CN114190555A - Drop pills with antioxidation efficacy and preparation method thereof - Google Patents
Drop pills with antioxidation efficacy and preparation method thereof Download PDFInfo
- Publication number
- CN114190555A CN114190555A CN202111555901.3A CN202111555901A CN114190555A CN 114190555 A CN114190555 A CN 114190555A CN 202111555901 A CN202111555901 A CN 202111555901A CN 114190555 A CN114190555 A CN 114190555A
- Authority
- CN
- China
- Prior art keywords
- parts
- content
- extract
- dripping
- dripping pill
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 238000003860 storage Methods 0.000 claims abstract description 18
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- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 17
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- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 claims description 20
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- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
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- 239000000944 linseed oil Substances 0.000 claims description 3
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- 239000003963 antioxidant agent Substances 0.000 description 11
- 235000006708 antioxidants Nutrition 0.000 description 11
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 11
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- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 2
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 2
- 235000005487 catechin Nutrition 0.000 description 2
- 229950001002 cianidanol Drugs 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 230000007760 free radical scavenging Effects 0.000 description 2
- 210000000224 granular leucocyte Anatomy 0.000 description 2
- 235000009569 green tea Nutrition 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 125000000468 ketone group Chemical group 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
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- 238000012986 modification Methods 0.000 description 2
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- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
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- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
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- 230000007547 defect Effects 0.000 description 1
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- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 description 1
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
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- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
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- 235000016709 nutrition Nutrition 0.000 description 1
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- 230000004792 oxidative damage Effects 0.000 description 1
- 238000005502 peroxidation Methods 0.000 description 1
- CMFNMSMUKZHDEY-UHFFFAOYSA-N peroxynitrous acid Chemical compound OON=O CMFNMSMUKZHDEY-UHFFFAOYSA-N 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
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- 150000003839 salts Chemical class 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
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- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Botany (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a dripping pill with an antioxidant effect, which comprises contents and a rubber shell, wherein the contents comprise the following components in parts by weight: 1-10 parts of haematococcus pluvialis, 1-10 parts of polygonum cuspidatum extract, 1-10 parts of passion flower extract, 1-10 parts of green tea extract, 20-80 parts of dispersing agent and 0.5-5 parts of lecithin; the rubber shell comprises the following components in parts by weight: 50-80 parts of gelatin, 5-40 parts of glycerol and 5-20 parts of water. The invention also provides a preparation method of the dripping pill with the antioxidant effect, which comprises the following steps: weighing → preparing the content → melting the glue → dripping → drying and selecting pills. The dripping pill has excellent antioxidant effect, and has the advantages of coating with rubber shell, odor isolation, no damage to effective components, and prolonged storage time.
Description
Technical Field
The invention relates to the technical field of health care products, in particular to a dripping pill with antioxidant effect and a preparation method thereof.
Background
Modern medicine believes that free radicals are harmful chemicals produced while human bodies metabolize, have strong oxidizability, harm normal cells of human bodies, cause cell viability reduction, and cause body aging and a series of chronic diseases. Research shows that the supplement of the antioxidant has obvious effect on improving the antioxidant capacity of the organism.
Astaxanthin, also known as astaxanthin and lobster shell pigment, is a red natural carotenoid, has strong antioxidant activity, can remove excessive active oxygen in the body, and thus has the functions of preventing various diseases such as aging, cardiovascular diseases, inflammation, senile dementia, cancer and the like, haematococcus pluvialis is fresh water unicellular green alga, can accumulate a large amount of astaxanthin under specific conditions such as strong light, little nitrogen, high salt and the like, and the content of the astaxanthin can reach about 1.5-4.0 percent of the dry weight of cells.
Resveratrol is a polyphenol compound, mainly comes from rhizoma Polygoni Cuspidati extract, and has antibacterial, antiinflammatory, antioxidant, liver protecting, and cardiovascular and cerebrovascular protecting effects.
Passiflora edulis is a herbaceous vine of Passiflora in Passifloraceae, also called passion fruit and passion fruit. Researches show that the passion fruit peel polysaccharide has good nutritional value and medicinal value, such as antioxidant function and anti-inflammatory function, and can enhance cellular immunity.
The tea polyphenol consists of more than 30 phenolic substances, the main components of the tea polyphenol are catechin and derivatives thereof, the catechin and the derivatives thereof are main chemical components with health care function in tea, and the content of the tea polyphenol in the green tea is higher and accounts for 15-30% of the weight of the green tea. The tea polyphenols have antioxidant, radiation-proof, antiaging, blood lipid reducing, and blood sugar lowering effects.
There is not the same type of antioxidant dripping pill in the existing market, the dripping pill has the advantages of concentrated drug effect, high bioavailability, rapid curative effect and the like, but the traditional dripping pill adopts a substrate with viscosity to mix with the content for easy forming, but the activity of the content can still be influenced by the mixing of the substrate and the content, the concentration of the active ingredients is diluted, the preparation of the substrate is more complicated, the general outer layer of the dripping pill has no package, the smell can not be isolated, the dripping pill is easy to oxidize when contacting with air, the activity of the content is influenced, some dripping pills can be packaged by adopting a coating process, but the coating process is more complex, secondary processing is carried out after the dripping pills, the production efficiency is poor, and the coating is easy to fall off. Therefore, a new technical solution is needed to solve the above problems.
