CN107752017A - A kind of preparation method of ginseng submicron powder soft capsule - Google Patents
A kind of preparation method of ginseng submicron powder soft capsule Download PDFInfo
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- CN107752017A CN107752017A CN201711094314.2A CN201711094314A CN107752017A CN 107752017 A CN107752017 A CN 107752017A CN 201711094314 A CN201711094314 A CN 201711094314A CN 107752017 A CN107752017 A CN 107752017A
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- ginseng
- soft capsule
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- submicron powder
- powder
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- 235000003140 Panax quinquefolius Nutrition 0.000 title claims abstract description 126
- 235000008434 ginseng Nutrition 0.000 title claims abstract description 125
- 241000208340 Araliaceae Species 0.000 title claims abstract description 117
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 title claims abstract description 117
- 239000000843 powder Substances 0.000 title claims abstract description 81
- 239000007901 soft capsule Substances 0.000 title claims abstract description 69
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 34
- 238000000034 method Methods 0.000 claims abstract description 34
- 230000001954 sterilising effect Effects 0.000 claims abstract description 33
- 229920000159 gelatin Polymers 0.000 claims abstract description 32
- 235000019322 gelatine Nutrition 0.000 claims abstract description 32
- 238000000227 grinding Methods 0.000 claims abstract description 19
- 108010010803 Gelatin Proteins 0.000 claims abstract description 18
- 239000008273 gelatin Substances 0.000 claims abstract description 18
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 18
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 18
- 235000011187 glycerol Nutrition 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 238000010894 electron beam technology Methods 0.000 claims abstract description 16
- 230000005855 radiation Effects 0.000 claims abstract description 16
- 239000001828 Gelatine Substances 0.000 claims abstract description 14
- 239000000084 colloidal system Substances 0.000 claims abstract description 14
- 210000002726 cyst fluid Anatomy 0.000 claims abstract description 14
- 238000004806 packaging method and process Methods 0.000 claims abstract description 14
- 239000006187 pill Substances 0.000 claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 14
- 239000000375 suspending agent Substances 0.000 claims abstract description 14
- 238000003860 storage Methods 0.000 claims abstract description 13
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 8
- 239000008158 vegetable oil Substances 0.000 claims abstract description 8
- 239000002775 capsule Substances 0.000 claims description 41
- 238000012856 packing Methods 0.000 claims description 26
- 235000002789 Panax ginseng Nutrition 0.000 claims description 17
- 239000002245 particle Substances 0.000 claims description 16
- 235000013305 food Nutrition 0.000 claims description 14
- 239000003595 mist Substances 0.000 claims description 14
- 230000008569 process Effects 0.000 claims description 14
- 229910052782 aluminium Inorganic materials 0.000 claims description 13
- 238000007689 inspection Methods 0.000 claims description 13
- 238000009413 insulation Methods 0.000 claims description 13
- 238000004513 sizing Methods 0.000 claims description 13
- 238000005057 refrigeration Methods 0.000 claims description 12
- 238000001035 drying Methods 0.000 claims description 11
- 240000005373 Panax quinquefolius Species 0.000 claims description 10
- 240000004371 Panax ginseng Species 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 9
- 235000008390 olive oil Nutrition 0.000 claims description 7
- 239000004006 olive oil Substances 0.000 claims description 7
- UGMCXQCYOVCMTB-UHFFFAOYSA-K dihydroxy(stearato)aluminium Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[Al](O)O UGMCXQCYOVCMTB-UHFFFAOYSA-K 0.000 claims description 6
- 239000001856 Ethyl cellulose Substances 0.000 claims description 5
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 5
- 235000013871 bee wax Nutrition 0.000 claims description 5
- 239000012166 beeswax Substances 0.000 claims description 5
- 239000010495 camellia oil Substances 0.000 claims description 5
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 5
- 229920001249 ethyl cellulose Polymers 0.000 claims description 5
- 239000006185 dispersion Substances 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 235000019719 rose oil Nutrition 0.000 claims description 4
- 239000010666 rose oil Substances 0.000 claims description 4
- 230000003116 impacting effect Effects 0.000 claims description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 2
- 241000196324 Embryophyta Species 0.000 claims description 2
- 235000011089 carbon dioxide Nutrition 0.000 claims description 2
- 239000002270 dispersing agent Substances 0.000 claims 1
- 230000005611 electricity Effects 0.000 claims 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims 1
- 238000004090 dissolution Methods 0.000 abstract description 8
