CN102058560B - Dihydromyricetin soft capsules and preparation method thereof - Google Patents
Dihydromyricetin soft capsules and preparation method thereof Download PDFInfo
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- CN102058560B CN102058560B CN2010106123280A CN201010612328A CN102058560B CN 102058560 B CN102058560 B CN 102058560B CN 2010106123280 A CN2010106123280 A CN 2010106123280A CN 201010612328 A CN201010612328 A CN 201010612328A CN 102058560 B CN102058560 B CN 102058560B
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Abstract
The invention discloses dihydromyricetin soft capsules and a preparation method thereof. The content of the dihydromyricetin soft capsules are prepared from the following raw materials in percentage by weight: 10 to 15 percent of dihydromyricetin and 85 to 90 percent of diluent, wherein the diluents is one or more of vegetable oil, polyethylene glycol and propylene glycol. The preparation method comprises: heating the diluent; adding dihydromyricetin powder formed by ball milling and by sieving with an 80-mesh sieve into the diluent; keeping the temperature after thermal dissolution is finished; and filling into soft capsule shells made from size, plasticizer, purified water and additive, sizing and drying. The dihydromyricetin soft capsules have functions of resisting oxidation, eliminating free radicals in human bodies, diminishing inflammation, relieving pain, reducing blood pressure, reducing fat, resisting tumor, relieving alcoholism, preventing alcoholic liver and fatty liver, inhibiting liver cell deterioration, reducing liver cancer morbidity and the like. The special formula of the capsule shells contributes to the quick dissolution of the capsules, so the content of the capsules can be absorbed by human bodies. The soft capsules are convenient to take.
Description
Technical field
The present invention relates to functional food, field of health care products, specifically, providing a kind of is the soft capsule and preparation method thereof of main constituent with the dihydromyricetin.
Background technology
Dihydromyricetin (Dihydromyricetin, DMY) claim ampelopsin again, it is a kind of active skull cap components, belong to the polyhydroxy flavanonol, existing documents and materials report has multiple pharmacologically active, as free radical in antioxidation, the removing human body, antiinflammatory, analgesia, blood pressure lowering, blood fat reducing, antitumor, also have all multiactions such as sickness rate of removing alcoholism, prevention alcoholic liver, fatty liver, the deterioration of inhibition hepatocyte, reducing hepatocarcinoma, be widely used in medical domain.Closely during the last ten years, along with the development and use of dihydromyricetin high-load plant resources Ampelopsis grossedentata, successively there are multiple products such as " Maoyanmei tea ", " Ampelopsis grossedentata total flavone sheet " to put on market.
In the modern medicinal agents field, soft capsule is a kind of novel form that grows up behind tablet, hard capsule, injection etc., and it can and be encapsulated in the glued membrane functional materials solution or the quantitative pressure injection of suspension, forms big or small, different seal capsule.Soft capsule has taking convenience, good looking appearance, and content is accurate, and disintegrate absorbs fast, the bioavailability height, the functional materials good stability is difficult for plurality of advantages such as the moisture absorption, good airproof performance, can be used for a plurality of fields of functional food, health product and pharmacy.Particularly, become the main flow dosage form of 21st century solid preparation along with the raising of China's soft capsule pharmaceutical machine automaticity.The present invention seeks to this novel form is applied in the dihydromyricetin product development.
Summary of the invention
The object of the present invention is to provide a kind of compound recipe dihydromyricetin cellulose soft capsules, it has free radical in the human body of removing, and blood pressure lowering, blood fat reducing, antitumor are removed effects such as alcoholism, prevention alcoholic liver.Another bright purpose of we is to provide a kind of compound recipe dihydromyricetin preparation of soft capsule method.
Technical scheme of the present invention is: a kind of dihydromyricetin cellulose soft capsules, it is characterized in that, content is formulated by following raw materials by weight percent: dihydromyricetin 10~15%, and diluent 85~90%, described diluent are one or more in vegetable oil, Polyethylene Glycol and the propylene glycol, its preparation method is that diluent is heated, put into the dihydromyricetin powder of crossing 80 mesh sieves through ball milling, insulation after thermosol finishes, the soft capsule shell of packing into, typing, dry.
What optimize is that the weight ratio of described content is a dihydromyricetin 12.5%, diluent 87.5%.
Described dihydromyricetin is to be raw material with Vitaceae Ampelopsis Ampelopsis grossedentata children young stem and leaf, separates through microwave water extraction, macroporous resin adsorption, and recrystallization, drying forms, dihydromyricetin purity 〉=90%.