Disclosure of Invention
The invention aims to provide a dripping pill with antioxidant effect and a preparation method thereof, wherein the dripping pill has excellent antioxidant effect, is wrapped by a rubber shell, has no smell, has no damage to effective components, and prolongs the storage time.
In order to achieve the technical purpose and achieve the technical requirements, the invention adopts the technical scheme that: a dripping pill with an antioxidant effect comprises contents and a rubber shell, wherein the contents comprise the following components in parts by weight: 1-10 parts of haematococcus pluvialis, 1-10 parts of polygonum cuspidatum extract, 1-10 parts of passion flower extract, 1-10 parts of green tea extract, 20-80 parts of dispersing agent and 0.5-5 parts of lecithin; the rubber shell comprises the following components in parts by weight: 50-80 parts of gelatin, 5-40 parts of glycerol and 5-20 parts of water.
As a preferable technical scheme, the dispersing agent comprises one or more of sunflower seed oil, linseed oil, safflower seed oil and medium chain triglyceride.
Preferably, the content of astaxanthin in the haematococcus pluvialis is not less than 4%, and the passion fruit peel polysaccharide in the passion fruit extract is not less than 4%.
Preferably, the resveratrol content in the polygonum cuspidatum extract is not less than 90%, and the tea polyphenol content in the green tea extract is not less than 50%.
As a preferred technical solution, the lecithin is non-transgenic lecithin.
The invention also provides a preparation method of the dripping pill with the antioxidant effect, which comprises the following steps:
s1: weighing: accurately weighing the raw materials and the auxiliary materials according to the batch production and the product formula, and completely crushing all solid powder materials and sieving the crushed solid powder materials by a 100-200-mesh sieve;
s2: preparing contents: putting haematococcus pluvialis, polygonum cuspidatum extract, passion flower extract and green tea extract in a formula ratio into a dispersing agent, stirring for 10-20 minutes, grinding by using a colloid mill, pumping liquid once at a compressed air pressure of 0.4MPa, an upper limit temperature of 50 ℃ and a flow rate of 5-7 s, homogenizing by using a high-pressure homogenizer with a processing pressure of 20000psi at the maximum and a flow rate of 300-400ml/min, adding phospholipid, continuously stirring for 20-40 minutes until the content with the flowability meeting the requirement is obtained, defoaming, and pouring into a content storage tank of a pill dropping machine with double-layer dropping heads for later use;
s3: glue melting: mixing purified water and glycerol, heating to 60 +/-10 ℃, adding gelatin, heating to 80 +/-10 ℃, heating for 15-25 minutes, degassing, standing for 15-25 minutes, and clarifying the glue solution for later use;
s4: dripping: pouring the glue solution into a glue solution storage tank of a dripping pill machine with a double-layer dripper, keeping an oil bath at 60-70 ℃, setting the dripper temperature at 60-70 ℃, the condensate temperature at 5-10 ℃, and the flow rate ratio of the glue solution to the content at 1 (2-5), and adjusting the height of a discharge port of the dripping pill machine with the double-layer dripper to ensure that the content and the glue solution can be smoothly dripped into the condensate through the double-layer dripper without adhesion, wherein the dripping pills dripped into the condensate are formed into spheres under the action of surface tension, and are gradually cooled and solidified for forming;
s5: drying and pill selection: pre-drying the solidified and molded dropping pills for 1-2 hours by a rotating cage, putting the dropping pills into a drying chamber for static drying for 20-30 hours, selecting the dried dropping pills, and packaging to obtain finished products.
As a preferred technical scheme: the condensate in the step 4 is liquid paraffin oil or dimethyl silicone oil.
As a preferred technical scheme: the viscosity of the content of the step 2 is not more than 100mm2/s。
As a preferable technical scheme, the fineness of the solid material in the content in the step 2 is 10 nm-200 nm.
The invention has the beneficial effects that:
1) astaxanthin in haematococcus pluvialis has unsaturated ketone groups and hydroxyl groups and has extremely strong capacity of clearing free radicals, resveratrol in a polygonum cuspidatum extract can clear free radicals and repair damaged DNA, passion fruit peel polysaccharide in the passion fruit extract has good capacity of clearing the hydroxyl free radicals, tea polyphenol in a green tea extract has good capacity of clearing oxygen free radicals and can protect oxidative damage DNA, lecithin can encapsulate the astaxanthin, the resveratrol, the passion fruit peel polysaccharide and the tea polyphenol, and the activity of effective components is prevented from being reduced, the added value of the active ingredients is improved, the astaxanthin, the resveratrol, the passion fruit peel polysaccharide and the tea polyphenol have excellent synergistic effect, can completely eliminate free radicals and delay aging, and has the effects of resisting bacteria, resisting inflammation, resisting oxidation, protecting the liver, protecting the heart and cerebral vessels and the like; meanwhile, the content of the dripping pill is wrapped by a rubber shell, which is beneficial to the effects of concentrating the drug effect, reducing the oxidation of the content, preventing the content from losing efficacy, isolating smell and the like.