- 230000008901 benefit Effects 0.000 abstract description 5
- 238000004140 cleaning Methods 0.000 abstract 1
- 239000003292 glue Substances 0.000 description 11
- 238000012360 testing method Methods 0.000 description 10
- 241000894006 Bacteria Species 0.000 description 8
- 239000000725 suspension Substances 0.000 description 3
- 230000000259 anti-tumor effect Effects 0.000 description 2
- 235000013402 health food Nutrition 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 206010013911 Dysgeusia Diseases 0.000 description 1
- UFNDONGOJKNAES-UHFFFAOYSA-N Ginsenoside Rb1 Natural products CC(=CCCC(C)(OC1OC(COC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1O)C3CCC4(C)C3C(O)CC5C6(C)CCC(OC7OC(CO)C(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C(C)(C)C6CC(O)C45C)C UFNDONGOJKNAES-UHFFFAOYSA-N 0.000 description 1
- 208000007443 Neurasthenia Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 229940089161 ginsenoside Drugs 0.000 description 1
- 229930182494 ginsenoside Natural products 0.000 description 1
- GZYPWOGIYAIIPV-JBDTYSNRSA-N ginsenoside Rb1 Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)O[C@@](C)(CCC=C(C)C)[C@@H]1[C@@H]2[C@@]([C@@]3(CC[C@H]4C(C)(C)[C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)CC[C@]4(C)[C@H]3C[C@H]2O)C)(C)CC1)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GZYPWOGIYAIIPV-JBDTYSNRSA-N 0.000 description 1
- TXEWRVNOAJOINC-UHFFFAOYSA-N ginsenoside Rb2 Natural products CC(=CCCC(OC1OC(COC2OCC(O)C(O)C2O)C(O)C(O)C1O)C3CCC4(C)C3C(O)CC5C6(C)CCC(OC7OC(CO)C(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C(C)(C)C6CCC45C)C TXEWRVNOAJOINC-UHFFFAOYSA-N 0.000 description 1
- PWAOOJDMFUQOKB-WCZZMFLVSA-N ginsenoside Re Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@@H]2[C@H]3C(C)(C)[C@@H](O)CC[C@]3(C)[C@@H]3[C@@]([C@@]4(CC[C@@H]([C@H]4[C@H](O)C3)[C@](C)(CCC=C(C)C)O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C)(C)C2)O[C@H](CO)[C@@H](O)[C@@H]1O PWAOOJDMFUQOKB-WCZZMFLVSA-N 0.000 description 1
- AOGZLQUEBLOQCI-UHFFFAOYSA-N ginsenoside-Re Natural products CC1OC(OCC2OC(OC3CC4(C)C(CC(O)C5C(CCC45C)C(C)(CCC=C(C)C)OC6OC(CO)C(O)C(O)C6O)C7(C)CCC(O)C(C)(C)C37)C(O)C(O)C2O)C(O)C(O)C1O AOGZLQUEBLOQCI-UHFFFAOYSA-N 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/40—Shaping or working of foodstuffs characterised by the products free-flowing powder or instant powder, i.e. powder which is reconstituted rapidly when liquid is added
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Nutrition Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
It is as follows the step of this method the present invention relates to a kind of preparation method of ginseng submicron powder soft capsule：（1）The selection of raw material, prepare：Ginseng is chosen, cleaning, is dried, coarse crushing；（2）It is prepared by Ultramicro-powder：Electron beam radiation disinfection, ultramicro grinding are used to the ginseng after coarse crushing；（3）Prepare soft capsule：Take ginseng submicron powder to be added in vegetable oil, while add suspending agent, colloid mill is well mixed, and obtains cyst fluid；Gelatin, glycerine, water are dissolved in proportion, filtered, obtains gelatine size, using all automatic Drop pill machine dripping soft capsule；（4）Packaging, storage；Present invention employs the method for electron beam radiation disinfection, and sterilizing is thorough, pollution-free and residual hazard；Ultramicro-powder has the advantages that dissolution rate is fast, dissolution rate is high, and absorptivity is high, bioavilability is high, masks the bad smell of ginseng, ensure that the quality of product.
Description
Technical field
The invention belongs to health food processing technique field, more particularly to a kind of preparation side of ginseng submicron powder soft capsule
Method.
Background technology
Ginseng, which has, to reinforce vital energy, and veins takes off admittedly, reinforces the spleen to benefit the lung, promotes the production of body fluid to quench thirst；The effect of tranquilize the mind and promote the intelligence, its mild-natured, taste
Sweet, slight bitter, tepor, can be the good merchantable brand of good merchantable brand in help class product, it is just very popular since ancient times；Chemistry, pharmacology
Learn and clinical research proves：Ginseng, which has enhancing memory, improves immunity, anti-aging and a variety of pharmacology such as antitumor makees
With；Clinically it is used for the treatment for treating the disease such as angiocarpy, neurasthenia, antitumor, anti-oxidant；So ginseng is not only medicine
Product, also widely use in recent years in health food；At present, the sterilizing of ginseng uses Co 60 illuminating method, it is understood that there may be
The risk of residual；The Ultramicro-powder that ginseng carries out ultramicro grinding has that dissolution rate is fast, dissolution rate is high, and absorptivity is high, biological utilisation
Spend the advantages that high；But Ultramicro-powder has the characteristic reunited again, it is difficult to be scattered among liquid medium, the dissolution speed of product is hindered
Degree.
