CN101732201A - Reduced coenzyme Q10 essence oil and preparation method thereof - Google Patents
Reduced coenzyme Q10 essence oil and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a method for conveniently and effectively producing reduced coenzyme Q10 essence oil by using high-purity reduced coenzyme Q10. The reduced coenzyme Q10 essence oil has excellent quality, has efficiency eight times than that of an oxidized coenzyme Q10 and can be used for cleaning and nursing skin of each part of face, eyes, breasts, abdomen, hands and body. The method is suitable for industrial production. In a method for producing soft capsule or bottled reduced coenzyme Q10 essence oil by adding vegetable fat as a solvent and essence, at least one type of vegetable oil is used as the solvent and at least one type of essence is used for blending. At least one type of bottled capsule is used as the package, so a functional component of reduced coenzyme Q10 can be protected from performing molecular oxidation action to obtain a high-quality reduced coenzyme Q10 essence oil product.
Description
Technical field
The present invention relates to produce easily and effectively the method for reduced coenzyme Q 10 essence oil, can be used for the skin clean and the nursing of face, eye, chest, abdominal part, hand and each one of human body.
Background technology
Oxidized coenzyme Q10 has been widely used in cosmetic field abroad, be many with cream, frost, agent wherein, and the reduced coenzyme Q 10 raw material has just gone on the market in the international market, and people are still waiting to understand to it.
Reduced coenzyme Q 10 is a kind of principal mode that has the human body cell tautomeric structure, and this form plays the effect of direct transmission electronics and proton in vivo, and the function of 8 times of potentiation is arranged than oxidized coenzyme Q10.There is technical difficulty at external acquisition reduced coenzyme Q 10, mainly be that it is subjected to air and auroral poles easily to be oxidized into oxidized coenzyme Q10, though oxidized coenzyme Q10 also is the version of needed by human body, but because oxidized coenzyme Q10 character is orange-yellow powder, use as cosmetics, can only add by trace, its efficacy effect of oxidized coenzyme Q10 of trace is restricted.And its character of reduced coenzyme Q 10 is the pure white crystal, and the addition restriction is broken in cosmetics.At present, highly purified reduced coenzyme Q 10 source is difficulty very, so the application of reduced coenzyme Q 10 cosmetics comprises that the product of elite oils cosmetics does not still have bibliographical information and product appearance.
Summary of the invention
The high-purity reduced coenzyme Q 10 that the present invention seeks to produce with Yuxi Jiankun Biotechnology Pharmaceutical Co., Ltd. is a raw material, add the antioxidative vegetable oil, mix through heating, add essence then, perfumery at a certain temperature forms the mixture that contains the high-purity reduced coenzyme Q 10 essence oil, in processing, when preserving, be used to prevent to contain reduced coenzyme Q 10 essence oil oxidation and the stable easy and suitable method that keeps its quality, with cleaning and the nursing that is used for skin.
The inventor is through research, the reduced coenzyme Q 10 of finding different content purity to cosmetics essential oils product quality to influence gap bigger, select for use different oils and fatss most important by molecular oxygen oxidation to preventing to contain reduced coenzyme Q 10 in the essential oils.
The present patent application people finds that further when the interpolation natural essence carried out perfumery, the temperature the when quality of essence, perfumery, the intensity of stirring etc. also directly influenced the quality and the stability of product.
Reduced coenzyme Q 10 essence oil is characterized in that: the reduced coenzyme Q 10 that contains purity 〉=98%, the natural edible oils and fats, natural essence, described reduced coenzyme Q 10 is independent reduced coenzyme Q 10 crystal or is the mixture that contains the reduced coenzyme Q 10 raw material that solvent forms with the natural edible oils and fats, natural edible oils and fats shared weight ratio in essential oils is 95-98%, and natural essence shared weight ratio in essential oils is 0.01%-1%; The mixture that contains the reduced coenzyme Q 10 raw material shared amount in essential oils is 5%～60%.
Described is that in greasy weight ratio, the content of reduced coenzyme Q 10 in oils and fats is more than 1%～3% or 3% in the mixture that contains the reduced coenzyme Q 10 raw material of solvent formation with the natural edible oils and fats.
