CN1271592A - Health-care oil for reducing cholesterol and its preparing process - Google Patents

Health-care oil for reducing cholesterol and its preparing process Download PDF

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CN1271592A
CN1271592A CN99105934A CN99105934A CN1271592A CN 1271592 A CN1271592 A CN 1271592A CN 99105934 A CN99105934 A CN 99105934A CN 99105934 A CN99105934 A CN 99105934A CN 1271592 A CN1271592 A CN 1271592A
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oil
health
cholesterol
active substances
biological active
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CN1104252C (en
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宋广巍
黎大爵
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Institute of Botany of CAS
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Abstract

A health-care oil for reducing cholesterol, total fat and triglyceride in blood and suppressing the generation and development of atherosclerosis is prepared through preparing conditioning oil with safflower seed oil and rice bran oil in ratio of (0.3-1) : (1-1.8), preparing physiologic active substance with oenothera odorata oil and VE in ratio of (1-2) : (1-2) through mixing, and finally, mixing said conditioning oil with physiologic active substance in ratio of (1-10) : (0.01-0.1), and optionally mixing with sesame oil to reduce the peculiar smell of oenothera odorata oil.

Description

Health-care oil for reducing cholesterol and method for making thereof
The invention belongs to the edible health product, particularly health-care oil for reducing cholesterol and method for making thereof.
World Health Organization (WHO) announces that the whole world has 1,200 ten thousand people to die from the cardiovascular diseases every year, accounts for first of the cause of death.The women who dies from heart disease and stroke in Poland is more than the man, accounts for 59% of women's sum.Some countries in the Russia and the Central Asia account for 70% of all women's causes of the death.The cardiovascular diseases is the main cause of millions upon millions of resident's mortalities in the western countries, and the U.S. has 400,000 people to die from this disease every year, and in France, the mortality rate of cardiovascular disease accounts for 60% of death toll.At present, cardiovascular and cerebrovascular disease has occupied the first place of China human mortality population.Sickness rate such as coronary heart disease, fatty liver constantly rises, and is example with cardiovascular diseases's sickness rate, and 1958 is 17,30/,100,000, rises to 29,30/,100,000 in 27.1%, 1979 year that accounts for mortality rate, accounts for 52% of dead sum.Beijing's trouble in 1986 myocardial infarction is in hospital and death toll doubled before 10 years respectively.This shows that the cardiovascular diseases has become the most serious disease of the China and the whole world, be human first killer.
France's atherosclerosis and cholesterol research coordination committee studies show that: hypercholesterolemia is cardiovascular diseases's prime culprit.Cholesterol height (average every the rising in 2.3 grams) is the primary factor of bringing out coronary artery disease.By reducing the cholesterol ratio in the blood, can reduce the outbreak of coronary artery disease.One by U.S.'s National Institutes of Health initiation studies show that, significantly reduces cholesterol level and may open the blood vessel that some is narrowed down by athero.Reduce the satisfied fatty acid in the food, increase the component of unsaturated fatty acid, can reduce the accumulation of cholesterol in the tremulous pulse.Because unsaturated fatty acid can quicken cholesterol decomposition, make it become cholic acid, and then reduce content of cholesterol in the blood.
Sickness rate such as coronary heart disease, fatty liver constantly rises, and age of onset more and more shifts to an earlier date, and the calculus relevant with high fat diet also is obvious ascendant trend.A heart medical specialist of army hospital general, Taiwan is studied 1100 pre-official students recently, found that wherein in 14.5% the every 100ml blood of people to contain more than the cholesterol 200mg, and other has 1.4% people to contain more than the 240mg, all above normal index.American physician finds arteriosclerotic generation is promptly arranged, though do not show any symptom at that time among 18 years old youth to the people's that is killed in an automobile accident obduction.This shows that the control cholesterol should be picked up from the doll, the Childhood is reduced the danger that suffers from a heart complaint in life possibly just based on edible low fat food, has kept normal growth simultaneously.
