CN104783185B - It is a kind of that there is strengthen immunity, health food of function of physical fatigue alleviation and preparation method thereof - Google Patents
It is a kind of that there is strengthen immunity, health food of function of physical fatigue alleviation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of health food with strengthen immunity, function of physical fatigue alleviation, it is prepared from by the raw material of following parts by weight：Ginseng 1 30, maca 5 40, pupa albumen 1 30, green-tea extract 10 40, Poria cocos 10 40.The invention also discloses the preparation technology of above-mentioned health food, using ginseng, maca, pupa albumen, green-tea extract (theanine), Poria cocos as raw material, extracted, separation, concentration, granulation or the technique such as tabletting and coating are made.The present invention is based on Chinese Traditional Medicine " preventiveing treatment of disease " theory and remedial proposal of the modern medicine to sub-health state, new resource food and integration of drinking and medicinal herbs food are used for raw material, it is safe and reliable, suitable long-term taking, prescription is simple, and compatibility is reasonable, synergistic function is obvious between each raw material, experiments prove that it has the effect of the gentle physical fatigue of significant strengthen immunity, and preparation technology is simply, stably, and product quality is stably and controllable.
Description
Technical field
It is specially a kind of that there is strengthen immunity, the guarantor of function of physical fatigue alleviation the present invention relates to field of health care food
Health food and preparation method thereof.
Background technology
In society now, natural environment deterioration, bad life habits, health knowledge are deficient and social competition's pressure
Increase, allow increasing people to be in " sub-health state ".Limbs fatigue, spiritual not good enough, hypoimmunity, easily catches a cold, the heart
Throb with fear shortness of breath, hyposexuality, insomnia forgetfulness, the portrayal for being increasingly becoming without appetite etc. more and more people's animations.Human body is sub-
Health status is turning into the topic that the whole mankind pays close attention to.One, the World Health Organization predicts that sex investigation is shown, whole world inferior health
Population ratio reaches 75%, and the harmfulness of inferior health is considered 21 world human health heads arranged side by side with AIDS by medical field
Number formidable enemy.
Though traditional Chinese medicine is without " sub-health state " one word, " before more than 2000 years, the traditional Chinese medical science, which just has, ' above attacks not treating the disease affected to control not
Disease ' ' preventiveing treatment of disease ' thought, " be long-standing to the understanding of sub-health state.Physical fatigue can be considered a kind of in the traditional Chinese medical science
The disease such as overstrain, consumptive disease caused by the aggravating activities bigger than labor intensity." fatigue " one word is first appeared in Han dynasty Zhang Zhongjing《Gold is deficient will
Slightly》, it is believed that fatigue is similar with " spleen fatiguing disease ", it is believed that the tired interpretation of the cause, onset and process of an illness caused by the deficiency of vital energy, to have " overstrain may lead to decline of vital energy, labor is then panted sweating,
It is inside and outside all to get over, therefore gas consumption " discussion.In addition, the traditional Chinese medical science has natural contact with immune.We say that hypoimmunity holds often
Easily ill, the traditional Chinese medical science then thinks " healthy tendency deposits interior, and heresy can not be done ", and so-called " healthy tendency " is immunocompetence.The traditional Chinese medical science thinks the shape of health
State is " yin and yang in equilibrium ", and a side is excessively hyperfunction, disorderly between each system of internal body, then causes disease, so-called " it is high, do harm to,
It is system to hold ".
Although having some at present has strengthen immunity or health food for relieving physical fatigue and medicine, different journeys
That spends has single function, DeGrain, largely uses rare tonic Chinese herbal medicine, effective component extraction rate.
The content of the invention
The invention provides a kind of health food with strengthen immunity, function of physical fatigue alleviation, pass through ginseng, agate
Coffee, pupa albumen, green-tea extract, the synergy of Poria cocos five tastes food, with the gentle solution muscle power of significant strengthen immunity
The effect of fatigue.