The present patent application people further confirms, contain highly purified reduced coenzyme Q 10 essence oil, the preservation of its preparation and packaging product and use, the oxidation of avoiding molecular oxygen is even more important, on preparation and packing is the oxidation of blocker molecule oxygen, carry out shading, secluding air, easy to use, do not influence product quality.
The preparation method of reduced coenzyme Q 10 essence oil of the present invention, contain following processing step:
In the flask that protective atmosphere and band stirring are housed, add the natural edible oils and fats, add the reduced coenzyme Q 10 of purity 〉=98% again; feed nitrogen, start stirring, heating in water bath; progressively heat up, reduced coenzyme Q 10 is dissolved gradually, reaction; sampling is after the inspection crystal is fully miscible, under nitrogen and stirring state; be cooled to 10 ℃; add essence, shading, secluding air continue to stir; stop to stir; filter check, the dark light resistant container of packing into; sealing; bottling, the dress box is processed into the flexible glue scrotiform with the product of making after the perfumery that contains reduced coenzyme Q 10.The purity of described reduced coenzyme Q 10 〉=98%, and be independent reduced coenzyme Q 10 crystal or the mixture that contains the reduced coenzyme Q 10 raw material.Protective atmosphere is argon, helium or nitrogen; Mixing speed is at 60～80 commentaries on classics/min.
Described essence is yellow seed oil of sunflower, Aglaia odorata oil Xiao Fructus Amomi Rotundus oil, cloth forest-grass oil, celery flower oil, seed oil of Herba Apii graveolentis, Oleum Caryophylli, natural carnation oil, evening primrose oil, the Rhizoma Cyperi seed oil, eucalyptus oil, Oleum Pelargonii Graveolentis, the Spanish jasmin quintessence oil, juniper berry oil, month laurel oil, Oleum lavandula angustifolia, Indian oil of verbena, petit grain lemon oil, Fructus Citri Limoniae oil, litsea cubeba oil, the white orchid quintessence oil, Flos micheliae Albae oil, the Flos micheliae Albae leaf oil, osmanthus essential oil, rose oil, Flos Rosae Rugosae quintessence oil, Oleum Santali albi, bergamot oil, the sophora flower quintessence oil, Oleum Menthae Rotundifoliae, the tree moss quintessence oil, Flos Tagetis Erectae oil, valerian oil, fragrant Oleum Pini, stevia rebaudiana oil, wintergreen oil, Cananga odorata oil, at least a in fragrant breeze Oleum Camelliae or the lemongrass oil; The essence use amount is 1 ‰ of essential oils total amount～2 ‰.
The described content that contains the mixture of reduced coenzyme Q 10 raw material is 5%～60% of essential oils total amount; Temperature when the described mixture that contains the reduced coenzyme Q 10 raw material prepares is 50 ℃～75 ℃ or room temperature.Described soft capsule contains the agent of titanium dioxide lucifuge, and is that dark pigment is the above bulky grain soft capsule of 1000mg/ grain.
Described natural edible oils and fats is: Oleum Vitis viniferae, pine-seed oil, a blue or green thorn oil, walnut oil, Oleum Cocois, Petiolus Trachycarpi oil, palm-kernel oil, Semen Lini oil, Camellia oil, brown rice germ oil, American Avocado Tree oil, Oleum Brassicae campestris, Testa oryzae oil, Oleum Arachidis hypogaeae semen, Semen Maydis oil, Semen Tritici aestivi germ oil, soybean oil, Oleum Perillae, Oleum Gossypii semen, sunflower seed oil, kapok seed oil, evening primrose oil, the Butyrospermum fatty oil, sage oil, cupu oil, at least a or two above and usefulness in Oleum sesami or the safflower oil, use when a kind of, preferred pinus yunnanensis faranch seed oil, a blue or green thorn oil, Oleum Vitis viniferae, evening primrose oil, Testa oryzae oil, more preferably evening primrose oil, a blue or green thorn oil or Oleum Vitis viniferae, preferred especially Oleum Vitis viniferae.
