CN104825573A - Anti-fatigue application of raspberry seed oil - Google Patents
Anti-fatigue application of raspberry seed oil Download PDFInfo
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- CN104825573A CN104825573A CN201510168779.2A CN201510168779A CN104825573A CN 104825573 A CN104825573 A CN 104825573A CN 201510168779 A CN201510168779 A CN 201510168779A CN 104825573 A CN104825573 A CN 104825573A
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- fructus rubi
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Abstract
The present invention provides application of raspberry seed oil to the preparation of anti-fatigue drugs, health products or food. Pharmacological studies find that raspberry seed oil has very significant anti-fatigue effect, so that the invention further expands the development and utilization of raspberry, and has significant social value and market value.
Description
Technical field
The invention belongs to field of health care products, be specifically related to the novelty teabag of Fructus Rubi seed oil resisting fatigue.
Background technology
Along with the quickening of modern life rhythm, the aggravation of social competition, the muscle power of people, the tired long term accumulation such as mental, psychological, the factors such as diet is unhealthy in addition, environmental radiation increases, cause people's interior free yl too much, make increasing people be in " subhealth state " state.Free radical is a kind of asymmetric, unstable atom because losing an electronics or molecule, has very large energy.Free radical always attempts to capture an electronics to reach new balance, and the materials such as lipid, protein, saccharide and DNA for this reason in its meeting attack cells tissue, this just causes the peroxidating of lipid, the inactivation of the anaenzyme of protein, the oxidative damage etc. of DNA.In addition, when people are tired, can create a large amount of metabolite in body, as lactic acid, carbon dioxide, serum urea nitrogen etc., this kind of material gathers in vivo, stimulates human tissue cell and nervous system.Health is in fatigue state for a long time, can cause the adverse consequences such as hormone in vivo Metabolic disorder, nervous system regulatory function exception, hypoimmunity.
Fructus Rubi (Rubus idaeus L.) has another name called Rubus corchorifolius Linn. f., Fructus Rubi corchorifolii Immaturus, Fructus Rubi etc., belongs to Rosaceae rubus.Fructus Rubi is mainly distributed in temperate zone, the Northern Hemisphere and frigid zone, and its fruit is the little aggregate fruit of many slurries, the sweet micro-acid of taste.Fructus Rubi contains polysaccharide, organic acid, flavone, anthocyanidin, and the various active compositions such as polyphenol, vitamin, mineral element, volatile oil, tannin, have high nutritive value and medical care effect, be described as " gold fruit ".
Fructus Rubi seed occurs usually used as the by-product in Fructus Rubi product processing, accounts for 30% ~ 50% of Fructus Rubi dry fruit weight.Fructus Rubi seed oil content is very high, can reach 14% ~ 18%, is that a kind of desirable Vegetable oil lipoprotein extracts raw material.Fructus Rubi seed oil has high nutrition and health care and is worth.Research shows, containing a large amount of unsaturated fatty acid in Fructus Rubi seed oil, be main mainly with oleic acid, linoleic acid, linolenic acid, wherein linoleic acid content is more than 50%, apparently higher than Oleum Arachidis hypogaeae semen, Oleum Brassicae campestris, Semen Armeniacae Amarum wet goods edible oil.And saturated fatty acid content is far below soybean oil, Oleum Arachidis hypogaeae semen and some animal oil.It is active that Fructus Rubi seed oil has the various biological such as blood fat reducing, blood pressure lowering, memory reinforcing, anti-cancer.In addition, Fructus Rubi seed oil also has antiinflammatory, the effect such as sun-proof, moist.
At present, yet there are no the report that Fructus Rubi seed oil has anti-fatigue effect.
Summary of the invention
The object of the present invention is to provide the novelty teabag of Fructus Rubi seed oil.
Particularly, the invention provides the purposes in the oily medicine in preparation resisting fatigue of Fructus Rubi seed, health product or food.