2) In the preparation process of the dripping pill, in order to enable the rubber shell to wrap the content, a double-layer dripper is adopted, and the process parameters are strictly controlled, so that the rubber shell can wrap the content well, and the phenomena of leakage and the like can not occur.
Detailed Description
The invention is further described below with reference to examples;
the invention provides a dripping pill with an antioxidant effect, which comprises contents and a rubber shell, wherein the contents comprise the following components in parts by weight: 1-10 parts of haematococcus pluvialis, 1-10 parts of polygonum cuspidatum extract, 1-10 parts of passion flower extract, 1-10 parts of green tea extract, 20-80 parts of dispersing agent and 0.5-5 parts of lecithin; the rubber shell comprises the following components in parts by weight: 50-80 parts of gelatin, 5-40 parts of glycerol and 5-20 parts of water.
The oxygen generates superoxide anion, hydrogen peroxide, hydroxyl free radical and singlet oxygen in the process of reducing the oxygen into water, the active oxygen plays an important role in the process of lipid peroxidation, and the influence factors of the dripping pill on oxidation resistance, the oxidation resistance efficiency and the scavenging effect of different systems on oxygen free radical are various.
The astaxanthin in haematococcus pluvialis contains conjugated double bonds, and each aromatic ring at two ends of the chemical structure of the astaxanthin contains a hydroxyl group and an unsaturated ketone group, so that the astaxanthin has remarkable oxidation resistance, can quench singlet oxygen and directly remove oxygen radicals, can improve the activity of glutathione peroxidase and reduce the damage of malonaldehyde, and thus protects damaged cells.
Resveratrol in rhizoma Polygoni Cuspidati extract belongs to flavonoid, and can reduce H2O2The resveratrol can inhibit the generation of platelet oxygen free radicals and reduce the generation of platelet oxygen free radicals activated by thrombin, and can reduce the level of malondialdehyde in blood, generally, the antioxidant capacity of resveratrol is in dependence on dosage, but the blood concentration of the resveratrol reaches the peak value after the resveratrol is taken into a human body to a certain amount, then the blood concentration of the resveratrol can not rise any more no matter how much resveratrol is taken, which has certain deviation from the generally accepted dependence relationship between the antioxidant capacity of the resveratrol and the dosage in the industry, and the reaction can be generated when the intake of the resveratrol is too much, the excessive resveratrol phenolic hydroxyl is consumed in the anti-oxidation process, if the reduction cannot be carried out in time, the peroxidation is promoted, and the inventor sets the range of the giant knotweed rhizome extract to 1-10 parts.
The passion flower extract contains passion flower peel polysaccharide which is a high molecular compound, the passion flower peel polysaccharide has strong capacity of eliminating hydroxyl free radicals and 1, 1-diphenyl-2-trinitrophenylhydrazine free radicals, and the passion flower peel polysaccharide is set to be 1-10 parts by the inventor.
The green tea extract contains a large amount of tea polyphenol, the tea polyphenol can well remove free radicals generated by a polymorphonuclear leukocyte system in an oxygen radical system generated by the polymorphonuclear leukocyte system, a superoxide anion free radical system is generated by illuminating the riboflavin/ethylene diamine tetraacetic acid system and the xanthine/xanthine oxidase system, the superoxide anion free radicals in the system are removed by the tea polyphenol, curcumin, vitamin C and resveratrol respectively, and the removal rate of the tea polyphenol is superior to that of other substances; the tea polyphenol has strong cleaning capability on oxygen free radicals in a myocardial ischemia reperfusion system, can be complexed with iron ions, and can react with the oxygen free radicals to form semiquinone free radicals, so the tea polyphenol has strong cleaning capability on lipid free radicals, and the tea polyphenol also has good inhibition effect on peroxynitrite oxidation activity, but the cleaning capability of the tea polyphenol on hydroxyl free radicals is not obvious, and the invention sets the range of the green tea extract at 1-10 parts.
The inventor finds that the improvement of the antioxidant capacity is not obvious when the inventor selects the components of the contents, and the inventor finds that the astaxanthin, the resveratrol, the tea polyphenol and the passion fruit peel polysaccharide have good synergistic effect, the astaxanthin has strong single oxygen quenching capacity and strong oxygen radical scavenging capacity, the resveratrol can protect the oxidized and damaged DNA, and has good free radical scavenging capacity in a platelet free radical system, the tea polyphenol has strong free radical scavenging capacity in a plurality of systems, and the addition of the passion fruit peel polysaccharide promotes the scavenging capacity of hydroxyl free radicals and stable free radicals, so that the excellent synergistic effect is generated.
The inventor also needs to consider another important factor in selecting the contents, namely the fluidity of the contents during the preparation process. The effective components in the invention are solid, suspension is prepared before preparing the dripping pill, the viscosity of the suspension is generally larger than that of pure oil contents due to a special dispersion system of the suspension, and the preparation process of the traditional dripping pill is as follows: the contents and the matrix are mixed, and then the mixture is dripped into the condensate by a dripping pill machine to prepare the dripping pills, the dripping pills are all solid, the traditional dripping pills have low requirements on the fluidity of the contents, the dripping pills on the current market are not coated by rubber, not only have cognitive deviation, but also have process difficulty, in the traditional process, the rubber can not coat the contents of the suspension, can be adhered with the suspension, and the dripping pills can not be formed, so the dripping pills coated by the rubber are not available on the market, even if the so-called multilayer dripping pills exist, the dripping pills are prepared by the dripping pill machine, and then are coated by a coating process, so the dripping pills are easy to fall off, and the effect is not good.
