CN103800435A - Seal oil soft capsule - Google Patents
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- CN103800435A CN103800435A CN201410049436.XA CN201410049436A CN103800435A CN 103800435 A CN103800435 A CN 103800435A CN 201410049436 A CN201410049436 A CN 201410049436A CN 103800435 A CN103800435 A CN 103800435A
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Abstract
The invention relates to a health-care capsule capable of reducing blood fat, and particularly relates to a seal oil soft capsule. The capsule is prepared from pure natural seal oil imported from Canada as a main material, and naturally extracted purple perilla seed oil, lecithin and natural vitamin E. The seal oil soft capsule is pure natural, free of a side effect, convenient to take, and rapid and complete to absorb, has the effects of obviously reducing blood fat, reducing blood pressure, and reducing cholesterol.
Description
Technical field
The present invention relates to a kind of health-caring capsule that can reduce blood fat, particularly relate to a kind of soft capsule of fur seal.
Background technology
Hyperlipidemia is a kind of systemic disease, refers in blood T-CHOL or triglyceride is too high or HDL-C is too low, and modern medicine is referred to as dyslipidemia.Hyperlipidemia to the infringement of health be concealment, gradually, carrying out property and general, its direct infringement is to accelerate systemic atherosclerosis, because the vitals of whole body all will rely on tremulous pulse blood supply, oxygen supply, once tremulous pulse is stopped up by atheromatous plaque, will cause serious consequence.The renal failure that arteriosclerosis causes etc., all closely related with hyperlipidemia.A large amount of research datas show, hyperlipidemia is the independent and important risk factor of apoplexy, coronary heart disease, myocardial infarction, cardiac sudden death.
In recent years, the generation of hyperlipidemia is more and more, in order to reduce blood fat, suppress the generation of cardiovascular and cerebrovascular disease, in prior art, mostly adopt chemical synthetic drug to cure high fat of blood, although can play certain effect, these chemicalses have certain side effect.
Summary of the invention
In order to overcome above-mentioned deficiency, it is major ingredient that the present invention adopts the Adeps Phocae vitulinae of pure natural Canada import, is equipped with the Oleum Perillae, lecithin, natural complex E oil of natural extract and the blood fat reducing that a kind of pure natural of making has no side effect, the health-caring capsule that improves memory.
The each component of this capsule is according to weight portion meter, and its proportioning is: Adeps Phocae vitulinae 60-80 part, Oleum Perillae 10-30 part, lecithin 10-30 part, natural complex E oil 0.1-1 part, gelatin 5-10 part, water 5-10 part, glycerol 2-6 part.
Fur seal, has another name called " fur sea lion ", " fur sea dog " or " lug sea dog ", a subfamily of Carnivora Pinnipedia Otariidae.Fur seal is deep-sea mammal, lives in minimum subzero 50 ℃ of high and cold waters in the Canadian northern Arctic Circle, take famous and precious morrhua as food, has assembled thick fat in body.
In the present invention, Adeps Phocae vitulinae used is taken from fur seal subcutaneous fat, refines through existing science of technology processing, obtains being the refine Adeps Phocae vitulinae of micro-yellow, transparency liquid shape.In Adeps Phocae vitulinae, be rich in many carbon of OMEGA-3 unsaturated fatty acid of needed by human, the content of its DPA, DHA, EPA is up to 25%, the clean free of contamination natural ecological environment in the arctic in addition, and fur seal becomes the source of OMEGA-3 type unsaturated fatty acid best in the Nature.Wherein:
EPA: be called as blood clean element, can effectively clean blood, blood dirt, blood vessel wall deposit, reduce triglyceride and low density lipoprotein, LDL content, increase the content of high density lipoprotein, and then thrombosis in can anti-Hemostatic Oral Liquid, can make unobstructed blood vessel.
DHA: can reduce the formation of triglyceride in blood, cholesterol and pre-preventing thrombosis, reduce blood fat, prevention cardiovascular disease.
