CN103284151A - Omega-3 unsaturated vegetable combined oil with effect of reducing blood fat - Google Patents
Omega-3 unsaturated vegetable combined oil with effect of reducing blood fat Download PDFInfo
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Abstract
The invention provides an omega-3 composition with an effect of reducing blood fat. The omega-3 composition comprises oleic acid, linoleic acid, alpha-linolenic acid, vitamin E, sesamin, sesamol, procyanidine and perillaldehyde. The omega-3 composition utilizes the synergistic effect of all the components and can be applied to preparation of health-care food or food. The composition can be obtained by matching of single compounds according to certain proportion and also can comprise multiple materials containing the compounds. To be exact, the composition can be prepared by sunflower seed oil, grape seed oil, black sesame oil, perilla oil, perilla volatile oil and sesame lignan according to certain proportion. The composition provided by the invention has the active components with the effects of reducing cholesterol in blood, adjusting the metabolism, reducing triglyceride and low-density lipoprotein, inhibiting the synthesis of the triglyceride, increasing excretion of various lipids in the body and resisting oxidization and the like, thus achieving the effect of reducing the blood fat and having obvious controlling effect to complications.
Description
Technical field
The invention belongs to medicine and field of food, is the composition that a kind of natural products with relevant diseases such as anti-curing hyperlipemias is made.
Background technology
Hyperlipemia is the metabolic disease relevant with angiocardiopathy, refers to that one or more lipids are higher than normally in the blood plasma because fat metabolism or running unusually, make.The main harm of hyperlipemia is to cause atherosclerotic, and then causes numerous relevant diseases, this disease to the infringement of health be concealment, gradually, carrying out property and general.Its direct infringement is to accelerate systemic atherosclerosis, because the vitals of whole body all will rely on artery blood supply, oxygen supply, in case artery is stopped up by atheromatous plaque, will cause serious consequence.The renal failure that artery sclerosis causes etc., all closely related with hyperlipemia.A large amount of research datas show that hyperlipemia is cerebral apoplexy, coronary heart disease, myocardial infarction, cardiac sudden death is independent and important risk.The incidence of disease height of these cardiac and cerebral vascular diseases, harm is big, and disease progression is dangerous, and its death rate accounts for about the half of human general mortality rate.The medicine of regulating blood lipoid is a lot of at present, mainly is divided into following three classes: (1) Statins, to reduce cholesterol, as simvastatin, Provastain etc.; (2) the special class of shellfish: to reduce triglycerides, as promise weighing apparatus, lipanthyl etc.; (3) natural drug class, all effective to reducing cholesterol and triglycerides, and can increasing high density lipoprotein, have the effect of comprehensive adjustment blood fat, and side effect is little, as the safe board Colestid of dragon etc.Because it is a process slowly that blood fat increases, the harmful effect that blood fat is particularly eliminated in the adjusting of blood fat needs the process of a continuous action too, so the patient should select the tangible medicine of effect for reducing fat according to the different situations of self.Therefore, the fat-reducing medicament safe and effective, that toxic and side effect is little, hyperlipemic patients is needed just.This patent that we invent meets the application of natural drug aspect the treatment high fat of blood of this condition just.
The composition with effect for reducing blood fat that the present invention is made up of oleic acid, linoleic acid, alpha-linolenic acid, vitamin E, sesamin, sesamol, OPC, perillaldehyde, this composition can be the composition that above compound is formed according to a certain percentage, also can be that other plurality of raw materials that contain above compound are formed.Oleic acid, linoleic acid and vitamin E are present in sunflower oil, grape-kernel oil, black mole sesame oil, the perilla herb oil; Be rich in a large amount of alpha-linolenic acid (ω-3) in the perilla herb oil; OPC is present in the grape-kernel oil; Sesamin and sesamol are the main component of sesame lignan; Perillaldehyde is the purple perilla main component of essential oil.So, the composition that above composition can proportionally be made up of sunflower oil, grape-kernel oil, black sesame oil, perilla herb oil, sesame wood phenol, purple perilla volatile oil also can be to contain the composition that other raw materials of oleic acid, linoleic acid, alpha-linolenic acid, vitamin E, sesamin, sesamol, OPC, perillaldehyde are formed according to a certain percentage.Said composition is to become natural products combination oil by the active ingredient innovative combination, from several different mechanism of action treatment hyperlipemia of starting with, reaches combination of long drives and drop shots, and the effect for the treatment of both principal and secondary aspect of disease is in the hope of having significant breakthrough and raising from curative effect and security.
