CN107361324A - A kind of cod liver oil soft capsule and preparation method thereof - Google Patents
A kind of cod liver oil soft capsule and preparation method thereof Download PDFInfo
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- CN107361324A CN107361324A CN201710553723.8A CN201710553723A CN107361324A CN 107361324 A CN107361324 A CN 107361324A CN 201710553723 A CN201710553723 A CN 201710553723A CN 107361324 A CN107361324 A CN 107361324A
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- liver oil
- cod
- cod liver
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- 235000012716 cod liver oil Nutrition 0.000 title claims abstract description 128
- 239000003026 cod liver oil Substances 0.000 title claims abstract description 128
- 239000007901 soft capsule Substances 0.000 title claims abstract description 128
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 239000002775 capsule Substances 0.000 claims abstract description 56
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 50
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 50
- 239000002994 raw material Substances 0.000 claims abstract description 33
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
- A23L17/20—Fish extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/60—Fish, e.g. seahorses; Fish eggs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention belongs to health product technology field, and in particular to a kind of cod liver oil soft capsule and preparation method thereof.Cod liver oil soft capsule provided by the invention, it is made up of capsule skin and the content enclosed in capsule skin, content includes the raw material of following weight in every 1000 cod liver oil soft capsules：The 520g of cod-liver oil 480, the 1.5g of vitamin E 0.5；Capsule skin includes the raw material of following weight in every 1000 cod liver oil soft capsules：The 250g of gelatin 230, the 120g of glycerine 105, the 350g of purified water 320.Cod liver oil soft capsule provided by the invention can effectively reduce fishlike smell; easily received by crowd; it is easy to store easy for carrying and eating; easily absorb; and do not influence the absorption to other nutrition; product quality is stable, shelf lives length, has enhancing development, protection eyesight, promotes a variety of effects such as calcium uptake, strengthen immunity, enhancing memory.
Description
Technical field
The invention belongs to health product technology field, and in particular to a kind of cod liver oil soft capsule and preparation method thereof.
Background technology
Cod, category vertebrate, Vertebrate, teleost guiding principle, cod mesh.Cod is mostly to live in ocean bottom
With the cold water fishes of lower floor in deep-sea, each ocean in the world are widely distributed in.Moisture is 45.1% in cod liver, albumen
Matter content is 3.2%, content of ashes 0.9%, and fat content reaches 50.8%, and unrighted acid accounts for total fatty acid content
84.1%, wherein EPA content reaches 25.2%, DHA content 7.6%, has higher nutritive value and medical value.
In recent years, with the development of China's Foreign Trade, there are a large amount of cod imports, the output and processing capacity of cod are increasingly
Expand, producing and generating substantial amounts of accessory substance, including fish head, steck, fish-skin and internal organ etc., these by-products in process
Thing is largely directly processed into the relatively low fish meal of economic value, does not obtain high-valued utilization.Cod liver is cod
The Main By product of processing, the serial polyunsaturated fatty acids of more ω -3 are contained in cod-liver oil, and contain abundant dimension life
Plain A and vitamin D.Numerous studies show, the serial polyunsaturated fatty acids of ω -3, in platelet aggregation-against, anti arteriosclerosis, suppression
Tumour growth processed, improve brain function and retinal function etc. there is good physiological function.
Chinese patent CN102488718B discloses a kind of fish oil soft capsule, including content and capsule material, content include
The raw material of following parts by weight：30 parts -50 parts of deep sea fish oil, 20 parts -50 parts of vegetable oil, deep sea fish oil are tunny fish oil, cod oil
With any of shark oil deep sea fish oil or the two or more mixtures mixed in any proportion；Vegetable oil is algae oil, purple
Any of perilla oil and pine-seed oil vegetable oil or the two or more mixtures mixed in any proportion；Institute in deep sea fish oil
The percentage by weight of contained docosahexaenoic acid is more than 40% in the docosahexaenoic acid and algae oil that contain.
Chinese patent CN103656098B discloses a kind of composite fish oil soft capsule and preparation method thereof, and it is by soft capsule
Content composition in body and soft capsule, feature are：By weight percentage weigh fish oil 38%~62%, vitamin E 3%~
5%th, grape seed extract 4%~8%, ginkgo biloba p.e 6%~10%, garlic oil 15%~25%, the and of beeswax 5%~7%
Lecithin 5%~7%, mix, grind, degassing, obtaining content；By 100:100:40 ratios weigh gelatin, water, glycerine, heating
Material, degassing, obtained capsule body filtrate；By capsule body filtrate and content by weight：1:2~4 ratio is sent into pelleting
Pelleting in machine, then dry through sizing, wash ball, choosing is picked, packed, get product.