DPA: be called " anti-angiogenic hardening element " by expert, DPA is that Adeps Phocae vitulinae is exclusive only exists in Adeps Phocae vitulinae and human milk, is that a kind of essential fatty acid and human body self cannot synthesize.Can effectively stimulate vascular smooth muscle endotheli ocytosis, repair blood vessel, vessel softening, makes blood vessel wall keep smooth and soft, prevents cholesterol deposits; Improvement and anti-human body arteries are atherosis.
In the present invention, Oleum Perillae used is to obtain from the ripe seed of Labiatae medicinal plants Folium Perillae, it is a kind of natural oil of high degree of unsaturation, contained Main Ingredients and Appearance is alpha-linolenic acid, and its content is up to 50%-70%, and alpha-linolenic acid can change into 20 carbon 5 olefin(e) acids (EPA) and 22 carbon 6 olefin(e) acids (DHA) after taking in human body under the effect of enzyme.
In Oleum Perillae, abundant linolenic acid has the effect that reduces cholesterol in serum, triglyceride, low density lipoprotein, LDL and very low density lipoprotein (VLDL), thereby inhibition thrombosis, the stalk match of prevention cardiac muscle and cerebral infarction match, alpha-linolenic acid can also reduce blood viscosity, increase blood oxygen carrying content in addition, suppress the synthetic of triglyceride, increase the excretion of various lipids in body, so the effect of Oleum Perillae blood fat-reducing blood pressure-decreasing is obvious especially, especially more outstanding to hyperlipidemia and borderline hypertension effect.Alpha-linolenic acid in Oleum Perillae can effectively suppress lipogenesis, and reduces fat and excreted, the edible formation that can prevent fatty liver every day.
In the present invention, lecithin used is to adopt prior art extract and come through science processing from Semen sojae atricolor, and lecithin is the basic substance of life, and human life be unable to do without its nourishing and protection from start to finish.Described lecithin has following effect:
" street cleaner " of blood vessel: the effect that lecithin has emulsifying, cuts grease, can promote blood circulation, improve serum lipids, remove peroxide, Blood Cholesterol and neutral fat content are reduced, reduce fat in the holdup time of blood vessel, promotes the dissipation of atherosis speckle, prevent that the tunica intima being caused by cholesterol from damaging.Take lecithin hyperlipidemia and hypercholesterolemia are had to significant effect, thereby can prevent and treat arteriosclerosis (hypertension, myocardial infarction, cerebral hemorrhage).
Effectively dissolve cholelithiasis: in body, too much cholesterol can precipitate, thereby form cholelithiasis, cholelithiasis 90% is made up of cholesterol.Main component in bile is lecithin, also has in addition moisture content, cholesterol, mineral and pigment etc., and lecithin can be by unnecessary cholesterol decomposition, digestion and absorption, thereby makes the cholesterol in bile keep liquid.Can effectively prevent the formation of cholelithiasis if absorb a certain amount of lecithin every day, and also can play to established cholelithiasis the effect of dissolving.
Natural complex E oil is to adopt the prior art natural Vitamin E that separating-purifying goes out from soybean oil.This natural Vitamin E, owing to not producing in process of production chemical reaction, has kept the original physiologically active of vitamin E and natural attribute, the utilization that is more easily absorbed by the body, and also safety is also higher than synthesising complex E, is more suitable for long-term taking.There are some researches show at present, the antioxidation of natural Vitamin E and defying age performance indications are all several times in synthetic vitamin E.In addition; vitamin E is a kind of high-efficiency antioxidant agent; can protect biomembrane to avoid suffering the infringement of peroxide; improve cutaneous circulation, improve lipid metabolism, reduce lipids contents; prevent atherosis; protection blood vessel, hinders arterial endothelial cell " foamed " and balance endotheliocyte cholesterol metabolism, reduces atherosclerotic sickness rate.
