CN113575939A - Cod liver oil soft capsule for enhancing immunity and preparation method thereof - Google Patents
Cod liver oil soft capsule for enhancing immunity and preparation method thereof Download PDFInfo
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- CN113575939A CN113575939A CN202110779282.XA CN202110779282A CN113575939A CN 113575939 A CN113575939 A CN 113575939A CN 202110779282 A CN202110779282 A CN 202110779282A CN 113575939 A CN113575939 A CN 113575939A
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- soft capsule
- liver oil
- cod
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- 239000007901 soft capsule Substances 0.000 title claims abstract description 80
- 239000003026 cod liver oil Substances 0.000 title claims abstract description 54
- 235000012716 cod liver oil Nutrition 0.000 title claims abstract description 54
- 230000002708 enhancing effect Effects 0.000 title claims abstract description 18
- 230000036039 immunity Effects 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title abstract description 13
- 108010010803 Gelatin Proteins 0.000 claims abstract description 13
- 229920000159 gelatin Polymers 0.000 claims abstract description 13
- 239000008273 gelatin Substances 0.000 claims abstract description 13
- 235000019322 gelatine Nutrition 0.000 claims abstract description 13
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 13
- 239000002994 raw material Substances 0.000 claims abstract description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 24
- 238000002156 mixing Methods 0.000 claims description 23
- 238000001035 drying Methods 0.000 claims description 22
- 239000003292 glue Substances 0.000 claims description 13
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical group CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 12
- 238000000227 grinding Methods 0.000 claims description 12
- 239000000725 suspension Substances 0.000 claims description 12
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 claims description 10
- 239000001354 calcium citrate Substances 0.000 claims description 10
- 235000013337 tricalcium citrate Nutrition 0.000 claims description 10
- 238000010438 heat treatment Methods 0.000 claims description 9
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 8
- 239000000661 sodium alginate Substances 0.000 claims description 8
- 235000010413 sodium alginate Nutrition 0.000 claims description 8
- 229940005550 sodium alginate Drugs 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 239000008169 grapeseed oil Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 238000003825 pressing Methods 0.000 claims description 7
- 239000008213 purified water Substances 0.000 claims description 7
- 238000007493 shaping process Methods 0.000 claims description 7
- 244000269722 Thea sinensis Species 0.000 claims description 6
- 229940075507 glyceryl monostearate Drugs 0.000 claims description 6
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims description 6
- -1 polyphenol palmitate Chemical class 0.000 claims description 6
- 235000013824 polyphenols Nutrition 0.000 claims description 6
- 239000003963 antioxidant agent Substances 0.000 claims description 4
- 230000003078 antioxidant effect Effects 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 4
- 239000003995 emulsifying agent Substances 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 2
- 230000003647 oxidation Effects 0.000 abstract description 2
- 238000007254 oxidation reaction Methods 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 5
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
- 102000004877 Insulin Human genes 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 229940125396 insulin Drugs 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 210000000496 pancreas Anatomy 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 210000004712 air sac Anatomy 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011162 core material Substances 0.000 description 1
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 235000021323 fish oil Nutrition 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 1
- 229940012843 omega-3 fatty acid Drugs 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/256—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from seaweeds, e.g. alginates, agar or carrageenan
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/275—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of animal origin, e.g. chitin
- A23L29/281—Proteins, e.g. gelatin or collagen
- A23L29/284—Gelatin; Collagen
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/20—Removal of unwanted matter, e.g. deodorisation or detoxification
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/20—Removal of unwanted matter, e.g. deodorisation or detoxification
- A23L5/27—Removal of unwanted matter, e.g. deodorisation or detoxification by chemical treatment, by adsorption or by absorption
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Abstract
The invention discloses a cod liver oil soft capsule for enhancing immunity, which comprises a content and a soft capsule skin, wherein the weight ratio of the content to the soft capsule skin is 0.66-0.68: 1; the content comprises the following raw materials in parts by weight: 360 parts of cod liver oil 330-; the soft capsule skin comprises the following raw materials in parts by weight: 250 parts of gelatin 230-. The invention also provides a preparation method of the immunity-enhancing cod-liver oil soft capsule. The invention has good oxidation resistance and preparation stability.
