CN106902150A - Co-Q10 purple perilla soft capsule prescription and preparation method - Google Patents
Co-Q10 purple perilla soft capsule prescription and preparation method Download PDFInfo
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- CN106902150A CN106902150A CN201710157886.4A CN201710157886A CN106902150A CN 106902150 A CN106902150 A CN 106902150A CN 201710157886 A CN201710157886 A CN 201710157886A CN 106902150 A CN106902150 A CN 106902150A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
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Abstract
A kind of Co-Q10 purple perilla soft capsule prescription and preparation method.Content is Co-Q10, the vitamin E of 30g, the Purple Perilla Seed Oil of 369g, the beeswax composition of 72g of 30g, soft capsule skin is the burnt sugar coloring composition of gelatin, the glycerine of 117g, the purified water of 235g and the 11.2g of 235g, the soft capsule weight that content and soft capsule skin proportioning are produced is 0.5g/, immunity is the defense mechanism of human body itself, it is any foreign matter (virus, bacterium etc.) of human bioequivalence and the external intrusion of elimination, processes the ability of aging, damage, death, the own cells of denaturation and identification and treatment vivo mutations cell and virus infected cell.The body of hypoimmunity is easy to infected or cancer stricken.The present invention is applied to field of medicaments.
Description
Technical field：
The present invention relates to a kind of Co-Q10 purple perilla soft capsule and preparation method.
Background technology：
Immunity is the defense mechanism of human body itself, is any foreign matter (virus, the bacterium of human bioequivalence and the external intrusion of elimination
Deng), process aging, damage, death, the own cells of denaturation and identification and treatment vivo mutations cell and virus infected cell
Ability.The body of hypoimmunity is easy to infected or cancer stricken.
The content of the invention：
It is an object of the invention to provide a kind of Co-Q10 purple perilla soft capsule and preparation method, there is provided a kind of work(of strengthen immunity
The medicine of energy.
Above-mentioned purpose is realized by following technical scheme：
Co-Q10 purple perilla soft capsule, its composition includes：Content and soft capsule skin, the parts by weight of described content raw material
Than：The Co-Q10 of 25-35g, the vitamin E of 25-35g, the Purple Perilla Seed Oil of 360-375g, the beeswax of 70-75g.
Described Co-Q10 purple perilla soft capsule, the ratio of weight and number of described content raw material：The Co-Q10 of 30g, 30g
Vitamin E, the Purple Perilla Seed Oil of 369g, the beeswax of 72g.
Described Co-Q10 purple perilla soft capsule, the ratio of weight and number of described soft capsule skin raw material：The gelatin of 235g,
The burnt sugar coloring composition of the glycerine of 117g, the purified water of 235g and 11.2g, what said above thing and described soft capsule skin are matched somebody with somebody
Soft capsule weight than producing is 0.5g/.
Described Co-Q10 purple perilla soft capsule, described enzyme Q10 purple perilla soft capsules be purification of air rank be 100,000 grades
Workshop in produce, it is ensured that pilot process is pollution-free.
A kind of preparation method of described Co-Q10 purple perilla soft capsule, the method comprises the following steps：
（1）The preparation of raw material
Sieving, weighing：Co-Q10 and vitamin E are crossed into 100 mesh sieves respectively, is weighed by recipe quantity, mixed 30 minutes, it is standby；
（2）Glue is prepared
Glycerine, gelatin the putting glue tank of recipe quantity are taken, after being heated to 60-80 DEG C, the gelatin of recipe quantity is added, stirred complete to gelatin
Portion dissolves, and vacuumizes, and vacuum is 0.08Mpa, 30 minutes to glue bubble-free, glue is crossed into 100 mesh sieves, in quiet in glue-storing barrel
Put, glue is incubated 55 DEG C -60 DEG C;
（3）Feed liquid dispensing
Take during recipe quantity beeswax, Purple Perilla Seed Oil put preparing tank, be heated to 65 ± 2 DEG C, stirring makes beeswax melt completely, and mixing is equal
It is even, oily wax liquor is obtained, 40 DEG C are then cooled to, described raw material is added, stir, 15-30 points is stirred in vacuum emulsifying machine
Clock, vacuumizes, vacuum -0.05MPa~-0.08Mpa, to feed liquid bubble-free, obtains feed liquid within 20 minutes；
（4）Pelleting
Glue, feed liquid are transferred into soft capsule pellet processing machine carries out compacting pelletization, and it is 0.5g to control every loading amount of capsule 's content；
（5）Sizing
The soft capsule that will be pressed is placed in rotating cage, is shaped under conditions of 30-40%, 18-26 DEG C of temperature in relative humidity
About 1.5-2.0 hours；
（6）Dry
Obtained soft capsule is uniformly laid in basin, in relative humidity under conditions of 20-30%, 15-25 DEG C of temperature
Drying is qualified to moisture content.