Ginseny spleen invigorating, lung channel, the heart channel of Hang-Shaoyin, tool reinforce vital energy, and veins takes off admittedly reinforces the spleen to benefit the lung, and promotes the production of body fluid, the function of calming the nerves；Maca
Return kidney,liver,spleen to pass through, with warming kidney and enhancing body, strengthen muscles and bones, cold dispelling, analgesic, the function of adjusting blood vessels；Pupa albumen have reducing blood lipid,
Norcholesterol, it is hypoglycemic, improve immunity function, protection liver, promote fecundity, it is antitumor and increase intelligence, protection eyesight,
A variety of functions such as anti-aging；Green-tea extract (theanine) has antitumor, raising human immunological competence, delayed motion tired
The multiple efficacies such as labor, hypertensive tranquilizing, protection nerve, improvement memory, depression of alleviating, mitigation alcoholic liver injury；Poria cocos is returned
The heart, lung, spleen, kidney channel, have clearing damp and promoting diuresis, the function of invigorating the spleen calming heart.This five kinds of integration of drinking and medicinal herbs foods with use, play strengthening spleen and nourishing stomach,
Nourishing liver and kidney, boosting qi and nourishing yin, the effect strengthened the body resistance to consolidate the constitution, play traditional Chinese medical science organic conception advantage, regulation mechanism of qi, conditioning viscera make gas
Blood negative and positive tend to balance, the normal organic operation of each function, reach the effect of the gentle physical fatigue of strengthen immunity, effectively
Improve sub-health state.
To achieve these goals, the present invention is adopted the following technical scheme that：
One kind has strengthen immunity, health food for relieving physical fatigue, is made up of the raw material of following parts by weight：Ginseng
1-10, maca 5-15, pupa albumen 1-10, green-tea extract (theanine) 30-40, Poria cocos 30-40.
The effect of the present invention to improve the gentle physical fatigue of its strengthen immunity is optimized as foundation to formula.
The raw material of above-mentioned parts by weight can be more preferably：Ginseng 5-15, maca 10-20, Silkworm pupa protein 5-15, green tea
Extract (theanine) 20-30, Poria cocos 20-30.
The raw material of above-mentioned parts by weight can be more preferably：It is ginseng 10-20, maca 20-30, Silkworm pupa protein 10-20, green
Tea extraction (theanine) 10-20, Poria cocos 10-20.
The raw material of above-mentioned parts by weight can be more preferably：Ginseng 15, maca 25, Silkworm pupa protein 15, green-tea extract (tea ammonia
Acid) 15, Poria cocos 15.
By improving the ratio of ginseng, maca, pupa albumen in prescription, the ratio of green-tea extract and Poria cocos is reduced,
Optimizing raw material composition and ratio, can effectively improve effect of the gentle physical fatigue of its strengthen immunity.
Each raw material sources difference is as follows in above-mentioned formula：
Ginseng：For Araliaceae ginseng Panax ginseng C.A.Mey. drying root and rhizome, sweet, slight bitter,
It is mild-natured, returns spleen, lung, the heart channel of Hang-Shaoyin.With reinforcing vital energy, veins takes off admittedly reinforces the spleen to benefit the lung, and promotes the production of body fluid, the function of calming the nerves, available for physically weak pre-
De-, spleen eating less, heart failure etc..Modern medicine and pharmacology research shows, ginseng mainly containing a variety of ginsenosides, carbohydrate, volatile oil,
The composition such as peptide, amino acid, trace element and organic acid, multivitamin, choline and enzyme.With antifatigue, strengthen immunity, resist
Tumour, the hypoglycemic and anti-ageing effect of waiting for a long time.
Maca (Lepidium meyenii Walp.)：It is the Andes for being grown in 4000~4500 meters of Peru's height above sea level
A kind of crucifer, be used as the existing long history of the plant of dietotherapeutic, tradition in andes region maca root tuber
For improving fecundity, increase energy.China introduces and popularizing planting the end of the nineties, in Lijiang, yunnan, Sichuan Rice
The ground scale plantation such as city Aden.
Modern study shows that maca has antifatigue, improvement sexual function, anti-oxidant, suppression hyperplasia of prostate, alleviates climacteric
The multiple efficacies such as phase syndrome, strengthen immunity.Maca is a kind of food resource being worth with better nutritivity, mainly eats portion
Protein content in point root is higher, and amino acid composition is reasonable, it is necessary to amino acid content, unrighted acid ratio, potassium, calcium,
The trace element such as magnesium, zinc is all higher, and contains a large amount of branched-chain amino acids and a certain amount of taurine, FAO (Food and Agriculture Organization of the United Nation) suggestion people
Pass through edible maca and improve underfed symptom.In addition to abundant nutritional ingredient, maca also contains a variety of secondary metabolites
Matter：It is maca ene (macaene), alkaloid (including macamide macamide), glucosinolate and its hydrolysate, sterol, many
Phenols and other compositions, these secondary metabolites are considered as having substantial connection with the health-care efficacy of maca.