The Chinese patent medicine of China treatment coronary heart disease, angina pectoris and myocardial infarction has a lot: as " medicine for cardiac infarction " of Hong Xiufang, " the red river ginseng decoction of Six Ingredients " of Li Haiwang etc., " TAOHONG SIWU TANG " of Xie Renming, " side invigorates blood circulation No. two " of Bao Yanxi etc., " intending the excessive desert Siberian cocklebur of stilbene certainly " that Sunyang is bright etc.Also put down in writing the prescription of many treatment cardiovascular and cerebrovascular diseases in " national medical product complete works ", as " Pill of thirteen integrants including Flos Carthami ", " Flos Carthami injection ", " ligustrazine " and " Radix Salviae Miltiorrhizae Tabellae " etc.In addition, also having the inclination Flos Chrysanthemi is the Flos Chrysanthemi electuary, Flos Chrysanthemi coronary disease sheet, chrysanthemum publicly price-reduction tabletting etc. of Main Ingredients and Appearance.More than be that Main Ingredients and Appearance is made by Flos Carthami, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Flos Chrysanthemi, be mainly used in the treatment Chinese Traditional Medicines, all be to reach therapeutic purposes by cholesterol level and the blood viscosity that reduces blood of human body, though curative effect is preferably arranged, but still have the following disadvantages:
1) can only be used for the treatment of cardiovascular and cerebrovascular disease, and not accomplish to prevent the generation of this disease;
2) Zhi Liao means are the cholesterol levels that reduce in the blood of human body, but the cholesterol in the blood is not low more good more, cholesterol is low excessively, be that low cholesterol can cause that the neuron cell performance changes, and damage brain cell and human immunocyte, and low cholesterol will be followed potein deficiency and malnutrition and damage immune function of human body.
3) take for a long time, will inevitably have side effects.
At present, the health food that also has some to have the cholesterol reducing effect on the market as safflower oil, Radix Oenotherae erythrosepalae oil, fish oil, Testa oryzae oil, sunflower oil or the like, also all is to reach the health care purpose by cholesterol level and the blood viscosity that reduces blood of human body.Though certain health-care effect is arranged, also exists weak point:
1) price that has is higher, and general wage-earners are difficult to bear.As " limited public affairs are developed in Xinjiang Flos Carthami king industry
Department " " fragrant good fortune grand " safflower oil retail price of exploitation is 58 yuan/kilogram (prices in 1998);
" I adds this deep-sea to the healthy series of the Wei Ersi that Beijing Wei Ersi health care Advisory Co., Ltd produces
Fish oil ", retail price in 1998 is 80 yuan/bottle (100 dresses).
2) mouthfeel that has is bad, takes inconvenience.As Radix Oenotherae erythrosepalae oil, the abnormal flavour that allows the people be difficult to accept is arranged;
3) the cholesterol reducing DeGrain that has.As sunflower oil, result of the test shows: restrain every day edible 60, connects
After the continuous edible week, cholesterol descends 9%; And edible safflower seed oil also only descends 14%.
The objective of the invention is to overcome the deficiency of above-mentioned existence, provide a kind of price lower, taking convenience, novel health-care oil for reducing cholesterol and method for making thereof that cholesterol reducing is effective prevent cardiovascular and cerebrovascular disease to do from the doll in the hope of accomplishing.
Technical scheme of the present invention is to realize (weight proportion) like this: health-care oil for reducing cholesterol comprises safflower oil, Testa oryzae oil, Radix Oenotherae erythrosepalae oil, vitamin E, with safflower oil and Testa oryzae oil is mixed oil, be made into oils and fats with biological active substances with Radix Oenotherae erythrosepalae oil, vitamin E etc., safflower oil: Testa oryzae oil=0.3-1: 1-1.8 wherein, Radix Oenotherae erythrosepalae oil: vitamin E=1-2: 1-2, mixed oil: biological active substances=1-10: 0.01-0.1.
The method for making of health-care oil for reducing cholesterol comprises safflower oil, Testa oryzae oil, Radix Oenotherae erythrosepalae oil, vitamin E, safflower oil and Testa oryzae oil by safflower oil: Testa oryzae oil (weight proportion)=0.3-1: 1-1.8 mixes, and makes mixed oil; With Radix Oenotherae erythrosepalae oil and biological active substances vitamin E, press Radix Oenotherae erythrosepalae oil: vitamin E=1-2 again: 1-2 mixes, and makes the oils and fats with biological active substances; Then, be mixed oil with safflower oil and Testa oryzae oil, to mix with oils and fats with biological active substances, its proportioning is mixed oil: biological active substances=1-10: 0.01-0.1; Miscella is precipitated, filters, and the clear liquor that obtains at last is health-care oil for reducing cholesterol.
In order to reduce the abnormal flavour of Radix Oenotherae erythrosepalae oil, in biological active substances, can add Oleum sesami again, its proportioning is a Radix Oenotherae erythrosepalae oil: vitamin E: Oleum sesami (weight proportion)=1-2: 1-2: 1-5, make clarifying biological active substances oils and fats by precipitating, filtering, and the said biological active substances of the present invention not only is only limited to vitamin E.
The pharmacology and the effect of health-care oil for reducing cholesterol provided by the invention are as follows:
