CN104783185A - Healthcare food with functions of improving immunity and relieving physical fatigue and preparation method of healthcare food - Google Patents
Healthcare food with functions of improving immunity and relieving physical fatigue and preparation method of healthcare food Download PDFInfo
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Abstract
The invention discloses a healthcare food with functions of improving immunity and relieving physical fatigue. The healthcare food is prepared from the following raw materials in parts by weight: 1-30 parts of ginseng, 5-40 parts of maca, 1-30 parts of silkworm pupa protein, 10-40 parts of green tea extract and 10-40 parts of poria cocos. The invention further discloses a preparation process of the healthcare food. The healthcare food is prepared by taking the ginseng, the maca, the silkworm pupa protein, the green tea extract (theanine) and the poria cocos as the raw materials and performing processes of extraction, separation, concentration, granulation or tabletting, coating and the like. The healthcare food adopts new resource foods and medicinal and edible foods as the raw materials based on a 'preventive treatment of disease' theory of traditional Chinese medicine and prevention and treatment suggestions of modern medicine to sub-health status, and is safe, reliable and suitable for long-term administration; a formula is simple; the raw materials are reasonably combined and have a remarkable synergistic effect; experiments prove that the healthcare food has remarkable effects of improving the immunity and relieving the physical fatigue; moreover, the preparation process is simple and stable, and the product quality is stable and controllable.
Description
Technical field
The present invention relates to field of health care food, be specially a kind of health food and preparation method thereof with develop immunitypty, alleviating physical fatigue function.
Background technology
In society now, the increasing of the deficient and social competition's pressure of natural environment deterioration, bad life habits, health knowledge, allows increasing people be in " sub-health state ".Limbs fatigue, spirit is not good enough, and hypoimmunity, easily catches a cold, palpitation, hyposexuality, insomnia forgetfulness, does not have appetite etc. to become the portrayal of more and more people's animation gradually.Human body sub-health status is becoming the topic that the whole mankind pays close attention to.World Health Organization's predictability investigation display, whole world inferior health population ratio reaches 75%, and the harmfulness of inferior health is thought the 21 world human health No.1 formidable enemy arranged side by side with AIDS by medical circle.
Though traditional Chinese medicine is without " sub-health state " word, " before more than 2000 years, ' preventiveing treatment of disease ' thought that the traditional Chinese medical science just has ' above attacking preventing diseases instead for the treatment of diseases ', " are long-standing to the understanding of sub-health state.Physical fatigue can be considered the disease such as overstrain, consumptive disease that a kind of aggravating activities larger than labour intensity causes in the traditional Chinese medical science." fatigue " one word first appeared in Han dynasty Zhang Zhongjing " Synopsis Golden Chamber ", think tired similar with " spleen fatiguing disease ", think that the interpretation of the cause, onset and process of an illness of fatigue is caused by the deficiency of vital energy have the discussion of " overstrain may lead to decline of vital energy, labor is then panted sweating, inside and outsidely all gets over, therefore gas consumption ".In addition, the traditional Chinese medical science has natural contacting with immunity.We say often, hypoimmunity, and easily ill, the traditional Chinese medical science is then thought " healthy tendency deposit in, heresy can not be done ", and so-called " healthy tendency " is immunocompetence.The traditional Chinese medical science thinks that healthy state is " yin and yang in equilibrium ", and a side is too hyperfunction, disorderly between each system of internal body, then cause disease, so-called " high then evil, holding is system ".
Although at present more existing there is health food and the medicine of develop immunitypty or alleviating physical fatigue, in various degree there is function singleness, DeGrain, a large amount of problem such as use famous and precious tonic Chinese herbal medicine, effective component extraction rate too low.
Summary of the invention
The invention provides a kind of health food with develop immunitypty, alleviating physical fatigue function, by the synergy of ginseng, agate coffee, pupa albumen, green-tea extract, Poria cocos five tastes food, there is the effect of significant develop immunitypty and alleviating physical fatigue.