The traditional dripping pills without rubber skin have the following defects: 1. the odor cannot be isolated; 2. the contents are easy to lose efficacy after being directly contacted with air; 3. the storage time is short. The inventor finds that the rubber is easily adhered to the content of the suspension and cannot be molded, if the dripping pill with the rubber shell is prepared by a dripping pill machine with a double-layer dripper, the content is required to have certain fluidity, so when the inventor selects the components of the content and the proportion of the components, the content has the fluidity meeting the requirement after mixing in consideration of the fluidity requirement, and through repeated experiments, the mixture obtained in step 2 in the invention before a colloid mill has the fluidity meeting the requirement, and then the fluidity of the suspension is lower than 100mm through the colloid mill and homogenization treatment2/s。
In some embodiments, the dispersing agent comprises one or more of sunflower seed oil, linseed oil, safflower seed oil and medium chain triglyceride, most preferably, the dispersing agent adopts medium chain triglyceride, the medium chain triglyceride is easily absorbed by human body, can be completely absorbed into small intestinal mucosa and enters into cells without bile salt, the generated medium chain fatty acid does not need to be re-esterified and synthesized into triglyceride in intestinal cells, and directly enters into liver from portal vein in the form of fatty acid, and is rapidly and efficiently decomposed in liver to generate energy, the medium chain fatty acid can rapidly supply energy to body, does not form fat accumulation in body, has the functions of improving cardiovascular function, burning fat and the like, is suitable for AIDS patients, diabetes patients and obesity patients, and has certain anti-adhesion effect per se to provide a certain fluidity basis for the contents.
In some embodiments, the content of astaxanthin in haematococcus pluvialis is not less than 4%, the content of passion flower pericarp polysaccharide in passion flower extract is not less than 4%, the content of resveratrol in polygonum cuspidatum extract is not less than 90%, and the content of tea polyphenol in green tea extract is not less than 50%, so that the content of effective components in the content meets the requirement, and the antioxidant effect is improved.
In some embodiments, the lecithin is non-transgenic lecithin, and the lecithin wraps the particles in the content to play a role in membranization, improve dispersion uniformity of the particles in the content, and play a role in lubrication.
The invention also provides a preparation method of the dripping pill with the antioxidant effect, which comprises the following steps:
s1: weighing: accurately weighing the raw materials and the auxiliary materials according to the batch production and the product formula, and completely crushing all solid powder materials and sieving the crushed solid powder materials by a 100-200-mesh sieve;
s2: preparing contents: putting haematococcus pluvialis, polygonum cuspidatum extract, passion flower extract and green tea extract according to the formula ratio into a dispersing agent, stirring for 10-20 minutes, passing through a colloid mill, pumping liquid once at a compressed air pressure of 0.4MPa, an upper limit temperature of 50 ℃ and a flow rate of 5-7 s, homogenizing by using a high-pressure homogenizer with a processing pressure of 20000psi at the maximum and a flow rate of 300-400ml/min, adding phospholipid, continuously stirring for 20-40 minutes to obtain a content with satisfactory fluidity, wherein the fineness of solid materials in the content reaches 10-200 nm, defoaming, pouring the content into a content storage tank of a dropping pill machine with double-layer dropping heads for later use, and further measuring the viscosity of the content by using a capillary viscometer under the condition of 35 ℃, wherein the viscosity of the content is less than or equal to 100mm2The content has good fluidity and is more uniformly dispersed by adopting a method of combining a colloid mill and a high-pressure homogenizer;
s3: glue melting: mixing purified water and glycerol, heating to 60 +/-10 ℃, adding gelatin, heating to 80 +/-10 ℃, heating for 15-25 minutes, degassing, standing for 15-25 minutes, and clarifying the glue solution for later use;
s4: dripping: pouring the glue solution into a glue solution storage tank of a dripping pill machine with a double-layer dripper, keeping an oil bath at 60-70 ℃, setting the dripper temperature at 60-70 ℃, the condensate temperature at 5-10 ℃, and the flow rate ratio of the glue solution to the content at 1 (2-5), adjusting the height of a discharge port of the dripping pill machine with the double-layer dripper to ensure that the content and the glue solution can be smoothly dripped into the condensate through the double-layer dripper without adhesion, forming the dripping pills dripped into the condensate into a spherical shape under the action of surface tension, gradually cooling and solidifying for forming, further, leading the condensate to be liquid paraffin oil or dimethyl silicone oil, leading the content to be suspension, strictly controlling the oil bath temperature and the dripper temperature when the dripping pill machine with the double-layer dripper is operated, preventing the dripping pills from being incapable of forming due to overhigh temperature or the glue solution and the content from adhering due to overlow temperature, and strictly controlling the flow rate ratio of the dripping pills to the content at 1 (2-5), the glue solution can wrap the content and has no adhesion phenomenon in the condensate;
s5: drying and pill selection: pre-drying the solidified and formed dropping pills for 1-2 hours by a rotating cage, putting the dropping pills into a drying chamber for static drying for 20-30 hours, selecting the dried dropping pills, and packaging to obtain finished products, so that the dropping pills with the rubber shells can be obtained by strictly controlling the temperature of a dripper, the temperature of an oil bath, the temperature of a condensate and the flow rate ratio of a rubber solution to contents and drying.