Gelatin in the present invention, glycerol, water are the materials that does capsule shell, and three adopts suitable proportioning, have significantly improved the character that affects capsule skin, as disintegrate, toughness, viscosity etc., and production efficiency while also having improved pelleting simultaneously.
Through inventor's the discovery that studies for a long period of time, when the each component of capsule is according to weight portion meter, its proportioning is: when Adeps Phocae vitulinae 70-80 part, Oleum Perillae 15-25 part, lecithin 15-25 part, natural complex E oil 0.1-0.5 part, gelatin 7-9 part, water 7-9 part, glycerol 3-5 part, and better effects if.
The concrete preparation process of soft capsule of fur seal of the present invention is:
(1) batching: take in proportion Adeps Phocae vitulinae, Oleum Perillae, lecithin, day vitamin E oil, mix homogeneously under normal temperature and pressure, filters filtrate for later use;
(2) change glue: gelatin is added to the water in proportion, soaks 1-2h at 30-40 ℃, again feed liquid is warming up to 65-75 ℃ after being warming up to 50-60 ℃ of evacuation, insulation 1-2h; Then add in proportion after the abundant stirring and evenly mixing of glycerol evacuation again, the glue dissolving is for subsequent use;
(3) pelleting: by the glue in the filtrate in step (1) and step (2), insert in full-automatic encapsulating machine, be pressed into soft capsule;
(4) sizing: in temperature 18-25 ℃, under humidity 20%-40% condition, step (3) gained soft capsule is shaped, shaping time 10-30h;
(5) wash ball: use the food grade ethanol of 75-95% to clean step (4) gained soft capsule, remove the paraffin oil on soft capsule surface.
(6) dry: be 25 ℃ by the soft capsule after cleaning in temperature, dry under the condition that relative humidity is 30%, obtain product.
In actual production, inventor find, 30-40 ℃ soak 1-2h can make gelatin fully absorb water, swelling, for gelatin is dissolved in water ready completely.Make gelatin degeneration as excess Temperature can make gelatin immersion process, affect the quality of final capsule shell; The too low gelatin swelling process time of temperature can be elongated, and generally soaking 1-2h gelatin just can be fully swelling good.
For drum in glue is comparatively fast extracted out, be unlikely to again glue to be extracted into blocking pipe in vacuum line, in of the present inventionization glue step, evacuation final vacuum degree is 0.07Mpa.
In fixating shape step, in order to guarantee that capsule rapid draing moisture is up to standard and not destroy capsule skin, setting temperature 18-25 ℃, humidity 20%-40%.Make because capsule skin adopts gelatin, excess Temperature can destroy capsule skin, makes soft gelatin capsule distortion; Temperature is too low, extends drying time.Ambient humidity is too high, makes soft gelatin capsule long drying time, the too low air conditioning system energy of wasting.Under this condition, general sizing sizing 10-30h.In like manner, drying condition of the present invention is 25 ℃ of temperature, relative humidity 30%.
The soft capsule specification that the present invention finally makes is 0.5g/ grain.
Feature of the present invention and excellent results are as follows: the soft capsule of fur seal that the present invention is prepared, to adopt the Adeps Phocae vitulinae of pure natural Canada import as major ingredient, the health-caring capsule that a kind of pure natural that is equipped with the Oleum Perillae, lecithin, natural complex E oil of natural extract and make has no side effect, production technology of the present invention is advanced simple, soft capsule form makes its taking convenience, absorbs rapidly completely, there is nutrient safe, have no side effect, there is effect of obvious blood fat reducing, blood pressure lowering, cholesterol reducing.
The specific embodiment
Disclosed is below only preferred embodiment of the present invention, certainly can not limit with this interest field of the present invention, and any modification of therefore being done with the claims in the present invention, equivalent variations, improvement etc., all should be included in the scope that the present invention is contained.Raw material of the present invention is commercially available, wherein the preferred Canadian import Adeps Phocae vitulinae of Adeps Phocae vitulinae.