Ginseny spleen invigorating, lung channel, the heart channel of Hang-Shaoyin, tool reinforces vital energy, and multiple arteries and veins takes off admittedly, reinforces the spleen to benefit the lung, promotes the production of body fluid, the function of calming the nerves; Agate coffee returns kidney,liver,spleen warp, has warming kidney to invigorate yang, strengthens muscles and bones, the function of loose cold, pain relieving, tune blood vessels; Pupa albumen have reducing blood lipid, norcholesterol, hypoglycemic, improve immunity function, protection liver, promote fecundity, antitumor and increase intelligence, vision protection, the several functions such as delay senility; Green-tea extract (theanine) have antitumor, improve human immunological competence, delayed motion fatigue, hypertensive tranquilizing, neuroprotective, Improving memory power, alleviate depression disease, alleviate the multiple efficacies such as alcoholic liver injury; The Poria cocos thoughts of returning home, lung, spleen, kidney channel, tool clearing damp and promoting diuresis, the function of the peaceful heart of invigorating the spleen.These five kinds of integration of drinking and medicinal herbs foods are with using, play strengthening spleen and nourishing stomach, nourishing liver and kidney, boosting qi and nourishing yin, the effect of strengthening the body resistance to consolidate the constitution, play traditional Chinese medical science organic conception advantage, regulate mechanism of qi, conditioning viscera, negative and positive of qi and blood is tended to balance, the normal organic operation of each function, reaches the effect of develop immunitypty and alleviating physical fatigue, effectively improves sub-health state.
To achieve these goals, the present invention adopts following technical scheme:
There is a health food for develop immunitypty, alleviating physical fatigue, be made up of the raw material of following weight portion: ginseng 1-10, agate coffee 5-15, pupa albumen 1-10, green-tea extract (theanine) 30-40, Poria cocos 30-40.
The present invention, to improve effect of its develop immunitypty and alleviating physical fatigue for foundation, is optimized formula.
The raw material of above-mentioned weight portion can more preferably: ginseng 5-15, agate coffee 10-20, Silkworm pupa protein 5-15, green-tea extract (theanine) 20-30, Poria cocos 20-30.
The raw material of above-mentioned weight portion can more preferably: ginseng 10-20, agate coffee 20-30, Silkworm pupa protein 10-20, green-tea extract (theanine) 10-20, Poria cocos 10-20.
The raw material of above-mentioned weight portion can be more preferably: ginseng 15, agate coffee 25, Silkworm pupa protein 15, green-tea extract (theanine) 15, Poria cocos 15.
By improving ginseng, agate coffee, the ratio of pupa albumen in prescription, reduce the ratio of green-tea extract and Poria cocos, optimizing raw material composition and ratio, effectively can improve effect of its develop immunitypty and alleviating physical fatigue.
In above-mentioned formula, each raw material sources are as follows respectively:
Ginseng: be the dry root and rhizome of Araliaceae ginseng Panax ginseng C.A.Mey., sweet, the micro-hardship of taste, property is put down, and returns spleen, lung, the heart channel of Hang-Shaoyin.Have and reinforce vital energy, multiple arteries and veins takes off admittedly, reinforces the spleen to benefit the lung, promotes the production of body fluid, the function of calming the nerves, can be used for empty pre-de-, the insufficiency of the spleen food of body less, in heart failure etc.Modern medicine and pharmacology research shows, ginseng is mainly containing compositions such as multiple ginsenoside, carbohydrate, volatile oil, peptide, amino acid, trace element and organic acid, multivitamin, choline and enzymes.There is antifatigue, develop immunitypty, antitumor, the hypoglycemic and anti-ageing effect of waiting for a long time.
Agate coffee (Lepidium meyenii Walp.): be the Andean a kind of crucifer of growth Peru's height above sea level 4000 ~ 4500 meters, have long history at mountain area, Andean agate coffee block root as the plant of dietotherapeutic, be conventionally used to and improve fecundity, increase energy.China introduced and popularizing planting the end of the nineties, now in ground scale plantations such as Lijiang, yunnan, Daocheng, Sichuan Aden.
Modern study shows that agate coffee has antifatigue, improvement function, anti-oxidant, the multiple efficacies such as Suppress hyperplasia of prostate, alleviation climacteric metancholia, develop immunitypty.Agate coffee is a kind of food resource having better nutritivity and be worth; protein content in main edible part root is higher; amino acid composition rationally; the trace elements such as essential amino acids content, unrighted acid ratio, potassium, calcium, magnesium, zinc are all higher; and containing a large amount of branched-chain amino acid and a certain amount of taurine, FAO (Food and Agriculture Organization of the United Nation) suggestion people improve underfed symptom by edible agate coffee.Except abundant nutritional labeling, agate coffee is also containing multiple secondary metabolites: agate coffee alkene (macaene), alkaloid (comprising macamide macamide), glucosinolate and hydrolysate, sterol, Polyphenols and other composition, these secondary metabolites are considered to there is substantial connection with the health-care efficacy of agate coffee.