The content of the invention
The present invention provides a kind of preparation method of ginseng submicron powder soft capsule, its technical scheme to solve Problems Existing
It is：
A kind of preparation method of ginseng submicron powder soft capsule is as follows the step of this method：
（1）The selection of raw material, prepare：Ginseng is chosen, cleans, dehydrate, ginseng is subjected to coarse crushing into bulky grain；
（2）It is prepared by Ultramicro-powder：Electron beam radiation disinfection is used to the ginseng after coarse crushing, by the ginseng after sterilizing, utilizes Ultramicro-powder
Broken machine carries out ultramicro grinding, and ginseng submicron powder is made；
（3）Prepare soft capsule：Take ginseng submicron powder to be added in vegetable oil dispersion, while add 0.1%~0.5% food medicine
Level suspending agent, is sufficiently mixed uniformly using colloid mill, obtains cyst fluid, standby；Gelatin, glycerine, water are dissolved in proportion, filtered, is obtained
Gelatine size, insulation is standby, using all automatic Drop pill machine dripping soft capsule；
（4）Packaging：By the soft capsule after dripping carry out sizing dry, wash capsule, the capsule that dries in the air, inspection capsule after product first use plastic-aluminum
Dress is wrapped inside in packing machine, then carries out outer packing with complex pocket and carton, and it is qualified to examine, storage.
Preferably, the low-temperature vacuum drying temperature is 45 ~ 55 DEG C, moisture≤3.5%, and ginseng is carried out into coarse crushing into 3
~ 5mm bulky grain.
Preferably, the sterilizing beam energy is 3 ~ 4MeV, and sterilization time is 2 ~ 4h.
Preferably, the ginseng is sun-dried ginseng, Korean ginseng, American Ginseng, red ginseng.
Preferably, dry ice is added during the ultramicro grinding to crush in lower temperature to ensure to crush, the particle diameter being ground into
For 1 ~ 15 u m micro mist；Crush temperature -5 ~ 0 DEG C.
Preferably, the ginseng submicron powder particle diameter is 1 ~ 10u m.
Preferably, the ginseng submicron powder is broken, by the ginseng after sterilizing into micronizer, is crushed using impacting type,
ON cycle refrigeration plant ensures crushing process in low-temperature grinding during crushing, and the particle diameter being ground into is 5 ~ 15u m micro mist, powder
Broken temperature is -5 ~ 0 DEG C.
Preferably, the vegetable oil dispersion be tea oil, rose oil, olive oil, the unsaturated lipid of the vegetable oil
Fat acid content >=90%.
Preferably, the suspending agent is beeswax, aluminum monostearate, ethyl cellulose.
Preferably, the gelatin, glycerine, water are 1 in proportion：0.35~0.6：0.9~1.35.
Beneficial effects of the present invention are：
The method for employing electron beam radiation disinfection, the risk that Co 60 irradiation there may be residual is avoided, is sterilized at normal temperatures
Thoroughly, pollution-free and residual hazard；Ultramicro-powder has the advantages that dissolution rate is fast, dissolution rate is high, and absorptivity is high, bioavilability is high；
The present invention is that ginseng submicron powder is made to uniform suspension in advance, is then wrapped again in soft capsule, can cover the bad of ginseng
Smell, solve the problems, such as that Ultramicro-powder difficulty is scattered in medium, improve the dissolution rate of product, while the quality for passing through particle diameter distribution
Control preferably ensure that the quality of product.
Brief description of the drawings
Fig. 1 is present invention process flow chart.
Wherein sterilize to wash, cool capsule and gelatin, glycerine, water gelatin slurry process be in D level clean areas.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, below in conjunction with the accompanying drawings and specific implementation
The invention will be further described for example.