Health-care oil for reducing cholesterol provided by the invention is made mixed oil with safflower oil or safflower oil and Testa oryzae oil.Flos Carthami is a kind of important Chinese crude drug of China, and is early on the books in China's medical science monumental work Compendium of Material Medica.As seen, the useful for a long time safflower oil of our elder generation is cured the disease or the dietetic therapy experience.Contain stearic acid, Palmic acid, oleic acid and linoleic acid in the safflower oil, its linoleic acid content is up to 75-86%.Linoleic acid is the necessary fatty acid of human body, so-called must fatty acid, be meant that body self can not synthesize, must from food, absorb and by machine indispensable fatty acid not, so be referred to as essential fatty acid (EPA).They are again prostaglandin, thromboxane, and the precursor of biological active substances such as leukotriene, thought in the past that essential fatty acid comprised three kinds of linoleic acid, linolenic acid and arachidonic acids, but sure essential fatty acid is a linoleic acid at present, though linolenic acid and arachidonic acid also have the point of essential fatty acid, can be synthetic by linoleic acid.Linoleic acid has remarkable effect at treatment atherosclerosis, cardiac disease, and as the linoleic acid that the BJ Pharmaceutical Co., Ltd. produces, its main component is exactly a linoleic acid.Medically demonstrating important medical treatment and health care value.Safflower oil has the meaning of cardiovascular and cerebrovascular vessel " clear stasis of blood agent ".
Testa oryzae oil: mainly contain triterpene alcohol orizanol (Triterpene alcohol ferulate), common name Hi-Z (Oryzano1) also contains multiple glyceride and free fatty (wherein Palmic acid reaches 50% approximately); Also have Squalene (Squalene), ferulic acid (Ferulic acid), sterol, high fatty alcohol, hydrocarbon, phospholipid, lipoprotein, VITAMIN B15, B1 and E family.In plant oil, Testa oryzae oil is to contain the low oil of linoleic acid, but contains the unsaturated fatty acid active substance, and the effect of blood fat reducing is also fine.
Radix Oenotherae erythrosepalae oil is that Radix Oenotherae erythrosepalae oil contains 70% linoleic acid, 7-14% linolenic acid, multiple discord fatty acids such as 11% oleic acid and 6% Palmic acid approximately by Radix Oenotherae erythrosepalae (the Oenothera biennis L.) oil that seed pressed.And be unique plant seed that is rich in gamma-Linolenic acid.Linolenic acid is in vivo through prolonging carbochain, is derivatized to two height-R-linolenic acid and forms the precursor of I prostanoid, and diseases such as arteriosclerosis, coronary heart disease, thrombosis are had therapeutical effect.Recently research and a large amount of clinical observations show: Radix Oenotherae erythrosepalae oil has the hypercholesterolemia reducing mass formed by blood stasis, triglyceride reducing, effects such as high density lipoprotein increasing cholesterol.In recent years both at home and abroad to having carried out some researchs, confirm that it has multiple pharmacological effect such as blood fat reducing and antiplatelet aggregation and thrombosis, arrhythmia, fat-reducing.
Vitamin E can be kept the normal function of growth organ pipe and organism metabolism is had desirable influence, strengthens people's body constitution and vigor, and powerful antioxidation is arranged, by force to prevent the deposition of cholesterol, prevention and treatment arteriosclerosis, delaying senility course.Be used for coronary heart disease, arteriosclerosis, cerebrovascular sclerosis, gallbladder dysfunction, muscular dystrophy etc.
The brainstrust at U.S. Harvard Medical School Cardiovascular Disease Study center is found, hypercholesterolemia can be added to suffer from the danger of cardiovascular disease, but low cholesterolemia can cause that also the neuron cell film properties changes, and damage brain cell and human immunocyte, and low blood cholesterol levels will follow potein deficiency and malnutrition, finally damage immune function of human body.Therefore cholesterol is not low more good more.In fact, cholesterol is not separately with sanguimotor, and it and protein molecule be common to form a kind of microgranule that is called as lipoprotein.Optimal total cholesterol level should be less than per 100 milliliters 200 milligrams in the blood, and content is high more, and danger is big more.All have 20% to 30% to be present in the high density lipoprotein (HDL) approximately in the cholesterol; Remaining major part is to be made of low density lipoprotein, LDL (LDL).HDL is commonly called " good " cholesterol, because it can carry out coronary artery to cholesterol, thereby prevents obstruction of artery.Studies show that HDL content is high more in the blood, the ratio that human body is suffered from coronary heart disease is just low more.The male should reach per 100 milliliters of 35-55 milligrams, women 45-65 milligram.Rise 35 milligrams if the content of HDL is lower than per minute, human body will increase the danger of suffering from coronary heart disease.The every reduction of the content of HDL 1mg/ decilitre, the danger that suffers from a heart complaint will increase by 2% to 3%.And, if the content of HDL reaches or is higher than 60mg, in fact just can play the cardiopathic effect that prevents.The adult who does not have coronary heart disease, the content of LDL should be lower than per minute and rises 130mg in the blood, belongs to higherly between 130-159mg, meets or exceeds 160mg and belongs to too high.What make really that heart suffers damage is not cholesterol itself, but relevant in the cholesterol with low-density albumen, and obtain the part of oxidation in vivo.