Embodiment 1
A kind of soft capsule of fur seal, the each component of this capsule is according to weight portion meter, and its proportioning is: 60 parts of Adeps Phocae vitulinaes, 25 parts of Oleum Perillae, 25 parts, lecithin, 0.2 part of natural complex E oil, 5 parts, gelatin, 5 parts, water, 3 parts of glycerol.
Its concrete preparation process is:
(1) batching: take in proportion Adeps Phocae vitulinae, Oleum Perillae, lecithin, day vitamin E oil, mix homogeneously under normal temperature and pressure, filters filtrate for later use;
(2) change glue: gelatin is added to the water in proportion, soaks 2h at 30 ℃, be warming up to 50 ℃ and be evacuated to 0.07MPa, then feed liquid is warming up to 65 ℃, insulation 2h; Then after adding in proportion the abundant stirring and evenly mixing of glycerol, be evacuated to 0.07MPa, the glue dissolving is for subsequent use again;
(3) pelleting: by the glue in the filtrate in step (1) and step (2), insert in full-automatic encapsulating machine, be pressed into the soft capsule that specification is 0.5g/ grain;
(4) sizing: in 18 ℃ of temperature, under humidity 20% condition, step (3) gained soft capsule is shaped, shaping time 30h;
(5) wash ball: use 95% food grade ethanol scouring step (4) gained soft capsule, remove the paraffin oil on soft capsule surface.
(6) dry: be 25 ℃ by the soft capsule after cleaning in temperature, dry under the condition that relative humidity is 30%, obtain product.
Embodiment 2
A kind of soft capsule of fur seal, the each component of this capsule is according to weight portion meter, and its proportioning is: 70 parts of Adeps Phocae vitulinaes, 30 parts of Oleum Perillae, 30 parts, lecithin, 0.3 part of natural complex E oil, 9 parts, gelatin, 9 parts, water, 5 parts of glycerol.
Its concrete preparation process is:
(1) batching: take in proportion Adeps Phocae vitulinae, Oleum Perillae, lecithin, day vitamin E oil, mix homogeneously under normal temperature and pressure, filters filtrate for later use;
(2) change glue: gelatin is added to the water in proportion, soaks 1h at 40 ℃, be warming up to 60 ℃ and be evacuated to 0.07MPa and feed liquid be warming up to 75 ℃ again, insulation 1h; Then after adding in proportion the abundant stirring and evenly mixing of glycerol, be evacuated to 0.07MPa, the glue dissolving is for subsequent use again;
(3) pelleting: by the glue in the filtrate in step (1) and step (2), insert in full-automatic encapsulating machine, be pressed into the soft capsule that specification is 0.5g/ grain;
(4) sizing: in 25 ℃ of temperature, under humidity 40% condition, step (3) gained soft capsule is shaped, shaping time 10h;
(5) wash ball: use 75% food grade ethanol scouring step (4) gained soft capsule, remove the paraffin oil on soft capsule surface.
(6) dry: be 25 ℃ by the soft capsule after cleaning in temperature, dry under the condition that relative humidity is 30%, obtain product.
Embodiment 3
A kind of soft capsule of fur seal, the each component of this capsule is according to weight portion meter, and its proportioning is: 80 parts of Adeps Phocae vitulinaes, 15 parts of Oleum Perillae, 15 parts, lecithin, 0.5 part of natural complex E oil, 10 parts, gelatin, 10 parts, water, 6 parts of glycerol.