Pupa albumen：For the hydrolysate of Bombycidae insect silkworm Bymbyx mori (Linnaeus) drying pupa, silkworm chrysalis
Albumen is the main functional component of silkworm chrysalis, with very high nutrition and medical value.Modern age pharmaceutical research shows, pupa albumen
With promotion fat metabolism, liver cell regeneration, reducing blood lipid, norcholesterol, hypoglycemic, raising immunity function, protection liver, promotion
Fecundity, strong, anticancer, diuresis etc. act on and increased a variety of functions such as intelligence, protection eyesight, anti-aging.
Green-tea extract (theanine)：For using the leaf of Theaceae Camellia tea tree (Camellia sinensis) as original
Expect, the technique such as extracted, filtering, concentration is made, the fresh refreshing taste with camerlsed and similar monosodium glutamate.Theanine (L-Theanine)
It is distinctive one kind in tealeaves, medicine accounts for the 50% of free amino acid of tea total amount.Modern study shows:Theanine has anti-swollen
Knurl, improve human immunological competence, delayed motion fatigue, hypertensive tranquilizing, protection nerve, improve memory, alleviate depression, subtract
Light alcohol is to multiple efficacies such as the injuries of liver.
Poria cocos：It is sweet, light for On Polyporaceae Poria cocos Poria cocos (Schw.) Wolf dry sclerotia, it is mild-natured,
The thoughts of returning home, lung, spleen, kidney channel.With clearing damp and promoting diuresis, the function of invigorating the spleen calming heart.It is confused and worried available for spleen eating less, insomnia of palpitating with fear
Deng.Modern medicine and pharmacology research shows that Poria cocos main component is β-pachyman and three mushroom class compound second phthalein pachymic acids, pachymic acid
With 3 beta-hydroxy wool steroid trienic acids.With functions such as raising immunity, antifatigue, antitumor, anti-hepatic sclerosis.
The formula of above-mentioned raw materials composition, formulation can be capsule or tablet.In process, can be according to actual feelings
Condition, adds appropriate maltodextrin, starch and makees adhesive, sodium carboxymethyl starch is made the processing aids such as disintegrant, preferably improved
Processing characteristics.Generally, the addition of maltodextrin is 10~30 parts of parts by weight.
The described preparation method with strengthen immunity and health food for relieving physical fatigue, comprises the following steps：
(1) maca for weighing formula ratio is put in extractor, plus 5-20 times is measured 50%-95%v/v edible alcohols in 50-80 DEG C
Lower stirring is extracted 2-4 times, and each 1-4h, filtering, merging filtrate obtains filter residue 1 and filtrate 1；
(2) ginseng, the Poria cocos of formula ratio are added into filter residue 1, plus 10-25 times is measured water and extracts 1- in stirring at 60-100 DEG C
4h, filtering, obtains filter residue 2 and filtrate 2, measures water in stirring extraction 1-4h at 60-100 DEG C to filter residue 2 plus 8-18 times, obtains the He of filter residue 3
Filtrate 3；
(3) merging filtrate 1, filtrate 2 and filtrate 3, disk centrifugal separator (6000-9000 revs/min of rotating speed, deslagging cycle 240-
720s, flow 20-80L/min) after centrifugal filtration, filtrate is placed in vacuum concentration pot, be concentrated in vacuo (50~70 DEG C of temperature, very
0.07~0.1MPa of reciprocal of duty cycle) to Solid content content be 10%-40% (20 DEG C), obtain concentrate；The green tea for weighing formula ratio is extracted
Thing (theanine), pupa albumen, maltodextrin and suitable quantity of water, add above-mentioned concentrate, stir, be assigned to Solid content content
For 25%-70% (20 DEG C), upper spray drying tower carries out mist projection granulating, nozzle bore 0.5-1.5mm, EAT 170-220
DEG C, 80-110 DEG C of leaving air temp, flow 200-1000L/h obtains granule.
(4) capsule is made through capsule filling machine in granule or tablet is made through tabletting, coating.