Health-care oil for reducing cholesterol of the present invention can be made bottling, barrelling or make capsule preparations.The health-care oil for reducing cholesterol that provides is made of safflower oil, Testa oryzae oil, Radix Oenotherae erythrosepalae, vitamin E and Semen Sesami wet goods raw material, contains linoleic acid, gamma-Linolenic acid, vitamin E etc.; A large amount of linoleic acids can prevent that human body lacks linoleic acid disease in safflower oil, the Testa oryzae oil, linoleic acid, gamma-Linolenic acid and vitamin E etc. can reduce the content of cholesterol in the blood, total fat, triglyceride, the content of low density lipoprotein, LDL (LDL) (bad cholesterol) in the cholesterol particularly, can suppress atherosclerosis takes place, develops, anti-hemostatic tube solidifies, and can prevent and treat the generation of cardiovascular and cerebrovascular disease effectively.
Accompanying drawing 1: pure safflower oil, pure Testa oryzae oil, pure sunflower oil and health-care oil for reducing cholesterol are to the variation of cholesterol in the blood.
▲ pure safflower oil ◆ pure Testa oryzae oil ● pure sunflower oil
■ example 1 health-care oil for reducing cholesterol * example 2 health-care oil for reducing cholesterol * example 3 health-care oil for reducing cholesterol
Below in conjunction with embodiment technical scheme of the present invention is described further.
Research worker with Institute of Botany, Chinese Academy of Sciences is an object, is test oil with pure safflower oil, pure Testa oryzae oil, pure sunflower oil and health-care oil for reducing cholesterol.Every kind of each 10 people of oily testee, restrain every day edible 10, and the time of test is 10 days.Result of the test such as following table (averaging), cholesterol level change curve in the human body such as accompanying drawing 1.
0 day cholesterol 3 days cholesterol 6 days cholesterol 10 days cholesterol
Pure Testa oryzae oil 226mg/dl ?210mg/dl ?195mg/dl ?185mg/dl
Embodiment 1 health-care oil for reducing cholesterol 222mg/dl ?207mg/dl ?189mg/dl ?164mg/dl
Pure safflower oil 214mg/dl ?209mg/dl ?195mg/dl ?184mg/dl
Embodiment 2 health-care oil for reducing cholesterol 208mg/dl ?199mg/dl ?180mg/dl ?171mg/dl
Embodiment 3 health-care oil for reducing cholesterol 202mg/dl ?195mg/dl ?185mg/dl ?178mg/dl
Pure sunflower oil 205mg/dl ?202mg/dl ?194mg/dl ?186mg/dl
By test, the result shows: edible pure sunflower oil, and cholesterol descends 9.27%; Edible pure safflower oil descends 14.02%; Edible pure Testa oryzae oil descends 18.14%; The health-care oil for reducing cholesterol of edible embodiment 2 descends 17.79%.The health-care oil for reducing cholesterol of embodiment 1 descends 25.68%.The health-care oil for reducing cholesterol of embodiment 3 descends 11.88%.
Can reach a conclusion from above result of the test, this health-care oil for reducing cholesterol, especially embodiment 1, has tangible cholesterol reducing health-care effect.And from the selling price of market raw material, this health care oil has very high functional price ratio, and the people who is fit to each age group is edible.
Embodiment 1
Safflower oil 30 grams are mixed with Testa oryzae oil 70 grams, make mixed oil; Again Radix Oenotherae erythrosepalae oil 2 grams are mixed with biological active substances vitamin E2 gram, make oils and fats with biological active substances; In order to reduce the abnormal flavour of Radix Oenotherae erythrosepalae oil, in biological active substances, add Oleum sesami 5 grams again, then, be mixed oil with safflower oil and Testa oryzae oil, mix with oils and fats with biological active substances; Miscella is precipitated, filters, and the clear liquor that obtains 100 grams at last is health-care oil for reducing cholesterol.
Embodiment 2
Safflower oil 15 grams are mixed with Testa oryzae oil 85 grams, make mixed oil; Again Radix Oenotherae erythrosepalae oil 2 grams are mixed with biological active substances vitamin E2 gram, make oils and fats with biological active substances; In order to reduce the abnormal flavour of Radix Oenotherae erythrosepalae oil, in biological active substances, add Oleum sesami 5 grams again, then, be mixed oil with safflower oil and Testa oryzae oil, mix with oils and fats with biological active substances; Miscella is precipitated, filters, and the clear liquor that obtains 100 grams at last is health-care oil for reducing cholesterol.
Embodiment 3
Safflower oil 50 grams are mixed with Testa oryzae oil 50 grams, make mixed oil; Again Radix Oenotherae erythrosepalae oil 2 grams are mixed with biological active substances vitamin E2 gram, make oils and fats with biological active substances; In order to reduce the abnormal flavour of Radix Oenotherae erythrosepalae oil, in biological active substances, add Oleum sesami 5 grams again, then, be mixed oil with safflower oil and Testa oryzae oil, mix with oils and fats with biological active substances; Miscella is precipitated, filters, and the clear liquor that obtains 100 grams at last is health-care oil for reducing cholesterol.