Oleic acid can reduce T-CHOL and bad cholesterol, and useful cholesterol does not but descend.Linoleic acid is the aliphatic acid of needed by human, and it constitutes the basis of various cells, the effect that has the metabolism regulated, keeps the blood pressure balance, reduces cholesterol in the blood, helps absorption vitamin C and E.Vitamin E can prevent unrighted acid undue oxidation in vivo, helps lend some impetus to the activity of capillary, improves the circulatory system, thereby prevents artery sclerosis and other vascular diseases.Alpha-linolenic acid (ω-3) is characteristic active component in the deep sea fish oil, has the effect that reduces cholesterol in serum, triglycerides, low-density lipoprotein and VLDL, thereby inhibition thrombosis, the stalk match of prevention cardiac muscle and cerebral infarction match, alpha-linolenic acid can also reduce blood viscosity, increase the blood oxygen carrying content in addition, suppress the synthetic of triglycerides, increase the drainage of various lipids in the body, so it is the effect of blood fat-reducing blood pressure-decreasing is obvious especially, especially more outstanding to high fat of blood and borderline hypertension effect.It is synthetic that alpha-linolenic acid can effectively suppress fat, and reduce fat it is excreted, and every day is edible can prevent the formation of fatty liver.OPC has the protection blood vessel elasticity, the prevention cholesterol is hoarded at vascular wall and reduced blood platelet and solidifies, and simultaneously, has tangible oxidation resistance.Sesamin has anti-hypertension and cardiovascular hypertrophy, protects the liver, anti-oxidant, reduce cholesterol, suppress effects such as cutaneum carcinoma.Sesamol is the important fragrance component of sesame oil, also is the important stay in grade agent of sesame oil.Sesamol has very strong oxidation resistance, is usually used in the antioxidant of food, medicine.Perillaldehyde is the purple perilla main component of essential oil, has antibiotic, anti-inflammatory, calmness, analgesic activity, is a kind of natural perfume material.
In sum, said composition has tangible improvement from different action target spots and approach to hyperlipemia with different effective substances, blood fat to hyperlipemic patients is adjusted to perfect condition, so said composition can be used for preparing health products or the food with relevant diseases such as anti-curing hyperlipemias.Before the present invention finishes, the composition that does not also have the relevant oleic acid of bibliographical information, linoleic acid, alpha-linolenic acid, vitamin E, sesamin, sesamol, OPC, perillaldehyde to form, effect with reducing blood lipid, the composition that does not also have bibliographical information to be made up of sunflower oil, grape-kernel oil, black sesame oil, perilla herb oil, sesame wood phenol, purple perilla volatile oil has the effect of reducing blood lipid.
Summary of the invention
The inventor rest on a scientific basis theory, through repetition test, the combination oil of being formed by oleic acid, linoleic acid, α-leukotrienes, vitamin E, sesamin, sesamol, OPC, perillaldehyde with effect for reducing blood fat.The present invention also selects for use raw material edible, that contain chemical composition in the above composition to form according to a certain percentage, formed by sunflower oil, grape-kernel oil, black sesame oil, perilla herb oil, sesame wood phenol, purple perilla volatile oil specifically, effect with reducing blood lipid, this composition material easily obtains and takes safety for a long time, has obvious practicability and novelty.
When the present invention carries out combination collocation at each raw material of choosing health food, must consider the effect that they can be brought into play separately and the trade-off effect that they are arranged in pairs or groups and can produce.At first, can descend blood total cholesterol and bad cholesterol of oleic acid; Linoleic acid has the metabolism of adjusting, keeps the blood pressure balance, reduces cholesterol in the blood; Vitamin E can prevent unrighted acid undue oxidation in vivo, helps lend some impetus to the activity of capillary, improves the circulatory system, thereby prevents artery sclerosis and other vascular diseases; Alpha-linolenic acid has the effect that reduces cholesterol in serum, triglycerides, low-density lipoprotein and VLDL, thereby inhibition thrombosis, prevention miocardial infarction and cerebral infarction, alpha-linolenic acid can also reduce blood viscosity, increase the blood oxygen carrying content in addition, suppress the synthetic of triglycerides, increase the drainage of various lipids in the body, it is synthetic effectively to suppress fat, and reduce fat it is excreted, can prevent the formation of fatty liver; OPC has the protection blood vessel elasticity, the prevention cholesterol is hoarded at vascular wall and reduced blood platelet and solidifies, and simultaneously, has tangible oxidation resistance; Sesamin has anti-hypertension and cardiovascular hypertrophy, protects the liver, anti-oxidant, reduce cholesterol, suppress effects such as cutaneum carcinoma; Sesamol is the important fragrance component of this composition, also is important stay in grade agent, has very strong oxidation resistance; Perillaldehyde also is the main fragrance component of this composition, has antibiotic, anti-inflammatory, calmness, analgesic activity, is a kind of natural perfume material.So all product share, can mutually promote, synergy mutually, reach the purpose of real reducing blood lipid, the effect that has control high fat of blood syndrome simultaneously.