Because the present invention adopts natural edible oils and fats, flavor deployment, and through special processing and packing, makes the mixture of reduced coenzyme Q 10 essence oil give full play to efficacy effect, can prevent oxidation, stabilized product quality again simultaneously.
Product quality excellence of the present invention has the effect than 8 times of oxidized coenzyme Q10 potentiation.Can be used for the skin clean and the nursing of face, eye, chest, abdominal part, hand and each one of human body.
The specific embodiment
For realizing the said goods, its purity of high-purity reduced form Q10 〉=98% that the present invention uses, it can be independent reduced coenzyme Q 10 crystal, it also can be the mixture that contains the reduced coenzyme Q 10 raw material, shared ratio has no particular limits in the total amount in essential oils (being reduced coenzyme Q 10 and greasy gross weight), using content is 5%, or more than 5%, preferred content is 20%, or more than 20%, more preferably content is 25%, or more than 25%, special preferred content is 40%, or more than 40%, on be limited to 60% (having under the situation that oils and fats exists).
The natural edible oils and fats that uses among the present invention, from extracted form natural plant, comprise Oleum Vitis viniferae, pine-seed oil, a blue or green thorn oil, walnut oil, Oleum Cocois, Petiolus Trachycarpi oil, palm-kernel oil, Semen Lini oil, Camellia oil, brown rice germ oil, American Avocado Tree oil, Oleum Brassicae campestris, Testa oryzae oil, Oleum Arachidis hypogaeae semen, Semen Maydis oil, Semen Tritici aestivi germ oil, soybean oil, Oleum Perillae, Oleum Gossypii semen, sunflower seed oil, kapok seed oil, evening primrose oil, the Butyrospermum fatty oil, sage oil, cupu oil, Oleum sesami, safflower oil is selected for use a kind of at least, also can more than 2 kinds or 2 kinds and use, use when a kind of preferred pinus yunnanensis faranch seed oil, a blue or green thorn oil, Oleum Vitis viniferae, evening primrose oil, Testa oryzae oil.More preferably evening primrose oil, green grass or young crops are stung an oil, Oleum Vitis viniferae.Preferred especially Oleum Vitis viniferae.
When stating the mixture of at least a natural edible-plant oils and fats and high-purity reduced coenzyme Q 10 dissolved form in the use; greasy amount is had no particular limits; but consider the dissolubility of reduced coenzyme Q 10; then in greasy weight ratio; usually the content of reduced coenzyme Q 10 in oils and fats is more than 1% or 1%; more than preferred 1.5% or 1.5%, more preferably more than 2% or 2%, more than preferred especially 3% or 3%.
The high-purity reduced coenzyme Q 10 is dissolved in greasy temperature in above-mentioned, in course of dissolution temperature is had no particular limits, and considers the fusing point situation higher slightly than oxidized coenzyme Q10 of reduced coenzyme Q 10, solution temperature is selected 50 ℃, preferred 60 ℃, more preferably 70 ℃, preferred especially 75 ℃.Contain high-purity reduced coenzyme Q 10 and greasy mixture if use, when preparing, the temperature of using when adding the oils and fats preparation also has no particular limits, and can consider to be 25 ℃ at normal temperatures again, and preferred 40 ℃, more preferably 50 ℃, preferred especially 60 ℃.
When the heating for dissolving reduced coenzyme Q 10 prepares essential oils, must under inert gas shielding, stir, there are not special requirement for noble gas, can be argon, helium, nitrogen, preferably under nitrogen protection, carry out.Mixing speed also is not particularly limited, can be at 60 commentaries on classics/min, and preferred 70 commentaries on classics/min, more preferably 80 commentaries on classics/min stir.
