure is 130mmHg, and diastolic pressure is 88mmHg, and blood pressure recovers normal substantially, dizziness,
Shortness of breath and palpitation symptom is wholly absent.
Huang, female, 60 years old, hyperpietic, with the symptoms such as dizziness, headache, tinnitus, hand and foot numbness, in October, 2015
Within 10th, measure blood pressure: shrinking pressure is 170mmHg, and diastolic pressure is 110mmHg, and on November 3rd, 2015 starts to take flexible glue of the present invention
Capsule, after 3 months, measures blood pressure on February 5th, 2016: shrinking pressure is 143mmHg, and diastolic pressure is 90mmHg, and antihypertensive effect is obvious,
Dizziness, headache, tinnitus symptom are well improved.Continuing to take to daily inspection in June 20 in 2016, blood pressure recovers normal, body
Body is in order.
Model, man, 43 years old, hyperpietic, with uncomfortable in chest, tachypnea, tired symptom, measures blood pressure on March 8th, 2016:
Shrinking pressure is 158mmHg, and diastolic pressure is 100mmHg, on March 20th, 2016 starts to take soft capsule of the present invention, after 3 months,
Measure blood pressure on June 18th, 2016: shrinking pressure is 129mmHg, and diastolic pressure is 86mmHg, and blood pressure was down in normal range, health
Situation feels comfortable.
Zhang, man, 48 years old, hypertension companion's hyperlipemic patients, daily inspection in October 20 blood pressure in 2015 and blood fat: shrinking pressure is
160mmHg, diastolic pressure is 110mmHg, T-CHOL 8.16mmol/L, triglyceride 2.85mmol/L, HDL-C
1.02mmol/L, low density cholesterol 4.78mmol/L, with paroxysmal vertigo, uncomfortable in chest, headache syndromes.On November 1st, 2015
Start to take soft capsule of the present invention, feel health after one month comfortable relatively before.After 3 months, daily test in January 30 in 2016
Look into: shrinking pressure is 142mmHg, and diastolic pressure is 95mmHg, and blood pressure is decreased obviously, T-CHOL 5.13mmol/L, triglyceride
1.56mmol/L, HDL-C 1.84mmol/L, low density cholesterol 3.28mmol/L, blood lipids index recovers normal.Continue
Continuing and take to daily inspection in March 28 in 2016, blood pressure recovers normal, and health feels good.
Liu, man, 58 years old, hyperlipemic patients, on August 7th, 2015 health check-up blood fat: triglyceride 16.85mmol/L, highly dense
Degree cholesterol 0.77mmol/L, low density cholesterol 6.64mmol/L.Numb limbs and tense tendons, symptom of having a dizzy spell often occur, takes
Crossing multiple blood lipid-lowering medicine, effect is undesirable.On August 21st, 2015 starts to take soft capsule of the present invention, and is careful in one's diet, 2
After Yue, malaise symptoms has been alleviated and has been improved.On February 30th, 2016 physical examination result: triglyceride 2.70mmol/L, high density gallbladder
Sterin 0.98mmol/L, low density cholesterol 4.16mmol/L.Continuing to take to daily inspection in May 25 in 2016, every blood fat refers to
Mark all recovers normal.
Lee, female, 55 years old, hyperlipemic patients, on January 6th, 2016 biochemical analysis: T-CHOL 7.46mmol/L, glycerol
Three ester 5.51mmol/L, HDL-C 0.84mmol/L, low density cholesterol 4.85mmol/L, have dizziness, both hands often
Numb.On January 18th, 2016 starts to take soft capsule of the present invention, after 2 months, and daily inspection in March 15 in 2016: T-CHOL
5.53mmol/L, triglyceride 2.76mmol/L, HDL-C 1.32mmol/L, low density cholesterol 3.45mmol/L,
Dizziness be improved significantly.Adhering to taking to 10 daily inspections in 06 month in 2016, blood lipids index is normal.
Claims (5)
1. an antioxidation hypertension and hyperlipemia SOD Semen Lini oil soft capsule, it is characterised in that: containing super oxidation in described soft capsule
Thing dismutase (SOD), Semen Lini oil, green tea extract EGCG, astaxanthin and trehalose, each in every 500mg soft capsule content
Constituent content is:
Superoxide dismutase (SOD) 3000-6000 unit of activity,
Semen Lini oil 250～420mg,
Trehalose 50～100 mg,
Green tea extract EGCG 10～100 mg,
Astaxanthin 5～50 mg.
A kind of antioxidation hypertension and hyperlipemia SOD Semen Lini oil soft capsule the most according to claim 1, it is characterised in that: described
SOD be pig erythrocyte extract, its unit enzyme activity is 3000～8000U/mg.
