CN104382049A - Coenzyme Q10 softgel capsule and preparation method thereof - Google Patents
Coenzyme Q10 softgel capsule and preparation method thereof Download PDFInfo
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- CN104382049A CN104382049A CN201310359658.7A CN201310359658A CN104382049A CN 104382049 A CN104382049 A CN 104382049A CN 201310359658 A CN201310359658 A CN 201310359658A CN 104382049 A CN104382049 A CN 104382049A
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- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 title claims abstract description 67
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 title abstract description 10
- 239000002775 capsule Substances 0.000 title abstract description 8
- 235000017471 coenzyme Q10 Nutrition 0.000 title abstract 8
- 229940110767 coenzyme Q10 Drugs 0.000 title abstract 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 34
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims abstract description 34
- 235000013871 bee wax Nutrition 0.000 claims abstract description 30
- 239000012166 beeswax Substances 0.000 claims abstract description 30
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 25
- 235000012424 soybean oil Nutrition 0.000 claims abstract description 21
- 239000003549 soybean oil Substances 0.000 claims abstract description 21
- 239000007788 liquid Substances 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 108010010803 Gelatin Proteins 0.000 claims abstract description 17
- 239000008273 gelatin Substances 0.000 claims abstract description 17
- 229920000159 gelatin Polymers 0.000 claims abstract description 17
- 235000019322 gelatine Nutrition 0.000 claims abstract description 17
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 17
- 235000011187 glycerol Nutrition 0.000 claims abstract description 17
- 239000008213 purified water Substances 0.000 claims abstract description 17
- 239000004408 titanium dioxide Substances 0.000 claims abstract description 17
- 239000002994 raw material Substances 0.000 claims abstract description 15
- 238000001035 drying Methods 0.000 claims abstract description 4
- 239000007901 soft capsule Substances 0.000 claims description 29
- 239000003292 glue Substances 0.000 claims description 20
- 238000012856 packing Methods 0.000 claims description 12
- OIQPTROHQCGFEF-UHFFFAOYSA-L chembl1371409 Chemical compound [Na+].[Na+].OC1=CC=C2C=C(S([O-])(=O)=O)C=CC2=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 OIQPTROHQCGFEF-UHFFFAOYSA-L 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 239000001993 wax Substances 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 238000003860 storage Methods 0.000 claims description 4
- 239000000356 contaminant Substances 0.000 claims description 3
- 238000002844 melting Methods 0.000 claims description 3
- 230000008018 melting Effects 0.000 claims description 3
- 239000003921 oil Substances 0.000 claims description 3
- 235000019198 oils Nutrition 0.000 claims description 3
- 238000010926 purge Methods 0.000 claims description 3
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 3
- 229960000984 tocofersolan Drugs 0.000 claims description 2
- 239000002076 α-tocopherol Substances 0.000 claims description 2
- 235000004835 α-tocopherol Nutrition 0.000 claims description 2
- 229930003427 Vitamin E Natural products 0.000 abstract description 11
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 abstract description 11
- 235000019165 vitamin E Nutrition 0.000 abstract description 11
- 239000011709 vitamin E Substances 0.000 abstract description 11
- 229940046009 vitamin E Drugs 0.000 abstract description 11
- 230000000694 effects Effects 0.000 abstract description 10
- 230000009286 beneficial effect Effects 0.000 abstract description 4
- 238000005516 engineering process Methods 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 235000016709 nutrition Nutrition 0.000 abstract description 4
- 230000035764 nutrition Effects 0.000 abstract description 4
- 238000005265 energy consumption Methods 0.000 abstract description 3
- 235000013402 health food Nutrition 0.000 abstract description 3
- 208000033065 inborn errors of immunity Diseases 0.000 abstract description 3
- 231100000252 nontoxic Toxicity 0.000 abstract description 3
- 230000003000 nontoxic effect Effects 0.000 abstract description 3
- 208000028529 primary immunodeficiency disease Diseases 0.000 abstract description 3
- 208000024891 symptom Diseases 0.000 abstract description 3