Further, described medicine, health product or food reduce serum urea nitrogen, lactic acid, creatine kinase level, improves blood glucose, the medicine of lactate dehydrogenase levels, health product or food.
Wherein, described medicine, health product or food are peroral dosage form.
Further, described peroral dosage form is selected from tablet, soft capsule, pill, granule, powder, extractum or oral liquid.
Wherein, described soft capsule comprises the supplementary material of following mass percent: Fructus Rubi seed oil 55% ~ 75%, gelatin 10 ~ 20%, glycerol 5% ~ 15%, water 10 ~ 15%.
Further, described soft capsule comprises the supplementary material of following mass percent: Fructus Rubi seed oil 67% ~ 70%, gelatin 12 ~ 13%, glycerol 6% ~ 7%, water 12 ~ 13%.
Wherein, described Fructus Rubi seed oil adopts supercritical CO
2extraction prepares, and concrete operations are as follows: pulverized by Fructus Rubi seed, crosses 60 ~ 80 mesh sieves, and load in extraction kettle, extraction kettle pressure is 15 ~ 45Mpa, temperature is 30 DEG C ~ 55 DEG C, CO
2flow is 20 ~ 60L/h, extraction 40 ~ 120min; After two-stage decompression separation, namely obtain Fructus Rubi seed oil again, two-stage decompression separation condition is: using pressure be 5 ~ 7Mpa, temperature be 40 DEG C ~ 50 DEG C as one-level decompression separation, using pressure be 3 ~ 5Mpa, temperature is 30 DEG C ~ 40 DEG C and is separated as second depressurized.
Wherein, described Fructus Rubi is the fruit of Rosaceae rubus.
Wherein, described Fructus Rubi is selected from red raspberry or black raspberry.Choice for use red raspberry in the present invention's detailed description of the invention.
The present invention studies discovery, and Fructus Rubi seed oil has fine anti-fatigue effect, has significant social value and market value.
Accompanying drawing illustrates:
The impact of accompanying drawing 1 Fructus Rubi seed oil on blood urea nitrogen in mice serum;
The impact of accompanying drawing 2 Fructus Rubi seed oil on creatine kinase in mice serum;
The impact of accompanying drawing 3 Fructus Rubi seed oil on mouse blood sugar;
The impact of accompanying drawing 4 Fructus Rubi seed oil on lactic acid in mice serum;
The impact of accompanying drawing 5 Fructus Rubi seed oil on lactic acid dehydrogenase in mice serum;
Detailed description of the invention
Further illustrate the preparation method of Fructus Rubi seed oil and soft capsule thereof below in conjunction with detailed description of the invention, but the scope of protection of present invention is not limited to following embodiments:
Embodiment 1
1) Fructus Rubi seed oil preparation: Fructus Rubi seed oil preparation: pulverized by Fructus Rubi seed, crosses 80 mesh sieves and obtains Fructus Rubi seed powder.Take Fructus Rubi seed powder 500g, load in 1L extraction kettle and carry out supercritical CO
2extraction, extraction kettle pressure be 25Mpa, temperature is 40 DEG C, CO
2flow is extract 40min under the condition of 20L/h, namely obtains Fructus Rubi seed oil after two-stage decompression separation.Wherein, two-stage decompression separation refer to for take pressure as 5Mpa, temperature be 40 DEG C as one-level decompression separation, take pressure as 4.5Mpa, temperature be 30 DEG C and be separated as second depressurized.
2) proportioning is by mass percentage:
| Fructus Rubi seed oil | 67％ |
| Gelatin | 13％ |
| Glycerol | 7％ |
| Water | 13％ |
3) change glue: be added to the water by gelatin, soak 2h at 30 DEG C, after being warming up to 50 DEG C of evacuation, again feed liquid is warming up to 60 DEG C, insulation 2h.Add glycerol stir after evacuation again, the glue dissolved is for subsequent use.
