CN102488207A - Coenzyme Q10 soft capsule and its preparation method - Google Patents

Abstract

The invention discloses a coenzyme Q10 soft capsule, which comprises a gelatinous shell and content encapsulated therein. The content includes heath-caring liquid or semisolid. The gelatinous shell is 0.2-2mm in thickness and comprises, by weight, 30-70 parts of gelatin, 10-50 parts of plasticizer, 5-15 parts of water, and 0.1-3 parts of pigment. The content comprises, by weight, 105-150 parts of coenzyme Q10, 2-10 parts of suspending agent, and 70-100 parts of vegetable oil. The coenzyme Q10 soft capsule has the advantages of proportional reasonableness, economy, portability, convenience for taking, effectiveness and fastness in dissolution, high storing performance and the like, and has effective constituents more uniformly scattered as compared with similar products. In addition, a preparation method of the coenzyme Q10 soft capsule is easy in control and stable in quality.

Description

A kind of Co-Q10 soft capsule and preparation method thereof

Technical field

The present invention relates to a kind of health food and preparation method thereof, be specifically related to a kind of Co-Q10 soft capsule and preparation method.

Background technology

Co-Q10 is a kind of fat-soluble antioxidant; Co-Q10 is one of indispensable important element of human life; The nutrition of ability human activin cell and cellular energy; Have improve body immunity, strengthen anti-oxidant, delay senility and function such as enhances human body vigor, medically be widely used in disease of cardiovascular system.In recent years, extensively use it for nutrient and healthcare products and food additives both at home and abroad.

Patent: a kind of soft capsule and the preparation and application (patent No.: 2010101994052.9) propose a method that contains Co-Q10; Add that with Co-Q10 perilla herb oil, gelatin, glycerine, purified water, pigment, antholeucin etc. are that raw material is manufactured capsule, be mainly used in the treatment for cancer indication.But not mentioned daily health caring is used coenzyme Q10 capsule.Also rarer in the patent library at present is the edible natural product of primary raw material with the Co-Q10.

The appearance of soft capsule mainly is that the sealing of some oily matters that are difficult to enter the mouth is embraced in capsule, so that patient swallows easily, and along with the progress and the development of society, soft capsule also is widely used on a lot of wholesome health foods except being applied to medicine.Soft capsule has many good qualities, neat and artistic like: soft capsule, as to swallow, can cover medicine easily uncomfortable foul odour.Loading amount is evenly accurate, and solution loading amount precision can reach ± and 1%.Aqueous oiliness thing can directly be enclosed capsule, need not to use absorption, the additive of inclusion and so on, and soft capsule seals fully, and its thickness can prevent that oxygen gets into, and prolongs the product storage period.General soft capsule is processed by gelatin, glycerine and water, is the edible natural product.Can make enteric solubility soft capsule and sustained release preparation.The flavor of film, capsule, look, perfume (or spice), transparency, glossiness all can freely be selected, and compare with other roundel goods, and gloss appearance is good, and is noticeable.After the picked-up, content discharges rapidly, and bioavilability is high in the body.

Summary of the invention

Advantages such as the present invention provides a kind of functional preparation of soft capsule method, and the capsule of processing is bright to have reasonable mixture ratio, economy, carry instant, and effectively stripping is fast, and keeping quality is good, functional component looses even compared with similar products.Capsule comprises crust and content, and it is the active component with medical care effect that content comprises Co-Q10.

A kind of functional soft capsule; Comprise rubber and enclose the content in the rubber, wherein content is to have Co-Q10 and the vegetable oil of health care, the mixture of suspending agent, and rubber thickness is 0.2-2mm; The mass fraction proportioning that constitutes each component of rubber is: gelatin 30-70 branch; Plasticizer 10-50 part, water 5-15 branch, pigment 0.1-3 part.The quality of each composition of constitution content thing divides plain proportioning to be: Co-Q10 5-15 part, suspending agent 2-10 part, vegetable oil 70-100 part.