Its concrete preparation process is:
(1) batching: take in proportion Adeps Phocae vitulinae, Oleum Perillae, lecithin, day vitamin E oil, mix homogeneously under normal temperature and pressure, filters filtrate for later use;
(2) change glue: gelatin is added to the water in proportion, soaks 1.5h at 35 ℃, be warming up to 55 ℃ and be evacuated to 0.07MPa and feed liquid be warming up to 70 ℃ again, insulation 1.5h; Then after adding in proportion the abundant stirring and evenly mixing of glycerol, be evacuated to 0.07MPa, the glue dissolving is for subsequent use again;
(3) pelleting: by the glue in the filtrate in step (1) and step (2), insert in full-automatic encapsulating machine, be pressed into the soft capsule that specification is 0.5g/ grain;
(4) sizing: in 20 ℃ of temperature, under humidity 30% condition, step (3) gained soft capsule is shaped, shaping time 20h;
(5) wash ball: use 85% food grade ethanol scouring step (4) gained soft capsule, remove the paraffin oil on soft capsule surface.
(6) dry: be 25 ℃ by the soft capsule after cleaning in temperature, dry under the condition that relative humidity is 30%, obtain product.
Embodiment 4
A kind of soft capsule of fur seal, the each component of this capsule is according to weight portion meter, and its proportioning is: 65 parts of Adeps Phocae vitulinaes, 10 parts of Oleum Perillae, 10 parts, lecithin, 0.1 part of natural complex E oil, 7 parts, gelatin, 7 parts, water, 2 parts of glycerol.
Its concrete preparation process is:
(1) batching: take in proportion Adeps Phocae vitulinae, Oleum Perillae, lecithin, day vitamin E oil, mix homogeneously under normal temperature and pressure, filters filtrate for later use;
(2) change glue: gelatin is added to the water in proportion, soaks 1.7h at 32 ℃, be warming up to after 52 ℃ of evacuation to 0.07MPa and feed liquid be warming up to 67 ℃, insulation 1.3h; Then after adding in proportion the abundant stirring and evenly mixing of glycerol, be evacuated to 0.07MPa, the glue dissolving is for subsequent use again;
(3) pelleting: by the glue in the filtrate in step (1) and step (2), insert in full-automatic encapsulating machine, be pressed into the soft capsule that specification is 0.5g/ grain;
(4) sizing: in 25 ℃ of temperature, under humidity 25% condition, step (3) gained soft capsule is shaped, shaping time 15h;
(5) wash ball: use 80% food grade ethanol scouring step (4) gained soft capsule, remove the paraffin oil on soft capsule surface.
(6) dry: be 25 ℃ by the soft capsule after cleaning in temperature, dry under the condition that relative humidity is 30%, obtain product.
Embodiment 5
A kind of soft capsule of fur seal, the each component of this capsule is according to weight portion meter, and its proportioning is: 75 parts of Adeps Phocae vitulinaes, 20 parts of Oleum Perillae, 20 parts, lecithin, 0.4 part of natural complex E oil, 8 parts, gelatin, 8 parts, water, 4 parts of glycerol.
Its concrete preparation process is:
(1) batching: take in proportion Adeps Phocae vitulinae, Oleum Perillae, lecithin, day vitamin E oil, mix homogeneously under normal temperature and pressure, filters filtrate for later use;
(2) change glue: gelatin is added to the water in proportion, soaks 1.2h at 37 ℃, be warming up to after 52 ℃ of evacuation to 0.07MPa and feed liquid be warming up to 72 ℃, insulation 1.7h; Then after adding in proportion the abundant stirring and evenly mixing of glycerol, be evacuated to 0.07MPa, the glue dissolving is for subsequent use again;
(3) pelleting: by the glue in the filtrate in step (1) and step (2), insert in full-automatic encapsulating machine, be pressed into the soft capsule that specification is 0.5g/ grain;
(4) sizing: in 22 ℃ of temperature, under humidity 35% condition, step (3) gained soft capsule is shaped, shaping time 25h;
(5) wash ball: use 90% food grade ethanol scouring step (4) gained soft capsule, remove the paraffin oil on soft capsule surface.
(6) dry: be 25 ℃ by the soft capsule after cleaning in temperature, dry under the condition that relative humidity is 30%, obtain product.
Experimental example 1
Zoopery: use the soft capsule of fur seal of preparation in embodiment 1, the lipid-lowering effect of this product is tested.