A kind of preparation method of ginseng submicron powder soft capsule is as follows the step of this method：
（1）The selection of raw material, prepare：Ginseng is chosen, cleans, dehydrate, ginseng is subjected to coarse crushing into bulky grain；
（2）It is prepared by Ultramicro-powder：Electron beam radiation disinfection is used to the ginseng after coarse crushing, by the ginseng after sterilizing, utilizes Ultramicro-powder
Broken machine carries out ultramicro grinding, and ginseng submicron powder is made；
（3）Prepare soft capsule：Take ginseng submicron powder to be added in vegetable oil dispersion, while add 0.1%~0.5% food medicine
Level suspending agent, is sufficiently mixed uniformly using colloid mill, obtains cyst fluid, standby；Gelatin, glycerine, water are pressed 1：0.35~0.6：0.9~
1.35 ratios are dissolved, filtered, prepare glue, obtain gelatine size, insulation is standby, using all automatic Drop pill machine dripping soft capsule；
（4）Packaging：By the soft capsule after dripping carry out sizing dry, wash capsule, the capsule that dries in the air, inspection capsule after product first use plastic-aluminum
Dress is wrapped inside in packing machine, then carries out outer packing with complex pocket and carton.
Embodiment 1
A kind of preparation method of ginseng submicron powder soft capsule is as follows the step of this method：
（1）The selection of raw material, prepare：Korean ginseng 50kg to be chosen, cleans, dehydrate, drying temperature is 45 DEG C, moisture≤
3.5%, ginseng is subjected to coarse crushing into big 3 ~ 5mm bulky grain；
（2）It is prepared by Ultramicro-powder：Electron beam radiation disinfection is used to the ginseng after coarse crushing, sterilizing beam energy is 3MeV, sterilizing
Time is 4h, and the ginseng after sterilizing is crushed using micronizer, is opened using impacting type ultramicro grinding, during crushing
Circulation refrigeration equipment ensures crushing process in -5 ~ 0 DEG C of low-temperature grinding, and the particle diameter being ground into is 5 ~ 15u m micro mist, and people is made
Join Ultramicro-powder；
（3）Prepare soft capsule：Take ginseng submicron powder to be added in tea oil 100kg, while add 0.1% food pharmaceutical grade suspending
Agent beeswax, it is sufficiently mixed uniformly using colloid mill, obtains cyst fluid, it is standby；Gelatin, glycerine, water are pressed 1：0.35：1 ratio is dissolved, mistake
Filter, prepare glue, gelatine size is obtained, insulation is standby, using all automatic Drop pill machine dripping soft capsule；
（4）Packaging：By the soft capsule after dripping carry out sizing dry, wash capsule, the capsule that dries in the air, inspection capsule after product first use plastic-aluminum
Dress is wrapped inside in packing machine, then carries out outer packing with complex pocket and carton, and it is qualified to examine, storage.
Embodiment 2
A kind of preparation method of ginseng submicron powder soft capsule is as follows the step of this method：
（1）The selection of raw material, prepare：Sun-dried ginseng 25kg, Korean ginseng 25kg are chosen, cleans, dehydrate, drying temperature 50
DEG C, moisture≤3.5%, ginseng is subjected to coarse crushing into big 3 ~ 5mm bulky grain；
（2）It is prepared by Ultramicro-powder：Electron beam radiation disinfection is used to the ginseng after coarse crushing, sterilizing beam energy is 4MeV, sterilizing
Time is 2h, and the ginseng after sterilizing is crushed using micronizer, crushed using micronizer, is opened during crushing
Circulation refrigeration equipment ensures crushing process in -5 ~ 0 DEG C of low-temperature grinding, and the particle diameter being ground into is 1 ~ 10u m micro mist, and people is made
Join Ultramicro-powder；
（3）Prepare soft capsule：Take sun-dried ginseng, Korean ginseng ginseng submicron powder to be added in rose oil 100kg, while add 0.2%
Food pharmaceutical grade suspending agent beeswax, is sufficiently mixed uniformly using colloid mill, obtains cyst fluid, standby；Gelatin, glycerine, water are pressed 1：
0.45：1 ratio is dissolved, filtered, prepare glue, obtains gelatine size, insulation is standby, using all automatic Drop pill machine dripping soft capsule；
（4）Packaging：By the soft capsule after dripping carry out sizing dry, wash capsule, the capsule that dries in the air, inspection capsule after product first use plastic-aluminum
Dress is wrapped inside in packing machine, then carries out outer packing with complex pocket and carton, and it is qualified to examine, storage.