Beneficial effects of the present invention：
1. Co-Q10 (hydroxy decyl ubiquinone) is a kind of fat-soluble antioxidant, and the present invention is added after Co-Q10, can effectively be swashed
The nutrition of living person's body cell and cellular energy so that the present invention have more powerful raising body immunity, strengthen it is anti-oxidant, prolong
The function such as slow aging and enhancing human activity, the present invention can effectively suppress disease of cardiovascular system.In mice serum haemolysis
Plain determination experiment, antibody-producting cell detection experiment, Turnover of Mouse Peritoneal Macrophages phagocytosis chicken red blood cell experiment and mouse carbonic clearance
In experiment, its result again significant difference.Think that Co-Q10 purple perilla soft capsule has the work(of strengthen immunity according to evaluation criterion
Energy.
The Purple Perilla Seed Oil that is added of the present invention is a kind of natural oil of degree of unsaturation high, the present invention add perilla herb oil it
Afterwards so that product of the invention is under the common synergy of active ingredient to reducing cholesterol, reduction blood fat, preventing artery congee
Sample hardening, reduction cerebral thrombus and angiocardiopathy have more dauer effect；In the work of enzyme after alpha-linolenic acid intake human body
The olefin(e) acid of 20 carbon 5 (EPA) and the olefin(e) acid of 22 carbon 6 (DHA) can be changed into human body under, than deep sea fish oil preferably
It is free of cholesterol, and EPA and DHA has reducing blood lipid and improves the effect of memory；Foreign study shows that alpha-linolenic acid also has
Antiallergy and adaptability is improved in adverse circumstance and suppresses the effect of some cancer cells.It can not independently synthesize in human body, need
By food supply, the base feed channel as active ingredient of the invention.
Vitamin E（Vitamin E）It is a kind of liposoluble vitamin, the phenolic hydroxyl group on vitamin E phenyl ring is acetylation, ester
It is tocopherol to be hydrolyzed to after phenolic hydroxyl group, is one of topmost antioxidant.The present invention adds vitamin E to pass through and tocopherol
The promotion sex hormone secretion of alumnus with the synergy of other compositions, can be capable of, increase man's sperm motility and quantity；Maid
Sub- female hormone concentration increases, and improves fecundity, prevention of miscarriage, it may also be used for prevent and treat male sterility, burn, frostbite, hair
Thin angiorrbagia.There is remarkable result at aspects such as treatment climacteric metancholia, beauty.Particularly the present invention can effectively suppress eyes
Lipid peroxidation reaction in crystalline lens, makes peripheral vasodilation, improves blood circulation, pre- Anti-myopic eye occurrence and development.
Invention effect is checked：
1. material
1.1 tested materials
Sample Co-Q10 purple perilla soft capsule：Recommend dose 0.5g*1/people of day.
Experimental animal cleaning grade hero Balb/c mouse：Sichuan University's West China Experimental Animal Center
1.3 key instrument B-214 electronic balances：Beijing this instrument system Co., Ltd of match many cases；Electronic digital indicator；Shanghai
Sai Tuo hardware ＆ tools Co., Ltd；Model680 type ELIASAs；BIORAD.CO2 incubators：SANYO GS；722 spectrophotometers；
Shanghai analytical instrument factory.