Claims (4)

1. health-care oil for reducing cholesterol, it is characterized in that comprising safflower oil, Testa oryzae oil, Radix Oenotherae erythrosepalae oil, vitamin E, with safflower oil and Testa oryzae oil is mixed oil, be made into oils and fats with biological active substances with Radix Oenotherae erythrosepalae oil, vitamin E, safflower oil: Testa oryzae oil=0.3-1: 1-1.8 wherein, Radix Oenotherae erythrosepalae oil: vitamin E=1-2: 1-2, mixed oil: biological active substances=1-10: 0.01-0.1.
2. health-care oil for reducing cholesterol as claimed in claim 1 is characterized in that described biological active substances further comprises Oleum sesami, and its proportioning is a Radix Oenotherae erythrosepalae oil: vitamin E: Oleum sesami=1-2: 1-2: 1-5.
3. the method for making of claim 1 health-care oil for reducing cholesterol, it is characterized in that comprising safflower oil, Testa oryzae oil, Radix Oenotherae erythrosepalae oil, vitamin E, at first, safflower oil and Testa oryzae oil by safflower oil: Testa oryzae oil=0.3-1: 1-1.8 mixes, and makes mixed oil; With Radix Oenotherae erythrosepalae oil and biological active substances vitamin E, press Radix Oenotherae erythrosepalae oil: vitamin E=1-2 again: 1-2 mixes, and makes the oils and fats with biological active substances; Then, be mixed oil with safflower oil and Testa oryzae oil, to mix with oils and fats with biological active substances, its proportioning is mixed oil: biological active substances=1-10: 0.01-0.1; Miscella is precipitated, filters, and the clear liquor that obtains at last is health-care oil for reducing cholesterol.
4. health-care oil for reducing cholesterol method for making as claimed in claim 3, it is characterized in that biological active substances further comprises Oleum sesami, its proportioning is a Radix Oenotherae erythrosepalae oil: vitamin E: Oleum sesami=1-2: 1-2: 1-5, make clarifying biological active substances oils and fats by precipitating, filtering.
CN99105934A 1999-04-26 1999-04-26 Health-care oil for reducing cholesterol and its preparing process Expired - Fee Related CN1104252C (en)