Embodiment 3
A kind of preparation method of ginseng submicron powder soft capsule is as follows the step of this method：
（1）The selection of raw material, prepare：Sun-dried ginseng 50kg to be chosen, cleans, dehydrate, drying temperature is 55 DEG C, moisture≤
3.5%, ginseng is subjected to coarse crushing into big 3 ~ 5mm bulky grain；
（2）It is prepared by Ultramicro-powder：Electron beam radiation disinfection is used to the ginseng after coarse crushing, sterilizing beam energy is 3.5MeV, is gone out
The bacterium time is 3h, and the ginseng after sterilizing is crushed using micronizer, crushed using micronizer, is opened during crushing
Open circulation refrigeration equipment and ensure crushing process in -5 ~ 0 DEG C of low-temperature grinding, the particle diameter being ground into is 1 ~ 15u m micro mist, is made
Ginseng submicron powder；
（3）Prepare soft capsule：Take sun-dried ginseng Ultramicro-powder to be added in olive oil 100kg, while add 0.3% food pharmaceutical grade and help
Suspension ethyl cellulose, it is sufficiently mixed uniformly using colloid mill, obtains cyst fluid, it is standby；Gelatin, glycerine, water are pressed 1：0.55：1 ratio
Example is dissolved, filtered, prepare glue, obtains gelatine size, insulation is standby, using all automatic Drop pill machine dripping soft capsule；
（4）Packaging：By the soft capsule after dripping carry out sizing dry, wash capsule, the capsule that dries in the air, inspection capsule after product first use plastic-aluminum
Dress is wrapped inside in packing machine, then carries out outer packing with complex pocket and carton, and it is qualified to examine, storage.
Embodiment 4
A kind of preparation method of ginseng submicron powder soft capsule is as follows the step of this method：
（1）The selection of raw material, prepare：American Ginseng 50kg to be chosen, cleans, dehydrate, drying temperature is 55 DEG C, moisture≤
3.5%, ginseng is subjected to coarse crushing into big 3 ~ 5mm bulky grain；
（2）It is prepared by Ultramicro-powder：Electron beam radiation disinfection is used to the ginseng after coarse crushing, sterilizing beam energy is 3.5MeV, is gone out
The bacterium time is 3h, and the ginseng after sterilizing is crushed using micronizer, crushed using micronizer, is opened during crushing
Open circulation refrigeration equipment and ensure crushing process in -5 ~ 0 DEG C of low-temperature grinding, the particle diameter being ground into is 5 ~ 15u m micro mist, is made
Ginseng submicron powder；
（3）Prepare soft capsule：Take American Ginseng Ultramicro-powder to be added in olive oil 100kg, while add 0.4% food pharmaceutical grade and help
Suspension aluminum monostearate, it is sufficiently mixed uniformly using colloid mill, obtains cyst fluid, it is standby；Gelatin, glycerine, water are pressed 1：0.5：1.2 than
Example is dissolved, filtered, prepare glue, obtains gelatine size, insulation is standby, using all automatic Drop pill machine dripping soft capsule；
（4）Packaging：By the soft capsule after dripping carry out sizing dry, wash capsule, the capsule that dries in the air, inspection capsule after product first use plastic-aluminum
Dress is wrapped inside in packing machine, then carries out outer packing with complex pocket and carton, and it is qualified to examine, storage.
Embodiment 5
A kind of preparation method of ginseng submicron powder soft capsule is as follows the step of this method：
（1）The selection of raw material, prepare：Red ginseng 50kg to be chosen, cleans, dehydrate, drying temperature is 55 DEG C, moisture≤
3.5%, ginseng is subjected to coarse crushing into big 3 ~ 5mm bulky grain；
（2）It is prepared by Ultramicro-powder：Electron beam radiation disinfection is used to the ginseng after coarse crushing, sterilizing beam energy is 3.5MeV, is gone out
The bacterium time is 3h, and the ginseng after sterilizing is crushed using micronizer, crushed using micronizer, is opened during crushing
Open circulation refrigeration equipment and ensure crushing process in -5 ~ 0 DEG C of low-temperature grinding, the particle diameter being ground into is 1 ~ 10u m micro mist, is made
Ginseng submicron powder；
（3）Prepare soft capsule：Take ginseng submicron powder to be added in tea oil 100kg, while add 0.2% food pharmaceutical grade suspending
Agent ethyl cellulose, it is sufficiently mixed uniformly using colloid mill, obtains cyst fluid, it is standby；Gelatin, glycerine, water are pressed 1：0.52：1.2 than
Example is dissolved, filtered, prepare glue, obtains gelatine size, insulation is standby, using all automatic Drop pill machine dripping soft capsule；
（4）Packaging：By the soft capsule after dripping carry out sizing dry, wash capsule, the capsule that dries in the air, inspection capsule after product first use plastic-aluminum
Dress is wrapped inside in packing machine, then carries out outer packing with complex pocket and carton, and it is qualified to examine, storage.