Gelatin be from ox, sheep, fish, pig, the chicken the mixture of a kind of gelatin or two or more gelatin, its intensity of congealing is 80-250Bloom g, plasticizer is selected from one or both the mixture in glycerine, the sorbierite.

Capsule be shaped as olive shape or circle, the rubber outward appearance is opaque redness.

Through existing preparation preparation of soft capsule method, can prepare product except that soft capsule, in order to obtain more high-quality soft capsule, can carry out according to following method:

In a, Jiang Shui, plasticizer, being added to of the pigment glue jar, heating makes temperature rise to 60-80 ℃, adds gelatin and continues heating, is stirred to gelatin and all dissolves, and is evacuated to no bubble outside of the city, in heat-preserving container, is incubated then;

B, suspending agent is heated to entirely melts, add Co-Q10, vegetable oil stirs in charging basket, crosses 80 mesh sieves, and feed liquid as for stirring in the material-compound tank, is evacuated to no bubble, then feed liquid is positioned in the charging basket;

C, the glue in the heat-preserving container is joined in the glue box of encapsulating machine, 50-70 ℃ of glue box insulation, glue is tiled on the rotary drum along glue box slit uniformly; Cooling forming after adjustment rubber thickness reaches technological requirement, is poured into content in the hopper of soft capsule; The sprinkler body temperature is controlled at 35-55 ℃, carries out the pressure testing of pelleting and checks sealing of rubber, adjusts the loading amount of content simultaneously; Suppress after the accent machine is stable, and in loading amount, the rubber thickness of each 60 minutes sampling observation soft capsules;

D, the soft capsule that suppresses move on in the rotating cage through conveyer belt and finalize the design;

E, capsule changed over to carry out drying in the tray, reach the moisture requirement of product requirement, can obtain product of the present invention.

The present invention has following beneficial effect: have reasonable mixture ratio, economy, carry instant; Advantages such as effectively stripping is fast, and keeping quality is good, functional component looses evenly compared with similar products; And preparation technology of the present invention has control, the stay-in-grade characteristics of being easy to.

Description of drawings

Fig. 1 is a structural representation of the present invention.

Fig. 2 is a process chart of the present invention.

Among the figure, 1-content, 2-rubber.

The specific embodiment

Be described further below in conjunction with the accompanying drawing specific embodiments of the invention.

As shown in Figure 1, a kind of Co-Q10 soft capsule, it is shaped as olive shape; Comprise rubber (2) and content (1), wherein content (1) is Co-Q10 and the vegetable oil with health care, the mixture of suspending agent, and rubber (2) thickness is 0.2-2mm; The parts by weight proportioning that constitutes each component of rubber (2) is: gelatin 30-70 branch; Plasticizer 10-50 part, water 5-15 branch, pigment 0.1-3 part.Gelatin is selected from a kind of gelatin or the mixture of two or more gelatin in ox, sheep, fish, pig, the chicken, and its strength range of congealing is 80-250Bloom g, and as preferably, it is the gelatin of 180Bloom g that gelatin of the present invention adopts a kind of intensity of congealing from ox.Plasticizer is selected from glycerine, sorbierite and perhaps is both mixtures, and its portfolio ratio determines the hardness of soft capsule.

Constitution content thing (1) the ratio of each component is 11.25 parts of Co-Q10s, 86.25 parts of vegetable oil, and 2.5 parts of suspending agents, the parts by weight proportioning that constitutes each component of rubber is: 100 parts in gelatin, 40 parts of glycerine, 10 parts of purified water, 0.2 part of pigment.

