CN105582001A - Astaxanthin composition, preparation and preparation method of composition - Google Patents
Astaxanthin composition, preparation and preparation method of composition Download PDFInfo
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- CN105582001A CN105582001A CN201510999841.2A CN201510999841A CN105582001A CN 105582001 A CN105582001 A CN 105582001A CN 201510999841 A CN201510999841 A CN 201510999841A CN 105582001 A CN105582001 A CN 105582001A
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- Prior art keywords
- astaxanthin
- composition
- oil
- preparation
- acid
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- 239000001168 astaxanthin Substances 0.000 title claims abstract description 78
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 title claims abstract description 78
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Landscapes
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Abstract
The invention relates to astaxanthin composition, a preparation and a preparation method of the composition and belongs to the technical field of antioxidant chemicals. The astaxanthin composition comprises, in parts by weight, 5-80 parts of astaxanthin, 5-10 parts of unsaturated fatty acid, 5-10 parts of trehalose and 15-20 parts of vitamin E. The astaxanthin composition with excellent preservation stability, a preparation method of the composition as well as feed, foods, drinks, drugs and cosmetics which contain the astaxanthin composition and have excellent preservation stability can be provided.
Description
Technical field
The present invention relates to a kind of astaxanthin composition, preparation and preparation method thereof, belong to anti-oxidant chemicals technical field.
Background technology
Antioxidant nutriment comprises the multiple compound that can eliminate harmful free radical, and comprises some known dimension conventionallyRaw element, as vitamin A, vitamin C and vitamin E. Astaxanthin is a kind of containing oxygen carrotene or Alpha-hydroxy-one carotenoidsElement is a kind of effectively antioxidant. Astaxanthin to the antioxidation activity of some active oxygen higher than beta carotene, lutein,Lutern, alpha-tocopherol, research in recent years shows, it is anti-oxidant, antitumor and to strengthen immunity etc. many important that astaxanthin hasPhysiology and biological function, its antioxygenic property is stronger 100～500 times than vitamin E, stronger more than 10 times than carrotene,Animal experiment shows that astaxanthin has antitumor, anti-ultraviolet radiation, enhancing immunologic function, is powerful antioxidant and the fat of aquatic animalThe snperoxiaized inhibitor of matter; Can suppress the formation of senile plaque expelling, to ophthalmology disease, angiocardiopathy and rheumatoid arthritis alsoThere is mitigation.
But astaxanthin is hydrophobic material, in environment, be easy to oxidizedly, non-refractory high pressure, so astaxanthinApplication is restricted. In prior art, in preparation when relevant astaxanthin carrier, generally astaxanthin oil is dissolved in to acetone etc. organicSolvent, and adopt high pressure homogenizer and Ultrasonic Cell Disruptor to input energy from the external world, due to easily oxidation of astaxanthin itself, not resistance toBe subject to HTHP, so can cause the loss in production process with violent especially condition production.
Summary of the invention
The composition storage stability needs that contain astaxanthin are further improved, therefore the invention provides one and can haveThe astaxanthin composition of good stability, preparation.
According to a first aspect of the invention:
Astaxanthin composition, includes 5～10 parts of 5～80 parts of astaxanthins, unrighted acids, trehalose by weight5～20 parts of 5～10 parts, vitamin e1.
Above-mentioned composition, described unrighted acid be selected from DHA (DHA), eicosapentaenoic acid (EPA),Fish oil, linseed oil, borage oil, alpha-linolenic acid (ALA), gamma-Linolenic acid (GLA), CLA (CLA) or saw leafRepens extract.
Above-mentioned composition, astaxanthin is selected from natural extraction or synthetic astaxanthin, and its mass content is more than 0.5wt%, excellentMore than selecting 30wt%, more preferably more than 80wt%.
According to a second aspect of the invention, include the preparation of above-mentioned astaxanthin composition.
Described preparation, formulation is selected from finish, emulsifying agent, powder agent, capsule.
The preparation method of above-mentioned finish, comprises the steps: that astaxanthin composition and oil are mixed into dispersion liquid, grinds,Add again oil to be mixed to normal concentration; Described oil is edible oil.
Astaxanthin composition shared percentage by weight in finish is 0.5～90%.