Embodiment 6
A kind of preparation method of ginseng submicron powder soft capsule is as follows the step of this method：
（1）The selection of raw material, prepare：Sun-dried ginseng 25kg and American Ginseng 25kg is chosen, cleans, dehydrate, drying temperature 55
DEG C, moisture≤3.5%, ginseng is subjected to coarse crushing into big 3 ~ 5mm bulky grain；
（2）It is prepared by Ultramicro-powder：Electron beam radiation disinfection is used to the ginseng after coarse crushing, sterilizing beam energy is 3.5MeV, is gone out
The bacterium time is 3h, and the ginseng after sterilizing is crushed using micronizer, crushed using micronizer, is opened during crushing
Open circulation refrigeration equipment and ensure crushing process in -5 ~ 0 DEG C of low-temperature grinding, the particle diameter being ground into is 1 ~ 10u m micro mist, is made
Ginseng submicron powder；
（3）Prepare soft capsule：Take sun-dried ginseng, American Ginseng ginseng submicron powder to be added in olive oil 100kg, while add 0.5% food
Product pharmaceutical grade suspending agent beeswax, is sufficiently mixed uniformly using colloid mill, obtains cyst fluid, standby；Gelatin, glycerine, water are pressed 1：0.6：1
Ratio is dissolved, filtered, prepare glue, obtains gelatine size, insulation is standby, using all automatic Drop pill machine dripping soft capsule；
（4）Packaging：By the soft capsule after dripping carry out sizing dry, wash capsule, the capsule that dries in the air, inspection capsule after product first use plastic-aluminum
Dress is wrapped inside in packing machine, then carries out outer packing with complex pocket and carton, and it is qualified to examine, storage.
Embodiment 7
A kind of preparation method of ginseng submicron powder soft capsule is as follows the step of this method：
（1）The selection of raw material, prepare：Korean ginseng 25kg and American Ginseng 25kg is chosen, cleans, dehydrate, drying temperature 55
DEG C, moisture≤3.5%, ginseng is subjected to coarse crushing into big 3 ~ 5mm bulky grain；
（2）It is prepared by Ultramicro-powder：Electron beam radiation disinfection is used to the ginseng after coarse crushing, sterilizing beam energy is 3.5MeV, is gone out
The bacterium time is 3h, and the ginseng after sterilizing is crushed using micronizer, crushed using micronizer, is opened during crushing
Open circulation refrigeration equipment and ensure crushing process in -5 ~ 0 DEG C of low-temperature grinding, the particle diameter being ground into is 1 ~ 10u m micro mist, is made
Ginseng submicron powder；
（3）Prepare soft capsule：Take Korean ginseng, American Ginseng Ultramicro-powder to be added in olive oil 100kg, while add 0.3% food doctor
Medicine level suspending agent aluminum monostearate, is sufficiently mixed uniformly using colloid mill, obtains cyst fluid, standby；Gelatin, glycerine, water are pressed 1：
0.48：1.1 ratios are dissolved, filtered, prepare glue, obtain gelatine size, insulation is standby, using all automatic Drop pill machine dripping soft capsule；
（4）Packaging：By the soft capsule after dripping carry out sizing dry, wash capsule, the capsule that dries in the air, inspection capsule after product first use plastic-aluminum
Dress is wrapped inside in packing machine, then carries out outer packing with complex pocket and carton, and it is qualified to examine, storage.
Embodiment 8
A kind of preparation method of ginseng submicron powder soft capsule is as follows the step of this method：
（1）The selection of raw material, prepare：Red ginseng 25kg and American Ginseng 25kg to be chosen, cleans, dehydrate, drying temperature is 55 DEG C,
Moisture≤3.5%, ginseng is subjected to coarse crushing into big 3 ~ 5mm bulky grain；
（2）It is prepared by Ultramicro-powder：Electron beam radiation disinfection is used to the ginseng after coarse crushing, sterilizing beam energy is 3.5MeV, is gone out
The bacterium time is 3h, and the ginseng after sterilizing is crushed using micronizer, crushed using micronizer, is opened during crushing
Open circulation refrigeration equipment and ensure crushing process in -5 ~ 0 DEG C of low-temperature grinding, the particle diameter being ground into is 1 ~ 10u m micro mist, is made
Ginseng submicron powder；
（3）Prepare soft capsule：Take red ginseng, American Ginseng Ultramicro-powder to be added in olive oil 100kg, while add 0.1% food medicine
Level suspending agent aluminum monostearate, is sufficiently mixed uniformly using colloid mill, obtains cyst fluid, standby；Gelatin, glycerine, water are pressed 1：0.45：
0.9 ratio is dissolved, filtered, prepare glue, obtains gelatine size, insulation is standby, using all automatic Drop pill machine dripping soft capsule；
（4）Packaging：By the soft capsule after dripping carry out sizing dry, wash capsule, the capsule that dries in the air, inspection capsule after product first use plastic-aluminum
Dress is wrapped inside in packing machine, then carries out outer packing with complex pocket and carton, and it is qualified to examine, storage.