One of the object of the invention is, principle based on modern pathology molecular mechanism and Traditional Chinese medical theory combination, through a large amount of discovering, the composition that the sunflower oil that can take for a long time, grape-kernel oil, black sesame oil, perilla herb oil, sesame wood phenol, purple perilla volatile oil contain reaches suitable with the chemical composition of the described composition of claim 1 of the present invention through rationally forming.Can realize the pharmacologically active that the described composition of claim 1 has by the composition that sunflower oil, grape-kernel oil, black sesame oil, perilla herb oil, sesame wood phenol, purple perilla volatile oil are formed through allotment, and embodied the synergy characteristics of Chinese medicine composition, had tangible novelty and technological progress.
Two of the object of the invention is, by sunflower oil, grape-kernel oil, black sesame oil, perilla herb oil, sesame wood phenol, the combination oil that purple perilla volatile oil is formed, has cholesterol in the blood of reduction, regulate metabolism, reduce triglycerides and low-density lipoprotein, suppress the synthetic of triglycerides, increase the drainage of various lipids in the body, the composition of anti-oxidant isoreactivity, thereby reach the effect of reducing blood lipid, and its complication had tangible preventive and therapeutic effect, the effect that this natural composition reaches is that present existing chemicals and Chinese medicine preparation treatment hyperlipemia are not available, and this is the most outstanding contribution of the present invention.The present invention simultaneously has chemical composition and the antimicrobial chemical composition of natural perfume material, so this composition need not add any anticorrisive agent and essence, has tangible novelty.
Technical problem to be solved by this invention is to have the effect for reducing fat of falling by being different from the composition that single component forms, and said composition comprises oleic acid 100-450 part, linoleic acid 250-1000 part, leukotrienes 50-200 part, vitamin E 1-10 part, sesamin 1-10 part, sesamol 1-5 part, OPC 1-10 part, perillaldehyde 1-10 part.
Another technical problem to be solved by this invention is to be had by the composition that other raw materials that contain compositions such as oleic acid, linoleic acid, alpha-linolenic acid, vitamin E, sesamin, sesamol, OPC, perillaldehyde are formed the effect of reducing blood lipid, and said composition comprises sunflower oil 250-1000 part, grape-kernel oil 125-500 part, black sesame oil 75-300 part, perilla herb oil 75-300 part, purple perilla volatile oil 1-10 part, sesame lignan 1-10 part.
Another object of the present invention has provided the method for extracting active component respectively from sunflower seeds, grape pip, Semen sesami nigrum seed, purple perilla seed, the Semen sesami nigrum dregs of rice, perilla leaf, and this method comprises:
(1) gets sunflower seeds, through selecting materials, train stir-fry, physical squeezing, producing finally by the natural plant fibre filtering technique, obtain sunflower oil;
(2) get grape wine skin slag, heat drying skin slag, screening vinify skin slag, separation, the up-to-standard grape pip of sort out, grape-kernel oil is extracted in the hydraulic pressure cold press, filters, and gets grape-kernel oil;
(3) get Semen sesami nigrum, through selecting materials slow fire, vigorous fire and Wen Huosan awave parch of insulation, raise fume and dust, then the Semen sesami nigrum that fries send that oil press presses to, the dregs of fat separate, crude oil is after filtration, be pellucidity, obtain black sesame oil, the dregs of fat are standby;
(4) get the purple perilla seed, after selecting materials, moisture drying handled to 2%～10%, be cooled to environment temperature after, under cryogenic conditions, squeeze, get the cold pressing crude oil, the cold pressing crude oil namely gets perilla herb oil after precipitation, smart filter;
(5) get perilla leaf, through cleaning, utilize steam distillation to obtain the purple perilla naphtha, through dehydration, obtain purple perilla volatile oil then;
(6) get the sesame dregs of fat, add 8-12 times of water gaging, stir, mixing filters, repeat 2-3 time, add 6-12 with the sesame dregs of fat of water treatment and doubly measure 85% alcohol extract 2-3 time, each 1-3 hour, to filter, filtrate is concentrated, place, crystallization filters, and drying obtains sesame wood phenol;
(7) sunflower oil, black sesame oil, grape-kernel oil, perilla herb oil, purple perilla volatile oil, wooden phenol are proportionally mixed after, be mixed together with pharmaceutic adjuvant again, make oral formulations according to a conventional method.