Because fish oil has a bad smell, it is heavier fishlike smell to be present in existing fish oil soft capsule, is not easy from the sense of taste by people
The problems such as group receives.
The content of the invention
In view of the shortcomings of the prior art, it is an object of the invention to provide a kind of cod liver oil soft capsule and its preparation side
Method.Cod liver oil soft capsule provided by the invention can effectively reduce fishlike smell, easily received by the crowd of more than 1 years old, be easy to
Easy for carrying and eating, easily absorption, and do not influence the absorption to other nutrition is stored, product quality stabilization, shelf lives length, is contained
Have the nutriments such as DHA and EPA, can effectively replenishing vitamins A and vitamin D, there is enhancing development, protection eyesight, promote
Enter a variety of effects such as calcium uptake, strengthen immunity, enhancing memory.
The technical scheme is that：
A kind of cod liver oil soft capsule, it is made up of capsule skin and the content enclosed in capsule skin, every 1000 cods
Content includes the raw material of following weight in liver oil soft capsule：Cod-liver oil 480-520g, vitamin E 0.5-1.5g；Every 1000
Capsule skin includes the raw material of following weight in grain cod liver oil soft capsule：Gelatin 230-250g, glycerine 105-120g, purified water
320-350g。
Preferably, the cod liver oil soft capsule, content includes following weight in every 1000 cod liver oil soft capsules
Raw material：Cod-liver oil 499g, vitamin E 1g；Capsule skin includes the original of following weight in every 1000 cod liver oil soft capsules
Material：Gelatin 245g, glycerine 115g, purified water 330g.
Preferably, the cod liver oil soft capsule, content also includes following heavy in every 1000 cod liver oil soft capsules
The raw material of amount：Raspberry seed oil 10-16g, compound additive 0.2-0.5g.
Preferably, the cod liver oil soft capsule, content includes following weight in every 1000 cod liver oil soft capsules
Raw material：Cod-liver oil 499g, raspberry seed oil 12g, vitamin E 1g, compound additive 0.3g；Every 1000 cod-liver oil is soft
Capsule skin includes the raw material of following weight in capsule：Gelatin 245g, glycerine 115g, purified water 330g.
Preferably, the compound additive is made up of curcumin and fat-soluble tea polyphenol by weight 1-4: 5-8.
It is highly preferred that the compound additive is made up of curcumin and fat-soluble tea polyphenol by weight 2: 7.
Present invention also offers the preparation method of described cod liver oil soft capsule, comprise the following steps：
Glycerine and purified water are well mixed by S1, and 55-70 DEG C is warming up under heating stirring, add gelatin, stirring, stirring speed
Spend for 500-800r/min, mixing time 15-25min, obtain mixing liquid, above-mentioned mixing liquid is subjected to vacuum defoamation, in
Insulation stands 80-120min at 50 DEG C, obtains glue；
S2 takes cod-liver oil, adds vitamin E, stirring, mixing speed 400-600r/min, mixing time 40-
60min, obtain content；
Glue obtained by step S1 is flowed into glue box by S3 through sebific duct, and glue flows out to rotary drum from glue box, while hopper adds step
Content obtained by rapid S2, the thickness for adjusting rubber are 0.50-0.60mm, and sprinkler body temperature is adjusted to 40-50 DEG C, checks rubber crack
Intact, content perfusion, loading amount is adjusted to technological requirement, capsule and pill compacting, obtains soft capsule；
Soft capsule sizing obtained by step S3 is dried, produced by S4.
Preferably, 65 DEG C are warming up under the step S1 heating stirrings, adds gelatin, stirring, mixing speed 700r/
Min, mixing time 20min.
Preferably, the step S1 is incubated at 50 DEG C stands 90min.
Preferably, the step S2 is additionally added raspberry seed oil and compound additive.
Preferably, the step S2 mixing speeds are 500r/min, mixing time 50min.
Preferably, the thickness of the step S3 adjustment rubber is 0.55mm, and sprinkler body temperature is adjusted to 45 DEG C.
Cod liver oil soft capsule provided by the invention is prepared by raw materials such as cod-liver oil, vitamin E, gelatin, glycerine, water
Form.Cod liver oil soft capsule scientific formulation provided by the invention is reasonable, is mutually cooperateed between each composition, effectively reduces fish raw meat
Taste, easily received by the crowd of more than 1 years old, product quality is stable, can aid in protection eyesight, promotes calcium uptake and brain hair
Educate, strengthen immunity, enhancing memory.