Example 1
A dripping pill with antioxidant effect comprises, by weight, 5 parts of Haematococcus pluvialis, 5 parts of Polygonum cuspidatum extract, 5 parts of Passiflora edulis extract, 5 parts of green tea extract, 78 parts of medium chain triglyceride and 2 parts of non-transgenic lecithin; the glue shell comprises 65 parts of gelatin, 25 parts of glycerol and 10 parts of water by weight.
The haematococcus pluvialis contains 4% of astaxanthin, the polygonum cuspidatum extract contains 90% of resveratrol, the passion flower polysaccharide in the passion flower extract contains 4%, and the green tea extract contains 50% of tea polyphenol.
A preparation method of a dripping pill with antioxidant effect mainly comprises the following steps:
s1: weighing: accurately weighing the raw materials and the auxiliary materials according to the batch production and the product formula, and crushing all solid powder materials and sieving the crushed solid powder materials with a 100-mesh sieve;
s2: preparing contents: preparing contents: adding haematococcus pluvialis, rhizoma Polygoni Cuspidati extract, herba Passiflorae Caeruleae extract and green tea extract into dispersant, stirring for 10 min, grinding with colloid mill under compressed air pressure of 0.4MPa at 50 deg.C, and flowing at 5s for liquidHomogenizing with a high pressure homogenizer at 18000psi and 300ml/min, adding phospholipid, stirring for 20min to obtain content with solid material fineness of 50nm, defoaming, and measuring viscosity of the content at 35 deg.C with a capillary viscometer of 95mm2The mixture is poured into a content storage tank of a pill dropping machine with double-layer drippers for standby;
s3: glue melting: mixing purified water and glycerol, heating to 60 deg.C, adding gelatin, heating to 80 deg.C for 20min, degassing, standing for 20min to clarify the gelatin solution;
s4: dripping: pouring the glue solution into a glue solution storage tank of a pill dropping machine with double-layer drippers, keeping an oil bath at 65 ℃, setting the temperature of the drippers to 65 ℃, the temperature of liquid paraffin oil to 6 ℃, and the flow rate ratio of the glue solution to the content to be 1:3, adjusting the height of a discharge port to ensure that the content and the glue solution can be smoothly dripped into the liquid paraffin oil through the double-layer drippers without adhesion, and the dripping pills dripped into the liquid paraffin oil are formed into spheres under the action of surface tension and are gradually cooled and solidified for forming;
s5: drying and selecting pills: pre-drying the solidified dripping pills for 1.5h by a rotating cage, statically drying for 25h in a drying room, selecting the dried dripping pills, and packaging to obtain the finished products.
Example 2
A dripping pill with antioxidant effect comprises 10 parts of Haematococcus pluvialis, 10 parts of Polygonum cuspidatum extract, 5 parts of Passiflora incarnata extract, 5 parts of green tea extract, 65 parts of medium-chain triglyceride and 5 parts of non-transgenic lecithin by weight; the rubber shell comprises 80 parts by weight of gelatin, 15 parts by weight of glycerol and 5 parts by weight of water.
The haematococcus pluvialis contains 5% of astaxanthin, 92% of resveratrol in a polygonum cuspidatum extract, 5% of passion flower polysaccharide in a passion flower extract and 55% of tea polyphenol in a green tea extract.
A preparation method of a dripping pill with antioxidant effect mainly comprises the following steps:
s1: weighing: accurately weighing the raw materials and the auxiliary materials according to the batch production and the product formula, and completely crushing all solid powder materials and sieving the crushed solid powder materials with a 150-mesh sieve;
s2: preparing contents: adding haematococcus pluvialis, polygonum cuspidatum extract, passion flower extract and green tea extract according to the formula ratio into a dispersing agent, stirring for 20 minutes, passing through a colloid mill, pumping liquid once at the upper limit temperature of 50 ℃ and the flow rate of 6s, then carrying out homogenization treatment by using a high-pressure homogenizer at the treatment pressure of 20000psi and the flow rate of 350ml/min, then adding phospholipid, continuously stirring for 30 minutes to obtain a content, wherein the fineness of a solid material in the content is 56nm, and measuring the viscosity of the content to be 97mm by using a capillary viscometer at 35 ℃ after defoaming2The mixture is poured into a content storage tank of a pill dropping machine with double-layer drippers for standby;
s3: glue melting: mixing purified water and glycerol, heating to 70 deg.C, adding gelatin, heating to 90 deg.C for 25 min, degassing, standing for 25 min to clarify the gelatin solution;
s4: dripping: pouring the glue solution into a glue solution storage tank of a pill dropping machine with a double-layer dripper, keeping an oil bath at 70 ℃, setting the temperature of the dripper at 70 ℃, the temperature of liquid paraffin oil at 10 ℃, and the flow rate ratio of the glue solution to the content at 1:4, and adjusting the height of a discharge port of the pill dropping machine with the double-layer dripper, so that the content and the glue solution can be smoothly dripped into the liquid paraffin oil through the double-layer dripper without adhesion, and the dripping pills dripped into condensate are formed into spheres under the action of surface tension, and are gradually cooled and solidified for forming;
s5: drying and pill selection: pre-drying the solidified dripping pills for 2 hours by a rotating cage, statically drying for 30 hours in a drying room, selecting the dried dripping pills, and packaging to obtain finished products.