- 238000005303 weighing Methods 0.000 abstract 2
- 239000000499 gel Substances 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000013557 residual solvent Substances 0.000 abstract 1
- 238000007873 sieving Methods 0.000 abstract 1
- 230000001502 supplementing effect Effects 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 description 6
- 230000003078 antioxidant effect Effects 0.000 description 5
- 235000006708 antioxidants Nutrition 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 239000002932 luster Substances 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 229940088594 vitamin Drugs 0.000 description 4
- 229930003231 vitamin Natural products 0.000 description 4
- 235000013343 vitamin Nutrition 0.000 description 4
- 239000011782 vitamin Substances 0.000 description 4
- 150000003722 vitamin derivatives Chemical class 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000004062 sedimentation Methods 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- UGMCXQCYOVCMTB-UHFFFAOYSA-K dihydroxy(stearato)aluminium Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[Al](O)O UGMCXQCYOVCMTB-UHFFFAOYSA-K 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 206010016256 fatigue Diseases 0.000 description 2
- 208000006454 hepatitis Diseases 0.000 description 2
- 230000037111 immune power Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 235000010445 lecithin Nutrition 0.000 description 2
- 239000000787 lecithin Substances 0.000 description 2
- 229940067606 lecithin Drugs 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- -1 oxygen radical Chemical class 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000000375 suspending agent Substances 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 102000005606 Activins Human genes 0.000 description 1
- 108010059616 Activins Proteins 0.000 description 1
- 241000256844 Apis mellifera Species 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010008909 Chronic Hepatitis Diseases 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000006587 Glutathione peroxidase Human genes 0.000 description 1
- 108700016172 Glutathione peroxidases Proteins 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 102000019197 Superoxide Dismutase Human genes 0.000 description 1
- 108010012715 Superoxide dismutase Proteins 0.000 description 1
- 239000000488 activin Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000002929 anti-fatigue Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000003177 cardiotonic effect Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 206010019692 hepatic necrosis Diseases 0.000 description 1
- 230000007866 hepatic necrosis Effects 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000005204 segregation Methods 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 230000008326 skin blood flow Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention discloses a coenzyme Q10 softgel capsule which comprises the following ingredients, by weight, 45-55 parts of coenzyme Q10, 30-40 parts of natural vitamin E, 8-12 parts of beeswax, 300-310 parts of soybean oil, 95-105 parts of gelatin, 40-50 parts of glycerin, 95-105 parts of purified water, 0.2-0.3 part of sunset yellow and 0.25-0.35 part of titanium dioxide. The invention also discloses a preparation method of the coenzyme Q10 softgel capsule. The preparation method comprises steps as follows: receiving of raw materials, feeding, crushing, sieving, weighing, weighing, preparation of a feed liquid, preparation of a gel liquid, pelleting, tumble drying and the like. According to the coenzyme Q10 softgel capsule, a certain amount of natural vitamin E is added into coenzyme Q10 so as to overcome side effect of coenzyme Q10 and raise nutrition and health-care effects; and by supplementing soybean oil and beeswax to prepare the capsule, the product has more stable quality, is convenient to take, is safe and effective, can be taken for a long time, is an ideal health food for people with hypoimmunity and can help improve the symptom of fatigue. In addition, the production technology is simple, and energy consumption is low. Coenzyme Q10 is dispersed uniformly and is beneficial to be absorbed by human body. The product has good quality, is safe and nontoxic and has no residual solvent.
Description
Technical field
The present invention relates to a kind of health products of capsule preparations, particularly a kind of coenzyme Q 10 soft capsule and preparation method thereof.