The preparation method of mentioned emulsifier, comprises the steps: that astaxanthin composition mixes with finish, as oil phase, thenAdd water to carry out emulsification, obtain emulsion; Described oil phase and water mass ratio are 0.1:99.9～50:50 astaxanthin compositionIn emulsifying agent, shared percentage by weight is 0.5～90%.
The preparation method of above-mentioned powder agent, comprises the steps: astaxanthin composition to mix with water or organic solvent,After grinding, then be dried; Astaxanthin composition shared percentage by weight in powder agent is 0.5～90%.
According to a fourth aspect of the present invention, include feed, food, beverage, medicine, the cosmetic of above-mentioned astaxanthin compositionProduct.
Beneficial effect
According to the present invention, can provide excellent storage stability astaxanthin-containing composition and manufacture method thereof and contain this containing shrimp green grass or young cropsFeed, food, beverage, medicine, the cosmetics of the excellent storage stability of the composition of element.
In astaxanthin composition of the present invention, consist predominantly of by weight: 5～80 parts of astaxanthins, unsaturated lipid5～10 parts of fat acid, 5～10 parts of trehaloses, 5～20 parts of vitamin e1s.
As astaxanthin of the present invention, at least one in the derivatives such as the ester that comprises astaxanthin and astaxanthin. As long as in the present inventionSpecial instruction, is not always called them " astaxanthin ". The astaxanthin using in the present invention is except plant, algae and bacteriumOutside astaxanthin Deng natural goods, can use any astaxanthin as long as what obtain according to conventional methods. Described astaxanthin alsoThe oil that can be used as the astaxanthin-containing that the natural goods from containing astaxanthin obtains with separated/extracted thing form contains in combination of the present inventionIn thing. Described astaxanthin further also can suitably be refined and obtain the separated/extracted thing from this natural goods as required,Described natural goods can be enumerated such as green alga haematococcus, maritime bacterium, krill etc. As described astaxanthin, from quality, lifeThe angle of productive rate is set out particularly preferably from the material (also referred to as haematococcus extract) of haematococcus extraction and the pigment in krill source.Haematococcus extract can obtain as follows: above-mentioned raw materials cell membrane is pulverized, added acetone, ether, chloroform and alcohol (ethanol, methyl alcoholDeng) etc. the extraction such as organic solvent or supercritical carbon dioxide solvent, extract, thereby obtain. Also can be in additionComposite.
The trehalose adopting in the present invention can significantly improve the stability of the astaxanthin in composition, and its trehalose is as adjuvant energyEffectively improve shelf-life, ageing stability and oxidation stability. Trehalose, is the disaccharides that glucose and fructose form, sucroseIsomer, mainly obtain by the isomerization of sucrose. But in watery and grease time, trehalose easily goes outThe now problem of reunion crystallization along with the variation of temperature, can cause anti-degradation not high. And by adding unrighted acidMode can change the agglomeration traits of trehalose significantly, improves its action effect; The unrighted acid adopting in the present invention,Can be selected from DHA (DHA), eicosapentaenoic acid (EPA), fish oil, linseed oil, borage oil, α-flaxAcid (ALA), gamma-Linolenic acid (GLA), CLA (CLA) and Saw Palmetto P.E.
The vitamin E providing in the present invention, is a kind of natural antioxidant, and it has antioxidation, also has simultaneouslyPreferably oil is molten and dispersed, also can play better for dispersiveness and the stability of the astaxanthin composition of oily and emulsification shapeEffect.
The present invention mainly by the mutual synergy between astaxanthin, unrighted acid, trehalose, vitamin E from entiretyThe stability of upper raising preparation and dispersiveness.
Composition of the present invention, except above-mentioned composition, according to actual application needs, can also comprise other interpolationThing component, described additive component can comprise other components of one or more applicable foods. These comprise antioxidant,Emulsifying agent, anticorrisive agent, sweetener, essence, pH adjusting agent etc. Additive component is shared with the mixed mixture of compositionWeight percentage ranges can be maximum 89wt%, for example 10～89wt%, is more preferably 20～75wt%.