Pupa albumen: be the hydrolysate of the dry pupa of Bombycidae insect silkworm Bymbyx mori (Linnaeus), pupa albumen is the main functional component of silkworm chrysalis, has very high nutrition and medical value.Modern age, pharmaceutical research showed; pupa albumen has and promotes fat metabolism, liver cell regeneration, reducing blood lipid, norcholesterol, hypoglycemic, the several functions such as improve immunity function, protection liver, promote the effects such as fecundity, strong, anticancer, diuresis and increase intelligence, vision protection, delay senility.
Green-tea extract (theanine): for the leaf of Theaceae Camellia tea tree (Camellia sinensis) for raw material, make through techniques such as extracting, filter, be concentrated, there is the fresh refreshing taste of camerlsed and similar monosodium glutamate.Theanine (L-Theanine) is distinctive one in tealeaves, and medicine accounts for 50% of free amino acid of tea total amount.Modern study shows: theanine have antitumor, improve human immunological competence, delayed motion fatigue, hypertensive tranquilizing, neuroprotective, Improving memory power, alleviate depression disease, alleviate alcohol to multiple efficacies such as the injuries of liver.
Poria cocos: be the dry sclerotia of On Polyporaceae Poria cocos Poria cocos (Schw.) Wolf, taste is sweet, light, property is put down, the thoughts of returning home, lung, spleen, kidney channel.There is clearing damp and promoting diuresis, the function of the peaceful heart of invigorating the spleen.Can be used for insufficiency of the spleen food few, confused and worried, palpitation with fear insomnia etc.Modern medicine and pharmacology research shows, Poria cocos main component is β-pachyman and three mushroom compounds second phthalein pachymic acids, pachymic acid and 3 beta-hydroxy wool steroid trienic acids.There is functions such as improving immunity, antifatigue, antitumor, anti-cirrhosis.
The formula of above-mentioned raw materials composition, formulation can be capsule or tablet.In process, can add appropriate maltodextrin according to actual conditions, starch makes adhesive, sodium carboxymethyl starch makes the processing aids such as disintegrant, improves processing characteristics better.Generally, the addition of maltodextrin is weight portion 10 ~ 30 parts.
The described preparation method with the health food of develop immunitypty and alleviating physical fatigue, comprises the following steps:
(1) the agate coffee taking formula ratio is put in extractor, and add 5-20 times amount 50%-95%v/v edible alcohol and at 50-80 DEG C, stir extraction 2-4 time, each 1-4h, filter, merging filtrate, obtains filter residue 1 and filtrate 1;
(2) in filter residue 1, add ginseng, the Poria cocos of formula ratio, add 10-25 times of water gaging at 60-100 DEG C, stir extraction 1-4h, filter, obtain filter residue 2 and filtrate 2, add 8-18 times of water gaging to filter residue 2 at 60-100 DEG C, stir extraction 1-4h, obtain filter residue 3 and filtrate 3;
(3) merging filtrate 1, filtrate 2 and filtrate 3, disk centrifugal separator (rotating speed 6000-9000 rev/min, deslagging cycle 240-720s, flow 20-80L/min) after centrifugal filtration, filtrate is placed in vacuum concentration pot, Vacuum Concentration (temperature 50 ~ 70 DEG C, vacuum 0.07 ~ 0.1MPa) is 10%-40% (20 DEG C) to admittedly containing thing content, obtains concentrate; Take the green-tea extract (theanine) of formula ratio, pupa albumen, maltodextrin and suitable quantity of water, add above-mentioned concentrate, stir, be assigned to admittedly containing thing content be 25%-70% (20 DEG C), upper spray drying tower carries out mist projection granulating, nozzle bore 0.5-1.5mm, EAT 170-220 DEG C, leaving air temp 80-110 DEG C, flow 200-1000L/h, obtains granule.
(4) granule made capsule through capsule filling machine or make tablet through compressing tablet, dressing.