Laboratory animal: 40 of Wistar rats, female, body weight 150-200g, draws the animal center from Shandong Province.
High lipid food: normal feedstuff 69%, cholesterol 1%, Adeps Sus domestica 10%, yolk powder 10%, cholate 0.2%, sucrose 5%, milk powder 5%.
Enzymatic assays TC, TG, HDL-C test kit.
Experimental technique: feed rat with normal feedstuff and observe after 7 days, get tail blood, enzymatic assays serum total cholesterol (TC), triglyceride (TG), HDL-C (HDL-C), be divided into four groups of high fat matched groups, low dose group (0.8g/kgbw), middle dosage group (1.5g/kgbw), high dose group (04.5g/kgbw) according to TC level at random by animal.
From formal experiment, each treated animal is used high lipid food instead, and high fat matched group gives the vegetable oil gavage of same volume; Low dose group, middle dosage group, high dose group are diluted the soft soft capsule of Adeps Phocae vitulinae to desired concn gavage with vegetable oil; Gavage amount is all calculated by 0.5ml/100gbw, once a day, continuous 44 days, gets the every blood lipids index of tail hematometry.
Detecting and assessing foundation: Ministry of Public Health " function of health food is learned assessment process and the method for inspection ".
Experimental data foxprow software, carries out variance analysis with EPI software.
Experimental result:
The impact of table 1 soft capsule of fur seal on rat body weight
| Group | Number of animals (only) | Body weight (g) before experiment | Body weight (g) after experiment | Weightening finish (g) |
| High fat matched group | 10 | 173.7±109 | 262.3±8.6 | 886±165 |
| Low dose group | 10 | 174.1±9.1 | 259.7±6.9 | 85.6±11.4 |
| Middle dosage group | 10 | 175.2±10.1 | 262.6±11.6 | 874±13.0 |
| High dose group | 10 | 173.1±11.7 | 264.3±9.0 | 91.2±13.8 |
From table 1, in whole experimentation, each treated animal vegetative activity is normal, and the animal of the each dosage group of tested material and the comparison of high fat matched group, without significance (p > 0.05).
The impact of table 2 soft capsule of fur seal on hyperlipemia rat TC, TG, HDL-C
* with relatively p < 0.05** and relatively p < 0.01 of high fat matched group of high fat matched group
From table 2, give after high lipid food, after matched group experiment, compared with before experiment, serum TC, the TG of rat are all significantly increased, and show high blood lipid model establishment.Compared with matched group, high dose group extremely significantly reduces Serum TC level (p < 0.01); Low dose group can significantly reduce rat blood serum TG level (p < 0.05); Middle and high dosage group all can extremely significantly reduce rat blood serum TG level.
The impact of table 3 soft capsule of fur seal on Serum Lipids in Experimental HypercholesterolemicRats
| Group | Number of animals (only) | TC(％) | TG(％) | HDL-C(mmol/l) |
| Low dose group | 10 | -5.7 | -31.0 | +0.21 |
| Middle dosage group | 10 | -0.5 | -39.3 | +019 |
| High dose group | 10 | -24.6 | -31.1 | +0.16 |
From table 3, give after high lipid food, compared with matched group, the serum TC of each dosage group rat declines respectively 5.7%, 0.5%, 24.6%, the serum TG of each dosage group rat declines respectively 31.0%, 39.3%, 31.1%, the Serum HDL-C of each dosage group rat the 0.21(mmol/l that rises respectively), 0.19(mmol/l), 0.16(mmol/l).There is certain effect for reducing blood fat by the visible soft capsule of fur seal of the present invention of above data.
Experimental example 2
Adopt the soft capsule of fur seal described in the embodiment of the present invention 5, usage and dosage: oral, 2 of adult every days.
Suffer from hyperlipemia as subjects take 100, adopt and take for each person every day 2, take 30 days, after the oral soft capsule of fur seal of the present invention of experimenter, 85%-95% patient takes effect obviously or cures, and 5%-6% patient takes effect generally, and 2%-3% patient shows improvement.