Another object of the present invention has provided above-mentioned active component of separating in health food and the Application in Food of the anti-curing hyperlipemia of preparation from sunflower seeds, grape pip, Semen sesami nigrum seed, purple perilla seed, the Semen sesami nigrum dregs of rice, perilla leaf.Said composition adopts conventional extracting method, do not relate to the interpolation chemical substance, kept the abundant nutrition in the oil plant, no chemical solvent pollutes, do not contain any chemical preservation antioxidant, guaranteed not being destroyed of former effective components in plants, embodied the advantage of natural composition, and this composition green, not having any pollution, also is the another innovative point of this composition.
Because the present invention discloses the effect that the composition of being made up of the component of extracting in sunflower seeds, grape pip, Semen sesami nigrum seed, purple perilla seed, the Semen sesami nigrum dregs of rice, the perilla leaf has anti-curing hyperlipemia and relevant disease first; therefore; this composition cooperated separately or with other active constituent or auxiliary material make another kind of composition; so long as said composition is used for food or prevention and treatment high fat of blood and complication thereof, all belong to protection scope of the present invention.Composition of the present invention all has the effect of prevention and treatment high fat of blood when making any formulation.
The composition of being made up of oleic acid, linoleic acid, alpha-linolenic acid, vitamin E, sesamin, sesamol, OPC, perillaldehyde (being called for short composition 1) and the composition of being made up of sunflower oil, grape-kernel oil, black sesame oil, perilla herb oil, purple perilla volatile oil, sesame lignan (abbreviation composition 2) have effect for reducing blood fat, are confirmed by following pharmacodynamic experiment.
1, the present composition is to the influence of mouse TC, TG, HDL-C, LDL-C
Get 90 of male rats, be divided into 9 groups at random, except the blank group, all the other are respectively organized and give high lipid food every day: 2% cholesterol, 10% lard, 0.5% sodium taurocholate, 0.2% propylthiouracil, 87% basal feed.Except the blank group was freely drunk water, the hyperlipidemia model group gave equivalent physiological saline, and all the other are respectively organized per os and irritate stomach, and every day 1 time is according to table 1 grouping, administration, successive administration 15d.Fasting 12h after the medication measures serum total cholesterol (TC), triglyceride (TG), HDL-C (HDL-C), serum low-density LP cholesterol (LDL-C) content, the results are shown in Table 1.
Table 1, the present composition are to the result that influences of hyperlipidemia rats blood lipids index
* compare * P＜0.05 with model control group; * P＜0.01;
△ and normal group compare, △ P＜0.05; △ △ P＜0.01;
The result shows, model control group serum TC, TG, LDL-C value obviously raise, HDL-C descends, can obviously reduce serum TC, TG content with the model control group comparison present composition, significantly reduce serum low-density LP cholesterol (LDL-C) content, the content of serum high-density LP cholesterol (HDL-C) that significantly raise.
2, hepatic tissue MDA and SOD measure
Last is got behind the blood the animal sacrificed by decapitation, get rats'liver lobus sinister 0.1g and prepare 10% tissue homogenate, the centrifugal 15min of 3000r/min gets the centrifugal 10min of supernatant 1500r/min again, utilize total protein kit measurement protein concentration (Coomassie brilliant blue method), press the kit explanation and measure MDA and SOD.
Table 2, the present composition are to the influence of MDA in the liver tissues of rats and SOD
* compare * P＜0.05 with model control group; * P＜0.01;
△ and normal group compare, △ P＜0.05; △ △ P＜0.01;
The result shows that the high, medium and low dosage group of the present composition all has the ability of removing body lipid peroxidating product LPO, and with the increase of dosage, effect is strengthened.The ability that the SOD vigor is also had raising.The present composition 1 activity is better than composition 2 slightly.