Background technology
Co-Q10 is a kind of chemical constituent be extensively present in biological cell, has no side effect.It is the basis that human body cell energy manufactures, and has metabolic cardiotonic, definite effect.Co-Q10 is mainly used in the treatment of acute and chronic hepatitis, acute hepatic necrosis, extraordinary curative effect is had to angiocardiopathy and hypertension, it can also be used for the complex treatment of cancer, simultaneously unique effect in anti-ageing, antifatigue, fat-reducing and beauty treatment etc.Be yellow to orange-yellow crystalline powder under ubiquinone Q10 room temperature, fusing point lower (49-52 DEG C), odorless, tasteless, dissolve in chloroform, benzene, acetone, ether or benzinum, soluble,very slightly in ethanol, insoluble in water and methyl alcohol, be not easy to absorb in human body, bioavilability is very poor; Ubiquinone Q10 is to light sensitive, and meet light and resolve into red material, temperature and humidity is less on its impact.
In order to play the health-care efficacy of Co-Q10 to greatest extent, need the technique of science and the formula of science by the efficacy exertion of Co-Q10 out, waste could to be avoided, also avoid having side effects.
Summary of the invention
The object of this invention is to provide a kind of can develop immunitypty and coenzyme Q 10 soft capsule being beneficial to absorption of human body and preparation method thereof
For achieving the above object, the invention provides a kind of coenzyme Q 10 soft capsule, the content comprising flexible glue utricule and enclose in this flexible glue utricule, described content comprises stock and adjunct, described raw material comprises component Co-Q10 45-55 part of following weight portion, natural VE 30-40 part, described auxiliary material comprises component beeswax 8-12 part of following weight portion, soybean oil 300-310 part, described flexible glue utricule comprises component gelatin 95-105 part of following weight portion, glycerine 40-50 part, purified water 95-105 part, sunset yellow 0.2-0.3 part, titanium dioxide 0.25-0.35 part.
As the preferred technical solution of the present invention, described raw material comprises the component Co-Q10 50 parts of following weight portion, natural VE 36 parts, described auxiliary material comprises 10 parts, the component beeswax of following weight portion, soybean oil 304 parts, and described flexible glue utricule comprises 100 parts, the component gelatin of following weight portion, glycerine 45 parts, purified water 100 parts, sunset yellow 0.25 part, titanium dioxide 0.3 part.
Wherein, described Co-Q10 is the high-load Co-Q10 of 98%, and the d-alpha-tocopherol content of described natural VE is 70%.
Present invention also offers a kind of preparation method of coenzyme Q 10 soft capsule, comprise the following steps:
1) raw material is got: get in proportion and meet standard, all kinds of raw materials through being up to the standards, comprise Co-Q10, natural VE, soybean oil, beeswax, gelatin, glycerine, purified water, titanium dioxide, sunset yellow;
2) feeding: after each supplementary material removes external packing, inner packing enters 100,000 grades of clean areas by logistics corridor;
3) pulverize, sieve, weigh: Co-Q10 is pulverized, cross 100 mesh sieves, obtain fine powder, for subsequent use;
4) weigh: weigh Co-Q10, natural VE, soybean oil, beeswax, gelatin, glycerine, purified water, titanium dioxide, sunset yellow by formula rate;
5) preparation of content feed liquid: the beeswax taken, soybean oil are heated to 60-80 DEG C, after beeswax melting, be cooled to 30-50 DEG C, obtain oily wax liquid, by natural VE and the mixing of oily wax liquid, obtain mixed liquor, stir Co-Q10 fine powder and mixed liquor to obtain content feed liquid;
6) glue preparation: by glycerine, purified water, titanium dioxide, sunset yellow mixing, add gelatin when being heated to 68-75 DEG C, stir, vacuumize, use 100 mesh screen, leave standstill, be incubated at 55-60 DEG C, obtain glue;
7) pelleting: content feed liquid and the glue configured are pressed into soft capsule, temperature 18-26 DEG C, relative humidity 45%-50%, obtain soft capsule;
8) rotating cage is dry: shape dry 10-18h, drying room temperature 22-28 DEG C, humidity <30%;
9) ball is picked: remove substandard product;
10) ball is washed: the ethanol purge soft capsule adding 95% food-grade, washes away soft capsule surface and oil contaminant;
11) dry: temperature 25 DEG C-30 DEG C, humidity 35%, time 1h-2h;
12) inner packing: 60/bottle;
13) external packing;
14) check;
15) put in storage.