Compared with prior art, cod liver oil soft capsule provided by the invention has the advantage that：
(1) cod liver oil soft capsule provided by the invention can effectively reduce fishlike smell, easily by young crowd
Receive, suitable for more than 1 years old crowd.
(2) cod liver oil soft capsule provided by the invention contains the nutriments such as DHA and EPA, can effectively replenishing vitamins A
And vitamin D, there is enhancing development, protection eyesight, promote a variety of works such as calcium uptake, strengthen immunity, enhancing memory
With.
(3) cod liver oil soft capsule product quality provided by the invention is stable, shelf lives length.
(4) cod liver oil soft capsule provided by the invention is easy to store easy for carrying and eating, easily absorbs, and does not influence pair
The absorption of other nutrition.
Embodiment
Below by way of the description of embodiment, the invention will be further described, but this is not the limit to the present invention
System, those skilled in the art according to the present invention basic thought, various modifications may be made or improve, but without departing from this
The basic thought of invention, within the scope of the present invention.
Cod-liver oil of the present invention is purchased from Shaanxi Sen Fu natural products Co., Ltd, article No.：SFYGY210ZFY；Raspberry
Oil is purchased from Jiangxi Tai Cheng natural perfume materials Co., Ltd, and brand is safe really；Fat-soluble tea polyphenol is purchased from Hangzhou Pu Limei biologies section
Skill Co., Ltd, model：LTP-ZC01；Curcumin is purchased from Shaanxi Tyke bio tech ltd, model：Food-grade；It is bright
Glue is purchased from rich and smooth auspicious bio tech ltd, model：Food-grade.
Embodiment 1, a kind of cod liver oil soft capsule
The cod liver oil soft capsule is made up of capsule skin and the content enclosed in capsule skin, every 1000 cod livers
Content includes the raw material of following weight in fat capsule：Cod-liver oil 480g, vitamin E 0.5g；Every 1000 cod-liver oil
Capsule skin includes the raw material of following weight in soft capsule：Gelatin 230g, glycerine 105g, purified water 320g.
Preparation method：
Glycerine and purified water are well mixed by S1, and 55 DEG C are warming up under heating stirring, add gelatin, stirring, mixing speed
For 500r/min, mixing time 15min, mixing liquid is obtained, above-mentioned mixing liquid is subjected to vacuum defoamation, is incubated at 50 DEG C
80min is stood, obtains glue；
S2 takes cod-liver oil, adds vitamin E, stirring, mixing speed 400r/min, mixing time 40min, obtains interior
It is tolerant；
Glue obtained by step S1 is flowed into glue box by S3 through sebific duct, and glue flows out to rotary drum from glue box, while hopper adds step
Content obtained by rapid S2, the thickness for adjusting rubber are 0.50mm, and sprinkler body temperature is adjusted to 40 DEG C, check that rubber crack is intact, interior
Tolerant perfusion, loading amount are adjusted to technological requirement, capsule and pill compacting, obtain soft capsule；
Soft capsule sizing obtained by step S3 is dried, produced by S4.
Embodiment 2, a kind of cod liver oil soft capsule
The cod liver oil soft capsule is made up of capsule skin and the content enclosed in capsule skin, every 1000 cod livers
Content includes the raw material of following weight in fat capsule：Cod-liver oil 520g, vitamin E 1.5g；Every 1000 cod-liver oil
Capsule skin includes the raw material of following weight in soft capsule：Gelatin 250g, glycerine 120g, purified water 350g.
Preparation method：
Glycerine and purified water are well mixed by S1, and 70 DEG C are warming up under heating stirring, add gelatin, stirring, mixing speed
For 5800r/min, mixing time 25min, mixing liquid is obtained, above-mentioned mixing liquid is subjected to vacuum defoamation, protected at 50 DEG C
Temperature stands 120min, obtains glue；
S2 takes cod-liver oil, adds vitamin E, stirring, mixing speed 600r/min, mixing time 60min, obtains interior
It is tolerant；
Glue obtained by step S1 is flowed into glue box by S3 through sebific duct, and glue flows out to rotary drum from glue box, while hopper adds step
Content obtained by rapid S2, the thickness for adjusting rubber are 0.60mm, and sprinkler body temperature is adjusted to 50 DEG C, check that rubber crack is intact, interior
Tolerant perfusion, loading amount are adjusted to technological requirement, capsule and pill compacting, obtain soft capsule；
Soft capsule sizing obtained by step S3 is dried, produced by S4.