Strengthen immunity function evaluation methods
Internal organs/weight ratio measurement, delayed allergy are carried out to Co-Q10 purple perilla soft capsule；Vola pedis thickens method；ConA
The mouse spleen lymphocyte transformation experiment of induction；Mtt assay；Serum hemolysis are determined；Hemagglutination Method；Antibody-producting cell detection；Jerne
Improves slide method；Turnover of Mouse Peritoneal Macrophages phagocytosis chicken red blood cell experiment；Half intracorporal method；Mouse carbonic clearance is tested；NK cells are lived
Property determine；Determination of lactate dehydrogenase method.
Strengthen immunity functional evaluation result
The influence that 3.1 Co-Q10 purple perilla soft capsules are produced to mice serum blood lysin
Influence of the Co-Q10 purple perilla soft capsule of table 1 to mice serum blood lysin antibody product
| Dosage（g/kg·bw） | Number of animals/only | Optical density difference（X±S） |
| Control group | 11 | 188.37±11.89 |
| 0.28 | 11 | 193.36±11.28 |
| 0.56 | 10 | 199.19±9.46 |
| 0.84 | 10 | 202.30±9.89* |
Note：* represent and control group phase P<0.01
As shown in Table 1,0.28mg/kgbw and 0.56mg/kgbw dosage groups are compared with control group mice, antibody-producting cell
Number there are no significant difference（P>0.05）.0.84mg/kgbw dosage groups are compared with control group mice, and antibody product has conspicuousness
Difference（P<0.05）.
Influence of the Co-Q10 purple perilla soft capsule of table 2 to mouse antibodies cellulation
| Dosage（g/kg·bw） | Number of animals/only | Antibody-producting cell number/106（Splenocyte）（X±S） |
| Control group | 11 | 202.18±84.03 |
| 0.28 | 11 | 223.18±102.99 |
| 0.56 | 11 | 237.73±112.70 |
| 0.84 | 10 | 387.59±97.58** |
Note：* the P compared with control group is represented<0.05.
As shown in Table 2,0.28mg/kgbw and 0.56mg/kgbw dosage groups are compared with control group mice, antibody tormation
There was no significant difference for cell（P>0.05）；0.84mg/kgbw dosage groups are compared with control group mice, and antibody-producting cell number is equal
There is significant difference（P<0.01）.
Influence of the Co-Q10 purple perilla soft capsule to Turnover of Mouse Peritoneal Macrophages chicken red blood cell ability
Influence of the Co-Q10 purple perilla soft capsule of table 3 to Turnover of Mouse Peritoneal Macrophages chicken red blood cell ability
| Dosage（g/kg·bw） | Number of animals/only | Phagocytic percentage/%（X±S） | Phagocytic index（X±S） |
| Control group | 11 | 30.64±2.48 | 1.00±0.10 |
| 0.28 | 11 | 33.09±3.71 | 1.05±0.13 |
| 0.56 | 11 | 33.50±3.96 | 1.11±0.13 |
| 0.84 | 10 | 34.90±3.09 | 1.14±0.11* |
Note：* the P compared with control group is represented<0.05.
From table 3,0.28mg/kgbw and 0.56mg/kgbw dosage groups compared with control group mice, its abdominal cavity
Macrophage to the phagocytic percentage of chicken red blood cell, phagocytic index there are no significant difference（P>0.05）；0.84mg/kgbw agent
Compared with control group mice, its peritoneal macrophage has conspicuousness poor the phagocytic percentage of chicken red blood cell, phagocytic index to amount group
It is different（P<0.05）.
Influence of the Co-Q10 purple perilla soft capsule to mouse carbonic clearance
| Dosage（g/kg·bw） | Number of animals/only | Phagocytic index a（X±S） |
| Control group | 10 | 3.75±0.45 |
| 0.28 | 10 | 3.86±0.49 |
| 0.56 | 10 | 4.26±0.47* |
| 0.84 | 10 | 4.29±0.46* |
Note：* the P compared with control group is represented<0.05.