Embodiment 9
A kind of preparation method of ginseng submicron powder soft capsule is as follows the step of this method：
（1）The selection of raw material, prepare：Sun-dried ginseng 25kg and red ginseng 25kg to be chosen, cleans, dehydrate, drying temperature is 55 DEG C,
Moisture≤3.5%, ginseng is subjected to coarse crushing into big 3 ~ 5mm bulky grain；
（2）It is prepared by Ultramicro-powder：Electron beam radiation disinfection is used to the ginseng after coarse crushing, sterilizing beam energy is 3.5MeV, is gone out
The bacterium time is 3h, and the ginseng after sterilizing is crushed using micronizer, crushed using micronizer, is opened during crushing
Open circulation refrigeration equipment and ensure crushing process in -5 ~ 0 DEG C of low-temperature grinding, the particle diameter being ground into is 1 ~ 10u m micro mist, is made
Ginseng submicron powder；
（3）Prepare soft capsule：Take sun-dried ginseng, red ginseng submicron powder to be added in rose oil 100kg, while add 0.4% food doctor
Medicine level suspending agent ethyl cellulose, is sufficiently mixed uniformly using colloid mill, obtains cyst fluid, standby；Gelatin, glycerine, water are pressed 1：
0.46：1.2 ratios are dissolved, filtered, prepare glue, obtain gelatine size, insulation is standby, using all automatic Drop pill machine dripping soft capsule；
（4）Packaging：By the soft capsule after dripping carry out sizing dry, wash capsule, the capsule that dries in the air, inspection capsule after product first use plastic-aluminum
Dress is wrapped inside in packing machine, then carries out outer packing with complex pocket and carton, and it is qualified to examine, storage.
Embodiment 10
A kind of preparation method of ginseng submicron powder soft capsule is as follows the step of this method：
（1）The selection of raw material, prepare：Korean ginseng 25kg and red ginseng 25kg to be chosen, cleans, dehydrate, drying temperature is 55 DEG C,
Moisture≤3.5%, ginseng is subjected to coarse crushing into big 3 ~ 5mm bulky grain；
（2）It is prepared by Ultramicro-powder：Electron beam radiation disinfection is used to the ginseng after coarse crushing, sterilizing beam energy is 3.5MeV, is gone out
The bacterium time is 3h, and the ginseng after sterilizing is crushed using micronizer, crushed using micronizer, is opened during crushing
Open circulation refrigeration equipment and ensure crushing process in -5 ~ 0 DEG C of low-temperature grinding, the particle diameter being ground into is 1 ~ 10u m micro mist, is made
Ginseng submicron powder；
（3）Prepare soft capsule：Take Korean ginseng, red ginseng submicron powder to be added in tea oil 100kg, while add 0.2% food medicine
Level suspending agent aluminum monostearate, is sufficiently mixed uniformly using colloid mill, obtains cyst fluid, standby；Gelatin, glycerine, water are pressed 1：0.57：
1.35 ratios are dissolved, filtered, prepare glue, obtain gelatine size, insulation is standby, using all automatic Drop pill machine dripping soft capsule；
（4）Packaging：By the soft capsule after dripping carry out sizing dry, wash capsule, the capsule that dries in the air, inspection capsule after product first use plastic-aluminum
Dress is wrapped inside in packing machine, then carries out outer packing with complex pocket and carton, and it is qualified to examine, storage.
Capsule made from embodiment 1~10, is tested and analyzed, situation is as follows in the inventive method：
Assay method：
According to high performance liquid chromatography（One annex VI D of Chinese Pharmacopoeia version in 2015）Measure.
Standard requirement：
Every containing ginseng with ginsenoside Rg l（C42H72O14）And ginsenoside Re（C48H82O18）Total amount meter, must not be less than
0.40mg；With ginsenoside Rb1（C54H92O23）Meter, must not be less than 0.30mg.
Measurement result
The testing result of embodiment 1：
Every contains Rgl（C42H72O14）And Re（C48H82O18）：0.43mg, containing Rb1（C54H92O23）：0.32mg.
The testing result of embodiment 2：
Every contains Rgl（C42H72O14）And Re（C48H82O18）：0.44mg, containing Rb1（C54H92O23）：0.31mg.
The testing result of embodiment 3：
Every contains Rgl（C42H72O14）And Re（C48H82O18）：0.41mg, containing Rb1（C54H92O23）：0.35mg.
The testing result of embodiment 4：
Every contains Rgl（C42H72O14）And Re（C48H82O18）：0.42mg, containing Rb1（C54H92O23）：0.31mg.