Need the perfuming capable perfumery that progresses greatly in the preparation, comprise yellow seed oil of sunflower about essence, Aglaia odorata oil Xiao Fructus Amomi Rotundus oil, cloth forest-grass oil, celery flower oil, seed oil of Herba Apii graveolentis, Oleum Caryophylli, natural carnation oil, evening primrose oil, the Rhizoma Cyperi seed oil, eucalyptus oil, Oleum Pelargonii Graveolentis, the Spanish jasmin quintessence oil, juniper berry oil, month laurel oil, Oleum lavandula angustifolia, Indian oil of verbena, petit grain lemon oil, Fructus Citri Limoniae oil, litsea cubeba oil, the white orchid quintessence oil, Flos micheliae Albae oil, the Flos micheliae Albae leaf oil, osmanthus essential oil, rose oil, Flos Rosae Rugosae quintessence oil, Oleum Santali albi, bergamot oil, the sophora flower quintessence oil, Oleum Menthae Rotundifoliae, the tree moss quintessence oil, Flos Tagetis Erectae oil, valerian oil, fragrant Oleum Pini, stevia rebaudiana oil, wintergreen oil, Cananga odorata oil, fragrant phoenix Oleum Camelliae, at least a in the lemongrass oil.But consider that the user accepts and be inclined to advocating of nature to the cosmetics odor type, adopt wintergreen oil, Cananga odorata oil, lemongrass oil, Oleum Pelargonii Graveolentis, Oleum lavandula angustifolia, Oleum Menthae Rotundifoliae, osmanthus essential oil, Fructus Citri Limoniae oil, rose oil, the Flos Rosae Rugosae quintessence oil of natural extract.Preferred Oleum lavandula angustifolia, Cananga odorata oil, Oleum Pelargonii Graveolentis, osmanthus essential oil, more preferably Oleum lavandula angustifolia, Oleum Pelargonii Graveolentis, Flos Rosae Rugosae quintessence oil, especially preferably Flos Rosae Rugosae quintessence oil.
Have no particular limits on the consumption of above-mentioned use essence, consider that the ease of fragrance in the appropriate perfumery of cost and product and the processing is lost, the essence use amount is 1 ‰ of an essential oils total amount, and is preferred 1.5 ‰, more preferably 2 ‰.
In the perfumery process, temperature will be controlled especially, at-10 ~ 15 ℃, and preferred 10 ℃, more preferably 0 ~ 10 ℃, preferred-5 ~ 5 ℃ especially.
The product of making after the perfumery that contains reduced coenzyme Q 10 is shaped, adopt the condition of shading, secluding air, have no particular limits, dosage form of the present invention is a soft capsule, bottling automatically, preferred soft capsule dosage form.
Have no particular limits in soft capsule shaping and general soft capsule making, the soft capsule that preferably contains the agent of titanium dioxide lucifuge, the soft capsule that more preferably contains titanium dioxide and dark pigment lucifuge had especially preferably both contained titanium dioxide, the above bulky grain soft capsule of dark pigment 1000mg/ grain.
Bottled having no particular limits, preferably brown, black, dark bottle, box, plastic bag, aluminium lamination stampings bag, PTP packing, the stripping film packing, the aluminum packing that is shaped, adhesive film is packed.
Further specify flesh and blood of the present invention with example below, but content of the present invention is not limited to this.
Embodiment 1 adds the refining Oleum Vitis viniferae of 500ml in the 1000ml there-necked flask that the nitrogen protection band stirs is housed, add 15g content again and be 98% reduced coenzyme Q 10 crystal.Feed nitrogen, start stirring, heating in water bath progressively is warming up to 70 ℃, crystal is dissolved gradually, react after 2 hours, sampling, after checking that crystal is fully miscible, under nitrogen and stirring state, be cooled to 10 ℃, add Flos Rosae Rugosae quintessence oil 0.7g, continue to stir 20 minutes, stop to stir, filter check, the dark light resistant container of packing into, sealing, bottling, dress box.
Embodiment 2 adds the refining sage oil of 3000ml in the 5000ml there-necked flask that the stirring of nitrogen protection band is housed, add the sage oil mixture that 187g contains 40% reduced coenzyme Q 10 again.Feed nitrogen, start stirring, in water-bath, be warming up to 60 ℃, make it miscible evenly, check, qualified, be cooled to 0 ~ 5 ℃, add Cananga odorata oil 3g, keep temperature, continue to stir 30 minutes, filter, be up to the standards, on manual pellet press, carry out pelleting, specification 1000mg/ grain (content), soft gelatin capsule is through typing, wash ball, drying, choose ball, with qualified ball bottling, dress box.
