CN108175102A - A kind of preparation method of cod liver oil soft capsule - Google Patents
A kind of preparation method of cod liver oil soft capsule Download PDFInfo
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- CN108175102A CN108175102A CN201711212074.1A CN201711212074A CN108175102A CN 108175102 A CN108175102 A CN 108175102A CN 201711212074 A CN201711212074 A CN 201711212074A CN 108175102 A CN108175102 A CN 108175102A
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- liver oil
- soft capsule
- preparation
- cod
- cod liver
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- 239000003026 cod liver oil Substances 0.000 title claims abstract description 45
- 235000012716 cod liver oil Nutrition 0.000 title claims abstract description 45
- 239000007901 soft capsule Substances 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 239000003292 glue Substances 0.000 claims abstract description 15
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 14
- 235000021323 fish oil Nutrition 0.000 claims abstract description 11
- 108010010803 Gelatin Proteins 0.000 claims abstract description 10
- 239000008273 gelatin Substances 0.000 claims abstract description 10
- 229920000159 gelatin Polymers 0.000 claims abstract description 10
- 235000019322 gelatine Nutrition 0.000 claims abstract description 10
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 8
- 235000019501 Lemon oil Nutrition 0.000 claims abstract description 8
- 239000010501 lemon oil Substances 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 7
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000008213 purified water Substances 0.000 claims abstract description 7
- 239000011709 vitamin E Substances 0.000 claims abstract description 7
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 7
- 229940046009 vitamin E Drugs 0.000 claims abstract description 7
- 235000011187 glycerol Nutrition 0.000 claims abstract description 4
- 238000012856 packing Methods 0.000 claims description 20
- 239000007788 liquid Substances 0.000 claims description 10
- 238000004806 packaging method and process Methods 0.000 claims description 7
- 239000002775 capsule Substances 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
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- 238000003304 gavage Methods 0.000 description 5
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- 241000276435 Gadus Species 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 3
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 3
- 229930003316 Vitamin D Natural products 0.000 description 3
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 3
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 235000019197 fats Nutrition 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 235000019155 vitamin A Nutrition 0.000 description 3
- 239000011719 vitamin A Substances 0.000 description 3
- 235000019166 vitamin D Nutrition 0.000 description 3
- 239000011710 vitamin D Substances 0.000 description 3
- 150000003710 vitamin D derivatives Chemical class 0.000 description 3
- 229940045997 vitamin a Drugs 0.000 description 3
- 229940046008 vitamin d Drugs 0.000 description 3
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 208000005374 Poisoning Diseases 0.000 description 2
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
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- 239000008280 blood Substances 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
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- 235000019198 oils Nutrition 0.000 description 2
- 231100000572 poisoning Toxicity 0.000 description 2
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- 210000002966 serum Anatomy 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 229940031439 squalene Drugs 0.000 description 2
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 2
- 238000010257 thawing Methods 0.000 description 2
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- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
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- 206010018910 Haemolysis Diseases 0.000 description 1
- 108010006464 Hemolysin Proteins Proteins 0.000 description 1
- 206010019842 Hepatomegaly Diseases 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 235000019568 aromas Nutrition 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 238000010241 blood sampling Methods 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 239000003518 caustics Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 235000020669 docosahexaenoic acid Nutrition 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 235000020673 eicosapentaenoic acid Nutrition 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
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- 239000000194 fatty acid Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 239000003228 hemolysin Substances 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 231100000682 maximum tolerated dose Toxicity 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 238000003305 oral gavage Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000008279 sol Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 235000021081 unsaturated fats Nutrition 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Botany (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a kind of formulas of cod liver oil soft capsule, are related to medicines and health protection food technology field, containing following component：300 500 parts by weight of cod-liver oil, 30 60 parts by weight of tunny fish oil, 10 30 parts by weight of lemon oil, 150 300 parts by weight of gelatin, 5 10 parts by weight of vitamin E, 50 100 parts by weight of glycerine, 100 250 parts by weight of purified water.In addition, the preparation method the invention also discloses the cod liver oil soft capsule.Cod liver oil soft capsule provided by the invention has remarkable result to immunocompromised person, and whole collinear processing, avoid because fish oil it is unstable caused by nutrition leak, entire preparation process completes in certain clean area, it ensure that the cleaning of working environment, reduce influence of the environment to content and glue to the greatest extent.