A kind of antioxidation hypertension and hyperlipemia SOD Semen Lini oil soft capsule the most according to claim 1, it is characterised in that: described
Semen Lini oil be to use the Semen Lini oil that extracts from Semen Lini of physical squeezing method, its alpha-linolenic acid content >=50%.
A kind of antioxidation hypertension and hyperlipemia SOD Semen Lini oil soft capsule the most according to claim 1, it is characterised in that: described
Astaxanthin be natural algae extract, its astaxanthin mass content >=0.4wt%.
5. a preparation method for the antioxidation hypertension and hyperlipemia SOD Semen Lini oil soft capsule described in any one of Claims 1 to 4,
It is characterized in that: mainly include following preparation process:
(1) SOD of proportional quantity, green tea extract EGCG and trehalose were mixed 100 mesh sieves, must mix after using irradiation sterilization
Material；
(2) astaxanthin, the Semen Lini oil of compound with proportional quantity are uniformly mixed, grind with colloid mill and make intimate mixing
Liquid；
(3) intimate mixing liquid soft capsule filling process routinely is prepared SOD Semen Lini oil soft capsule.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109329416A (en) * | 2018-10-25 | 2019-02-15 | 杭州天龙集团有限公司 | A kind of nutriment and preparation method thereof rich in albumen linseed oil |
| CN114190555A (en) * | 2021-12-18 | 2022-03-18 | 江苏艾兰得营养品有限公司 | Drop pills with antioxidation efficacy and preparation method thereof |
| CN114271435A (en) * | 2021-12-24 | 2022-04-05 | 张越今 | EGCG pure natural nutritional noodles with effect of reducing high blood pressure, high blood lipid and high blood sugar and production process thereof |
| CN114504003A (en) * | 2022-02-08 | 2022-05-17 | 浙江省淡水水产研究所 | Disinfectant for in-vitro hatching of procambarus clarkia embryos and preparation method and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101590223A (en) * | 2008-05-26 | 2009-12-02 | 刘安荣 | A kind of SOD complex capsule and preparation method thereof |
| CN103719301A (en) * | 2013-12-24 | 2014-04-16 | 青岛银色世纪健康产业集团有限公司 | Healthy food taking astaxanthin oil as main material |
| CN104721264A (en) * | 2013-12-23 | 2015-06-24 | 无锡伟康生物科技有限公司 | Soft capsule with auxiliary effect of reducing blood sugar |
| CN105582001A (en) * | 2015-12-25 | 2016-05-18 | 南京泛成生物化工有限公司 | Astaxanthin composition, preparation and preparation method of composition |
-
2016
- 2016-08-17 CN CN201610681781.4A patent/CN106107997A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101590223A (en) * | 2008-05-26 | 2009-12-02 | 刘安荣 | A kind of SOD complex capsule and preparation method thereof |
| CN104721264A (en) * | 2013-12-23 | 2015-06-24 | 无锡伟康生物科技有限公司 | Soft capsule with auxiliary effect of reducing blood sugar |
| CN103719301A (en) * | 2013-12-24 | 2014-04-16 | 青岛银色世纪健康产业集团有限公司 | Healthy food taking astaxanthin oil as main material |
| CN105582001A (en) * | 2015-12-25 | 2016-05-18 | 南京泛成生物化工有限公司 | Astaxanthin composition, preparation and preparation method of composition |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109329416A (en) * | 2018-10-25 | 2019-02-15 | 杭州天龙集团有限公司 | A kind of nutriment and preparation method thereof rich in albumen linseed oil |
| CN114190555A (en) * | 2021-12-18 | 2022-03-18 | 江苏艾兰得营养品有限公司 | Drop pills with antioxidation efficacy and preparation method thereof |
| CN114190555B (en) * | 2021-12-18 | 2023-06-23 | 江苏艾兰得营养品有限公司 | A dripping pill with antioxidant effect and its preparation method |
| CN114271435A (en) * | 2021-12-24 | 2022-04-05 | 张越今 | EGCG pure natural nutritional noodles with effect of reducing high blood pressure, high blood lipid and high blood sugar and production process thereof |
| CN114504003A (en) * | 2022-02-08 | 2022-05-17 | 浙江省淡水水产研究所 | Disinfectant for in-vitro hatching of procambarus clarkia embryos and preparation method and application thereof |
| CN114504003B (en) * | 2022-02-08 | 2023-04-18 | 浙江省淡水水产研究所 | Disinfectant for in-vitro hatching of procambarus clarkia embryos and preparation method and application thereof |
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Application publication date: 20161116 |