Embodiment 3, a kind of cod liver oil soft capsule
The cod liver oil soft capsule is made up of capsule skin and the content enclosed in capsule skin, every 1000 cod livers
Content includes the raw material of following weight in fat capsule：Cod-liver oil 499g, vitamin E 1g；Every 1000 cod-liver oil is soft
Capsule skin includes the raw material of following weight in capsule：Gelatin 245g, glycerine 115g, purified water 330g.
Preparation method：
Glycerine and purified water are well mixed by S1, and 65 DEG C are warming up under heating stirring, add gelatin, stirring, mixing speed
For 700r/min, mixing time 20min, mixing liquid is obtained, above-mentioned mixing liquid is subjected to vacuum defoamation, is incubated at 50 DEG C
90min is stood, obtains glue；
S2 takes cod-liver oil, adds vitamin E, stirring, mixing speed 500r/min, mixing time 50min, obtains interior
It is tolerant；
Glue obtained by step S1 is flowed into glue box by S3 through sebific duct, and glue flows out to rotary drum from glue box, while hopper adds step
Content obtained by rapid S2, the thickness for adjusting rubber are 0.55mm, and sprinkler body temperature is adjusted to 45 DEG C, check that rubber crack is intact, interior
Tolerant perfusion, loading amount are adjusted to technological requirement, capsule and pill compacting, obtain soft capsule；
Soft capsule sizing obtained by step S3 is dried, produced by S4.
Embodiment 4, a kind of cod liver oil soft capsule
The cod liver oil soft capsule is made up of capsule skin and the content enclosed in capsule skin, every 1000 cod livers
Content includes the raw material of following weight in fat capsule：Cod-liver oil 480g, raspberry seed oil 10g, vitamin E 0.5g are compound
Additive 0.2g；Capsule skin includes the raw material of following weight in every 1000 cod liver oil soft capsules：Gelatin 230g, glycerine
105g, purified water 320g.
The compound additive is made up of curcumin and fat-soluble tea polyphenol by weight 1: 8.
Preparation method：
Glycerine and purified water are well mixed by S1, and 55 DEG C are warming up under heating stirring, add gelatin, stirring, mixing speed
For 500r/min, mixing time 15min, mixing liquid is obtained, above-mentioned mixing liquid is subjected to vacuum defoamation, is incubated at 50 DEG C
80min is stood, obtains glue；
S2 takes cod-liver oil, adds vitamin E, raspberry seed oil, compound additive, stirs, mixing speed 400r/min,
Mixing time is 40min, obtains content；
Glue obtained by step S1 is flowed into glue box by S3 through sebific duct, and glue flows out to rotary drum from glue box, while hopper adds step
Content obtained by rapid S2, the thickness for adjusting rubber are 0.50mm, and sprinkler body temperature is adjusted to 40 DEG C, check that rubber crack is intact, interior
Tolerant perfusion, loading amount are adjusted to technological requirement, capsule and pill compacting, obtain soft capsule；
Soft capsule sizing obtained by step S3 is dried, produced by S4.
Embodiment 5, a kind of cod liver oil soft capsule
The cod liver oil soft capsule is made up of capsule skin and the content enclosed in capsule skin, every 1000 cod livers
Content includes the raw material of following weight in fat capsule：Cod-liver oil 520g, raspberry seed oil 16g, vitamin E 1.5g are compound
Additive 0.5g；Capsule skin includes the raw material of following weight in every 1000 cod liver oil soft capsules：Gelatin 250g, glycerine
120g, purified water 350g.
The compound additive is made up of curcumin and fat-soluble tea polyphenol by weight 4: 5.
Preparation method：
Glycerine and purified water are well mixed by S1, and 70 DEG C are warming up under heating stirring, add gelatin, stirring, mixing speed
For 800r/min, mixing time 25min, mixing liquid is obtained, above-mentioned mixing liquid is subjected to vacuum defoamation, is incubated at 50 DEG C
120min is stood, obtains glue；
S2 takes cod-liver oil, adds vitamin E, raspberry seed oil, compound additive, stirs, mixing speed 600r/min,
Mixing time is 60min, obtains content；
Glue obtained by step S1 is flowed into glue box by S3 through sebific duct, and glue flows out to rotary drum from glue box, while hopper adds step
Content obtained by rapid S2, the thickness for adjusting rubber are 0.60mm, and sprinkler body temperature is adjusted to 50 DEG C, check that rubber crack is intact, interior
Tolerant perfusion, loading amount are adjusted to technological requirement, capsule and pill compacting, obtain soft capsule；
Soft capsule sizing obtained by step S3 is dried, produced by S4.