Description
Technical Field
The invention relates to the technical field of cod-liver oil, and particularly relates to a cod-liver oil soft capsule for enhancing immunity and a preparation method thereof.
Background
The cod meat is delicious and rich in nutrition, and can promote blood circulation and remove nodules; the swim bladder can enrich the blood and stop bleeding; the bone of cod can be used for treating tinea pedis; cod pancreas contains a large amount of insulin, and 12000IU of insulin can be extracted from 1kg of pancreas; cod liver can be used for extracting cod liver oil (oil content 20% -40%).
The cod liver oil contains rich vitamin A and D3, also contains rich omega-3 fatty acid, has the effects of fish oil and cod liver oil, and is a name of 'liquid gold'. The cod liver oil soft capsule in the current market has the problems that the active ingredients are easy to oxidize and deteriorate and the content and proportion are unstable; in addition, the capsule shell of the soft capsule mainly comprises gelatin, which is long in use when being dried, and the capsule shell is easy to harden or soften and deteriorate, and the like, and needs to be improved.
Disclosure of Invention
Based on the technical problems in the background art, the invention provides the immunity-enhancing cod-liver oil soft capsule and the preparation method thereof.
The invention provides a cod liver oil soft capsule for enhancing immunity, which comprises a content and a soft capsule skin, wherein the weight ratio of the content to the soft capsule skin is 0.66-0.68: 1;
the content comprises the following raw materials in parts by weight: 360 parts of cod liver oil 330-;
the soft capsule skin comprises the following raw materials in parts by weight: 250 parts of gelatin 230-.
Preferably, the weight of the soft capsule is 0.95-1.05 g/capsule.
Preferably, the antioxidant is tea polyphenol palmitate.
Preferably, the emulsifier is glyceryl monostearate.
Preferably, the particle size of the calcium citrate is 200-300 mesh.
The invention also provides a preparation method of the immunity-enhancing cod-liver oil soft capsule, which comprises the following steps:
s1, grinding and uniformly mixing the calcium citrate and the grape seed oil to obtain a suspension A; mixing cod liver oil and antioxidant to obtain solution B; grinding and uniformly mixing the suspension A, the solution B and the emulsifier to obtain a content;
s2, mixing sodium alginate, glycerol and purified water, heating, adding gelatin for dissolving, and removing bubbles to obtain a glue solution;
s3, pressing the contents and the glue solution into soft capsules, shaping and drying to obtain the immunity-enhancing cod-liver oil soft capsules.
Preferably, in S1, milling is carried out for 1-2h to obtain suspension A.
Preferably, in S2, heating is carried out to 60-70 ℃.
Preferably, in S3, the setting temperature is 15-20 ℃, the relative humidity during setting is 30-35%, and the setting time is 2-5 h.
Preferably, in S3, the drying method is: adjusting relative humidity to 20-25%, drying at 25-30 deg.C for 5-6 hr, adjusting relative humidity to 10-15%, and drying at 35-40 deg.C for 3-4 hr.
The preparation method of the invention is completed in a clean area of 10 ten thousand levels.
Has the advantages that:
according to the invention, the tea polyphenol palmitate and the grape seed oil are selected to be matched with each other in a proper proportion, so that the oxidation resistance of the cod liver oil is improved, the content of active ingredients is kept stable, the fishy smell of the cod liver oil can be improved, and the palatability is improved; the grape seed oil contains unsaturated fatty acid, so that nutritional ingredients can be further provided; proper amount of calcium citrate is added to supplement calcium element, and vitamin D in cod liver oil can promote calcium absorption; and calcium citrate may improve the taste of the present invention; gelatin is selected to be matched with sodium alginate and glycerol in a proper proportion, so that the problem that the soft capsule is easy to soften is solved, and the soft capsule has certain toughness and is prevented from hardening; in addition, a proper amount of sodium alginate is added, the temperature during drying can be increased, and the problem of long drying time can be solved by matching with a gradient drying method, so that the drying time is shortened, and the energy consumption is reduced.
Detailed Description
The technical solution of the present invention will be described in detail below with reference to specific examples.