Embodiment 3 adds the refining blue or green thorn oil of 3000ml in the 5000ml there-necked flask that the nitrogen protection band stirs is housed, add the green grass or young crops thorn oil mixture that 300g contains 25% reduced coenzyme Q 10 again.Feed helium, start stirring, in water-bath, be warming up to 65 ℃, make it miscible evenly, check, qualified, be cooled to-5 ~ 5 ℃, continue to stir 45 minutes, filter, be up to the standards sealing, the container of packing into.On manual pellet press, carry out pelleting, specification 1000mg/ grain (content), soft gelatin capsule is washed ball, drying, is chosen the ball operation through typing, is up to the standards, through aluminium lamination stampings bag or stripping film bag packing.
Claims (10)
1. reduced coenzyme Q 10 essence oil, it is characterized in that: the reduced coenzyme Q 10 that contains purity 〉=98%, the natural edible oils and fats, natural essence, described reduced coenzyme Q 10 is independent reduced coenzyme Q 10 crystal or is the mixture that contains the reduced coenzyme Q 10 raw material that solvent forms with the natural edible oils and fats, natural edible oils and fats shared weight ratio in essential oils is 95-98%, and natural essence shared weight ratio in essential oils is 0.01%-1%; The mixture that contains the reduced coenzyme Q 10 raw material shared amount in essential oils is 5%～60%.
2. a kind of reduced coenzyme Q 10 essence oil according to claim 1, it is characterized in that: described natural edible oils and fats is: Oleum Vitis viniferae, pine-seed oil, a blue or green thorn oil, walnut oil, Oleum Cocois, Petiolus Trachycarpi oil, palm-kernel oil, Semen Lini oil, Camellia oil, brown rice germ oil, American Avocado Tree oil, Oleum Brassicae campestris, Testa oryzae oil, Oleum Arachidis hypogaeae semen, Semen Maydis oil, Semen Tritici aestivi germ oil, soybean oil, Oleum Perillae, Oleum Gossypii semen, sunflower seed oil, kapok seed oil, evening primrose oil, the Butyrospermum fatty oil, sage oil, cupu oil, at least a or two above and usefulness in Oleum sesami or the safflower oil, use when a kind of, preferred pinus yunnanensis faranch seed oil, a blue or green thorn oil, Oleum Vitis viniferae, evening primrose oil, Testa oryzae oil, more preferably evening primrose oil, a blue or green thorn oil or Oleum Vitis viniferae, preferred especially Oleum Vitis viniferae.
3. a kind of reduced coenzyme Q 10 essence oil according to claim 1 is characterized in that: described natural essence is yellow seed oil of sunflower, Aglaia odorata oil Xiao Fructus Amomi Rotundus oil, cloth forest-grass oil, celery flower oil, seed oil of Herba Apii graveolentis, Oleum Caryophylli, natural carnation oil, evening primrose oil, the Rhizoma Cyperi seed oil, eucalyptus oil, Oleum Pelargonii Graveolentis, the Spanish jasmin quintessence oil, juniper berry oil, month laurel oil, Oleum lavandula angustifolia, Indian oil of verbena, petit grain lemon oil, Fructus Citri Limoniae oil, litsea cubeba oil, the white orchid quintessence oil, Flos micheliae Albae oil, the Flos micheliae Albae leaf oil, osmanthus essential oil, rose oil, Flos Rosae Rugosae quintessence oil, Oleum Santali albi, bergamot oil, the sophora flower quintessence oil, Oleum Menthae Rotundifoliae, the tree moss quintessence oil, Flos Tagetis Erectae oil, valerian oil, fragrant Oleum Pini, stevia rebaudiana oil, wintergreen oil, Cananga odorata oil, at least a in fragrant phoenix Oleum Camelliae or the lemongrass oil.
4. a kind of reduced coenzyme Q 10 essence oil according to claim 1, it is characterized in that: described is in the mixture that contains the reduced coenzyme Q 10 raw material of solvent formation with the natural edible oils and fats, in greasy weight ratio, the content of reduced coenzyme Q 10 in oils and fats is more than 1%～3% or 3%.