Antioxidant can adopt tocopherols as alpha-tocopherol, alpha-tocopherol palmitate, alpha-tocopherol acetate, tertiary fourthBase hydroxy-methylbenzene, butylhydroxy anisole, ascorbic acid, its salt and ester, for example sodium ascorbate, Calcium Ascorbate, anti-The fatty acid ester of bad blood acyl phosphate, ascorbic acid is as Vitamin C acyl stearate and Vitamin C acyl palmitate and ethoxyquin.
The example of emulsifying agent is lipophile dispersant especially, be for example the fatty acid ester of ascorbic acid as Vitamin C acyl palmitate,Polyglyceryl fatty acid ester ricinoleate as poly-in polyglycereol-3-, fatty acid esters of sorbitan, especially anhydro sorbitol C10～C28 fatty acid ester.
As pH adjusting agent, can be included in preparation compositions of the present invention to improve or to reduce preparation compositions of the present inventionPH. The pH of described preparation compositions can be lowered or improve, the effect of perceiveing for sense organ, or for improving physics and chemistry spyProperty, the solubility of the compound that for example increase is dissolved. PH adjusting agent can refer to acidulant or basifier. For example, lactic acid, lemonLemon acid, malic acid, potassium hydroxide, calcium hydroxide and magnesium hydroxide.
Anticorrisive agent, the non-limiting example that is optionally included in the anticorrisive agent in preparation compositions of the present invention comprises: acetic acid,Citric acid, benzoic acid, sorbic acid, sulfur dioxide, Potassium Benzoate, potassium sorbate.
As essence, preferably use grease essence and the powdered flavors such as one kind or two or more natural essence, compound essence, but alsoBe not particularly limited. For example, wintergreen, cinnamon oil, menthol oil, oleum menthae viridis, lime oil, lavender oil, arbusterol,Vanilione
As this sweetener, preferably conventional sweetener, for example, select at least from maltitol, sucrose, glucose, glucan1 kind.
As the form of composition of the present invention, can enumerate oily, emulsification aqueous, Powdered etc. Aqueous as emulsification, excellentThe emulsification of electing oil-in-water type as is aqueous. Powder composition for example can be by being dried to prepare by aqueous emulsification.
When the composition of astaxanthin-containing of the present invention is oily, for example can be by each component of the composition of ormal weight with oil with arbitrarilyMode be uniformly mixed, can be also to adopt under normal temperature or the condition of heating to carry out; In some embodiments, canEach component of composition is first mixed into suspension with oil, after grinding, then adds oil to be diluted to desired concn,This mode can ensure that the component in final oil-containing solutions has less particle diameter, has avoided the reunion of component and can makeThe dispersiveness of oil is improved, and as the device for grinding, can use the known conventional equipment of those skilled in the art,For example ball mill, ball mill or colloid mill, the D[4 that wherein particle in this suspension has, 3] average particle size (volumeWeighted average diameter) be 0.5～50 μ m, particularly 0.7～30 μ m, especially 1～20 μ m. Average particle size is specialBe 1.2～10 μ m. The present composition shared percentage by weight in grease can be 0.5～90%, can be also 20～70%, can be also 40～50% etc. Here oil used is mainly edible oil, and it is right that edible oil refers in the context of the inventionThe oil that food allows, the i.e. oil to animal and/or human nutrition permission. Edible oil can be synthesize, mineral, plant or animal comeSource. Example is that vegetable oil is as soya-bean oil, palm oil, palm-kernel oil, sunflower seed oil, maize germ oil, Linseed oil, dishSeed oil, safflower oil, wheat-germ oil, rice bran oil, coconut oil, apricot kernel oil, avocado oil, jojoba oil, hazelnut oil, walnut oil,The triglycerides of peanut oil, pistachio nut oil, medium chain (C8～C10) vegetable fatty acid, also has semi-synthetic triglycerides in addition,For example caprylic/capric triglyceride, also have in addition oleostearin, paraffin oil, tristerin, myristic acid isopropyl esters,Adipic acid diisopropyl ester, 2 ethyl hexanoic acid acetyl stearyl, liquid Parleam, saualane, squalene, in additionAlso have animal oil & fat as fish oil, comprise mackerel oil, sparattus fish oil, tunny fish oil, sole oil, cod oil and salmon oil withAnd lanolin.