As shown in Table 4,0.28mg/kgbw dosage groups are compared with control group mice, and its peritoneal macrophage is red to chicken thin
There was no significant difference for the phagocytic percentage of born of the same parents（P>0.05）;0.56mg/kgbw and 0.84mg/kgbw dosage groups and control group
Mouse is compared, and its peritoneal macrophage has significant difference P to the phagocytic percentage of chicken red blood cell<0.05.
Brief description of the drawings：
Accompanying drawing 1 is technological process of production schematic diagram of the invention.
Specific embodiment：
Embodiment 1：
A kind of Co-Q10 purple perilla soft capsule prescription, its composition includes：Content and soft capsule skin, described content raw material
Ratio of weight and number：The Co-Q10 of 30g, the vitamin E of 30g, the Purple Perilla Seed Oil of 369g, the beeswax composition of 72g, described flexible glue
The ratio of weight and number of capsule skin raw material：The burnt sugar coloring composition of the gelatin of 235g, the glycerine of 117g, the purified water of 235g and 11.2g, with
The soft capsule weight that upper described content and described soft capsule skin proportioning are produced is 0.5g/.
Embodiment 2：
Co-Q10 purple perilla soft capsule prescription according to embodiment 1, described content and described soft capsule skin composition honeybee
Glue soft capsule, described bee glue soft capsule is produced in the workshop that purification of air rank is 100,000 grades, and pilot process is pollution-free.
Embodiment 3：
A kind of preparation method of the described Co-Q10 purple perilla soft capsule prescription of one of embodiment 1-2, the method includes following step
Suddenly：
（1）It is prepared by raw material
Sieving, weighing：Co-Q10 and vitamin E are crossed into 100 mesh sieves respectively, is weighed by recipe quantity, mixed 30 minutes, it is standby.
（2）Glue is prepared
Glycerine, gelatin the putting glue tank of recipe quantity are taken, after being heated to 60-80 DEG C, the gelatin of recipe quantity is added, stirred complete to gelatin
Portion dissolves, and vacuumizes（Vacuum is -0.08Mpa）Glue, to glue bubble-free, is crossed 100 mesh sieves, in glue-storing barrel by 30 minutes
Stand, 55 DEG C -60 DEG C of glue insulation is standby.
（3）Feed liquid dispensing
Take during recipe quantity beeswax, Purple Perilla Seed Oil put preparing tank, be heated to 65 ± 2 DEG C, stirring makes beeswax melt completely, and mixing is equal
It is even, obtain oily wax liquor.Then 40 DEG C are cooled to.Described raw material is added, is stirred, 15-30 points is stirred in vacuum emulsifying machine
Clock, vacuumizes（Vacuum -0.05MPa~-0.08MPa）To feed liquid bubble-free, feed liquid is obtained within 20 minutes, it is standby.
（4）Pelleting
Glue, feed liquid are transferred into soft capsule pellet processing machine carries out compacting pelletization, and it is 0.5g to control every loading amount of capsule 's content.
（5）Sizing
The soft capsule that will be pressed is placed in rotating cage, is shaped under conditions of 30-40%, 18-26 DEG C of temperature in relative humidity
About 1.5-2.0 hours.
（6）Dry
Obtained soft capsule is uniformly laid in basin, in relative humidity under conditions of 20-30%, 15-25 DEG C of temperature
Dry 24 hours qualified with up to moisture content.
（7）Select ball
Dried soft capsule is placed in the special-shaped ball of rejecting on lamp inspection desk, big piller, bubble ball, oil leak ball etc. underproof soft
Capsule.
（8）Inner packing
Packed with the medicinal polyester bottles of oral administration solid, 60 every bottle.
（9）External packing
Packaging intermediate products → put specification → fill big case → loading packing slip（One）→ joint sealing → label（Case）.（It is commercially available
Minimum package specification：60/bottle）
（10）Inspection, storage：
The finished product that will have been packed, randomly selects product, is tested according to the method described in quality standard and requirement, and it is qualified to check
Afterwards, finished product storage.
Claims (5)
1. a kind of Co-Q10 purple perilla soft capsule, its composition includes：Content and soft capsule skin, it is characterized in that：Described content
The ratio of weight and number of raw material：The Co-Q10 of 25-35g, the vitamin E of 25-35g, the Purple Perilla Seed Oil of 360-375g, 70-
The beeswax of 75g.