It is preferred that, described there is strengthen immunity and health food for relieving physical fatigue preparation method to include following step
Suddenly：
(1) maca for weighing formula ratio is put in extractor, plus 15 times of amount 75%v/v edible alcohols are extracted in stirring at 70 DEG C
2 times, each 2h, filtering, merging filtrate obtains filter residue 1 and filtrate 1；
(2) ginseng, the Poria cocos of formula ratio are added into filter residue 1, plus 20 times of amount water extract 2h in stirring at 90 DEG C, filter,
Filter residue 2 and filtrate 2 are obtained, 2h is extracted in stirring at 90 DEG C to filter residue 2 plus 12 times of amount water, obtains filter residue 3 and filtrate 3；
(3) merging filtrate 1, filtrate 2 and filtrate 3, disk centrifugal separator (7000 revs/min of rotating speed, deslagging cycle 240s, flow
50L/min) after centrifugal filtration, filtrate is placed in vacuum concentration pot, is concentrated in vacuo (temperature 50 C, vacuum 0.09MPa) to admittedly
Inclusion content is 25% (20 DEG C), obtains concentrate；Weigh green-tea extract (theanine), pupa albumen, the malt paste of formula ratio
Essence and suitable quantity of water, add above-mentioned concentrate, stir, and are assigned to Solid content content for 50% (20 DEG C), upper spray drying tower
Mist projection granulating is carried out, nozzle bore 1.1mm, 185 DEG C of EAT, 90 DEG C of leaving air temp, flow 600L/h obtains granule.
(4) capsule is made through capsule filling machine in granule or tablet is made through tabletting, coating.
Compared with prior art, beneficial effects of the present invention are：
The present invention uses new resource food and integration of drinking and medicinal herbs food for raw material, safe and reliable, suitable long-term taking, prescription letter
Single, rationally, synergistic function is obvious between each raw material, experiments prove that it has significant strengthen immunity and alleviation for compatibility
The effect of physical fatigue, and preparation technology is simply, stably, product quality is stably and controllable.
The present invention starts with from regulation function, is mutually combined using integration of drinking and medicinal herbs food with strong complementarity, Synergistic,
Strengthening spleen and nourishing stomach, nourishing liver and kidney, boosting qi and nourishing yin, strengthen the body resistance to consolidate the constitution, play traditional Chinese medical science organic conception advantage, regulation mechanism of qi, conditioning viscera make
Negative and positive of qi and blood tends to balance, the normal organic operation of each function, reaches the effect of the gentle physical fatigue of strengthen immunity, has
Effect improves sub-health state.
Embodiment
The present invention is described in further detail below by specific embodiment, but protection scope of the present invention is not by specific
Any limitation of embodiment, without departing from the idea case in the present invention described above, according to ordinary skill knowledge and used
With means, various replacements and change are made, all should be included within the scope of the invention.
Embodiment 1
One kind has strengthen immunity, health food for relieving physical fatigue, is made up of the raw material of following parts by weight：Ginseng
5th, maca 10, pupa albumen 5, green-tea extract (theanine) 30, Poria cocos 35, maltodextrin 10.
Specifically preparation technology is：By maca plus 8 times of amount 90%v/v edible alcohols in stirring extraction 3 times at 75 DEG C, every time
80min, filtering, merging filtrate obtains filter residue 1 and filtrate 1；Ginseng, the Poria cocos of formula ratio, plus 10 times of amount water are added into filter residue 1
2h is extracted in stirring at 100 DEG C, filtering obtains filter residue 2 and filtrate 2,2h is extracted in stirring at 100 DEG C to filter residue 2 plus 10 times of amount water,
Obtain filter residue 3 and filtrate 3；Merging filtrate 1, filtrate 2 and filtrate 3, disk centrifugal separator (6000 revs/min of rotating speed, deslagging cycle 720s,
Flow 80L/min) after centrifugal filtration, filtrate is placed in vacuum concentration pot, is concentrated in vacuo (temperature 60 C, vacuum 0.09MPa)
It is 25% (20 DEG C) to Solid content content, obtains concentrate；Weigh the green-tea extract (theanine), pupa albumen, wheat of formula ratio
Bud dextrin and suitable quantity of water, add above-mentioned concentrate, stir, and are assigned to Solid content content for 40% (20 DEG C), and upper spraying is dry
Dry tower carries out mist projection granulating, nozzle bore 0.5mm, 170 DEG C of EAT, 80 DEG C of leaving air temp, flow 250L/h, must be formulated
Grain, capsule, every weight 0.5g are made by granule according to the customary preparation methods of capsule.
Wherein, described green-tea extract (theanine) and pupa albumen take outsourcing mode, green-tea extract (tea ammonia
Acid) Sichuan Kang Jia bio tech ltd is purchased from, batch number is 140923-1；Pupa albumen is biological purchased from the new tencel in Huzhou
Technology Co., Ltd., batch number is 20150103.