Coenzyme Q 10 soft capsule of the present invention, has the health care of develop immunitypty, the low person of appropriate immune power, and instructions of taking and dose are oral, every day 1 time, and each 1, specification is 0.4g/ grain.Its significant composition is that every 100g contains Co-Q10 >=6.125g, vitamin E 3.15-11.34g, and general every 100g is containing Co-Q10 12.25g, vitamin E 6.3g.Soft capsule peel color and luster is orange, and content color and luster is orange, viscous liquid, free from admixture, has distinctive taste smell, free from extraneous odour.
Coenzyme Q 10 soft capsule of the present invention, a certain amount of natural VE is added in Co-Q10, the side effect of Co-Q10 can be overcome, improve its nutrition health-care functions, and be aided with soybean oil and beeswax makes capsule, such that product quality is more stable, taking convenience, and it is safe and effective, can long-term taking, be the health food that hypoimmunity crowd is desirable, can fatigue symptom be improved.And production technology is simple, energy consumption is low, and Co-Q10 is uniformly dispersed, and is beneficial to absorption of human body, good product quality, safety non-toxic, no solvent residue.
Detailed description of the invention
The following detailed description of the preferred technical solution of the present invention.
Embodiment one
Formula: described raw material comprises Co-Q10 47g, natural VE 38g, and described auxiliary material comprises beeswax 9g, soybean oil 308g, and described flexible glue utricule comprises gelatin 985g, glycerine 48g, purified water 98g, sunset yellow 0.22g, titanium dioxide 0.33g.
Each supplementary material is made 1000 (about 0.4g/ grains) altogether above.
Embodiment two
Formula: described raw material comprises Co-Q10 53g, natural VE 32g, and described auxiliary material comprises beeswax 11g, soybean oil 302g, and described flexible glue utricule comprises gelatin 9102g, glycerine 42g, purified water 102g, sunset yellow 0.28g, titanium dioxide 0.27g.
Each supplementary material is made 1000 (about 0.4g/ grains) altogether above.
Embodiment three
Formula: described raw material comprises Co-Q10 50g, natural VE 36g, and described auxiliary material comprises beeswax 10g, soybean oil 304g, and described flexible glue utricule comprises gelatin 100g, glycerine 45g, purified water 100g, sunset yellow 0.25g, titanium dioxide 0.3g.
Each supplementary material is made 1000 (about 0.4g/ grains) altogether above.
A preparation method for coenzyme Q 10 soft capsule, comprises the following steps:
1) raw material is got: get in proportion and meet standard, all kinds of raw materials through being up to the standards, comprise Co-Q10, natural VE, soybean oil, beeswax, gelatin, glycerine, purified water, titanium dioxide, sunset yellow;
2) feeding: after each supplementary material removes external packing, inner packing enters 100,000 grades of clean areas by logistics corridor;
3) pulverize, sieve, weigh: Co-Q10 is pulverized, cross 100 mesh sieves, obtain fine powder, for subsequent use;
4) weigh: weigh Co-Q10, natural VE, soybean oil, beeswax, gelatin, glycerine, purified water, titanium dioxide, sunset yellow by formula rate;
5) preparation of content feed liquid: the beeswax taken, soybean oil are heated to 60-80 DEG C, after beeswax melting, be cooled to 30-50 DEG C, obtain oily wax liquid, by natural VE and the mixing of oily wax liquid, obtain mixed liquor, stir Co-Q10 fine powder and mixed liquor to obtain content feed liquid;
6) glue preparation: by glycerine, purified water, titanium dioxide, sunset yellow mixing, add gelatin when being heated to 68-75 DEG C, stir, vacuumize, use 100 mesh screen, leave standstill, be incubated at 55-60 DEG C, obtain glue;
7) pelleting: content feed liquid and the glue configured are pressed into soft capsule, temperature 18-26 DEG C, relative humidity 45%-50%, obtain soft capsule;
8) rotating cage is dry: shape dry 10-18h, drying room temperature 22-28 DEG C, humidity <30%;
9) ball is picked: remove substandard product;
10) ball is washed: the ethanol purge soft capsule adding 95% food-grade, washes away soft capsule surface and oil contaminant;
11) dry: temperature 25 DEG C-30 DEG C, humidity 35%, time 1h-2h;
12) inner packing: 60/bottle;
13) external packing;
14) check;
15) put in storage.