4) pelleting: by Fructus Rubi seed oil raw material and step 2) gained glue inserts in full-automatic encapsulating machine, is pressed into soft capsule;
5) shape: in temperature 15 DEG C, to step 3 under humidity 20% condition) gained soft capsule shapes, and shaping time is 15h;
6) ball is washed: use the edible ethanol of 95% to clean step 4) gained soft capsule, remove the paraffin oil on soft capsule surface;
7) dry: by dry under temperature 40 DEG C of conditions for the soft capsule after cleaning;
8) pack: sort out useless ball, counting, packaging, obtain Fructus Rubi seed oil soft capsule.
Embodiment 2
1) Fructus Rubi seed oil preparation: Fructus Rubi seed oil preparation: pulverized by Fructus Rubi seed, crosses 80 mesh sieves and obtains Fructus Rubi seed powder.Take Fructus Rubi seed powder 500g, load in 1L extraction kettle and carry out supercritical CO
2extraction, extraction kettle pressure be 25Mpa, temperature is 40 DEG C, CO
2flow is extract 40min under the condition of 20L/h, namely obtains Fructus Rubi seed oil after two-stage decompression separation.Wherein, two-stage decompression separation refer to for take pressure as 5Mpa, temperature be 40 DEG C as one-level decompression separation, take pressure as 4.5Mpa, temperature be 30 DEG C and be separated as second depressurized.
2) proportioning is by mass percentage:
| Fructus Rubi seed oil | 70％ |
| Gelatin | 12％ |
| Glycerol | 6％ |
| Water | 12％ |
3) change glue: be added to the water by gelatin, soak 1.5h at 30 DEG C, after being warming up to 50 DEG C of evacuation, again feed liquid is warming up to 60 DEG C, insulation 1.5h.Add glycerol stir after evacuation again, the glue dissolved is for subsequent use.
6) pelleting: by Fructus Rubi seed oil raw material and step 2) gained glue inserts in full-automatic encapsulating machine, is pressed into soft capsule;
7) shape: in temperature 20 DEG C, to step 3 under humidity 30% condition) gained soft capsule shapes, and shaping time is 25h;
6) ball is washed: use the edible ethanol of 80% to clean step 4) gained soft capsule, remove the paraffin oil on soft capsule surface;
7) dry: by dry under temperature 40 DEG C of conditions for the soft capsule after cleaning;
8) pack: sort out useless ball, counting, packaging, obtain Fructus Rubi seed oil soft capsule.
In test example of the present invention, Fructus Rubi seed oil preparation amount is in oil.
The experiment of test example 1 Fructus Rubi seed oil resisting fatigue
The present invention to utilize in body pharmacodynamic experiment to evaluate the anti-fatigue ability of Fructus Rubi seed oil.Specific experiment method is as follows:
Kunming kind male and healthy mice (body weight: 25 ± 3g, age: 2 ~ 3 weeks) is divided into 4 groups, be respectively blank group and Fructus Rubi seed innage, in, low dose group.Fructus Rubi seed innage, in, the dosage of low dose group is respectively 120mg/kg, 60mg/kg and 30mg/kg, adopts gastric infusion, once a day.Blank group gives equivalent salad oil.Successive administration 14 days.Each group of mice starts to carry out adaptability swimming instruction in administration on the 7th day, and swimming time, by 10 minutes/day, increases progressively 5 minutes by sky.Test last day, mice, after 30 minutes, is placed in the swimming trunk went swimming of depth of water 30cm by administration, and water temperature controls at about 25 DEG C, swims 90 minutes.Have a rest and extract eyeball immediately after 60 minutes and get blood, the blood sample obtained is placed centrifugal (4 DEG C, 2000 turns, 15 minutes) in a moment in room temperature, obtains blood serum sample, frozen for subsequent use in-80 DEG C of refrigerators.
(1) impact of Fructus Rubi seed oil on mice serum blood urea nitrogen
The impact of table 1. Fructus Rubi seed oil on mice serum blood urea nitrogen
* P < 0.05, * * P < 0.01vs blank group
Serum urea nitrogen is one of important symbol of protein in body metabolism.Motion makes serum urea nitrogen raise, and it is the very sensitive index of evaluation body one of ability to bear when physical load.Body is poorer to load performance, and the increase of serum urea nitrogen is more obvious.