Embodiment 2
One kind has strengthen immunity, health food for relieving physical fatigue, is made up of the raw material of following parts by weight：Ginseng
10th, maca 20, pupa albumen 10, green-tea extract (theanine) 20, Poria cocos 25, maltodextrin 15.
Specifically preparation technology is：By maca plus 15 times amount 70%v/v edible alcohols in be stirred at reflux at 80 DEG C extract 2 times,
Each 2h, filtering, merging filtrate obtains filter residue 1 and filtrate 1；Ginseng, the Poria cocos of formula ratio, plus 15 times of amount water are added into filter residue 1
2h is extracted in stirring at 90 DEG C, filtering obtains filter residue 2 and filtrate 2, extract 2h in stirring at 90 DEG C to filter residue 2 plus 8 times of amount water, obtain
Filter residue 3 and filtrate 3；Merging filtrate 1, filtrate 2 and filtrate 3, disk centrifugal separator (7000 revs/min of rotating speed, deslagging cycle 240s, stream
Measure 30L/min) after centrifugal filtration, filtrate is placed in vacuum concentration pot, is concentrated in vacuo (temperature 50 C, vacuum 0.09MPa) extremely
Solid content content is 35% (20 DEG C), obtains concentrate；Weigh green-tea extract (theanine), pupa albumen, the malt of formula ratio
Dextrin and suitable quantity of water, add above-mentioned concentrate, stir, and are assigned to Solid content content for 50% (20 DEG C), upper spray drying
Tower carries out mist projection granulating, and nozzle bore 1.1mm, 200 DEG C of EAT, 97 DEG C of leaving air temp, flow 500L/h must be formulated
Grain, adds appropriate sodium carboxymethyl starch by granule and cooks disintegrant progress tabletting, tablet adds stomach dissolution type film coating agent and entered
Row coating produces tablet, every weight 1g.
Wherein, the manufacturing enterprise and batch number be the same as Example 1 of described green-tea extract (theanine) and pupa albumen.
Embodiment 3
One kind has strengthen immunity, health food for relieving physical fatigue, is made up of the raw material of following parts by weight：Ginseng
15th, maca 25, pupa albumen 15, green-tea extract (theanine) 15, Poria cocos 15, maltodextrin 15.
Specifically preparation technology is：By maca plus 20 times of amount 60%v/v edible alcohols in stirring extraction 4 times at 65 DEG C, every time
1.5h, filtering, merging filtrate obtains filter residue 1 and filtrate 1；Into filter residue 1 add formula ratio ginseng, Poria cocos, plus 20 times amount water in
3h is extracted in stirring at 70 DEG C, and filtering obtains filter residue 2 and filtrate 2, is extracted 3h in stirring at 70 DEG C to filter residue 2 plus 15 times of amount water, must be filtered
Slag 3 and filtrate 3；Merging filtrate 1, filtrate 2 and filtrate 3, disk centrifugal separator (9000 revs/min of rotating speed, deslagging cycle 480s, flow
50L/min) after centrifugal filtration, filtrate is placed in vacuum concentration pot, is concentrated in vacuo (temperature 70 C, vacuum 0.08MPa) to admittedly
Inclusion content is 12% (20 DEG C), obtains concentrate；Weigh green-tea extract (theanine), pupa albumen, the malt paste of formula ratio
Essence and suitable quantity of water, add above-mentioned concentrate, stir, and are assigned to Solid content content for 25% (20 DEG C), upper spray drying tower
Mist projection granulating is carried out, nozzle bore 0.7mm, 185 DEG C of EAT, 90 DEG C of leaving air temp, flow 700L/h obtains granule,
Capsule, every weight 0.5g is made according to the customary preparation methods of capsule in granule.
Wherein, the manufacturing enterprise and batch number be the same as Example 1 of described green-tea extract (theanine) and pupa albumen.
Embodiment 4
One kind has strengthen immunity, health food for relieving physical fatigue, is made up of the raw material of following parts by weight：Ginseng
20th, maca 25, pupa albumen 20, green-tea extract (theanine) 10, Poria cocos 10, maltodextrin 30.