3, the present composition is to the influence of liver fat change
Get left lobe of liver, immerse in the 20% neutral formalin solution and fix, conventional H E dyeing is observed under the light microscopic.The result shows that the no liver fat of blank tissue becomes, and the change of hyperlipidemia model liver fat reaches and is severe fatty liver more than 85%; It is 70% for the moderate fatty liver that the present composition 1 low dose group liver fat is altered an agreement, it is 63% for the moderate fatty liver that the present composition 2 low dose group liver fat are altered an agreement, to alter an agreement be 55% for slight fatty liver to dosage group liver fat in the present composition 1, to alter an agreement be 42% for slight fatty liver to dosage group liver fat in the present composition 2, and it is 30% to be slight fatty liver that the present composition 1 high dose group liver fat is altered an agreement.It is 23% for slight fatty liver that the present composition 2 high dose group liver fat are altered an agreement.Illustrate that the present composition has the effect that suppresses the fatty liver development and reverse fatty liver.
From above pharmacodynamic experiment as can be known, the present composition has the effect of the fatty liver that treatment hyperlipemia and high fat of blood cause, and takes for a long time and be free from side effects.
The present invention executes example by following experiment to be achieved (confirmation), but is not limited to this example.
Example 1The preparation method of composition 1
Get oleic acid 250g, linoleic acid 550g, leukotrienes 180g part, vitamin E 5g, sesamin 5g, sesamol 3g, OPC 5g, perillaldehyde 2g, mix, make 1000g.
Example 2The preparation method of composition 2
(1) gets sunflower seeds, remove impurity, training stir-fry, normal temperature squeezing, filter through right string, obtain sunflower oil;
(2) get grape wine skin slag, heat drying skin slag, screening vinify skin slag, separation, the up-to-standard grape pip of sort out, grape-kernel oil is extracted in the hydraulic pressure cold press, filters, and gets grape-kernel oil;
(3) get Semen sesami nigrum, through selecting materials, remove impurity, 20 ℃ of maintenances of slow fire 15 minutes, vigorous fire kept 10 minutes for 65 ℃, the temperature fire kept 20 minutes for 30 ℃, carry out parch, raise fume and dust, then the Semen sesami nigrum that fries send that oil press presses to, the dregs of fat separate, crude oil after filtration, be pellucidity, obtain black sesame oil, the dregs of fat are standby;
(4) get the purple perilla seed, through selecting materials, remove impurity, moisture drying is handled to less than 5%, be cooled to environment temperature after, under cryogenic conditions, squeeze, get the cold pressing crude oil, the cold pressing crude oil namely gets perilla herb oil after precipitation, smart filter;
(5) get perilla leaf, through cleaning, utilize steam distillation to obtain the purple perilla naphtha, through dehydration, obtain purple perilla volatile oil then;
(6) get the sesame dregs of fat, add 10 times of water gagings, stir, mixing filters, and repeats 3 times, measures 85% alcohol extracts 2 times for 8 times with the sesame dregs of fat adding of water treatment, and each 2 hours, to filter, filtrate concentrates, places, crystallization, filtration, drying obtains the wooden phenol of sesame;
(7) with sunflower oil 500ml, black sesame oil 145ml, grape-kernel oil 200ml, perilla herb oil 150ml, purple perilla volatile oil 5ml, sesame lignan 2g, mix, can, namely.
Claims (7)
1. a composition is characterized in that: be made up of oleic acid, linoleic acid, alpha-linolenic acid, vitamin E, sesamin, sesamol, OPC, perillaldehyde.
2. combination according to claim 1 is oily, it is characterized in that it is to be made by the compound of following weight parts:
Oleic acid 100-450 part, linoleic acid 250-1000 part, alpha-linolenic acid 50-200 part, vitamin E 1-10 part, sesamin 1-10 part, sesamol 1-5 part, OPC 1-10 part, perillaldehyde 1-10 part.
3. according to claim 1,2 described compositions, it is characterized in that, can be obtained by each compound direct matching, also can proportionally be formed by other raw materials that contain described each composition of claim 1.
4. composition according to claim 3 is characterized in that, it is to be made by the raw material of following weight parts:
Sunflower oil 250-1000 part, grape-kernel oil 125-500 part, black sesame oil 75-300 part, perilla herb oil 75-300 part, purple perilla volatile oil 1-10 part, sesame lignan 1-10 part.