Example 3
A dripping pill with antioxidant effect comprises 2 parts by weight of Haematococcus pluvialis, 2.5 parts by weight of Polygonum cuspidatum extract, 10 parts by weight of Passiflora edulis extract, 10 parts by weight of green tea extract, 75 parts by weight of medium-chain triglyceride and 0.5 part by weight of non-transgenic lecithin; the rubber shell comprises 80 parts of gelatin, 5 parts of glycerol and 15 parts of water by weight.
The haematococcus pluvialis contains 5% of astaxanthin, 92% of resveratrol in the polygonum cuspidatum extract, 6% of passion flower polysaccharide in the passion flower extract and 57% of tea polyphenol in the green tea extract.
A preparation method of a dripping pill with antioxidant effect mainly comprises the following steps:
s1: weighing: accurately weighing the raw materials and the auxiliary materials according to the batch production and the product formula, and completely crushing all solid powder materials and sieving the crushed solid powder materials with a 200-mesh sieve;
s2: preparing contents: adding haematococcus pluvialis, polygonum cuspidatum extract, passion flower extract and green tea extract according to the formula ratio into a dispersing agent, stirring for 15 minutes, passing through a colloid mill, pumping liquid once at the upper limit temperature of 50 ℃ and the flow rate of 5s, then carrying out homogenization treatment by using a high-pressure homogenizer at the treatment pressure of 20000psi and the flow rate of 400ml/min, then adding phospholipid, continuously stirring for 40 minutes to obtain a content, wherein the fineness of the content is 49.5nm, and the viscosity of the content is 98mm measured by using a capillary viscometer under the condition of 35 ℃ after defoaming2The mixture is poured into a content storage tank of a pill dropping machine with double-layer drippers for standby;
s3: glue melting: mixing purified water and glycerol, heating to 60 deg.C, adding gelatin, heating to 80 deg.C for 15 min, degassing, standing for 15 min to clarify the gelatin solution;
s4: dripping: pouring the glue solution into a glue solution storage tank of a dripping pill machine with a double-layer dripper, keeping an oil bath at 70 ℃, setting the temperature of the dripper at 70 ℃, the temperature of dimethyl silicon oil at 10 ℃, and adjusting the flow rate ratio of the glue solution to the content at 1:5, so that the content and the glue solution can be smoothly dripped into condensate through the double-layer dripper without adhesion, and the dripping pill dripped into the dimethyl silicon oil is formed into a sphere under the action of surface tension, and is gradually cooled, solidified and formed;
s5: drying and pill selection: pre-drying the solidified dripping pills for 2 hours by a rotating cage, statically drying for 30 hours in a drying room, selecting the dried dripping pills, and packaging to obtain finished products.
Comparative example 1
The formula and the proportion of the content are the same as those of the example 1, no rubber shell is generated, and the preparation method comprises the following steps:
s1: weighing: accurately weighing the raw materials and the auxiliary materials according to the batch production and the product formula, and crushing all solid powder materials and sieving the crushed solid powder materials with a 100-mesh sieve;
s2: preparing contents: preparing contents: putting haematococcus pluvialis, polygonum cuspidatum extract, passion flower extract and green tea extract in a formula ratio into a dispersing agent, stirring for 15 minutes, passing through a colloid mill, beating once at a compressed air pressure of 0.4MPa and an upper limit temperature of 50 ℃ and a flow rate of 5s, then adding phospholipid, and continuously stirring for 20 minutes to obtain a content;
s3: dripping: pouring the content into the content storage tank of the pill dropping machine, keeping the oil bath at 65 ℃, setting the dripper temperature at 65 ℃, setting the liquid paraffin oil temperature at 6 ℃, adjusting the height of the discharge port, forming the dropping pill dropped into the liquid paraffin oil into a spherical shape under the action of surface tension, and gradually cooling, solidifying and forming;
s4: drying and selecting pills: pre-drying the solidified dripping pills for 1.5h by a rotating cage, statically drying for 25h in a drying room, selecting the dried dripping pills, and packaging to obtain the finished products.
Comparative example 2
A dripping pill with antioxidant effect comprises, by weight, 5 parts of Haematococcus pluvialis, 15 parts of Polygonum cuspidatum extract, 5 parts of green tea extract, 78 parts of medium chain triglyceride and 2 parts of non-transgenic lecithin; the glue shell comprises 65 parts of gelatin, 25 parts of glycerol and 10 parts of water by weight.