Coenzyme Q 10 soft capsule of the present invention, a certain amount of natural VE is added in Co-Q10, the side effect of Co-Q10 can be overcome, improve its nutrition health-care functions, and be aided with soybean oil and beeswax makes capsule, such that product quality is more stable, taking convenience, and it is safe and effective, can long-term taking, be the health food that hypoimmunity crowd is desirable, can fatigue symptom be improved.And production technology is simple, energy consumption is low, and Co-Q10 is uniformly dispersed, and is beneficial to absorption of human body, good product quality, safety non-toxic, no solvent residue.
Co-Q10 is a kind of fat-soluble antioxidant, it is one of indispensable important element of human life, the nutrition of energy human activin cell and cellular energy, have improve body immunity, strengthen anti-oxidant, delay senility and strengthen the functions such as human activity, medically be widely used in disease of cardiovascular system, extensively use it for nutrient and healthcare products and food additives both at home and abroad.Co-Q10 is found in the U.S. early than nineteen fifty-seven, the same year Univ Edinburgh UK Peter doctor Mike because of research Co-Q10 and cell energy relation in contribution obtain the Nobel Prize.Oral easy absorption, Wistar system male white rat and rabbit per os give the Co-Q10 of 0.6mg/Kg, reach the highest blood concentration respectively after 1 hour and 2 hours, in blood mouse urine, 1.9% is discharged afterwards in Bipolar, discharge 85% in excrement, in Urine of Rabbits, discharge 2.9%, in excrement, discharge 91%.
Natural VE is a kind of liposoluble vitamin, also known as tocopherol, is one of topmost antioxidant.Can human metabolism be promoted, strengthen body endurance, improve immunity.In addition, vitamin e is a kind of high-efficiency antioxidant agent, and biomembrane can be protected to avoid suffering the infringement of peroxide, plays and improves skin blood circulation, the effect strengthening skin cell vitality and delay senility.Lack it, the adverse consequences such as skin is dry, coarse, overaging can be produced.The vitamin e quantity delivered of adult is 15 milligrams/day.Vitamin E is a kind of liposoluble vitamin be extensively present in natural animal-plant, to sour and thermally-stabilised, when there being oxygen to exist, being heated to 200 DEG C and still can keeping stable.And vitamin E has different physiological roles, be also one of needed by human vitamin.
Vitamin E is positioned on cell membrane; belong to fat-soluble chain rupture type antioxidant; it provides hydrogen ion to fat oxygen radical; make lipid peroxidation chain interruption; antioxidant system together with superoxide dismutase, glutathione peroxidase in constituting body, Cell protection film and intracellular nucleic acid are from the attack of free radical.In addition, vitamin E Hai Neng temper goes out singlet oxygen, improves the oxidation resistance of solvent naphtha.In formula of the present invention, add vitamin E as auxiliary material, can the Oxidative inactivation of available protecting Co-Q10.And natural VE is formed by Hydrolysis kinetics in natural plants, higher compared to synthesising complex E security, natural VE absorbs high 3.5 times than composite, and the half-life is longer, and physiologically active is about 3-8 times of composite.Thus the present invention selects natural VE as the major auxiliary burden added.