When the composition of astaxanthin-containing of the present invention is Powdered, can adopts each component is directly mixed, and can basisActual demand increases some pressed powder fillers in composition, for example pyrolysis silicic acid or silica gel, titanium dioxide, hydroxide asAluminium hydroxide, carbonate and bicarbonate are as sodium carbonate, sodium acid carbonate, potash, magnesium carbonate and calcium carbonate, and silicate is as siliconAcid sodium, magnesium silicate, talcum, calcium silicates, zinc silicate, tricalcium phosphate, sodium chloride, the material of the powder type of applicable food,For example the polysaccharide of optional modification is as starch, cellulose and methylcellulose. The present composition shared weight in Powdered thingPercentage can be 0.5～90%, can be also 20～70%, can be also 40～50% etc. Above-mentioned composition powder alsoCan be by first composition being scattered in water or organic solvent, then after grinding, obtain by dry mode;Organic solvent can be selected from methyl alcohol, ethanol, normal propyl alcohol, isopropyl alcohol, propane diols, Ethylene Glycol Methyl ether, 1,2-butanediol-1-Methyl ether, 1,2-PD-1-n-propyl ether, oxolane or acetone. Composition is in the time being dispersed into suspension, and composition is sharedMass percent scope can be 30～90%, can be also 40～80%, can be also 50～60% etc. In addition, dryCan carry out according to the conventional method of being produced powder by dispersion. Can be for example spraying be dried, spray cooling, freeze drying,Spraying preparation or mist projection granulating, wherein preferably spray drying and spraying preparation are sprayed under the inert powder of fluidisation in fluid bedDry.
The composition of astaxanthin-containing of the present invention is emulsification when aqueous, as the preferred finish using in the present invention, can enumerate poly-Stearine, Unigly GO 102S, polyglycereol isostearate, Myrj 45, polyoxyethylene isostearic acidEster, polyoxyethylene phytosterol, thylhexoic acid cetyl, saualane and oleic acid etc. Preparation process can be first by astaxanthinComposition is scattered in oil phase, grinds if desired, then oil phase and water are carried out to emulsion dispersion, forms emulsion. In emulsificationOil phase and the mass ratio of water be not particularly limited, taking oil phase/water phase mass ratio as 0.1:99.9～50:50, more preferably0.5:99.5～30:70,1:99～20:80 more preferably; The composition of astaxanthin-containing shared quality percentage in emulsifying agentCan be 0.5～90%, 30～90% than scope, can be also 40～80%, can be also 50～60% etc. Wherein, emulsificationStep can use common emulsifier unit (for example agitator, impeller stirring, homogenizer, the Continuous Flow of utilizing shear actionGeneral formula shear etc.) carry out emulsification, in order to make further the drop of uniform particle diameter, can carry out repeatedly. In addition, closeIn emulsification method can use natural emulsification method, surface chemistry emulsion process, electric emulsion process, capillary emulsion process, machinery emulsification method,Supersound method etc.
Astaxanthin composition provided by the present invention can be applied to as animal feed, human nutrition food, dietary supplements, medicineThing or cosmetics etc.
Detailed description of the invention
Below by detailed description of the invention, the present invention is described in further detail. But it will be understood to those of skill in the art that followingEmbodiment is only for the present invention is described, and should not be considered as limiting scope of the present invention. Unreceipted concrete technology or condition in embodimentPerson, according to the described technology of the document in this area or condition or carry out according to product description. Agents useful for same or instrument are notIndicate the person of production firm, being can be by the conventional products of commercial acquisition.
The value of expressing with range format should be interpreted as and not only comprise the number as scope limit value clearly listing in mode flexiblyValue, but also comprise all single numerical value or the subinterval that are encompassed within the scope of this, be clearly listed as just as each numerical value and subintervalEnumerate. For example, the concentration range of " about 0.1% to approximately 5% " should be understood to not only comprise clearly list approximately 0.1% toApproximately 5% concentration, also include single concentration in institute's how (as, 1%, 2%, 3% and 4%) and subinterval (for example,0.1% to 0.5%, 1% to 2.2%, 3.3% to 4.4%). Word used herein " comprises ", " comprising ", " having " or itsAny other variant is intended to contain comprising of non-exclusionism. For example, comprise list key element technique, method, article or equipment notMust be limited to those key elements, but can comprise that other are not clearly listed or to belong to this technique, method, article or equipment solidSome key elements.