Described soft capsule shell is made by the raw material of following weight ratio: sizing material 35%, plasticizer 22%, purified water 42% and additives 1%, described sizing material comprises gelatin, arabic gum, pectin, plasticizer comprises glycerol, sorbitol, and additives comprise antiseptic, antioxidant, essence and enteric material.
The manufacture method of soft capsule may further comprise the steps:
(1) sizing material is added in the glue pot, add the purified water heat of solution, airtight, 70-80 ' C insulation 3 hours;
(2) add plasticizer and additives respectively, stir, vacuumize degassing, glue is put into the heat-preserving container stand for standby use;
(3) glue injects by liquid reservoir and rolls the mould encapsulating machine and flow through on cylinder and form certain thickness adhesive tape;
(4) content that will prepare in advance adds in the blender, enters towards the roller die hole and is packed into adhesive tape, and filling formation is pressed into soft capsule, typing, and drying, packing.
Described enteric material material is a cellulose acetate, and antioxidant is propyl gallate.
Every heavy 500 ± 25mg of gained dihydromyricetin cellulose soft capsules, capsule 's content net weight 400 ± 20mg wherein contains dihydromyricetin effective ingredient 50 ± 2mg.
The present invention utilizes Ampelopsis grossedentata children young stem and leaf to be major ingredient for the dihydromyricetin that raw material extracts, be equipped with the diluent that vegetable oil, Polyethylene Glycol or propylene glycol are formed, have antioxidation, remove free radical in the human body, antiinflammatory, analgesia, blood pressure lowering, blood fat reducing, antitumor also have all multiactions such as sickness rate of removing alcoholism, prevention alcoholic liver, fatty liver, the deterioration of inhibition hepatocyte, reducing hepatocarcinoma.Special capsule shells prescription has the capsular rapid dissolving of interests, and favourable content is absorbed by the body, taking convenience.
The specific embodiment
Embodiment 1:
Get the raw materials ready by batch 10000 soft capsules of production, get dihydromyricetin standard extract 555g, ball milling is crossed 80 mesh sieves; Get refining Oleum Camelliae 38859, the dihydromyricetin powder is put in heating, and it is standby to put into heat-preserving container after thermosol finishes.Get gelatin 350g, add in the glue pot, add the airtight heat of solution of purified water 420ml, add glycerol 220g more respectively, methyl parahydroxybenzoate 9g, propyl gallate 1g stirs; Vacuumize degassing was 2 hours after thermosol finished, and glue is put into the heat-preserving container standing over night.Glue is rolled the mould encapsulating machine by the liquid reservoir injection in second day and on cylinder (temperature remains on about 90 ℃), flow through the certain thickness adhesive tape of formation.The content liquid of preparation is in advance added in the blender, enter towards the roller die hole and be packed into adhesive tape (temperature remains on 35~45 ℃), filling formation is pressed into soft capsule, typing, infrared drying.Dried soft capsule is rejected the underproof product of amount of fill, every heavy 500 ± 25mg of standard soft capsule, and capsule 's content net weight 400 ± 20mg wherein contains dihydromyricetin effective ingredient 50 ± 2mg.
Embodiment 2:
Get the raw materials ready by batch 10000 soft capsules of production, get dihydromyricetin standard extract 555g, ball milling is crossed 80 mesh sieves; Get refining Oleum Camelliae 3885g, the dihydromyricetin powder is put in heating, and it is standby to put into heat-preserving container after thermosol finishes.Get gelatin 200g, arabic gum 150g adds in the glue pot, adds the airtight heat of solution of purified water 420ml, adds glycerol 220g more respectively, cellulose acetate 9g, and propyl gallate 1g stirs; Vacuumize degassing was 2 hours after thermosol finished, and glue is put into the heat-preserving container standing over night.Glue is rolled the mould encapsulating machine by the liquid reservoir injection in second day and on cylinder (temperature remains on about 90 ℃), flow through the certain thickness adhesive tape of formation.The content liquid of preparation is in advance added in the blender, enter towards the roller die hole and be packed into adhesive tape (temperature remains on 35~45 ℃), filling formation is pressed into soft capsule, typing, infrared drying.Dried soft capsule is rejected the underproof product of amount of fill, every heavy 500 ± 25mg of standard soft capsule, and capsule 's content net weight 400 ± 20mg wherein contains dihydromyricetin effective ingredient 50 ± 2mg.
Above-mentioned example 1 is the content diluent with refining Oleum Camelliae, favourable soft capsule compression moulding; Oils and fats is based on unsaturated fatty acid, again with the dihydromyricetin prescription, and the reducing blood-lipid and anti-atheroscleorsis effect.Example 2 adds enteric material cellulose acetate, favourable raising functional component bioavailability.Select for use propyl gallate to make additives in the example 1 and 2, have the effect of anticorrosion, antioxidation, prolongation product storage life concurrently.