Embodiment 6, a kind of cod liver oil soft capsule
The cod liver oil soft capsule is made up of capsule skin and the content enclosed in capsule skin, every 1000 cod livers
Content includes the raw material of following weight in fat capsule：Cod-liver oil 499g, raspberry seed oil 12g, vitamin E 1g are compound to add
Add agent 0.3g；Capsule skin includes the raw material of following weight in every 1000 cod liver oil soft capsules：Gelatin 245g, glycerine 115g,
Purified water 330g.
The compound additive is made up of curcumin and fat-soluble tea polyphenol by weight 2: 7.
Preparation method：
Glycerine and purified water are well mixed by S1, and 65 DEG C are warming up under heating stirring, add gelatin, stirring, mixing speed
For 700r/min, mixing time 20min, mixing liquid is obtained, above-mentioned mixing liquid is subjected to vacuum defoamation, is incubated at 50 DEG C
90min is stood, obtains glue；
S2 takes cod-liver oil, adds vitamin E, raspberry seed oil, compound additive, stirs, mixing speed 500r/min,
Mixing time is 50min, obtains content；
Glue obtained by step S1 is flowed into glue box by S3 through sebific duct, and glue flows out to rotary drum from glue box, while hopper adds step
Content obtained by rapid S2, the thickness for adjusting rubber are 0.55mm, and sprinkler body temperature is adjusted to 45 DEG C, check that rubber crack is intact, interior
Tolerant perfusion, loading amount are adjusted to technological requirement, capsule and pill compacting, obtain soft capsule；
Soft capsule sizing obtained by step S3 is dried, produced by S4.
Comparative example 1, a kind of cod liver oil soft capsule
The cod liver oil soft capsule is made up of capsule skin and the content enclosed in capsule skin, every 1000 cod livers
Content includes the raw material of following weight in fat capsule：Cod-liver oil 499g, raspberry seed oil 12g, vitamin E 1g are compound to add
Add agent 0.3g；Capsule skin includes the raw material of following weight in every 1000 cod liver oil soft capsules：Gelatin 245g, glycerine 115g,
Purified water 330g.
The compound additive is made up of curcumin and fat-soluble tea polyphenol by weight 1: 1.
Preparation method is similar to Example 6.
As different from Example 6, the compound additive is by 1: 1 group by weight of curcumin and fat-soluble tea polyphenol
Into.
Comparative example 2, a kind of cod liver oil soft capsule
The cod liver oil soft capsule is made up of capsule skin and the content enclosed in capsule skin, every 1000 cod livers
Content includes the raw material of following weight in fat capsule：Cod-liver oil 499g, grape-kernel oil 12g, vitamin E 1g are compound to add
Add agent 0.3g；Capsule skin includes the raw material of following weight in every 1000 cod liver oil soft capsules：Gelatin 245g, glycerine 115g,
Purified water 330g.
The compound additive is made up of curcumin and fat-soluble tea polyphenol by weight 2: 7.
Preparation method is similar to Example 6.
As different from Example 6, raspberry seed oil is replaced with into grape-kernel oil.
The acute oral toxicity test of test example one, cod liver oil soft capsule
1st, tested material：Cod liver oil soft capsule prepared by embodiment 1-6, and cod prepared by comparative example 1 and comparative example 2
Liver oil soft capsule.
2nd, study subject：
SPF levels Kunming mouse 80, body weight 20g, male and female half and half, SPF level Wistar kinds rat 80, body weight 200g,
Male and female half and half.
3rd, test method：
3.1st, chmice acute Oral toxicity is tested
80 mouse are equally divided into 8 groups, every group 10, male and female half and half, distinguish tested embodiment 1-6 and comparative example 1
The cod liver oil soft capsule prepared with comparative example 2.Orally contaminated twice with 15.0g/kgBW dosage, interval 6h after fasting 16h
Poison (weighs tested material 50.00g, add peanut oil fully to be mixed, concentration 0.50g/mL to 100mL), and gavage amount is 0.15mL/
10gBW, to Continuous Observation after tested material 14 days.Record poisoning manifestations and death condition.