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100639562B1 (en) 2004-12-08 2006-10-30 박준선 Production of Korean Evening Primrose Oil
CN103284151A (en) * 2013-06-01 2013-09-11 赵全成 Omega-3 unsaturated vegetable combined oil with effect of reducing blood fat
CN103651953A (en) * 2013-12-06 2014-03-26 凤台县新大食用油脂有限公司 Rice bran oil with qi-benefiting and kidney-tonifying effects
CN104026255A (en) * 2014-05-12 2014-09-10 安徽省甘泉养蜂专业合作社 Health-care sesame oil capable of reducing cholesterol and preparation method thereof
CN105994690A (en) * 2016-05-18 2016-10-12 陕西科技大学 Grease composition with health care function and preparation method of grease composition
CN105994689A (en) * 2016-05-18 2016-10-12 陕西科技大学 Healthy grease composition and preparation method thereof
CN108634013A (en) * 2018-04-20 2018-10-12 管天球 A kind of preparation method for preventing cerebrovascular sclerosis tea oil
CN115152852A (en) * 2022-07-19 2022-10-11 内蒙古金格勒食品有限公司 Edible blend oil for preventing coronary heart disease

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1191677A (en) * 1997-11-07 1998-09-02 金松亭 Functional natural edible oil

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100639562B1 (en) 2004-12-08 2006-10-30 박준선 Production of Korean Evening Primrose Oil
CN103284151A (en) * 2013-06-01 2013-09-11 赵全成 Omega-3 unsaturated vegetable combined oil with effect of reducing blood fat
CN103651953A (en) * 2013-12-06 2014-03-26 凤台县新大食用油脂有限公司 Rice bran oil with qi-benefiting and kidney-tonifying effects
CN103651953B (en) * 2013-12-06 2016-01-20 凤台县新大食用油脂有限公司 A kind of rice bran oil with invigorating Qi and tonifying kidney effect
CN104026255A (en) * 2014-05-12 2014-09-10 安徽省甘泉养蜂专业合作社 Health-care sesame oil capable of reducing cholesterol and preparation method thereof
CN105994690A (en) * 2016-05-18 2016-10-12 陕西科技大学 Grease composition with health care function and preparation method of grease composition
CN105994689A (en) * 2016-05-18 2016-10-12 陕西科技大学 Healthy grease composition and preparation method thereof
CN108634013A (en) * 2018-04-20 2018-10-12 管天球 A kind of preparation method for preventing cerebrovascular sclerosis tea oil
CN115152852A (en) * 2022-07-19 2022-10-11 内蒙古金格勒食品有限公司 Edible blend oil for preventing coronary heart disease

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