Example 1
A cod liver oil soft capsule for enhancing immunity comprises content and soft capsule skin,
the formula of the contents is as follows:
the formula of the soft capsule shell is as follows:
the preparation method of the immunity-enhancing cod-liver oil soft capsule comprises the following steps:
s1, grinding 200-mesh calcium citrate and grape seed oil for 2 hours, and uniformly mixing to obtain a suspension A; mixing cod liver oil and tea polyphenol palmitate to obtain solution B; grinding and uniformly mixing the suspension A, the solution B and the glyceryl monostearate to obtain a content;
s2, mixing sodium alginate, glycerol and purified water uniformly, heating to 60 ℃, adding gelatin for dissolving, and removing bubbles to obtain a glue solution;
s3, pressing the content and the glue solution into soft capsules by a rolling-die soft capsule machine, then adjusting the relative humidity to 35%, shaping at 15 ℃ for 5h, adjusting the relative humidity to 20%, drying at 30 ℃ for 5h, adjusting the relative humidity to 15%, and drying at 35 ℃ for 4h to obtain the immunity-enhancing cod-liver oil soft capsule.
Example 2
A cod liver oil soft capsule for enhancing immunity comprises content and soft capsule skin,
the formula of the contents is as follows:
the formula of the soft capsule shell is as follows:
the preparation method of the immunity-enhancing cod-liver oil soft capsule comprises the following steps:
s1, grinding 300-mesh calcium citrate and grape seed oil for 1 hour, and mixing uniformly to obtain a suspension A; mixing cod liver oil and tea polyphenol palmitate to obtain solution B; grinding and uniformly mixing the suspension A, the solution B and the glyceryl monostearate to obtain a content;
s2, mixing sodium alginate, glycerol and purified water uniformly, heating to 70 ℃, adding gelatin for dissolving, and removing bubbles to obtain a glue solution;
s3, pressing the content and the glue solution into soft capsules by a rolling-mode soft capsule machine, then adjusting the relative humidity to 30%, shaping at 20 ℃ for 2h, adjusting the relative humidity to 25%, drying at 25 ℃ for 6h, adjusting the relative humidity to 10%, and drying at 40 ℃ for 3h to obtain the immunity-enhancing cod-liver oil soft capsule.
Example 3
A cod liver oil soft capsule for enhancing immunity comprises content and soft capsule skin,
the formula of the contents is as follows:
the formula of the soft capsule shell is as follows:
the preparation method of the immunity-enhancing cod-liver oil soft capsule comprises the following steps:
s1, grinding the 250-mesh calcium citrate and the grape seed oil for 1.5h, and mixing uniformly to obtain a suspension A; mixing cod liver oil and tea polyphenol palmitate to obtain solution B; grinding and uniformly mixing the suspension A, the solution B and the glyceryl monostearate to obtain a content;
s2, mixing sodium alginate, glycerol and purified water uniformly, heating to 65 ℃, adding gelatin for dissolving, and removing bubbles to obtain a glue solution;
s3, pressing the content and the glue solution into soft capsules by a rolling-die soft capsule machine, then adjusting the relative humidity to 32%, shaping at 18 ℃ for 4h, adjusting the relative humidity to 22%, drying at 27 ℃ for 5.5h, adjusting the relative humidity to 12%, and drying at 37 ℃ for 3.5h to obtain the immunity-enhancing cod-liver oil soft capsule.
Comparative example 1
A cod liver oil soft capsule comprises content and soft capsule skin,
the formula of the contents is as follows:
the formula of the soft capsule shell is as follows:
the preparation method of the cod liver oil soft capsule comprises the following steps:
s1, grinding and uniformly mixing 250-mesh calcium citrate, cod liver oil and glyceryl monostearate to obtain a content;
s2, mixing sodium alginate, glycerol and purified water uniformly, heating to 65 ℃, adding gelatin for dissolving, and removing bubbles to obtain a glue solution;
s3, pressing the content and the glue solution into soft capsules by a rolling-mode soft capsule machine, then adjusting the relative humidity to 32%, shaping at 18 ℃ for 4h, adjusting the relative humidity to 22%, drying at 27 ℃ for 5.5h, adjusting the relative humidity to 12%, and drying at 37 ℃ for 3.5h to obtain the cod liver oil soft capsule.