Specifically preparation technology is：By maca plus 10 times of amount 80%v/v edible alcohols in stirring extraction 3 times at 70 DEG C, every time
2.5h, filtering, merging filtrate obtains filter residue 1 and filtrate 1；Into filter residue 1 add formula ratio ginseng, Poria cocos, plus 25 times amount water in
2.5h is extracted in stirring at 85 DEG C, and filtering obtains filter residue 2 and filtrate 2, and 2.5h is extracted in stirring at 85 DEG C to filter residue 2 plus 18 times of amount water,
Obtain filter residue 3 and filtrate 3；Merging filtrate 1, filtrate 2 and filtrate 3, disk centrifugal separator (8000 revs/min of rotating speed, deslagging cycle 480s,
Flow 60L/min) after centrifugal filtration, filtrate is placed in vacuum concentration pot, is concentrated in vacuo (temperature 50 C, vacuum 0.09MPa)
It is 40% (20 DEG C) to Solid content content, obtains concentrate；Weigh the green-tea extract (theanine), pupa albumen, wheat of formula ratio
Bud dextrin and suitable quantity of water, add above-mentioned concentrate, stir, and are assigned to Solid content content for 66% (20 DEG C), and upper spraying is dry
Dry tower carries out mist projection granulating, and nozzle bore 1.5mm, 215 DEG C of EAT, 103 DEG C of leaving air temp, flow 900L/h must be formulated
Particle, adds appropriate sodium carboxymethyl starch by granule and cooks disintegrant progress tabletting, tablet adds stomach dissolution type film coating agent
It is coated and produces tablet, every weight 1g.
Wherein, the manufacturing enterprise and batch number be the same as Example 1 of described pupa albumen and green-tea extract (theanine).
Experimental example 5
Sample：It is made up of the raw material of following parts by weight：Ginseng 5, maca 10, pupa albumen 5, green-tea extract (theanine)
30th, Poria cocos 35；Ginseng 10, maca 20, pupa albumen 10, green-tea extract (theanine) 20, Poria cocos 25；Ginseng 15, maca 25,
Pupa albumen 15, green-tea extract (theanine) 15, Poria cocos 15；Ginseng 20, maca 25, pupa albumen 20, green-tea extract (tea
Propylhomoserin) 10, the proportioning of Poria cocos 10, by the extraction process of tablet in embodiment 3, sample 1, sample 2, sample 3, sample are made respectively
4。
Everyone (adult) 2 times a day, 1 every time, and adult's body weight is calculated by 60kg, and it is 33mg/kg BW to convert into dosage.With
20 times of adult human dose, i.e. 660mg/kg BW feeding trials mouse are simultaneously tested.
As a result：
1. influence of the sample to mouse weight
Table 1.1：The body weight increase situation of each group mouse
After table 1.1, the sample 30d of orally administration mouse various dose, the body weight and negative control of each sample group
Group is compared, difference that there are no significant (P ＞ 0.05), shows the sample on the body weight increase of mouse without influence.
2. influence of the sample to mice organs/body weight ratio
Table 1.2：Each group mice organs/body weight ratio situation
From after table 1.2, the sample 30d of orally administration mouse various dose, internal organs/weight ratio of each dosage group of sample
Both greater than negative control, wherein sample 2,3,4 groups of internal organs/weight ratio are noticeably greater than negative control group (P ＜ 0.05), show examination
The proportioning of 2,3,4 groups of sample can promote the growth of mouse immune organ, and the effect of 3 groups of sample is best, point out the proportioning tool of sample 3
Effect of immunity is improved, and is acted on most notable.
3. influence of the sample to the mice burden swimming time
Table 1.3：The walking weight load of each group mouse
From table 1.3, heavy burden (mouse weight 5%) swimming time of each sample group mouse of sample compares negative control group
It is long, and the swimming time of 2,3,4 groups of sample and negative control has significant difference (P ＜ 0.05), the wherein effect of sample 3 most
It is good, show that the sample has the effect of walking weight load of extension mouse, and the proportioning of sample 3 has the work(for improving immunity
Effect, is acted on most notable.
In summary, 3 groups of sample has remarkable efficacy in terms of strengthen immunity eases up physical fatigue, and effect is most
It is good.
Embodiment 6
Sample：Tablet prepared by embodiment 3 (dosage size is medium level, hereinafter referred to as sample in embodiment 1~4).
Everyone (adult) 2 times a day, 1 every time, and adult's body weight is calculated by 60kg, and it is 33mg/kg BW to convert into dosage.Respectively with adult
Dosage 5,10,20 times, i.e., 165,330,660mg/kg BW are basic, normal, high dosage group feeding trial mouse and are tested.