Description
Technical field
The present invention relates to medicines and health protection food technology fields, and in particular to a kind of preparation method of cod liver oil soft capsule.
Background technology
Gadus belongs to cold aqueous demersal fishes, one of marine economy fish produced for Northern Coastal Region.Its meat is white thin fresh and tender,
It is tasty and refreshing oiliness, many national using gadus as main edible fishes in the world.In Northern Europe, gadus is referred to as the " nutrition on dining table
Teacher " in addition to fresh food, is also processed into various aquatic foods, in addition gadus hepatomegaly and oil content height, rich in vitamin A and D, is
Extract the raw material of cod-liver oil.Also containing DHA, DPA, ARA necessary to human brain, eye development.Therefore, cod-liver oil becomes
Superfine product in cod-liver oil is known as " liquid golden ", and there is active ingredients for cod liver oil soft capsule kind currently on the market
Oxidizable rotten and content and ratio are unstable；The soft capsule term of validity is short, softgel shell easily hardens or softens the shortcomings of rotten.
Chinese Patent Application No. 201310241616.3 discloses a kind of cod liver oil soft capsule and preparation method thereof, special
Sign is to contain cod-liver oil 450-540g, natural VE 0.45-0.55g in the soft capsule of every 1000.To ensure microorganism
Index meets the requirements, and is completed in 100,000 grades of clean area from weighing, colloidal sol, dispensing, pelleting, sizing, drying.Through long-term steady
Qualitative test shows that the product are stablized in the term of validity 2 years, and active ingredient point content, microbiological indicator, character etc. meet regulation,
Soft capsule shell does not harden phenomena such as rotten.The invention shows that this product is fed for 30 days through safety experiment and has no bright to rat
Aobvious toxic side effect；Enhanced immunity function experiment shows that this product has the function of strengthen immunity.But supplementary material is relatively simple,
Reached nutritive validity is also not comprehensive enough.
Chinese Patent Application No. 201210262527.2 discloses a kind of skate liver oil and preparation method thereof, and feature exists
In：It is 0.76~1.13% (quality) that made cod-liver oil, which includes alkoxyglycerol content, and squalene content is 0.71~0.92%
(quality), EPA and DHA content are 25~28% (quality), and vitamin A content is 1200~1600IU/g, and vitamin D content is
120~150IU/g, other materials are lipid.Production stage is after ray fish liver is freezed defrosting again, chopping is carried out at enzymolysis
It manages, destroy the enzyme treatment is carried out, then centrifuge after enzymolysis, emulsion centrifuges again after freezing defrosting demulsification, Ran Houjing
Refining, using citric acid degumming, caustic soda-soda ash mixture (mass ratio 2:1) depickling, vacuum nitrogen filling packet after last low-temperature treatment
Dress.Invented technology operation is reasonable, and at low cost, mild condition, gained cod-liver oil peroxide value and acid value are very low, no nutrition stream
It loses, rich in vitamin A, vitamin D, EPA, DHA and most important squalene and alkoxyglycerol etc., enriched health care acts on,
It vacuumizes and rushes nitrogen packaging, be easy to preservation and market circulation.But manufacture craft is more complicated, raw material are not easy.
Invention content
The purpose of the present invention is to provide a kind of preparation method of cod liver oil soft capsule, to solve to cause in the prior art
Drawbacks described above.