Preferably, the described health food preparation method with develop immunitypty and alleviating physical fatigue comprises the following steps:
(1) the agate coffee taking formula ratio is put in extractor, adds 15 times amount 75%v/v edible alcohols and at 70 DEG C, stirs extraction 2 times, each 2h, and filter, merging filtrate, obtains filter residue 1 and filtrate 1;
(2) in filter residue 1, add ginseng, the Poria cocos of formula ratio, add 20 times of water gagings at 90 DEG C, stir extraction 2h, filter, obtain filter residue 2 and filtrate 2, add 12 times of water gagings to filter residue 2 at 90 DEG C, stir extraction 2h, obtain filter residue 3 and filtrate 3;
(3) merging filtrate 1, filtrate 2 and filtrate 3, disk centrifugal separator (rotating speed 7000 revs/min, deslagging cycle 240s, flow 50L/min) after centrifugal filtration, filtrate is placed in vacuum concentration pot, Vacuum Concentration (temperature 50 C, vacuum 0.09MPa) is 25% (20 DEG C) to admittedly containing thing content, obtains concentrate; Take the green-tea extract (theanine) of formula ratio, pupa albumen, maltodextrin and suitable quantity of water, add above-mentioned concentrate, stir, be assigned to admittedly containing thing content be 50% (20 DEG C), upper spray drying tower carries out mist projection granulating, nozzle bore 1.1mm, EAT 185 DEG C, leaving air temp 90 DEG C, flow 600L/h, obtains granule.
(4) granule made capsule through capsule filling machine or make tablet through compressing tablet, dressing.
Compared with prior art, beneficial effect of the present invention is:
The present invention adopts new resource food and integration of drinking and medicinal herbs food to be raw material, safe and reliable, suitable long-term taking, prescription is simple, compatibility is reasonable, and between each raw material, synergistic function is obvious, confirms that it has the effect of significant develop immunitypty and alleviating physical fatigue by experiment, and preparation technology is simple, stable, constant product quality is controlled.
The present invention starts with from adjustment function, use that integration of drinking and medicinal herbs food with strong complementarity combines mutually, Synergistic, strengthening spleen and nourishing stomach, nourishing liver and kidney, boosting qi and nourishing yin, to strengthen the body resistance to consolidate the constitution, play traditional Chinese medical science organic conception advantage, regulate mechanism of qi, conditioning viscera, negative and positive of qi and blood is tended to balance, the normal organic operation of each function, reach the effect of develop immunitypty and alleviating physical fatigue, effectively improve sub-health state.
Detailed description of the invention
Below by specific embodiment, the present invention is described in further detail; but protection scope of the present invention is not by any restriction of specific embodiment; without departing from the idea case in the present invention described above; according to ordinary skill knowledge and customary means; make various replacement and change, all should comprise within the scope of the invention.
Embodiment 1
There is a health food for develop immunitypty, alleviating physical fatigue, be made up of the raw material of following weight portion: ginseng 5, agate coffee 10, pupa albumen 5, green-tea extract (theanine) 30, Poria cocos 35, maltodextrin 10.
Concrete preparation technology is: agate coffee is added 8 times amount 90%v/v edible alcohols and at 75 DEG C, stir extraction 3 times, each 80min, and filter, merging filtrate, obtains filter residue 1 and filtrate 1; In filter residue 1, add ginseng, the Poria cocos of formula ratio, add 10 times of water gagings at 100 DEG C, stir extraction 2h, filter, obtain filter residue 2 and filtrate 2, add 10 times of water gagings to filter residue 2 at 100 DEG C, stir extraction 2h, obtain filter residue 3 and filtrate 3; Merging filtrate 1, filtrate 2 and filtrate 3, disk centrifugal separator (rotating speed 6000 revs/min, deslagging cycle 720s, flow 80L/min) after centrifugal filtration, filtrate is placed in vacuum concentration pot, Vacuum Concentration (temperature 60 C, vacuum 0.09MPa) is 25% (20 DEG C) to admittedly containing thing content, obtains concentrate; Take the green-tea extract (theanine) of formula ratio, pupa albumen, maltodextrin and suitable quantity of water, add above-mentioned concentrate, stir, be assigned to admittedly containing thing content be 40% (20 DEG C), upper spray drying tower carries out mist projection granulating, nozzle bore 0.5mm, EAT 170 DEG C, leaving air temp 80 DEG C, flow 250L/h, obtain granule, granule is made capsule according to the customary preparation methods of capsule, every heavy 0.5g.