3.2nd, rat acute toxicity test
80 rats are equally divided into 8 groups, every group 10, male and female half and half, distinguish tested embodiment 1-6 and comparative example 1
The cod liver oil soft capsule prepared with comparative example 2.Orally contaminated twice with 15.0g/kgBW dosage, interval 6h after fasting 16h
Poison (weighs tested material 50.00g, add peanut oil fully to be mixed, concentration 0.50g/mL to 100mL), and gavage amount is 0.15mL/
10gBW, to Continuous Observation after tested material 14 days.Record poisoning manifestations and death condition.
4th, result of the test：
Result of the test is as shown in Table 1 and Table 2.
Table 1：The acute toxicity tests of the cod liver oil soft capsule to mouse
Table 2：The acute toxicity tests of the cod liver oil soft capsule to rat
By observation, and by during experiment it can be seen from Tables 1 and 2, large and small mouse is showed no obvious poisoning manifestations, move
Thing is without death, each main organs also no abnormality seen in postmortem.This explanation, cod liver oil soft capsule prepared by the present invention are non-toxic.
Test example two, the experiment of cod liver oil soft capsule enhancing development
1st, tested material：Cod liver oil soft capsule prepared by embodiment 4-6, and cod prepared by comparative example 1 and comparative example 2
Liver oil soft capsule.
2nd, subjects：
SPF level Wistar rats 50, body weight 80g, male and female half and half.
3rd, test method：
50 rats are randomly divided into five groups, every group 10, male and female half and half.Embodiment 4, embodiment 5 are weighed respectively, are implemented
Cod liver oil soft capsule 60g prepared by example 6, comparative example 1 and comparative example 2, respectively plus peanut oil is diluted to 200mL, fully mixes, even
Continuous gavage 30 days, gavage amount is 0.5mL/10gBW.Animal single cage is fed, free diet, records food-intake of rat weekly
And a body weight, Continuous Observation 30 days.The outward appearance of observation animal, behavior, toxicity performance and death condition daily.Claim body weekly
Weight, food-intake.
4th, result of the test：
Result of the test is as shown in Table 3 and Table 4.
Table 3：Influence (g) of the cod liver oil soft capsule to rat body weight
| Starting weight | 7 days | 14 days | 21 days | 28 days | |
| Embodiment 4 | 80.2 | 136.9 | 185.3 | 233.5 | 281.6 |
| Embodiment 5 | 79.8 | 137.8 | 186.7 | 235.7 | 284.4 |
| Embodiment 6 | 80.1 | 139.2 | 188.1 | 238.4 | 288.7 |
| Comparative example 1 | 80.0 | 131.5 | 170.6 | 218.1 | 260.5 |
| Comparative example 2 | 80.3 | 132.6 | 174.9 | 221.8 | 265.8 |
Table 4：Influence (g) of the cod liver oil soft capsule to rat food-intake weekly
| First week | Second week | 3rd week | 4th week | |
| Embodiment 4 | 137.9 | 190.1 | 201.5 | 213.7 |
| Embodiment 5 | 139.2 | 194.6 | 206.8 | 218.6 |
| Embodiment 6 | 141.8 | 197.2 | 209.4 | 221.4 |
| Comparative example 1 | 128.2 | 174.7 | 182.4 | 192.3 |
| Comparative example 2 | 130.5 | 176.3 | 188.1 | 195.2 |
Oral gavage rat 30 days, interior during experiment, all animals do not occur food refusal phenomenon, and animal is without obvious poisoning
Symptom, activity and diet situation are normal.The cod-liver oil that it can be seen from table 3 and table 4 prepared by gavage embodiment of the present invention 4-6
The body weight increase of the rat of soft capsule, hence it is evident that the cod liver oil soft capsule prepared higher than gavage comparative example 1 and comparative example 2 it is big
Mouse, this explanation, cod liver oil soft capsule prepared by the present invention have the function that enhancing development.
The influence of test example three, cod liver oil soft capsule to mouse Jumping test
1st, tested material：Cod liver oil soft capsule prepared by embodiment 4-6, and cod prepared by comparative example 1 and comparative example 2
Liver oil soft capsule.
2nd, subjects：
SPF levels Kunming mouse 50, body weight 20g.
3rd, test method：
50 mouse are randomly divided into five groups, every group 10.Embodiment 4, embodiment 5, embodiment 6, contrast are weighed respectively
Cod liver oil soft capsule 3.0g prepared by example 1 and comparative example 2, respectively plus peanut oil is diluted to 200mL, fully mixes, continuous gavage
30 days, gavage amount was 0.2mL/10gBW, once a day.