The present invention is achieved through the following technical solutions, a kind of formula of cod liver oil soft capsule, by weight, packet
It includes：
Preferably, a kind of formula of cod liver oil soft capsule, by weight, including：
A kind of preparation method of cod liver oil soft capsule, includes the following steps：
(1) take meet the related request of company standard through examine qualified cod-liver oil, tunny fish oil, lemon oil, gelatin,
Supplementary material is removed outer packing by vitamin E, glycerine, purified water, and inner packing is by entering clean area between buffering；
(2) preparation of content feed liquid：By recipe ratio by cod-liver oil, tunny fish oil, lemon oil and vitamin E with stirring
Machine mixing 15-30min is mixed, obtains content feed liquid；
(3) preparation of glue：Gelatin, purified water mixing are weighed by formula rate, 55-75 DEG C of addition gelatin is heated to, stirs
It mixes, changes glue, vacuumize, filter (100 mesh), stand, heat preservation obtains glue；
(4) pelleting：Content feed liquid and glue are pressed into soft capsule, obtain the capsule of 0.5g-0.8g/；
(5) it shapes, is dry：Condition is respectively the time for 2-5h, 15-28 DEG C of temperature, relative humidity 25%-45%；Time
For 10-24h, 20-30 DEG C of temperature, relative humidity 20%-40%；
(6) it selects ball, wash ball：It is exactly to reject underproof product to select ball, and washes the greasy dirt that ball washes away soft capsule surface；
(7) redrying：Condition be time 1-2h, 20-25 DEG C of temperature, relative humidity 35%-55%；
(8) packaging, quality inspection, storage.
Preferably, holding temperature is 55-60 DEG C in the step (3).
Preferably, the condition of pelleting is 18-26 DEG C of temperature in the step (4), relative humidity 45%-55%.
Preferably, step (8) packaging is divided into inner packing and outer packing.
Preferably, the inner packing material therefor packing timber for meeting the medicinal polyester bottles of YBB00262002 oral administration solids
Material bottling；The outer packing packed in cases for meeting GB/T6543 single and double corrugated boxes for transport packages.
Using above technical scheme, compared with prior art, the present invention has the following advantages：
1st, the effective ingredient of cod-liver oil can improve the concentration of serum immunoglobulin IgG, IgM, enhance the clear of respiratory tract
It removes, swallow defense function, so as to enhance the premunition of body and respiratory system；The basis of tunny fish oil is Omega-3 systems
Row unsaturated fat EPA and DHA.EPA has reduction blood viscosity, dissolves fat extra in vascular wall, reduces triglyceride
And cholesterol (LDL) concentration, have the function that clear up thrombus, reduce blood fat, prevention and improve cardiovascular and cerebrovascular disease；Lemon oil master
It is that ramie is dilute to want ingredient, has strong citris aromas, increases the appetite of eater；Cod-liver oil contains abundant ω -3 fat
Acid due to the easy oxidation deterioration of omega-fatty acid, adds in vitamin E and carries out antioxidation.
2nd, the whole collinear processing of the present invention, avoid because fish oil it is unstable caused by nutrition leak, entire preparation process
It completes in the certain clean area of word, ensure that the cleaning of working environment, reduce environment to the greatest extent to content and glue
It influences.
Specific embodiment
To make the technical means, creative features, achievement of purpose and effectiveness of the invention easy to understand, with reference to specific
Embodiment, the present invention is further explained.