Because Co-Q10 can not dissolve completely in soybean oil, the slow sedimentation layering of meeting in production and old storage process, therefore need to add suspending agent wherein and prepare the suspension had good stability, ensure the suspension ability of product, prevent soft capsule before encapsulated, the sedimentation of solids in suspension in encapsulated process and after encapsulated, ensure the accurate of loading amount.Conventional oiliness suspending agent has wax lipid, lecithin, aluminum monostearate etc., and wherein beeswax is by affecting system viscosity and rheological property, and every stability indicator is changed.Lecithin, as surfactant, plays a role to redispersibility and change of size.Aluminum monostearate is a kind of thixotrope, is formed stablize thixotroping system when consumption 2% in vegetable oil.But consider the economic, practical of raw material and safety, the use of beeswax is the most extensive.Beeswax is the wax of honeybee secretion, and honeycomb is through getting rid of or a kind of organic mixture obtained after centrifugal segregation honey.Concentration of beeswax is larger, and plastic yield is larger, and the time starting to occur sedimentation more extends, and sinking speed is less, meets stokes formula.But concentration of beeswax is excessive, can cause product poor fluidity, the main component of beeswax is palmitic acid beeswax alcohol ester, simultaneously containing a small amount of free polyols, thus has certain emulsibility, and reduce surface tension, this also can make the sinking speed of suspension slow down.
Coenzyme Q 10 soft capsule of the present invention, has the health care of develop immunitypty, the low person of appropriate immune power, and instructions of taking and dose are oral, every day 1 time, and each 1, specification is 0.4g/ grain.Its significant composition is that every 100g contains Co-Q10 >=6.125g, vitamin E 3.15-11.34g, and general every 100g is containing Co-Q10 12.25g, vitamin E 6.3g.Soft capsule peel color and luster is orange, and content color and luster is orange, viscous liquid, free from admixture, has distinctive taste smell, free from extraneous odour.
Claims (4)
1. a coenzyme Q 10 soft capsule, it is characterized in that: the content comprising flexible glue utricule and enclose in this flexible glue utricule, described content comprises stock and adjunct, described raw material comprises component Co-Q10 45-55 part of following weight portion, natural VE 30-40 part, described auxiliary material comprises component beeswax 8-12 part of following weight portion, soybean oil 300-310 part, described flexible glue utricule comprises component gelatin 95-105 part of following weight portion, glycerine 40-50 part, purified water 95-105 part, sunset yellow 0.2-0.3 part, titanium dioxide 0.25-0.35 part.
2. a kind of coenzyme Q 10 soft capsule as claimed in claim 1, it is characterized in that: described raw material comprises the component Co-Q10 50 parts of following weight portion, natural VE 36 parts, described auxiliary material comprises 10 parts, the component beeswax of following weight portion, soybean oil 304 parts, and described flexible glue utricule comprises 100 parts, the component gelatin of following weight portion, glycerine 45 parts, purified water 100 parts, sunset yellow 0.25 part, titanium dioxide 0.3 part.
3. a kind of coenzyme Q 10 soft capsule as claimed in claim 1, is characterized in that: described Co-Q10 is the high-load Co-Q10 of 98%, and the d-alpha-tocopherol content of described natural VE is 70%.