Wherein, described green-tea extract (theanine) and pupa albumen take outsourcing mode, and green-tea extract (theanine) is purchased from Kang Jia bio tech ltd, Sichuan, and batch number is 140923-1; Pupa albumen is purchased from Huzhou Xintiansi Biotechnology Co. Ltd., and batch number is 20150103.
Embodiment 2
There is a health food for develop immunitypty, alleviating physical fatigue, be made up of the raw material of following weight portion: ginseng 10, agate coffee 20, pupa albumen 10, green-tea extract (theanine) 20, Poria cocos 25, maltodextrin 15.
Concrete preparation technology is: agate coffee is added 15 times amount 70%v/v edible alcohols stirring and refluxing at 80 DEG C and extract 2 times, each 2h, and filter, merging filtrate, obtains filter residue 1 and filtrate 1; In filter residue 1, add ginseng, the Poria cocos of formula ratio, add 15 times of water gagings at 90 DEG C, stir extraction 2h, filter, obtain filter residue 2 and filtrate 2, add 8 times of water gagings to filter residue 2 at 90 DEG C, stir extraction 2h, obtain filter residue 3 and filtrate 3; Merging filtrate 1, filtrate 2 and filtrate 3, disk centrifugal separator (rotating speed 7000 revs/min, deslagging cycle 240s, flow 30L/min) after centrifugal filtration, filtrate is placed in vacuum concentration pot, Vacuum Concentration (temperature 50 C, vacuum 0.09MPa) is 35% (20 DEG C) to admittedly containing thing content, obtains concentrate; Take the green-tea extract (theanine) of formula ratio, pupa albumen, maltodextrin and suitable quantity of water, add above-mentioned concentrate, stir, be assigned to admittedly containing thing content be 50% (20 DEG C), upper spray drying tower carries out mist projection granulating, nozzle bore 1.1mm, EAT 200 DEG C, leaving air temp 97 DEG C, flow 500L/h, obtains granule, granule is added appropriate sodium carboxymethyl starch and cooks disintegrant and carry out compressing tablet, tablet adds stomach dissolution type film coating agent to carry out dressing and namely obtains tablet, the heavy 1g of every sheet.
Wherein, described green-tea extract (theanine) and the manufacturing enterprise of pupa albumen and batch number are with embodiment 1.
Embodiment 3
There is a health food for develop immunitypty, alleviating physical fatigue, be made up of the raw material of following weight portion: ginseng 15, agate coffee 25, pupa albumen 15, green-tea extract (theanine) 15, Poria cocos 15, maltodextrin 15.
Concrete preparation technology is: agate coffee is added 20 times amount 60%v/v edible alcohols and at 65 DEG C, stir extraction 4 times, each 1.5h, and filter, merging filtrate, obtains filter residue 1 and filtrate 1; In filter residue 1, add ginseng, the Poria cocos of formula ratio, add 20 times of water gagings at 70 DEG C, stir extraction 3h, filter, obtain filter residue 2 and filtrate 2, add 15 times of water gagings to filter residue 2 at 70 DEG C, stir extraction 3h, obtain filter residue 3 and filtrate 3; Merging filtrate 1, filtrate 2 and filtrate 3, disk centrifugal separator (rotating speed 9000 revs/min, deslagging cycle 480s, flow 50L/min) after centrifugal filtration, filtrate is placed in vacuum concentration pot, Vacuum Concentration (temperature 70 C, vacuum 0.08MPa) is 12% (20 DEG C) to admittedly containing thing content, obtains concentrate; Take the green-tea extract (theanine) of formula ratio, pupa albumen, maltodextrin and suitable quantity of water, add above-mentioned concentrate, stir, be assigned to admittedly containing thing content be 25% (20 DEG C), upper spray drying tower carries out mist projection granulating, nozzle bore 0.7mm, EAT 185 DEG C, leaving air temp 90 DEG C, flow 700L/h, obtain granule, granule is made capsule according to the customary preparation methods of capsule, every heavy 0.5g.
Wherein, described green-tea extract (theanine) and the manufacturing enterprise of pupa albumen and batch number are with embodiment 1.