Next day after last gavage, carry out Jumping test.
Next day starts to train after last gavage.Animal is put into reaction chamber (on platform, under platform) and adapts to environment 3min, then
By on the copper grid in animal placing response case, 36v alternating current is passed to immediately.Animal is shocked by electricity, and its normal reaction is rebound
Platform (insulator), to hide noxious stimulation.Most animals again or may be skipped to repeatedly on copper grid, again rapid by electric shock
On rebound platform.After training once, animal is placed on the platform of reaction chamber, records the mistake that each mouse in 5min jumps off platform
Number and the incubation period for jumping off platform for the first time, in this, as school grade.After 24h resurvey testing.5 days postscripts of deconditioning
Recall regression experiment.
Recording each mouse, to jump off incubation period of platform, each mouse 3min numbers to be shocked by electricity and the animal shocked by electricity for the first time total
Number.
4th, result of the test：
Result of the test is as shown in table 5 and table 6.
Table 5：Cod liver oil soft capsule is on the preclinical influence of mouse Jumping test
Table 6：Influence of the cod liver oil soft capsule to mouse Jumping test errors number
Cod liver oil soft capsule can extend mouse Jumping test incubation period it can be seen from table 5 and table 6, reduce diving tower
Experimental error number.This explanation, cod liver oil soft capsule prepared by the present invention have the function that enhancing memory.
Test example four, the acceptable experiment of crowd's test-meal of cod liver oil soft capsule
1st, tested material：Cod liver oil soft capsule prepared by embodiment 4-6, and cod prepared by comparative example 1 and comparative example 2
Liver oil soft capsule.
2nd, study subject：150 trial volunteers.
3rd, test method：
Cod liver oil soft capsule prepared by embodiment 4-6, and cod-liver oil prepared by comparative example 1 and comparative example 2 are soft
Capsule allows 150 subject's test-meals, every time can only test-meal simultaneously it is a kind of, test-meal is another after being spaced 3h.Subject per's test-meal
Afterwards in terms of rubber melting speed and mouthfeel, give cod liver oil soft capsule product overall assessment, evaluation result to be acceptable and
It cannot receive.According to the evaluation result of crowd's test-meal, calculate crowd's test-meal according to formula below and be subjected to index.
Crowd's test-meal is subjected to index (%)=acceptable total crowd/, and take one's test total crowd × 100%
4th, result of the test：
Result of the test is as shown in table 7.
Table 7：Crowd's test-meal of cod liver oil soft capsule is subjected to index results
As can be seen from Table 7, crowd's test-meal of cod liver oil soft capsule prepared by the present invention is subjected to index, hence it is evident that is higher than
Cod liver oil soft capsule prepared by comparative example 1 and comparative example 2.This explanation, the easy quilt of the cod liver oil soft capsule for preparing of the present invention
People receives.Meanwhile trencherman's reaction is tried, cod liver oil soft capsule prepared by the present invention is integrally in good taste, without obvious fishlike smell.Separately
Outside, it is acceptant it has been observed that the crowd of more than 1 years old is in cod liver oil soft capsule prepared by the test-meal present invention, and do not occur
Phenomena such as being had the hiccups after test-meal.
Claims (10)
1. a kind of cod liver oil soft capsule, it is made up of capsule skin and the content enclosed in capsule skin, it is characterised in that every
Content includes the raw material of following weight in 1000 cod liver oil soft capsules：Cod-liver oil 480-520g, vitamin E 0.5-
1.5g；Capsule skin includes the raw material of following weight in every 1000 cod liver oil soft capsules：Gelatin 230-250g, glycerine 105-
120g, purified water 320-350g.
2. cod liver oil soft capsule as claimed in claim 1, it is characterised in that content in every 1000 cod liver oil soft capsules
Thing includes the raw material of following weight：Cod-liver oil 499g, vitamin E 1g；Capsule suitcase in every 1000 cod liver oil soft capsules
Include the raw material of following weight：Gelatin 245g, glycerine 115g, purified water 330g.
3. cod liver oil soft capsule as claimed in claim 1, it is characterised in that content in every 1000 cod liver oil soft capsules
Thing also includes the raw material of following weight：Raspberry seed oil 10-16g, compound additive 0.2-0.5g.