2. Co-Q10 purple perilla soft capsule according to claim 1, it is characterized in that：The weight portion of described content raw material
Number ratio：The Co-Q10 of 30g, the vitamin E of 30g, the Purple Perilla Seed Oil of 369g, the beeswax of 72g.
3. Co-Q10 purple perilla soft capsule according to claim 1 and 2, it is characterized in that：The weight of described soft capsule skin raw material
Amount portion rate：The burnt sugar coloring of the gelatin of 235g, the glycerine of 117g, the purified water of 235g and 11.2g, what said above thing and
The soft capsule weight that described soft capsule skin proportioning is produced is 0.5g/.
4. the Co-Q10 purple perilla soft capsule according to claim 1 or 2 or 3, it is characterized in that：Described bee glue soft capsule is
Produced in the workshop that purification of air rank is 100,000 grades, it is ensured that pilot process is pollution-free.
5. the preparation method of the described Co-Q10 purple perilla soft capsule of one of a kind of claim 1-4, it is characterized in that：The method bag
Include following steps：
（1）The preparation of raw material
Sieving, weighing：Co-Q10 and vitamin E are crossed into 100 mesh sieves respectively, is weighed by recipe quantity, mixed 30 minutes, it is standby；
（2）Glue is prepared
Glycerine, gelatin the putting glue tank of recipe quantity are taken, after being heated to 60-80 DEG C, the gelatin of recipe quantity is added, stirred complete to gelatin
Portion dissolves, and vacuumizes, and vacuum is 0.08Mpa, 30 minutes to glue bubble-free, glue is crossed into 100 mesh sieves, in quiet in glue-storing barrel
Put, glue is incubated 55 DEG C -60 DEG C;
（3）Feed liquid dispensing
Take during recipe quantity beeswax, Purple Perilla Seed Oil put preparing tank, be heated to 65 ± 2 DEG C, stirring makes beeswax melt completely, and mixing is equal
It is even, oily wax liquor is obtained, 40 DEG C are then cooled to, described raw material is added, stir, 15-30 points is stirred in vacuum emulsifying machine
Clock, vacuumizes, vacuum -0.05MPa~-0.08Mpa, to feed liquid bubble-free, obtains feed liquid within 20 minutes；
（4）Pelleting
Glue, feed liquid are transferred into soft capsule pellet processing machine carries out compacting pelletization, and it is 0.5g to control every loading amount of capsule 's content；
（5）Sizing
The soft capsule that will be pressed is placed in rotating cage, is shaped under conditions of 30-40%, 18-26 DEG C of temperature in relative humidity
About 1.5-2.0 hours；
（6）Dry
Obtained soft capsule is uniformly laid in basin, in relative humidity under conditions of 20-30%, 15-25 DEG C of temperature
Dry 24 hours qualified with up to moisture content.
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| CN201710157886.4A CN106902150A (en) | 2017-03-16 | 2017-03-16 | Co-Q10 purple perilla soft capsule prescription and preparation method |
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Cited By (4)
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| CN108236714A (en) * | 2018-01-29 | 2018-07-03 | 江苏神华药业有限公司 | Alleviate physical fatigue and assist the composition and its soft capsule of reducing blood lipid |
| CN110269883A (en) * | 2018-11-05 | 2019-09-24 | 中冠生物科技(珲春)有限公司 | A kind of composition and its application in the product for preparing blood pressure lowering |
| CN110585266A (en) * | 2019-09-18 | 2019-12-20 | 广东润和生物科技有限公司 | Application of composition of perilla seed oil and coenzyme Q10 |
| CN114009762A (en) * | 2021-11-01 | 2022-02-08 | 欣安贝药业科技盐城有限公司 | Coenzyme Q10 soft capsule for enhancing immunity and preparation method thereof |
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| CN114009762A (en) * | 2021-11-01 | 2022-02-08 | 欣安贝药业科技盐城有限公司 | Coenzyme Q10 soft capsule for enhancing immunity and preparation method thereof |
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