Embodiment 4
There is a health food for develop immunitypty, alleviating physical fatigue, be made up of the raw material of following weight portion: ginseng 20, agate coffee 25, pupa albumen 20, green-tea extract (theanine) 10, Poria cocos 10, maltodextrin 30.
Concrete preparation technology is: agate coffee is added 10 times amount 80%v/v edible alcohols and at 70 DEG C, stir extraction 3 times, each 2.5h, and filter, merging filtrate, obtains filter residue 1 and filtrate 1; In filter residue 1, add ginseng, the Poria cocos of formula ratio, add 25 times of water gagings at 85 DEG C, stir extraction 2.5h, filter, obtain filter residue 2 and filtrate 2, add 18 times of water gagings to filter residue 2 at 85 DEG C, stir extraction 2.5h, obtain filter residue 3 and filtrate 3; Merging filtrate 1, filtrate 2 and filtrate 3, disk centrifugal separator (rotating speed 8000 revs/min, deslagging cycle 480s, flow 60L/min) after centrifugal filtration, filtrate is placed in vacuum concentration pot, Vacuum Concentration (temperature 50 C, vacuum 0.09MPa) is 40% (20 DEG C) to admittedly containing thing content, obtains concentrate; Take the green-tea extract (theanine) of formula ratio, pupa albumen, maltodextrin and suitable quantity of water, add above-mentioned concentrate, stir, be assigned to admittedly containing thing content be 66% (20 DEG C), upper spray drying tower carries out mist projection granulating, nozzle bore 1.5mm, EAT 215 DEG C, leaving air temp 103 DEG C, flow 900L/h, obtains granule, granule is added appropriate sodium carboxymethyl starch and cooks disintegrant and carry out compressing tablet, tablet adds stomach dissolution type film coating agent to carry out dressing and namely obtains tablet, the heavy 1g of every sheet.
Wherein, the manufacturing enterprise of described pupa albumen and green-tea extract (theanine) and batch number are with embodiment 1.
Experimental example 5
Sample: be made up of the raw material of following weight portion: ginseng 5, agate coffee 10, pupa albumen 5, green-tea extract (theanine) 30, Poria cocos 35; Ginseng 10, agate coffee 20, pupa albumen 10, green-tea extract (theanine) 20, Poria cocos 25; Ginseng 15, agate coffee 25, pupa albumen 15, green-tea extract (theanine) 15, Poria cocos 15; The proportioning of ginseng 20, agate coffee 25, pupa albumen 20, green-tea extract (theanine) 10, Poria cocos 10, by the extraction process of tablet in embodiment 3, obtained sample 1, sample 2, sample 3, sample 4 respectively.
Everyone (adult) every day 2 times, each 1, adult's body weight is pressed 60kg and is calculated, and amounting to dosage is 33mg/kg BW.With adult human dose's 20 times, i.e. 660mg/kg BW feeding trial mouse testing.
Result:
1. sample is on the impact of Mouse Weight
Table 1.1: the body weight growth pattern of each group mouse
From table 1.1, after per os gives the sample 30d of mouse various dose, the body weight of each sample group is compared with negative control group, and difference that there are no significant (P > 0.05), shows that this sample increases without impact the body weight of mouse.
2. sample is on the impact of mice organs/body weight ratio
Table 1.2: respectively organize mice organs/body weight ratio situation
From table 1.2, after per os gives the sample 30d of mouse various dose, the internal organs/weight ratio of each dosage group of sample is all greater than negative control, wherein sample 2,3, internal organs/the weight ratio of 4 groups is significantly greater than negative control group (P < 0.05), shows sample 2,3, the proportioning of 4 groups can promote the growth of mouse immune organ, and the effect of 3 groups, sample is best, the proportioning of prompting sample 3 has the effect improving immunity, and effect is the most remarkable.
3. sample is on the impact of mice burden swimming time
Table 1.3: the walking weight load of each group mouse
From table 1.3, heavy burden (Mouse Weight 5%) swimming time of sample each sample group mouse is all than negative control group leader, and sample 2,3,4 groups have significant difference (P < 0.05) with the swimming time of negative control, and wherein sample 3 effect is best, show that this sample has the effect of the walking weight load extending mouse, and the proportioning of sample 3 has the effect improving immunity, acts on the most remarkable.