In the present embodiment and reference examples, each component of employing is mixed and is made composition, and weight proportion is as shown in the table, whereinUnit is weight portion, and unrighted acid adopts DHA.
Preparation method mixes each component by proportioning.
The preparation of embodiment 5 oily compositions
The present embodiment is mainly to adopt the above embodiments 1～4 and reference examples 1～3 astaxanthin composition as basic material, entersAnd be prepared into oily composition. Preparation method is as follows: by weight, add 15 by 20 parts of above-mentioned astaxanthin compositionsThe palm oil of part after mixing, then grinds 4 times with 0.4bar pressure in ball mill, every all over grinding about 10min, streamSpeed is that (470ml, is filled with the ZrO of 0.2～0.4mm to 60g/min for mill gap 0.05mm, 4180rpm2Ball), grind and finishAfter, then add the palm oil of 45 weight portions to mix, then measure the particle diameter of grease.
Granularity is used MalvernMastersizerS to measure at 22 DEG C. Before measuring, use grind with oil will be by grindingTo the suspension of astaxanthin derivatives to be diluted to concentration be 0.05wt%. The numeral of record is the equal particle diameter D[4 of body, 3]. In order to surveyDetermine the absolute content of astaxanthin derivatives in the suspension that can be obtained by the present invention, this suspension is dissolved in acetone, then logicalCross UV/VIS spectroscopic methodology (200-800nm) in the lower delustring of measuring this solution of 476nm (astaxanthin).
For more stable property, respectively claim by above-mentioned sample that again 100g is placed in little glass, and sealing simultaneously, in 50 DEG C of conditionsLower preservation 7 days, then carry out identical test, and calculate the degradation rate of astaxanthin by following formula:
Absorbance × 100% of degradation rate %=(absorbance of sample behind absorbance-7 of initial sample day)/initial sample.
As can be seen from the table, astaxanthin composition provided by the invention has good stability under oily condition, has grainThe advantage that footpath is little, degradation rate is low. Wherein in reference examples 1 owing to not adding unrighted acid, can not make trehalose divide preferablyLoose, make to store rear particle diameter and increase obviously, reunite serious; And in reference examples 2 owing to not adding trehalose, easily cause shrimp green grass or young cropsAfter storage, there is degraded in element; In reference examples 3, do not add trehalose to cause equally the larger problem of particle diameter of sample, butIt is little to be that particle diameter becomes large degree.
The preparation of embodiment 6 emulsions
The present embodiment is mainly to adopt the above embodiments 1～4 and reference examples 1～3 astaxanthin composition as basic material, entersAnd be prepared into emulsification shape composition. Preparation method is as follows: by weight, add in 10 parts of above-mentioned astaxanthin compositionsIn 15 parts of polyglycereol isostearates and 15 parts of thylhexoic acid cetyl, be warming up to 55 DEG C and mix, as oil phase; Again willAfter oil phase mixes with 50 parts of waters, at 60 DEG C, use homogenizer by oil phase mixing and emulsifying in water, particle size is reached10.0 μ m～15.0 μ m, wherein, particle size, for emulsification composition is diluted to 20 times with pure water, uses MalvernMastersizerS measures the equal particle diameter D[4 of body, 3 at 22 DEG C]; And adopt high speed column chromatography to measure the content of astaxanthin.
In addition, each emulsion, just preparing rear and preserving under the temperature conditions of 50 DEG C after 7 days, is used the mensuration after just preparingResult, as 100%, is calculated and under the temperature conditions of 50 DEG C, is preserved the content astaxanthin after 7 days.
For more stable property, respectively claim by above-mentioned sample that again 100g is placed in little glass, and sealing simultaneously, in 50 DEG C of conditionsLower preservation 7 days, then carry out identical test, and calculate the degradation rate of astaxanthin by following formula:
Content × 100% of degradation rate %=(content of sample behind content-7 of initial sample day)/initial sample.