Result of the test：
1. influence of the sample to mouse weight
Table 2.1：The body weight increase situation of each group mouse
Continued 2.1：The body weight increase situation of each group mouse
2.1 are the results are shown in Table, the original body mass of mouse is compared between each experimental group and negative control group, and it is poor that there are no significant
Different (P>0.05), i.e., the original body mass of mouse is more balanced between each group.
After table 2.1, the sample 30d of orally administration mouse various dose, immune group and antifatigue group of sample are each
The body weight of dosage group is compared with negative control group, difference that there are no significant (P ＞ 0.05), shows that the sample increases to the body weight of mouse
Length is without influence.
2. influence of the sample to mice organs/body weight ratio
Table 2.2：Each group mice organs/body weight ratio situation
From after table 2.2, the sample 30d of orally administration mouse various dose, internal organs/weight ratio of each dosage group of sample
Both greater than negative control, internal organs/weight ratio of wherein high dose group is noticeably greater than negative control group (P ＜ 0.05), shows the sample
Product can promote the accretion of the immune organ of mouse.
3. sample is on lymphopoietic influence
Table 2.3：Each group mouse lymphocyte proliferative conditions
From table 2.3, bone-marrow-derived lymphocyte, the T lymphocyte contents of each dosage group mouse of sample are above negative control
Group, and high, middle dose group has significant difference (P ＜ 0.05) compared with negative control, shows that the sample has and promotes mouse
Lymphopoietic effect.
4. the influence that sample is generated to Hemolysin
Table 2.4：Each group mice serum hemolytic antibody content
From table 2.4, each dosage group of sample can dramatically increase the small of the immunologic hypofunction that endoxan (CTX) is caused
The generation (P ＜ 0.05) of mouse hemolytic antibody, shows that the sample has the effect for promoting the generation of mouse hemolytic antibody.
5. influence of the sample to mouse carbonic clearance
Table 2.5：Phagocytic index situation in each group mouse carbonic clearance test
From table 2.5, mouse carbonic clearance experiment, the phagocytic index of each dosage group of sample is all higher than negative control group,
There is significant difference (P ＜ 0.05) in wherein high, middle dose group and the phagocytic index of negative control, show that the sample has increase
The effect of the phagocytic index of mouse.
6. sample swallows the influence of flesh red blood cell to Turnover of Mouse Peritoneal Macrophages
Table 2.6：Phagocytic index situation in each group mouse phagocytosis test
From table 2.6, mouse phagocytosis experiment, the phagocytic rate of each dosage group of sample and negative control, phagocytic index are equal
It has been risen that, wherein high, middle dose group has significant difference (P ＜ 0.05) compared with negative control, show that the sample has
Increase the phagocytic rate of Turnover of Mouse Peritoneal Macrophages phagocytosis flesh red blood cell and the effect of phagocytic index.
7. influence of the sample to the mice burden swimming time
Table 2.7：The walking weight load of each group mouse
From table 2.7, heavy burden (mouse weight 5%) swimming time of each dosage group mouse of sample compares negative control group
It is long, and the swimming time of high, middle dose group and negative control has significant difference (P ＜ 0.05), shows that the sample has and prolongs
The effect of the walking weight load of long mouse.
8. influence of the sample to the hepatic glycogen content of mouse
Table 2.8：Each group mouse hepatic glycogen measurement result
Table 2.8 is visible, and the hepatic glycogen content of each dosage group mouse of sample is above negative control group, and high, middle dose group
There is significant difference (P ＜ 0.05) with the hepatic glycogen content of negative control, show that the sample has the hepatic glycogen storage of increase mouse
Standby effect.
9. influence of the sample to the blood lactase acid value after mouse movement
Table 2.9：Blood lactase acid value after each group mouse movement
From table 2.9, after exercise after 0min and 20min, the blood lactase acid value of each dosage of sample is all significantly less than feminine gender
Control group (P ＜ 0.05), illustrates that sample has and significantly reduces mouse blood lactase acid value after motion, accelerate blood lactase acid value after mouse movement
The effect of recovery.