Embodiment: a kind of Co-Q10 preparation of soft capsule method may further comprise the steps:

(1) purified water 50-70 part, plasticizer 10-50 part is in being added to of the pigment 0.1-3 part glue jar; Heating makes temperature rise to 60-80 ℃; Add gelatin 30-70 branch, and continue heating and remain on 60-80 ℃, be stirred to gelatin and all dissolve; Being evacuated to glue does not have bubble, then 50-70 ℃ of insulation in heat-preserving container;

(2) suspending agent 2-10 part is heated to about 70 ℃ to melting adding Co-Q10 5-15 part, vegetable oil 70-100 part entirely; In charging basket, stir, cross 80 mesh sieves, with feed liquid as for stirring 2-3 hour in the material-compound tank; Be evacuated to no bubble, then feed liquid be positioned in the charging basket;

(3) glue in the heat-preserving container is joined in the glue box of encapsulating machine, 50-70 ℃ of glue box insulation, glue is tiled on the rotary drum along glue box slit uniformly; Cooling forming after adjustment rubber thickness reaches technological requirement, is poured into content in the hopper of soft capsule; The sprinkler body temperature is controlled at 35-55 ℃; The rubber THICKNESS CONTROL is carried out the pressure testing of pelleting and is checked sealing of rubber at 0.7-0.9mm, adjusts the loading amount 0.4g/ grain of content simultaneously; Suppress after the accent machine is stable, and in loading amount, the rubber thickness of per 60 minutes sampling observation soft capsules;

(4) pill that has pressed is finalized the design, placed 2.0-3.0 hour;

(5) under temperature 18-26 ℃ situation, capsule is carried out drying, divide 7%-10% until the oval soft capsule severe edema due to hypofunction of the spleen, relative humidity is 20-30%, can obtain capsule product of the present invention.

Claims (3)

1. Co-Q10 soft capsule is characterized in that: described soft capsule comprises rubber and encloses the content in the rubber that said content is liquid or the semisolid with health care; Said rubber thickness is 0.2-2mm, and the weight fraction proportioning that constitutes the rubber composition is: gelatin 30-70 part, plasticizer 10-50 part; Water 5-15 part, pigment 0.1-3 part, the weight fraction proportioning that the constitution content thing is formed is: Co-Q10 5-15 part; Suspending agent 2-10 part, vegetable oil 70-100 part.

2. a kind of Co-Q10 soft capsule according to claim 1 is characterized in that: said gelatin is that its intensity of congealing is 80-250Bloom g from a kind of gelatin in ox, sheep, fish, pig, the chicken or the mixture of two or more gelatin;

As preferably, a kind of intensity of congealing that gelatin is chosen as from ox is the gelatin of 180Bloom g.

3. Co-Q10 soft capsule preparation method, it may further comprise the steps:

(1) purified water 50-70 part, plasticizer 10-50 part is in being added to of the pigment 0.1-3 part glue jar; Heating makes temperature rise to 60-80 ℃; Add gelatin 30-70 branch, and continue heating and remain on 60-80 ℃, be stirred to gelatin and all dissolve; Being evacuated to glue does not have bubble, then 50-70 ℃ of insulation in heat-preserving container;

(2) suspending agent 2-10 part is heated to about 70 ℃ to melting adding Co-Q10 5-15 part, vegetable oil 70-100 part entirely; In charging basket, stir, cross 80 mesh sieves, with feed liquid as for stirring 2-3 hour in the material-compound tank; Be evacuated to no bubble, then feed liquid be positioned in the charging basket;

(3) glue in the heat-preserving container is joined in the glue box of encapsulating machine, 50-70 ℃ of glue box insulation, glue is tiled on the rotary drum along glue box slit uniformly; Cooling forming after adjustment rubber thickness reaches technological requirement, is poured into content in the hopper of soft capsule; The sprinkler body temperature is controlled at 35-55 ℃; The rubber THICKNESS CONTROL is carried out the pressure testing of pelleting and is checked sealing of rubber at 0.7-0.9mm, adjusts the loading amount 0.4g/ grain of content simultaneously; Suppress after the accent machine is stable, and in loading amount, the rubber thickness of per 60 minutes sampling observation soft capsules;

(4) pill that has pressed is finalized the design, placed 2.0-3.0 hour;

(5) under temperature 18-26 ℃ situation, capsule is carried out drying, divide 7%-10% until the oval soft capsule severe edema due to hypofunction of the spleen, relative humidity is 20-30%.

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