Embodiment 1
A kind of formula of cod liver oil soft capsule, by weight：
Embodiment 2
A kind of formula of cod liver oil soft capsule, by weight：
Embodiment 3
A kind of formula of cod liver oil soft capsule, by weight：
Embodiment 4
A kind of formula of cod liver oil soft capsule, by weight：
Embodiment 5
A kind of formula of cod liver oil soft capsule, by weight：
It is worth noting that, in embodiment 1-5, the preparation method of making cod liver oil soft capsule described above, packet
Include following steps：
(1) take meet the related request of company standard through examine qualified cod-liver oil, tunny fish oil, lemon oil, gelatin,
Supplementary material is removed outer packing by vitamin E, glycerine, purified water, and inner packing is by entering clean area between buffering；
(2) preparation of content feed liquid：By recipe ratio by cod-liver oil, tunny fish oil, lemon oil and vitamin E with stirring
Machine mixing 20min is mixed, obtains content feed liquid；
(3) preparation of glue：Gelatin, purified water mixing are weighed by formula rate, 60 DEG C of addition gelatin is heated to, stirs,
Change glue, vacuumize, filter (100 mesh), stand, heat preservation obtains glue；
(4) pelleting：Content feed liquid and glue are pressed into soft capsule, obtain the capsule of 0.5g/；
(5) it shapes, is dry：Condition is respectively the time for 4h, 25 DEG C of temperature, relative humidity 35%；Time is 12h, temperature
24 DEG C, relative humidity 30%；
(6) it selects ball, wash ball：It is exactly to reject underproof product to select ball, and washes the greasy dirt that ball washes away soft capsule surface；
(7) redrying：Condition be time 2h, 25 DEG C of temperature, relative humidity 45%；
(8) packaging, quality inspection, storage.
In addition, holding temperature is 55 DEG C in the step (3).In the step (4) condition of pelleting be 25 DEG C of temperature, phase
It is 50% to humidity.Step (8) packaging is divided into inner packing and outer packing.The inner packing material therefor is with meeting
The packaging material bottling of the medicinal polyester bottles of YBB00262002 oral administration solids；The outer packing is with meeting GB/T6543 transportation and packing
With the packed in cases of single corrugated case and double corrugated cases.
Acute toxicity test in mice：
Using maximum tolerated dose method, the Kunming mouse 20 that weight is 18-22g, half male and half female are selected.Take the present invention
Cod liver oil soft capsule content 50g adds 1% sodium carboxymethylcellulose to 100mL.Be spaced in one day to mouse 4 hours it is oral
Gavage 2 times, each gavage volume are 0.2mL/10g.bw, intergal dose 20.00g/kg.bw.Fasting 16 is small before gavage for the first time
When, it is observed continuously two weeks after gavage, records poisoning manifestations and death condition.Experimental result is as follows：
| Gender | Number of animals (only) | Approach | Dosage (g/kg.bw) | Death toll (only) | MTD(g/kg.bw) |
| It is female | 10 | Orally | 20 | 0 | >20.00 |
| It is male | 10 | Orally | 20 | 0 | >20.00 |
With the cod liver oil soft capsule content of the inventive samples of 20.00g/kg.bw dosage to the Kunming of two kinds of genders
Apparent poisoning symptom is had no after kind intragastric administration on mice, observes death in 14 days five.Animal subject execution is carried out solution dissect by the observation end of term
It looks into, the main organs such as liver,spleen,kidney, stomach, intestines, the heart, lung show no obvious abnormalities change.Illustrate cod-liver oil capsule of the present invention to elder brother
Bright kind of mouse male and female mouse maximal tolerance dose is more than 20.00g/kg.bw, belongs to nontoxic grade.
Cod liver oil soft capsule obtained by embodiment 1-5 and control group (nutrient solution) are subjected to measure of merit, test event
It is as follows：By the female sex-health ICR mouse of weight 20-25g 60, it is randomly divided into 6 groups, every group 10.By embodiment 1-5 and control group
This six groups of mouse of gavage respectively；Water is added to be configured to required concentration capsule 's content used in experiment, daily by the amount of 20mL/kg point
Other gavage is primary, and blank control group gives equivalent nutrient solution, and for successive administration after 20 days, cervical dislocation puts to death mouse, extracts eye
Ball blood sampling is characterized for the measure of serum hemolysin with antibody product；After spleen is taken to weigh, a part is used for antibody tormation
Test cell line is characterized with hemolysis plaque number, another part for ConA inductions mouse lymphocyte conversion test and small
Mouse NK cytoactive detections are characterized respectively with OD value (OD values) and NK cell activity.As a result it is as follows：
By experimental result it is found that the present invention can significantly improve the immunity of mouse.