In summary, the tablet prepared by the raw material proportioning and method of embodiment 3, respectively with 165,330,660mg/kg
BW (be respectively equivalent to human body recommended amounts 5,10,20 times) dosage gives mouse continuous gavage 30d, can not only improve mouse spleen,
Internal organs/weight ratio of thymus gland, promotes the increment of mouse lymphocyte, increases the content of mice serum hemolysin, is respectively increased small
Mouse carbonic clearance tests phagocytic index and phagocytic rate, the phagocytic index of phagocytosis test.Point out the sample that there is the work(of strengthen immunity
Energy；Simultaneously the walking weight load of mouse can be extended, the hepatic glycogen of the tired mouse of enhancing it is thick, reduce the blood breast after mouse movement
The generation of serum urea has no significant effect after acid number, the body weight increase and motion to mouse, points out the sample to have and alleviates muscle power
Fatigue function.Illustrate, sample has strengthen immunity, function of relieving physical fatigue.
Claims (1)
1. it is a kind of have strengthen immunity, the preparation method of the health food of function of physical fatigue alleviation, it is characterised in that by with
The raw material of lower parts by weight is prepared from：Ginseng 15, maca 25, Silkworm pupa protein 15, theanine 15, Poria cocos 15 and maltodextrin
15, comprise the following steps：
(1) maca for weighing formula ratio is put in extractor, plus 15 times of amount 75%v/v edible alcohols are extracted 2 times in stirring at 70 DEG C,
Each 2h, filtering, merging filtrate obtains filter residue 1 and filtrate 1；
(2) ginseng, the Poria cocos of formula ratio are added into filter residue 1, plus 20 times of amount water extract 2h in stirring at 90 DEG C, filtering must be filtered
Slag 2 and filtrate 2, extract 2h in stirring at 90 DEG C to filter residue 2 plus 12 times of amount water, obtain filter residue 3 and filtrate 3；
(3) merging filtrate 1, filtrate 2 and filtrate 3, after centrifugal filtration, filtrate is placed in vacuum concentration pot, is concentrated in vacuo to 20 DEG C
Lower Solid content content is 25%, obtains concentrate；Theanine, pupa albumen, maltodextrin and the suitable quantity of water of formula ratio are weighed, plus
Enter above-mentioned concentrate, stir, it is 50% to be assigned to Solid content content at 20 DEG C, is spray-dried, obtains granule；
Using disk centrifugal separator, centrifugal condition is：7000 revs/min of rotating speed, deslagging cycle 240s, flow 50L/min；Described spray
Mist granulation is carried out using spray drying tower, nozzle bore 1.1mm, 185 DEG C of EAT, 90 DEG C of leaving air temp, flow 600L/h；
(4) capsule is made through capsule filling machine in granule or tablet is made through tabletting, coating.
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| CN105250987A (en) * | 2015-11-05 | 2016-01-20 | 安徽生物肽产业研究院有限公司 | Silkworm pupa bioactive small peptide composition for enhancing immunity |
| CN105707853A (en) * | 2016-01-25 | 2016-06-29 | 广州一乾健乐健康科技有限责任公司 | Qi benefiting and blood supplementing human immunity improving health-care composition |
| CN105614874B (en) * | 2016-03-11 | 2019-04-05 | 海门品尚医药科技有限公司 | A kind of composition improving fatigue state |
| CN108379548A (en) * | 2018-02-09 | 2018-08-10 | 刘明秋 | It is a kind of have relieve fatigue drug or health-care food composition of effect and preparation method thereof |
| CN109567200A (en) * | 2018-12-28 | 2019-04-05 | 德化县仙铭生态农林有限公司 | One kind is for improving immunity and function of relieving physical fatigue sex-health products and preparation method thereof |
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| JP3572281B2 (en) * | 2001-09-17 | 2004-09-29 | 和弘 小谷 | Fermented health food using deep ocean water and method for producing the same |
| JP2007215534A (en) * | 2006-02-17 | 2007-08-30 | Yoshiaki Nagaura | Discovery of new extraction method |
| CN102273575B (en) * | 2011-08-26 | 2013-04-10 | 吉林紫鑫药业股份有限公司 | Ginseng and tuckahoe cream and production process thereof |
| CN102716263B (en) * | 2012-07-12 | 2014-08-06 | 云南滇隆制药有限公司 | Maca, ginseng and medlar composition and application thereof |
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| CN102870912A (en) * | 2012-09-22 | 2013-01-16 | 无锡爱迪信光电科技有限公司 | Tea with Maca leaves |
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| CN104224885A (en) * | 2014-09-11 | 2014-12-24 | 上海焦点生物技术有限公司 | Traditional Chinese medicine composition for relieving physical fatigue |
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