As can be seen from the table, astaxanthin composition provided by the invention still has good stability under emulsification condition.
The preparation of embodiment 7 powdered compositions
The present embodiment is mainly to adopt the above embodiments 1～4 and reference examples 1～3 astaxanthin composition as basic material, entersAnd be prepared into emulsification shape composition. Preparation method is as follows: by weight, add in 10 parts of above-mentioned astaxanthin compositionsIn 30 parts of ethanol, be warming up to 35 DEG C and mix, then grind 4 times with 0.4bar pressure in ball mill, every all over grinding about 10min,Flow velocity is that (470ml, is filled with the ZrO of 0.2～0.4mm to 60g/min for mill gap 0.05mm, 4180rpm2Ball), grind knotShu Hou, decompression distillation to volume reduces 1/3, then spray dry after, obtain powdered composition.
Claims (10)
1. astaxanthin composition, is characterized in that, includes 5～80 parts of astaxanthins, unrighted acid 5～10 by weightPart, 5～10 parts of trehaloses, 5～20 parts of vitamin e1s.
2. astaxanthin composition according to claim 1, is characterized in that: described unrighted acid is selected from 22 carbon sixOlefin(e) acid, eicosapentaenoic acid, fish oil, linseed oil, borage oil, alpha-linolenic acid, gamma-Linolenic acid, CLA orPerson's Saw Palmetto P.E.
3. astaxanthin composition according to claim 1, is characterized in that: astaxanthin is selected from the astaxanthin of natural extraction its matterAmount content is more than 0.5%wt; Or astaxanthin is selected from synthetic astaxanthin, its mass content is more than 20%wt.
4. include the preparation of astaxanthin composition claimed in claim 1.
5. preparation according to claim 4, is characterized in that, formulation is selected from finish, emulsifying agent, powder agent, capsule.
6. the preparation method of finish claimed in claim 4, is characterized in that, comprises the steps: that astaxanthin composition mixes with oilEvenly become dispersion liquid, grind, then add oil to be mixed to normal concentration; Described oil is edible oil.
7. the preparation method of finish claimed in claim 6, is characterized in that, astaxanthin composition shared weight percent in finishThan being 0.5～90%.
8. the preparation method of emulsifying agent claimed in claim 4, is characterized in that, comprises the steps: astaxanthin composition and finishMix, as oil phase, then add water to carry out emulsification, obtain emulsion; Described oil phase and water mass ratio are0.1:99.9～50:50; Astaxanthin composition shared percentage by weight in emulsifying agent is 0.5～90%.
9. the preparation method of powder agent claimed in claim 4, is characterized in that, comprise the steps: blue or green promotor composition and water orPerson's organic solvent mixes, and after grinding, then is dried; Astaxanthin composition shared weight hundred in powder agentProportion by subtraction is 0.5～90%.
10. include feed, food, beverage, medicine, the cosmetics of astaxanthin composition claimed in claim 1.
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| CN106107997A (en) * | 2016-08-17 | 2016-11-16 | 陈石良 | A kind of antioxidation hypertension and hyperlipemia SOD Semen Lini oil soft capsule and preparation method thereof |
| WO2018064966A1 (en) * | 2016-10-06 | 2018-04-12 | Beijing Gingko Group Biological Technology Co., Ltd. | Nutritional supplements affecting cardiovascular efficiency |
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| CN113925166A (en) * | 2020-12-14 | 2022-01-14 | 常州市第二人民医院 | Astaxanthin composition and preparation method thereof |
| CN112674335A (en) * | 2020-12-31 | 2021-04-20 | 山东蓝奥生物技术有限公司 | Astaxanthin-containing health oil and application thereof |
| CN113081906A (en) * | 2021-04-30 | 2021-07-09 | 广州市科能化妆品科研有限公司 | Astaxanthin composition and preparation method and application thereof |
| WO2022228268A1 (en) * | 2021-04-30 | 2022-11-03 | 广州市科能化妆品科研有限公司 | Astaxanthin composition, preparation method therefor, and application thereof |
| CN114306104A (en) * | 2021-12-29 | 2022-04-12 | 士齐生物研发中心（苏州工业园区）有限公司 | Astaxanthin-containing mixture and application thereof in cosmetics |
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