In conclusion cod liver oil soft capsule provided by the invention has immunocompromised person remarkable result, and whole
Collinear processing, avoid because fish oil it is unstable caused by nutrition leak, entire preparation process completes in certain clean area,
It ensure that the cleaning of working environment, reduce influence of the environment to content and glue to the greatest extent.
As known by the technical knowledge, the present invention can pass through the embodiment party of other essence without departing from its spirit or essential feature
Case is realized.Therefore, embodiment disclosed above, all things considered are all merely illustrative, not the only.Institute
Have within the scope of the present invention or be included in the invention in the change being equal in the scope of the present invention.
Claims (7)
1. a kind of formula of cod liver oil soft capsule, which is characterized in that by weight, including：
2. a kind of formula of cod liver oil soft capsule according to claim 1, which is characterized in that by weight, including：
3. according to the preparation method of claim 1-2 any one of them cod liver oil soft capsules, which is characterized in that including as follows
Step：
(1) related request for meeting company standard is taken through qualified cod-liver oil, tunny fish oil, lemon oil, gelatin, dimension is examined to give birth to
Supplementary material is removed outer packing by plain E, glycerine, purified water, and inner packing is by entering clean area between buffering；
(2) preparation of content feed liquid：By recipe ratio by cod-liver oil, tunny fish oil, lemon oil and vitamin E blender
15-30min is mixed, obtains content feed liquid；
(3) preparation of glue：Gelatin, purified water mixing are weighed by formula rate, 55-75 DEG C of addition gelatin is heated to, stirs, change
Glue vacuumizes, and filters (100 mesh), stands, and heat preservation obtains glue；
(4) pelleting：Content feed liquid and glue are pressed into soft capsule, obtain the capsule of 0.5g-0.8g/；
(5) it shapes, is dry：Condition is respectively the time for 2-5h, 15-28 DEG C of temperature, relative humidity 25%-45%；Time is 10-
For 24 hours, 20-30 DEG C of temperature, relative humidity 20%-40%；
(6) it selects ball, wash ball：It is exactly to reject underproof product to select ball, and washes the greasy dirt that ball washes away soft capsule surface；
(7) redrying：Condition be time 1-2h, 20-25 DEG C of temperature, relative humidity 35%-55%；
(8) packaging, quality inspection, storage.
4. a kind of preparation method of cod liver oil soft capsule according to claim 3, it is characterised in that：The step (3)
Middle holding temperature is 55-60 DEG C.
5. a kind of preparation method of cod liver oil soft capsule according to claim 3, it is characterised in that：The step (4)
The condition of middle pelleting be 18-26 DEG C of temperature, relative humidity 45%-55%.
6. a kind of preparation method of cod liver oil soft capsule according to claim 3, it is characterised in that：The step (8)
Packaging is divided into inner packing and outer packing.
7. a kind of preparation method of cod liver oil soft capsule according to claim 6, it is characterised in that：The inner packing institute
It is bottled with material with the packaging material for meeting the medicinal polyester bottles of YBB00262002 oral administration solids；The outer packing is with meeting GB/
The packed in cases of T6543 single and double corrugated boxes for transport packages.
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| CN201711212074.1A CN108175102A (en) | 2017-11-28 | 2017-11-28 | A kind of preparation method of cod liver oil soft capsule |
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| CN109259235A (en) * | 2018-08-31 | 2019-01-25 | 安徽济生元药业有限公司 | A kind of improvement eyesight promotes brain development cod liver oil soft capsule |
| CN109528677A (en) * | 2019-01-08 | 2019-03-29 | 广东海洋大学 | A kind of shark-liver oil softgel and its production method |
| CN112890197A (en) * | 2021-03-10 | 2021-06-04 | 湖南文理学院 | Fish oil product with health promotion effect |
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