4. cod liver oil soft capsule as claimed in claim 3, it is characterised in that content in every 1000 cod liver oil soft capsules
Thing includes the raw material of following weight：Cod-liver oil 499g, raspberry seed oil 12g, vitamin E 1g, compound additive 0.3g；Often
Capsule skin includes the raw material of following weight in 1000 cod liver oil soft capsules：Gelatin 245g, glycerine 115g, purified water 330g.
5. cod liver oil soft capsule as claimed in claim 3, it is characterised in that the compound additive is by curcumin and liposoluble
Property Tea Polyphenols by weight 1-4: 5-8 composition.
6. cod liver oil soft capsule as claimed in claim 5, it is characterised in that the compound additive is by curcumin and liposoluble
Property Tea Polyphenols by weight 2: 7 composition.
7. the preparation method of cod liver oil soft capsule as claimed in claim 1, it is characterised in that comprise the following steps：
Glycerine and purified water are well mixed by S1, and 55-70 DEG C is warming up under heating stirring, add gelatin, stirring, and mixing speed is
500-800r/min, mixing time 15-25min, obtains mixing liquid, above-mentioned mixing liquid is carried out into vacuum defoamation, in 50 DEG C
Lower insulation stands 80-120min, obtains glue；
S2 takes cod-liver oil, adds vitamin E, stirs, mixing speed 400-600r/min, mixing time 40-60min,
Obtain content；
Glue obtained by step S1 is flowed into glue box by S3 through sebific duct, and glue flows out to rotary drum from glue box, while hopper adds step S2
Gained content, the thickness for adjusting rubber are 0.50-0.60mm, and sprinkler body temperature is adjusted to 40-50 DEG C, check that rubber crack is complete
Good, content perfusion, loading amount is adjusted to technological requirement, capsule and pill compacting, obtains soft capsule；
Soft capsule sizing obtained by step S3 is dried, produced by S4.
8. the preparation method of cod liver oil soft capsule as claimed in claim 7, it is characterised in that the step S1 heating stirrings
Under be warming up to 65 DEG C, add gelatin, stirring, mixing speed 700r/min, mixing time 20min.
9. the preparation method of cod liver oil soft capsule as claimed in claim 7, it is characterised in that the step S2, which is additionally added, to be covered
Basin oil and compound additive.
10. the preparation method of cod liver oil soft capsule as claimed in claim 7, it is characterised in that the step S3 adjusts glue
The thickness of skin is 0.55mm, and sprinkler body temperature is adjusted to 45 DEG C.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108175102A (en) * | 2017-11-28 | 2018-06-19 | 芜湖市诺康生物科技有限公司 | A kind of preparation method of cod liver oil soft capsule |
| CN109259235A (en) * | 2018-08-31 | 2019-01-25 | 安徽济生元药业有限公司 | A kind of improvement eyesight promotes brain development cod liver oil soft capsule |
| CN113575939A (en) * | 2021-07-09 | 2021-11-02 | 安徽济生元药业有限公司 | Cod liver oil soft capsule for enhancing immunity and preparation method thereof |
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| CN103284153A (en) * | 2013-06-18 | 2013-09-11 | 汤臣倍健股份有限公司 | Cod liver oil soft capsule and preparation method thereof |
| CN104825573A (en) * | 2015-04-04 | 2015-08-12 | 中国科学院西北高原生物研究所 | Anti-fatigue application of raspberry seed oil |
| CN104857105A (en) * | 2015-04-04 | 2015-08-26 | 青海瑶池生物科技有限公司 | Soft capsule based on raspberry fruit oil and application and preparation method thereof |
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| CN1377643A (en) * | 2001-04-02 | 2002-11-06 | 中南大学 | Health article containing tea polyphenol for resisting poor uranium bomb and preventing leukemia |
| CN102058099A (en) * | 2009-11-13 | 2011-05-18 | 金士力佳友(天津)有限公司 | Health care food for losing weight |
| CN103284153A (en) * | 2013-06-18 | 2013-09-11 | 汤臣倍健股份有限公司 | Cod liver oil soft capsule and preparation method thereof |
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| CN108175102A (en) * | 2017-11-28 | 2018-06-19 | 芜湖市诺康生物科技有限公司 | A kind of preparation method of cod liver oil soft capsule |
| CN109259235A (en) * | 2018-08-31 | 2019-01-25 | 安徽济生元药业有限公司 | A kind of improvement eyesight promotes brain development cod liver oil soft capsule |
| CN113575939A (en) * | 2021-07-09 | 2021-11-02 | 安徽济生元药业有限公司 | Cod liver oil soft capsule for enhancing immunity and preparation method thereof |
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