4. a preparation method for coenzyme Q 10 soft capsule, is characterized in that comprising the following steps:
1) raw material is got: get in proportion and meet standard, all kinds of raw materials through being up to the standards, comprise Co-Q10, natural VE, soybean oil, beeswax, gelatin, glycerine, purified water, titanium dioxide, sunset yellow;
2) feeding: after each supplementary material removes external packing, inner packing enters 100,000 grades of clean areas by logistics corridor;
3) pulverize, sieve, weigh: Co-Q10 is pulverized, cross 100 mesh sieves, obtain fine powder, for subsequent use;
4) weigh: weigh Co-Q10, natural VE, soybean oil, beeswax, gelatin, glycerine, purified water, titanium dioxide, sunset yellow by formula rate;
5) preparation of content feed liquid: the beeswax taken, soybean oil are heated to 60-80 DEG C, after beeswax melting, be cooled to 30-50 DEG C, obtain oily wax liquid, by natural VE and the mixing of oily wax liquid, obtain mixed liquor, stir Co-Q10 fine powder and mixed liquor to obtain content feed liquid;
6) glue preparation: by glycerine, purified water, titanium dioxide, sunset yellow mixing, add gelatin when being heated to 68-75 DEG C, stir, vacuumize, use 100 mesh screen, leave standstill, be incubated at 55-60 DEG C, obtain glue;
7) pelleting: content feed liquid and the glue configured are pressed into soft capsule, temperature 18-26 DEG C, relative humidity 45%-50%, obtain soft capsule;
8) rotating cage is dry: shape dry 10-18h, drying room temperature 22-28 DEG C, humidity <30%;
9) ball is picked: remove substandard product;
10) ball is washed: the ethanol purge soft capsule adding 95% food-grade, washes away soft capsule surface and oil contaminant;
11) dry: temperature 25 DEG C-30 DEG C, humidity 35%, time 1h-2h;
12) inner packing: 60/bottle;
13) external packing;
14) check;
15) put in storage.
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| CN105124590A (en) * | 2015-09-23 | 2015-12-09 | 威海紫光金奥力生物技术有限公司 | Coenzyme Q10 soft capsule for enhancing immunity |
| CN106389375A (en) * | 2016-08-18 | 2017-02-15 | 安士生物科技（中山）有限公司 | A coenzyme Q<10> soft capsule preventing oxidation and relieving physical fatigue and a preparing method thereof |
| CN106562937A (en) * | 2016-10-20 | 2017-04-19 | 山东健康源生物工程有限公司 | Coenzyme Q10 soft capsule and preparation method thereof |
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| CN114009762A (en) * | 2021-11-01 | 2022-02-08 | 欣安贝药业科技盐城有限公司 | Coenzyme Q10 soft capsule for enhancing immunity and preparation method thereof |
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| CN105124590A (en) * | 2015-09-23 | 2015-12-09 | 威海紫光金奥力生物技术有限公司 | Coenzyme Q10 soft capsule for enhancing immunity |
| CN106389375A (en) * | 2016-08-18 | 2017-02-15 | 安士生物科技（中山）有限公司 | A coenzyme Q<10> soft capsule preventing oxidation and relieving physical fatigue and a preparing method thereof |
| CN106562937A (en) * | 2016-10-20 | 2017-04-19 | 山东健康源生物工程有限公司 | Coenzyme Q10 soft capsule and preparation method thereof |
| CN108175102A (en) * | 2017-11-28 | 2018-06-19 | 芜湖市诺康生物科技有限公司 | A kind of preparation method of cod liver oil soft capsule |
| CN109394725A (en) * | 2018-12-05 | 2019-03-01 | 天津铸源健康科技集团有限公司 | A kind of ubiquinone10Soft capsule and preparation method thereof |
| CN109497562A (en) * | 2018-12-26 | 2019-03-22 | 广东润源中天生物科技有限公司 | A kind of selenium-rich vitamin E soft capsule and preparation method thereof |
| CN110367494A (en) * | 2019-08-23 | 2019-10-25 | 北京嘉酿科技有限公司 | A kind of Co-Q10 honey synthesis technology |
| CN111297821A (en) * | 2019-12-20 | 2020-06-19 | 康道生物（南通）有限公司 | Coenzyme Q10 capsule and preparation process thereof |
| CN114009762A (en) * | 2021-11-01 | 2022-02-08 | 欣安贝药业科技盐城有限公司 | Coenzyme Q10 soft capsule for enhancing immunity and preparation method thereof |
| CN114191407A (en) * | 2021-12-17 | 2022-03-18 | 宣城柏维力生物工程有限公司 | Quick sleep-aiding type quick-melting dropping pill and preparation method thereof |
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