As shown in table 1 and Fig. 1, compared with blank group, each dosage group of Fructus Rubi seed oil all extremely significantly can reduce the urea nitrogen content of mice serum, and presents dose-dependence (* * P < 0.01vs blank group).Illustrate that Fructus Rubi seed oil can increase the ability to bear of mice body to sports load.
(2) impact of Fructus Rubi seed oil on creatine kinase in mice serum
The impact of table 2. Fructus Rubi seed oil on creatine kinase in mice serum
* P < 0.05, * * P < 0.01vs blank group
Creatine kinase and energy metabolism closely related, it participates in glucolytic control, the energy supply of mitochondrial respiratory machine muscle contraction.Research shows, after a large amount of motion, the creatine kinase activity in serum significantly raises.In serum, the change of creatine kinase can reflect the adaptedness of body to motion, and adaptedness is higher, and serum creatine kinase activity can reduce even recovers normal level.
From table 2 Fig. 2, Fructus Rubi seed oil obviously can reduce the activity of creatine kinase in mice serum, and presents dose-dependence.Wherein, in Fructus Rubi seed oil, dosage group has significant difference (* P < 0.05vs blank) compared with blank; Fructus Rubi seed oil high dose group has pole significant difference (* * P < 0.01vs blank group) compared with blank.Illustrate, Fructus Rubi seed oil can improve the adaptability of mice to motion.
(3) impact of Fructus Rubi seed oil on mouse blood sugar
The impact of table 3. Fructus Rubi seed oil on blood glucose in mice serum
* P < 0.01vs blank group
As shown in table 3 and Fig. 3, Fructus Rubi seed oil obviously can increase the content of mice serum blood glucose, and presents dose-dependence.Wherein, in Fructus Rubi seed innage, dosage group has pole significant difference (* * P < 0.01vs blank group) compared with blank.(4) impact of Fructus Rubi seed oil on lactic acid in mice serum (LD) content
The impact of table 4. Fructus Rubi seed oil on lactic acid in mice serum
* P < 0.01vs blank group
Lactic acid is produced by anaerobic metabolism, and it exists the stability destroying organismic internal environment, affects the normal performance of cardiovascular system, Musculoskeletal function, causes tired generation.
In table 4 and Fig. 4, each lactic acid content (* * P < 0.01vs blank group) that all extremely significantly can reduce mice serum of Fructus Rubi seed oil, and present dose-dependence.
(5) impact of Fructus Rubi seed oil on lactic acid dehydrogenase in mice serum (LDH) content
The impact of table 5. Fructus Rubi seed oil on lactic acid dehydrogenase in mice serum
* P < 0.01vs blank group
Lactic acid in lactic acid dehydrogenase energy decomposer, in timely purged body, lactic acid has very positive effect for the elimination of fatigue.As shown in table 5 and Fig. 5, Fructus Rubi seed oil obviously can increase the content of lactic acid dehydrogenase in mice serum, and presents dose-dependence.Wherein, each dosage group of Fructus Rubi seed oil has pole significant difference (* * P < 0.01vs blank group) compared with blank.
Claims (9)
1. the purposes in the medicine of resisting fatigue, health product or food prepared by Fructus Rubi seed oil.
2. purposes according to claim 1, is characterized in that: described medicine, health product or food reduce serum urea nitrogen, lactic acid, creatine kinase level, improves blood glucose, the medicine of lactate dehydrogenase levels, health product or food.
3. purposes according to claim 1 and 2, is characterized in that: described medicine, health product or food are peroral dosage form.
4. the purposes according to claims 1 to 3 any one, is characterized in that: described peroral dosage form is selected from tablet, soft capsule, pill, granule, powder, extractum or oral liquid.