Claims (5)
1. dihydromyricetin cellulose soft capsules, it is characterized in that, content is formulated by following raw materials by weight percent: dihydromyricetin 10~15%, and diluent 85~90%, described diluent are one or more in Oleum Camelliae, Polyethylene Glycol and the propylene glycol, its preparation method is that diluent is heated, put into the dihydromyricetin powder of crossing 80 mesh sieves through ball milling, insulation after thermosol finishes, the soft capsule shell of packing into, typing, dry.
Described soft capsule shell is made by the raw material of following weight ratio: sizing material 35%, plasticizer 22%, purified water 42% and additives 1%, described sizing material comprises a kind of in gelatin, arabic gum, the pectin, plasticizer is a kind of in glycerol and the sorbitol, additives are the mixture of antiseptic, antioxidant, essence and enteric material
The manufacture method of soft capsule may further comprise the steps:
(1) sizing material is added in the glue pot, add the purified water heat of solution, airtight, 70-80 ℃ is incubated 3 hours;
(2) add plasticizer and additives respectively, stir, vacuumize degassing, glue is put into the heat-preserving container stand for standby use;
(3) glue injects by liquid reservoir and rolls the mould encapsulating machine and flow through on cylinder and form certain thickness adhesive tape;
(4) content that will prepare in advance adds in the blender, enters towards the roller die hole and is packed into adhesive tape, and filling formation is pressed into soft capsule, typing, and drying, packing,
Described enteric material material is a cellulose acetate, and described antioxidant is propyl gallate.
2. dihydromyricetin cellulose soft capsules according to claim 1 is characterized in that, the weight ratio of content is a dihydromyricetin 12.5%, diluent 87.5%.
3. dihydromyricetin cellulose soft capsules according to claim 1 is characterized in that, described dihydromyricetin is to be raw material with Vitaceae Ampelopsis Ampelopsis grossedentata children young stem and leaf, separate through microwave water extraction, macroporous resin adsorption, recrystallization, drying forms, dihydromyricetin purity 〉=90%.
4. dihydromyricetin cellulose soft capsules according to claim 1 is characterized in that, every heavy 500 ± 25mg of gained dihydromyricetin cellulose soft capsules, and capsule 's content net weight 400 ± 20mg wherein contains dihydromyricetin effective ingredient 50 ± 2mg.
5. dihydromyricetin preparation of soft capsule method as claimed in claim 4, it is characterized in that, soft capsule shell is made by the raw material of following weight ratio: sizing material 35%, plasticizer 22%, purified water 42% and additives 1%, described sizing material comprises a kind of in gelatin, arabic gum and the pectin, plasticizer is a kind of in glycerol and the sorbitol, additives are the mixture of antiseptic, antioxidant, essence and enteric material
The manufacture method of soft capsule may further comprise the steps:
(1) sizing material is added in the glue pot, add the purified water heat of solution, airtight, 70-80 ' C ℃ is incubated 3 hours;
(2) add plasticizer and additives respectively, stir, vacuumize degassing, glue is put into the heat-preserving container stand for standby use;
(3) glue injects by liquid reservoir and rolls the mould encapsulating machine and flow through on cylinder and form certain thickness adhesive tape;
(4) content that will prepare in advance adds in the blender, enters towards the roller die hole and is packed into adhesive tape, and filling formation is pressed into soft capsule, typing, and drying, packing.
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US9211298B2 (en) * | 2012-11-16 | 2015-12-15 | Song Gao | Compositions containing enriched natural crocin and/or crocetin, and their therapeutic or nutraceutical uses |
CN104224745A (en) * | 2013-06-09 | 2014-12-24 | 天津药物研究院 | A capsule shell of a traditional Chinese medicine soft capsule and a preparing method thereof |
CN111251521B (en) * | 2018-12-03 | 2022-07-22 | 沈欣 | Method for preparing liquid bead pill |
US20200215027A1 (en) * | 2018-12-28 | 2020-07-09 | Robert K. Prud'homme | Dihydromyricetin nanoemulsion formulations and methods for forming them |
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CN1257711C (en) * | 2003-12-05 | 2006-05-31 | 石药集团中奇制药技术(石家庄)有限公司 | Butyl benzene phthalein soft capsule and its preparation method |
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Patent Citations (2)
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CN1257711C (en) * | 2003-12-05 | 2006-05-31 | 石药集团中奇制药技术(石家庄)有限公司 | Butyl benzene phthalein soft capsule and its preparation method |
CN1785245A (en) * | 2005-11-28 | 2006-06-14 | 宛六一 | Method for preparing composite traditional Chinese medicine soft capsule |
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