In sum, 3 groups, sample has remarkable efficacy in develop immunitypty and alleviating physical fatigue, and best results.
Embodiment 6
Sample: tablet (dosage size is medium level in embodiment 1 ~ 4, hereinafter referred to as sample) prepared by embodiment 3.Everyone (adult) every day 2 times, each 1, adult's body weight is pressed 60kg and is calculated, and amounting to dosage is 33mg/kg BW.Respectively with adult human dose's 5,10,20 times, namely 165,330,660mg/kg BW is basic, normal, high dosage group feeding trial mouse and tests.
Result of the test:
1. sample is on the impact of Mouse Weight
Table 2.1: the body weight growth pattern of each group mouse
Continued 2.1: the body weight growth pattern of each group mouse
The results are shown in Table 2.1, the original body mass of mouse compares with between negative control group in each experimental group, difference that there are no significant (P>0.05), and namely the original body mass of mouse is comparatively balanced between each group.
From table 2.1, after per os gives the sample 30d of mouse various dose, the body weight of immune group and each dosage group of the sample of antifatigue group is compared with negative control group, and difference that there are no significant (P > 0.05), shows that this sample increases without impact the body weight of mouse.
2. sample is on the impact of mice organs/body weight ratio
Table 2.2: respectively organize mice organs/body weight ratio situation
From table 2.2, after per os gives the sample 30d of mouse various dose, internal organs/the weight ratio of each dosage group of sample is all greater than negative control, wherein internal organs/the weight ratio of high dose group is significantly greater than negative control group (P < 0.05), shows that this sample can promote the accretion of the immune organ of mouse.
3. sample is on lymphopoietic impact
Table 2.3: each group mouse lymphocyte proliferative conditions
From table 2.3, the bone-marrow-derived lymphocyte of sample each dosage group mouse, T lymphocyte content are all higher than negative control group, and height, middle dosage group all have significant difference (P < 0.05) compared with negative control, show that this sample has the effect promoting mouse lymphocyte propagation.
4. sample impact that Hemolysin is generated
Table 2.4: each group mice serum hemolytic antibody content
From table 2.4, the each dosage group of sample significantly can increase the generation (P < 0.05) of the mouse hemolytic antibody of the immunologic hypofunction that endoxan (CTX) causes, and shows that this sample has the effect promoting that mouse hemolytic antibody generates.
5. sample is on the impact of mouse carbonic clearance
Table 2.5: phagocytic index situation in the test of each group mouse carbonic clearance
From table 2.5, in the experiment of mouse carbonic clearance, the phagocytic index of each dosage group of sample is all greater than negative control group, wherein there is significant difference (P < 0.05) in the phagocytic index of high, middle dosage group and negative control, shows that this sample has the effect of the phagocytic index increasing mouse.
6. sample engulfs the erythrocytic impact of flesh to Turnover of Mouse Peritoneal Macrophages
Table 2.6: phagocytic index situation in each group mouse phagocytosis test
From table 2.6, mouse engulfs in experiment, phagocytic rate, the phagocytic index of each dosage group of sample and negative control rise all to some extent, wherein there is significant difference (P < 0.05) in high, middle dosage group compared with negative control, and showing that this sample has increases the effect that Turnover of Mouse Peritoneal Macrophages engulfs the erythrocytic phagocytic rate of flesh and phagocytic index.
7. sample is on the impact of mice burden swimming time
Table 2.7: the walking weight load of each group mouse
From table 2.7, heavy burden (Mouse Weight 5%) swimming time of sample each dosage group mouse is all than negative control group leader, and the swimming time of height, middle dosage group and negative control has significant difference (P < 0.05), show that this sample has the effect of the walking weight load extending mouse.
8. sample is on the impact of the hepatic glycogen content of mouse
Table 2.8: each group Mouse Liver glycogen measurement result
Table 2.8 is visible, the hepatic glycogen content of sample each dosage group mouse is all higher than negative control group, and the hepatic glycogen content of height, middle dosage group and negative control all has significant difference (P < 0.05), show that this sample has the effect increasing mouse liver glycogen reserves.
9. sample is on the impact of the blood lactase acid value after mouse movement
Table 2.9: the blood lactase acid value after each group mouse movement
From table 2.9, after exercise after 0min and 20min, the blood lactase acid value of each dosage of sample is all significantly less than negative control group (P < 0.05), interpret sample has the obviously rear Mouse Blood Lactate of minimizing motion, the effect that after accelerating mouse movement, blood lactase acid value is recovered.