5. purposes according to claim 4, is characterized in that: described soft capsule comprises the supplementary material of following mass percent: Fructus Rubi seed oil 55% ~ 75%, gelatin 10 ~ 20%, glycerol 5% ~ 15%, water 10 ~ 15%.
6. purposes according to claim 5, is characterized in that: described soft capsule comprises the supplementary material of following mass percent: Fructus Rubi seed oil 67% ~ 70%, gelatin 12 ~ 13%, glycerol 6% ~ 7%, water 12 ~ 13%.
7. the purposes according to claim 1 ~ 6 any one, is characterized in that: described Fructus Rubi seed oil adopts supercritical CO
2extraction prepares, and concrete operations are as follows: pulverized by Fructus Rubi seed, crosses 60 ~ 80 mesh sieves, and load in extraction kettle, extraction kettle pressure is 15 ~ 45Mpa, temperature is 30 DEG C ~ 55 DEG C, CO
2flow is 20 ~ 60L/h, extraction 40 ~ 120min; After two-stage decompression separation, namely obtain Fructus Rubi seed oil again, two-stage decompression separation condition is: using pressure be 5 ~ 7Mpa, temperature be 40 DEG C ~ 50 DEG C as one-level decompression separation, using pressure be 3 ~ 5Mpa, temperature is 30 DEG C ~ 40 DEG C and is separated as second depressurized.
8. the purposes according to claim 1 ~ 7 any one, is characterized in that: described Fructus Rubi is the fruit of Rosaceae rubus.
9. the purposes according to claim 1 ~ 8 any one, is characterized in that: described Fructus Rubi is selected from red raspberry or black raspberry.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106947583A (en) * | 2017-04-20 | 2017-07-14 | 江南大学 | A kind of preparation method of raspberry seed oil and products thereof |
| CN107361324A (en) * | 2017-07-08 | 2017-11-21 | 广州富诺健康科技股份有限公司 | A kind of cod liver oil soft capsule and preparation method thereof |
| CN108142587A (en) * | 2018-01-24 | 2018-06-12 | 青海大学 | A kind of composition containing Seabuckthorm Seed Oil |
| CN108566992A (en) * | 2017-03-08 | 2018-09-25 | 周森荣 | Goldenrain tree seeds of trees vegetable oil |
| CN110150353A (en) * | 2019-06-06 | 2019-08-23 | 福建省卡尔顿食品有限公司 | A kind of fermentation bread and preparation method thereof |
-
2015
- 2015-04-04 CN CN201510168779.2A patent/CN104825573B/en active Active
Non-Patent Citations (5)
| Title |
|---|
| 李晓波等: "树莓种子油成分的研究", 《西南农业大学学报（自然科学版）》 * |
| 梁添等: "大学生血浆多不饱和脂肪酸含量及其与疲劳的关系", 《第二军医大学学报》 * |
| 胡慧等: "70%VO2max疲劳运动和口服不饱和脂肪酸对血清雄激素的影响", 《中国运动医学杂志》 * |
| 胡慧等: "口服不饱和脂肪酸对运动能力影响的生理学观察", 《天津体育学院学报》 * |
| 辛秀兰等: "红树莓籽油的脂肪酸成分分析", 《食品研究与开发》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108566992A (en) * | 2017-03-08 | 2018-09-25 | 周森荣 | Goldenrain tree seeds of trees vegetable oil |
| CN106947583A (en) * | 2017-04-20 | 2017-07-14 | 江南大学 | A kind of preparation method of raspberry seed oil and products thereof |
| CN107361324A (en) * | 2017-07-08 | 2017-11-21 | 广州富诺健康科技股份有限公司 | A kind of cod liver oil soft capsule and preparation method thereof |
| CN108142587A (en) * | 2018-01-24 | 2018-06-12 | 青海大学 | A kind of composition containing Seabuckthorm Seed Oil |
| CN110150353A (en) * | 2019-06-06 | 2019-08-23 | 福建省卡尔顿食品有限公司 | A kind of fermentation bread and preparation method thereof |
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| CN104825573B (en) | 2018-06-22 |
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