Comparative example 2
A cod liver oil soft capsule comprises content and soft capsule skin,
the formula of the contents is as follows: making cod liver oil 345g into 1000 granules;
the formula of the soft capsule shell is as follows:
the preparation method of the cod liver oil soft capsule comprises the following steps:
mixing glycerol and purified water, heating to 65 deg.C, adding gelatin for dissolving, and removing bubbles to obtain glue solution;
pressing cod liver oil and gelatin solution into soft capsule with rolling-mode soft capsule machine, adjusting relative humidity to 32%, shaping at 18 deg.C for 4 hr, adjusting relative humidity to 25%, and drying at 20 deg.C for 15 hr to obtain cod liver oil soft capsule.
Test 1
The crushing strength and moisture content of the soft capsules obtained in examples 1 to 3 and comparative examples 1 to 2 were measured; the results are shown in Table 1.
The method for measuring the water content of the soft capsule skin comprises the following steps: taking 10 soft capsules, squeezing and breaking, absorbing the core material by paper, and measuring the moisture content of the soft capsule skin by a moisture meter.
The determination method of the crushing strength comprises the following steps: placing the soft capsule in the middle of a sample tray of a hardness tester, abutting against a fixed baffle, starting a switch of the tester, advancing a push rod at a fixed speed of 1mm/s, extruding the soft capsule, and recording the pressure of the push rod when the soft capsule is broken.
TABLE 1 test results
As can be seen from Table 1, the drying time of the present invention is much shorter than that of comparative example 2, and the moisture of the final soft capsule shell is not much different; the crushing strength of the present invention is better than that of comparative example 2.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (10)
1. A cod liver oil soft capsule for enhancing immunity comprises contents and a soft capsule skin, and is characterized in that the weight ratio of the contents to the soft capsule skin is 0.66-0.68: 1;
the content comprises the following raw materials in parts by weight: 360 parts of cod liver oil 330-;
the soft capsule skin comprises the following raw materials in parts by weight: 250 parts of gelatin 230-.
2. The immunity enhancing cod liver oil soft capsule of claim 1, wherein the weight of the soft capsule is 0.95-1.05 g/capsule.
3. The immunity enhancing cod liver oil soft capsule according to claim 1 or 2, wherein the antioxidant is tea polyphenol palmitate.
4. The immunity enhancing cod liver oil soft capsule according to any one of claims 1 to 3, wherein the emulsifier is glyceryl monostearate.
5. The immunity enhancing cod liver oil soft capsule according to any one of claims 1 to 4, wherein the particle size of the calcium citrate is 200-300 mesh.
6. A method for preparing the cod liver oil soft capsule for enhancing immunity according to any one of claims 1 to 5, comprising the steps of:
s1, grinding and uniformly mixing the calcium citrate and the grape seed oil to obtain a suspension A; mixing cod liver oil and antioxidant to obtain solution B; grinding and uniformly mixing the suspension A, the solution B and the emulsifier to obtain a content;
s2, mixing sodium alginate, glycerol and purified water, heating, adding gelatin for dissolving, and removing bubbles to obtain a glue solution;
s3, pressing the contents and the glue solution into soft capsules, shaping and drying to obtain the immunity-enhancing cod-liver oil soft capsules.
7. The method for preparing cod-liver oil soft capsules for enhancing immunity according to claim 6, wherein in S1, grinding is performed for 1-2h to obtain suspension A.
8. The method for preparing cod liver oil soft capsule for enhancing immunity according to claim 6 or 7, wherein in S2, heating is performed to 60-70 ℃.
9. The method for preparing cod-liver oil soft capsules for enhancing immunity according to any one of claims 6 to 8, wherein in S3, the setting temperature is 15 to 20 ℃, the relative humidity during setting is 30 to 35%, and the setting time is 2 to 5 hours.
10. The method for preparing cod-liver oil soft capsules for enhancing immunity according to any one of claims 6 to 9, wherein in S3, the drying method is: adjusting relative humidity to 20-25%, drying at 25-30 deg.C for 5-6 hr, adjusting relative humidity to 10-15%, and drying at 35-40 deg.C for 3-4 hr.
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