In sum, by tablet prepared by pulp furnish and the method for embodiment 3, respectively with 165,330, the dosage of 660mg/kg BW (being equivalent to human body recommended amounts 5,10,20 times respectively) is to the continuous gavage 30d of mouse, internal organs/the weight ratio of mouse spleen, thymus gland can not only be improved, promote the increment of mouse lymphocyte, increase the content of mice serum hemolysin, improve phagocytic rate, the phagocytic index of mouse carbonic clearance test phagocytic index and phagocytosis test respectively.This sample is pointed out to have the function of develop immunitypty; The walking weight load of mouse can be extended simultaneously, strengthen the hepatic glycogen of tired mouse thick, reduce the blood lactase acid value after mouse movement, the body weight growth of mouse and the generation of the rear serum urea of motion are had no significant effect, points out this sample to have alleviating physical fatigue function.Illustrate, sample has develop immunitypty, the function of alleviating physical fatigue.
Claims (7)
1. there is a health food for develop immunitypty, alleviating physical fatigue function, it is characterized in that, be prepared from by the raw material of following weight portion: ginseng 1-10, agate coffee 5-15, pupa albumen 1-10, green-tea extract 30-40, Poria cocos 30-40.
2. there is the health food of develop immunitypty, alleviating physical fatigue function as claimed in claim 1, it is characterized in that, be prepared from by the raw material of following weight portion: ginseng 5-15, agate coffee 10-20, Silkworm pupa protein 5-15, green-tea extract 20-30, Poria cocos 20-30.
3. there is the health food of develop immunitypty, alleviating physical fatigue function as claimed in claim 1, it is characterized in that, be prepared from by the raw material of following weight portion: ginseng 10-20, agate coffee 20-30, Silkworm pupa protein 10-20, green-tea extract 10-20, Poria cocos 10-20.
4. there is the health food of develop immunitypty, alleviating physical fatigue function as claimed in claim 1, it is characterized in that, be prepared from by the raw material of following weight portion: ginseng 15, agate coffee 25, Silkworm pupa protein 15, green-tea extract 15, Poria cocos 15.
5. the health food with develop immunitypty, alleviating physical fatigue function as described in any one of claim 1-4, it is characterized in that, described raw material also adds maltodextrin, and the addition of maltodextrin is weight portion 10 ~ 30.
6. the preparation method of health food with develop immunitypty, alleviating physical fatigue function according to claim 5, is characterized in that, comprise the following steps:
(1) the agate coffee taking formula ratio is put in extractor, and add 8-20 times amount 50%-95%v/v edible alcohol and at 60-80 DEG C, stir extraction 2-4 time, each 1-3h, filter, merging filtrate, obtains filter residue 1 and filtrate 1;
(2) in filter residue 1, add ginseng, the Poria cocos of formula ratio, add 10-25 times of water gaging at 60-100 DEG C, stir extraction 1-3h, filter, obtain filter residue 2 and filtrate 2, add 8-18 times of water gaging to filter residue 2 at 60-100 DEG C, stir extraction 1-3h, obtain filter residue 3 and filtrate 3;
(3) merging filtrate 1, filtrate 2 and filtrate 3, after centrifugal filtration, filtrate is placed in vacuum concentration pot, is 10%-40% admittedly, obtains concentrate at Vacuum Concentration to 20 DEG C containing thing content; Take the green-tea extract of formula ratio, pupa albumen, maltodextrin and suitable quantity of water, add above-mentioned concentrate, stir, admittedly containing thing content at being assigned to 20 DEG C is 25%-70%, carries out spraying dry, obtains granule;
(4) granule made capsule through capsule filling machine or make tablet through compressing tablet, dressing.
7. the preparation method of health food according to claim 6, is characterized in that, in described step (3), adopt disk centrifugal separator, centrifugal condition is: rotating speed 6000-9000 rev/min, deslagging cycle 240-720s, flow 20-80L/min; Described mist projection granulating adopts spray drying tower to carry out, nozzle bore 0.5-1.5mm, EAT 170-220 DEG C, leaving air temp 80-110 DEG C, flow 200-1000L/h.
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