5. the preparation method of a reduced coenzyme Q 10 essence oil is characterized in that containing following processing step:
In the flask that protective atmosphere and band stirring are housed; add the natural edible oils and fats, add independent reduced coenzyme Q 10 crystal again or be the mixture that contains the reduced coenzyme Q 10 raw material that solvent forms, feed nitrogen with the oils and fats; start stirring; heating in water bath progressively is warming up to, and crystal or mixture are dissolved gradually; reaction; sampling is after the inspection crystal is fully miscible, under nitrogen and stirring state; be cooled to 0 ℃～10 ℃; add essence, shading; secluding air continues to stir 25～45 minutes; stop to stir; filter check, the dark light resistant container of packing into; sealing; bottling, the dress box is processed into the flexible glue scrotiform with the essential oils product of making after the perfumery that contains reduced coenzyme Q 10.
6. the preparation method of a kind of reduced coenzyme Q 10 essence oil according to claim 5 is characterized in that: the purity of described reduced coenzyme Q 10 〉=98%.
7. the preparation method of a kind of reduced coenzyme Q 10 essence oil according to claim 5, it is characterized in that: described protective atmosphere is argon, helium or nitrogen; Mixing speed is at 60～80 commentaries on classics/min.
8. the preparation method of a kind of reduced coenzyme Q 10 essence oil according to claim 5, it is characterized in that: described natural essence is yellow seed oil of sunflower, Aglaia odorata oil Xiao Fructus Amomi Rotundus oil, cloth forest-grass oil, celery flower oil, seed oil of Herba Apii graveolentis, Oleum Caryophylli, natural carnation oil, evening primrose oil, the Rhizoma Cyperi seed oil, eucalyptus oil, Oleum Pelargonii Graveolentis, the Spanish jasmin quintessence oil, juniper berry oil, month laurel oil, Oleum lavandula angustifolia, Indian oil of verbena, petit grain lemon oil, Fructus Citri Limoniae oil, litsea cubeba oil, the white orchid quintessence oil, Flos micheliae Albae oil, the Flos micheliae Albae leaf oil, osmanthus essential oil, rose oil, Flos Rosae Rugosae quintessence oil, Oleum Santali albi, bergamot oil, the sophora flower quintessence oil, Oleum Menthae Rotundifoliae, the tree moss quintessence oil, Flos Tagetis Erectae oil, valerian oil, fragrant Oleum Pini, stevia rebaudiana oil, wintergreen oil, Cananga odorata oil, at least a in fragrant phoenix Oleum Camelliae or the lemongrass oil; The essence use amount is 1 ‰ of essential oils total amount～2 ‰.
9. the preparation method of a kind of reduced coenzyme Q 10 essence oil according to claim 5, it is characterized in that: the amount of reduced coenzyme Q 10 raw mix is 5%～60% in the described essential oils; Temperature when described essential oils reduced coenzyme Q 10 is dissolved in oils and fats is 50 ℃～75 ℃ or room temperature.
10. the preparation method of a kind of reduced coenzyme Q 10 essence oil according to claim 5, it is characterized in that: described soft capsule contains the agent of titanium dioxide lucifuge, and for dark pigment be the above bulky grain soft capsule of 1000mg/ grain.
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| CN105030607A (en) * | 2015-08-07 | 2015-11-11 | 广西象州县一丹生物技术有限公司 | Photoaging-preventing pure natural vegetable oil cleansing lotion and preparation method thereof |
| CN106902150A (en) * | 2017-03-16 | 2017-06-30 | 桦南仙紫食品科技有限公司 | Co-Q10 purple perilla soft capsule prescription and preparation method |
| CN108852863A (en) * | 2017-05-10 | 2018-11-23 | 滕州市悟通香料有限责任公司 | A kind of handguard capsule |
| CN109125133A (en) * | 2018-10-24 | 2019-01-04 | 西安惟颐生物科技有限公司 | Female chest maintains compound essential oil |
| CN110279618A (en) * | 2019-08-14 | 2019-09-27 | 河南科技学院 | A kind of preparation method of the oleogel of immobilized Co-Q10 |
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Application publication date: 20100616 |