Claims (5)
1. a soft capsule of fur seal, it is characterized in that: the each component of this capsule is according to weight portion meter, and its proportioning is: Adeps Phocae vitulinae 60-80 part, Oleum Perillae 10-30 part, lecithin 10-30 part, natural complex E oil 0.1-1 part, gelatin 5-10 part, water 5-10 part, glycerol 2-6 part.
2. soft capsule of fur seal according to claim 1, it is characterized in that: the each component of this capsule is according to weight portion meter, and its proportioning is: Adeps Phocae vitulinae 70-80 part, Oleum Perillae 15-25 part, lecithin 15-25 part, natural complex E oil 0.1-0.5 part, gelatin 7-9 part, water 7-9 part, glycerol 3-5 part.
3. the method for preparing soft capsule of fur seal described in claim 1 or 2, is characterized in that: its concrete steps are:
(1) batching: take in proportion Adeps Phocae vitulinae, Oleum Perillae, lecithin, day vitamin E oil, mix homogeneously under normal temperature and pressure, filters filtrate for later use;
(2) change glue: gelatin is added to the water in proportion, soaks 1-2h at 30-40 ℃, again feed liquid is warming up to 65-75 ℃ after being warming up to 50-60 ℃ of evacuation, insulation 1-2h; Then add in proportion after the abundant stirring and evenly mixing of glycerol evacuation again, the glue dissolving is for subsequent use;
(3) pelleting: by the glue in the filtrate in step (1) and step (2), insert in full-automatic encapsulating machine, be pressed into soft capsule;
(4) sizing: in temperature 18-25 ℃, under humidity 20%-40% condition, step (3) gained soft capsule is shaped, shaping time 10-30h;
(5) wash ball: use the food grade ethanol of 75-95% to clean step (4) gained soft capsule, remove the paraffin oil on soft capsule surface.
(6) dry: be 25 ℃ by the soft capsule after cleaning in temperature, dry under the condition that relative humidity is 30%, obtain product.
4. the preparation method of soft capsule of fur seal according to claim 3, is characterized in that: in step (2), after evacuation, vacuum is 0.07Mpa.
5. the preparation method of soft capsule of fur seal according to claim 3, is characterized in that: in step (3), soft capsule specification is 0.5g/ grain.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104055117A (en) * | 2014-06-29 | 2014-09-24 | 宁波市成大机械研究所 | Seal oil soft capsule containing arachidonic acid |
| CN104082752A (en) * | 2014-06-29 | 2014-10-08 | 宁波市成大机械研究所 | Squalene containing seal oil soft capsules |
| CN104082741A (en) * | 2014-06-29 | 2014-10-08 | 宁波市成大机械研究所 | Soft seal oil capsule containing astaxanthin |
| CN104187674A (en) * | 2014-09-07 | 2014-12-10 | 宁波市成大机械研究所 | Seal oil soft capsule containing ginkgo biloba extract |
| CN104187675A (en) * | 2014-09-07 | 2014-12-10 | 宁波市成大机械研究所 | Seal oil soft capsule containing ginkgo biloba oil |
| CN104187676A (en) * | 2014-09-07 | 2014-12-10 | 宁波市成大机械研究所 | Seal oil soft capsule containing kudzuvine root extract |
| CN104922405A (en) * | 2015-07-15 | 2015-09-23 | 庆阳中庆农产品有限公司 | Three-oil one-lycopene soft capsule and preparation method thereof |
| CN107198248A (en) * | 2017-06-06 | 2017-09-26 | 四川阿尔康生物工程有限责任公司 | A kind of plant oil composition of antiatherosclerosis |
| CN109259238A (en) * | 2018-11-18 | 2019-01-25 | 福建省安职教育服务有限公司 | A kind of preparation method of seal oil auxiliary blood fat reducing soft capsule |
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