The haematococcus pluvialis contains 4% of astaxanthin, the polygonum cuspidatum extract contains 90% of resveratrol, the passion flower polysaccharide in the passion flower extract contains 4%, and the green tea extract contains 50% of tea polyphenol.
The preparation method is the same as that of example 1.
Comparative example 3
A dripping pill with antioxidant effect comprises 10 parts by weight of Haematococcus pluvialis, 8 parts by weight of Polygonum cuspidatum extract, 10 parts by weight of Passiflora incarnata extract, 10 parts by weight of green tea extract, 75 parts by weight of medium-chain triglyceride and 0.5 part by weight of non-transgenic lecithin; the glue shell comprises 90 parts of gelatin, 12 parts of glycerol and 25 parts of water by weight.
The haematococcus pluvialis contains 5% of astaxanthin, 92% of resveratrol in the polygonum cuspidatum extract, 6% of passion flower polysaccharide in the passion flower extract and 57% of tea polyphenol in the green tea extract.
A preparation method of a dripping pill with antioxidant effect mainly comprises the following steps:
s1: weighing: accurately weighing the raw materials and the auxiliary materials according to the batch production and the product formula, and completely crushing all solid powder materials and sieving the crushed solid powder materials with a 200-mesh sieve;
s2: preparing contents: adding haematococcus pluvialis, rhizoma Polygoni Cuspidati extract, herba Passiflorae Caeruleae extract and green tea extract into dispersant, stirring for 20min, grinding with colloid mill, and measuring the viscosity of the content with capillary viscometer to 145mm2The mixture is poured into a content storage tank of a pill dropping machine with double-layer drippers for standby;
s3: glue melting: mixing purified water and glycerol, heating to 60 deg.C, adding gelatin, heating to 80 deg.C for 15 min, degassing, standing for 15 min to clarify the gelatin solution;
s4: dripping: pouring the glue solution into a glue solution storage tank of a dripping pill machine with a double-layer dripper, keeping an oil bath at 70 ℃, setting the dripper temperature at 70 ℃, the dimethyl silicon oil temperature at 10 ℃, and the flow rate ratio of the glue solution to the content at 1:5, and adjusting the height of a discharge port of the dripping pill machine with the double-layer dripper, wherein the content is adhered to the glue solution and cannot be formed.
Exposure experiments
The purpose of the test is as follows: whether the drop pill product can effectively relieve the oxidation of the functional components is checked.
Test subjects: the dropping pills in example 1 and comparative example 1.
The test method comprises the following steps: example 1 and comparative example 1 were exposed to air for 30 days, respectively, and the acid value and peroxide value of the contents were compared as shown in tables 1 and 2.
TABLE 1 acid value Change before and after the test
Item | Before testing | After the test |
Example 1 | 0.04mgKOH/g | 0.06mgKOH/g |
Comparative example 1 | 0.05mgKOH/g | 0.28mgKOH/g |
TABLE 2 peroxide Change before and after the test
And (3) test results:
the exposure test result shows that the acid value and the peroxide value of the content in the example 1 are not obviously changed before and after the test, and the acid value and the peroxide value of the content in the comparative example 1 are obviously increased compared with those before the test after the test in the comparative example 1, so that the dropping pill can effectively relieve the oxidation of the functional components.
Animal experiments
The purpose of the test is as follows: checking whether the dripping pill product has the health care function of oxidation resistance.
Test subjects: 30C 57BL/6 mice, weighing 18-22 g, were divided into three groups of 10 mice each.
Test materials: the dropping pills prepared in examples 1 to 3 and comparative example 2 and a non-toxic placebo.
The test method comprises the following steps: the first group is orally taken 1 time per day (gavage), 1 pill per time (0.04g), placebo is continuously taken for 1 month, the second group is orally taken 1 time per day (gavage), 1 pill per time (0.04g), the dropping pill of example 1 is continuously taken for 1 month, the third group is orally taken 1 time per day (gavage), 1 pill per time (0.04g), the dropping pill of example 2 is continuously taken for 1 month, the fourth group is orally taken 1 time per day (gavage), 1 pill per time (0.04g), the dropping pill of example 3 is continuously taken for 1 month, the fifth group is orally taken 1 time per day (gavage), 1 pill per time (0.04g) and the dropping pills of comparative example 2 are continuously taken for 1 month, and tail blood is taken to detect the contents of superoxide dismutase (SOD) and Malondialdehyde (MDA) in the blood serum of the mice.