5. composition according to claim 4 is characterized in that: the preparation method of described combination oil may further comprise the steps:
(1) gets sunflower seeds, through selecting materials, train stir-fry, physical squeezing, producing finally by the natural plant fibre filtering technique, obtain sunflower oil;
(2) get grape wine skin slag, heat drying skin slag, screening vinify skin slag, separation, the up-to-standard grape pip of sort out, grape-kernel oil is extracted in the hydraulic pressure cold press, filters, and gets grape-kernel oil;
(3) get Semen sesami nigrum, through selecting materials slow fire, vigorous fire and Wen Huosan awave parch of insulation, raise fume and dust, then the Semen sesami nigrum that fries send that oil press presses to, the dregs of fat separate, crude oil is after filtration, be pellucidity, obtain black sesame oil, the dregs of fat are standby;
(4) get the purple perilla seed, after selecting materials, moisture drying handled to 2%～10%, be cooled to environment temperature after, under cryogenic conditions, squeeze, get the cold pressing crude oil, the cold pressing crude oil namely gets perilla herb oil after precipitation, smart filter;
(5) get perilla leaf, through cleaning, utilize steam distillation to obtain the purple perilla naphtha, through dehydration, obtain purple perilla volatile oil then;
(6) get the sesame dregs of fat, add 8-12 times of water gaging, stir, mixing filters, repeat 2-3 time, add 6-12 with the sesame dregs of fat of water treatment and doubly measure the 70-95% alcohol extract 2-3 time, each 1-3 hour, to filter, filtrate is concentrated, place, crystallization filters, and drying obtains the sesame lignan;
(7) sunflower oil, black sesame oil, grape-kernel oil, perilla herb oil, purple perilla volatile oil, sesame lignan are proportionally mixed after, be mixed together with pharmaceutic adjuvant again, make oral formulations according to a conventional method.
6. mainly formed by sesamin and sesamol according to claim 4,5 described sesame lignans.
7. the composition of the arbitrary claim of claim 1-5 is in preparation blood fat reducing healthcare food and Application in Food.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102845539A (en) * | 2012-09-19 | 2013-01-02 | 河南茗轩食品科技有限公司 | Dietary flaxseed blend oil and preparation method thereof |
| CN105532924A (en) * | 2015-12-09 | 2016-05-04 | 四川飚毅中药材科技有限公司 | Radix paeoniae alba seed oil |
| CN109156545A (en) * | 2018-08-28 | 2019-01-08 | 神威药业集团有限公司 | A kind of composition and preparation method thereof with regulating blood lipid action |
| CN116056694A (en) * | 2020-08-03 | 2023-05-02 | 富尔玛株式会社 | Digestive lipase activity inhibitor, inhibitor for increasing blood triglyceride concentration, and fat absorption inhibitor |
| CN116270607A (en) * | 2023-01-06 | 2023-06-23 | 南京财经大学 | A composition with intestinal flora regulating effect |
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| CN1271592A (en) * | 1999-04-26 | 2000-11-01 | 中国科学院植物研究所 | Health-care oil for reducing cholesterol and its preparing process |
| CN1312071A (en) * | 2001-01-17 | 2001-09-12 | 大连金州北乐生物技术研究所 | Linolic acid and linolenic acid capsule and its making process |
| CN101091708A (en) * | 2006-06-22 | 2007-12-26 | 沈阳东宇药业有限公司 | Composition for reducing blood fat, and preparation method |
| CN103053711A (en) * | 2011-10-18 | 2013-04-24 | 王龙体 | Life-prolonging health-care edible oil |
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| CN1271592A (en) * | 1999-04-26 | 2000-11-01 | 中国科学院植物研究所 | Health-care oil for reducing cholesterol and its preparing process |
| CN1312071A (en) * | 2001-01-17 | 2001-09-12 | 大连金州北乐生物技术研究所 | Linolic acid and linolenic acid capsule and its making process |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102845539A (en) * | 2012-09-19 | 2013-01-02 | 河南茗轩食品科技有限公司 | Dietary flaxseed blend oil and preparation method thereof |
| CN105532924A (en) * | 2015-12-09 | 2016-05-04 | 四川飚毅中药材科技有限公司 | Radix paeoniae alba seed oil |
| CN109156545A (en) * | 2018-08-28 | 2019-01-08 | 神威药业集团有限公司 | A kind of composition and preparation method thereof with regulating blood lipid action |
| CN116056694A (en) * | 2020-08-03 | 2023-05-02 | 富尔玛株式会社 | Digestive lipase activity inhibitor, inhibitor for increasing blood triglyceride concentration, and fat absorption inhibitor |
| CN116270607A (en) * | 2023-01-06 | 2023-06-23 | 南京财经大学 | A composition with intestinal flora regulating effect |
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Application publication date: 20130911 |