Experimental data:
TABLE 3 Change in serum MDA content before and after the test
Item | Before testing | After the test |
First group | 6.46±0.35μml/ml | 6.55±0.96μml/ml |
Second group | 6.63±0.57μml/ml | 5.91±0.67μml/ml |
Third group | 6.42±0.68μml/ml | 5.83±0.54μml/ml |
Fourth group | 6.71±0.32μml/ml | 6.05±0.47μml/ml |
Fifth group | 6.57±0.3μml/ml | 6.32±0.74μml/ml |
TABLE 4 serum SOD Activity Change before and after the test
And (3) test results:
animal test results show that the MDA content and the SOD activity of the serum of a control group of mice before and after the first group of experiments are not obviously changed, the superoxide dismutase (SOD) activity in the serum of the mice is obviously enhanced and the Malondialdehyde (MDA) content is obviously reduced after the second group to the fourth group of experiments and before the experiments, although the superoxide dismutase (SOD) activity in the serum of the mice is enhanced and the Malondialdehyde (MDA) content is reduced after the fifth group of experiments and before the experiments, the effect is not as good as that of 5 parts of the passion flower extract on the contrary by adding 15 parts of the polygonum cuspidatum extract, so that the synergistic effect of the passion flower extract and other substances is better, the antioxidant capacity of the dropping pill can be obviously improved, and the mixture ratio of the substances is not more and is better. The tests show that the dripping pill has definite antioxidant health-care function; it was found by comparative example 3 that the viscosity of the suspension was not satisfactory, and the contents were adhered to the gum solution and could not be formed.
The foregoing examples are given solely for the purpose of illustrating the invention and are not to be construed as limiting the embodiments, and other variations and modifications in form thereof will be suggested to those skilled in the art upon reading the foregoing description, and it is not necessary or necessary to exhaustively enumerate all embodiments and all such obvious variations and modifications are deemed to be within the scope of the invention.
Claims (9)
1. A dripping pill with antioxidant effect comprises contents and a rubber shell, and is characterized in that: the content comprises the following components in parts by weight: 1-10 parts of haematococcus pluvialis, 1-10 parts of polygonum cuspidatum extract, 1-10 parts of passion flower extract, 1-10 parts of green tea extract, 20-80 parts of dispersing agent and 0.5-5 parts of lecithin; the rubber shell comprises the following components in parts by weight: 50-80 parts of gelatin, 5-40 parts of glycerol and 5-20 parts of water.
2. The dripping pill with antioxidant effect as claimed in claim 1, wherein: the dispersing agent comprises one or more of sunflower seed oil, linseed oil, olive oil and medium chain triglyceride.
3. The dripping pill with antioxidant effect as claimed in claim 1, wherein: the content of astaxanthin in haematococcus pluvialis is not less than 4%, and the passion fruit peel polysaccharide in the passion fruit extract is not less than 4%.
4. The dripping pill with antioxidant effect as claimed in claim 1, wherein: the resveratrol content in the polygonum cuspidatum extract is not less than 90%, and the tea polyphenol content in the green tea extract is not less than 50%.
5. The method for preparing a dripping pill with antioxidant effect as claimed in claim 1, wherein the method comprises the following steps: the lecithin is non-transgenic lecithin.
6. The method for preparing a dripping pill with antioxidant effect as claimed in any one of claims 1 to 5, wherein: the method comprises the following steps:
s1: weighing: accurately weighing the raw materials and the auxiliary materials according to the batch production and the product formula, and completely crushing all solid powder materials and sieving the crushed solid powder materials by a 100-200-mesh sieve;
s2: preparing contents: putting haematococcus pluvialis, polygonum cuspidatum extract, passion flower extract and green tea extract in a formula ratio into a dispersing agent, stirring for 10-20 minutes, grinding by using a colloid mill, pumping liquid once at a compressed air pressure of 0.4MPa, an upper limit temperature of 50 ℃ and a flow rate of 5-7 s, homogenizing by using a high-pressure homogenizer with a processing pressure of 20000psi at the maximum and a flow rate of 300-400ml/min, adding phospholipid, continuously stirring for 20-40 minutes until the content with the flowability meeting the requirement is obtained, defoaming, and pouring into a content storage tank of a pill dropping machine with double-layer dropping heads for later use;
s3: glue melting: mixing purified water and glycerol, heating to 60 +/-10 ℃, adding gelatin, heating to 80 +/-10 ℃, heating for 15-25 minutes, degassing, standing for 15-25 minutes, and clarifying the glue solution for later use;
s4: dripping: pouring the glue solution into a glue solution storage tank of a dripping pill machine with a double-layer dripper, keeping an oil bath at 60-70 ℃, setting the dripper temperature at 60-70 ℃, the condensate temperature at 5-10 ℃, and the flow rate ratio of the glue solution to the content at 1 (2-5), and adjusting the height of a discharge port of the dripping pill machine with the double-layer dripper to ensure that the content and the glue solution can be smoothly dripped into the condensate through the double-layer dripper without adhesion, wherein the dripping pills dripped into the condensate are formed into spheres under the action of surface tension, and are gradually cooled and solidified for forming;
s5: drying and pill selection: pre-drying the solidified and molded dropping pills for 1-2 hours by a rotating cage, putting the dropping pills into a drying chamber for static drying for 20-30 hours, selecting the dried dropping pills, and packaging to obtain finished products.
7. The method for preparing a dripping pill with antioxidant effect as claimed in claim 6, wherein the method comprises the following steps: the condensate in the step 4 is liquid paraffin oil or dimethyl silicone oil.
8. The method for preparing a dripping pill with antioxidant effect as claimed in claim 6, wherein the method comprises the following steps: the viscosity of the content of the step 2 is not more than 100mm2/s。
9. The method for preparing a dripping pill with antioxidant effect as claimed in claim 6, wherein the method comprises the following steps: the fineness of the solid material in the content in the step 2 is 10 nm-200 nm.
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