The testing result of embodiment 5：
Every contains Rgl（C42H72O14）And Re（C48H82O18）：0.43mg, containing Rb1（C54H92O23）：0.33mg.
The testing result of embodiment 6：
Every contains Rgl（C42H72O14）And Re（C48H82O18）：0.41mg, containing Rb1（C54H92O23）：0.34mg.
The testing result of embodiment 7：
Every contains Rgl（C42H72O14）And Re（C48H82O18）：0.43mg, containing Rb1（C54H92O23）：0.31mg.
The testing result of embodiment 8：
Every contains Rgl（C42H72O14）And Re（C48H82O18）：0.45mg, containing Rb1（C54H92O23）：0.31mg.
The testing result of embodiment 9：
Every contains Rgl（C42H72O14）And Re（C48H82O18）：0.42mg, containing Rb1（C54H92O23）：0.32mg.
The testing result of embodiment 10：
Every contains Rgl（C42H72O14）And Re（C48H82O18）：0.41mg, containing Rb1（C54H92O23）：0.33mg.
The embodiment of the present invention is the foregoing is only, is not intended to limit the invention, for this area
For technical staff, the present invention can have various modifications and variations.That is made within the spirit and principles of the invention is any
Modification, equivalent substitution, improvement etc., should be included in the scope of the protection.
Claims (10)
1. a kind of preparation method of ginseng submicron powder soft capsule, it is characterised in that as follows the step of this method：
（1）The selection of raw material, prepare：Ginseng is chosen, cleans, dehydrate, ginseng is subjected to coarse crushing into bulky grain；
（2）It is prepared by Ultramicro-powder：Electron beam radiation disinfection is used to the ginseng after coarse crushing, by the ginseng after sterilizing, utilizes Ultramicro-powder
Broken machine carries out ultramicro grinding, and ginseng submicron powder is made；
（3）Prepare soft capsule：Take ginseng submicron powder to be added in vegetable oil dispersion, while add 0.1%~0.5% food doctor
Medicine level suspending agent, is sufficiently mixed uniformly using colloid mill, obtains cyst fluid, standby；Gelatin, glycerine, water are dissolved in proportion, filtered,
Gelatine size is obtained, insulation is standby, using all automatic Drop pill machine dripping soft capsule；
（4）Packaging：By the soft capsule after dripping carry out sizing dry, wash capsule, the capsule that dries in the air, inspection capsule after product first use plastic-aluminum
Dress is wrapped inside in packing machine, then carries out outer packing with complex pocket and carton, and it is qualified to examine, storage.
2. the preparation method of a kind of ginseng submicron powder soft capsule according to claim 1, it is characterised in that the low temperature is true
Empty drying temperature is 45 ~ 55 DEG C, moisture≤3.5%, and ginseng is carried out into coarse crushing into 3 ~ 5mm bulky grain.
A kind of 3. preparation method of ginseng submicron powder soft capsule according to claim 1, it is characterised in that the sterilizing electricity
Beamlet energy is 3 ~ 4MeV, and sterilization time is 2 ~ 4h.
4. the preparation method of a kind of ginseng submicron powder soft capsule according to claim 1, it is characterised in that the ginseng is
Sun-dried ginseng, Korean ginseng, American Ginseng, red ginseng.
A kind of 5. preparation method of ginseng submicron powder soft capsule according to claim 1, it is characterised in that the Ultramicro-powder
Add dry ice when broken to crush in lower temperature to ensure to crush, the particle diameter being ground into is 1 ~ 15 u m micro mist；Crush temperature
- 5 ~ 0 DEG C of degree.
6. the preparation method of a kind of ginseng submicron powder soft capsule according to claim 1, it is characterised in that the ginseng surpasses
Grain size of micropowder is 1 ~ 10u m.
7. the preparation method of a kind of ginseng submicron powder soft capsule according to claim 1, it is characterised in that the ginseng surpasses
Crushing of Ultrafine, by the ginseng after sterilizing into micronizer, crushed using impacting type, ON cycle refrigeration plant ensures during crushing
For crushing process in low-temperature grinding, the particle diameter being ground into is 5 ~ 15u m micro mist, and it is -5 ~ 0 DEG C to crush temperature.
A kind of 8. preparation method of ginseng submicron powder soft capsule according to claim 1, it is characterised in that the vegetable oil
Dispersant is tea oil, rose oil, olive oil, unsaturated fatty acid content >=90% of the vegetable oil.
A kind of 9. preparation method of ginseng submicron powder soft capsule according to claim 1, it is characterised in that the food doctor
Medicine level suspending agent is beeswax, aluminum monostearate, ethyl cellulose.
A kind of 10. preparation method of ginseng submicron powder soft capsule according to claim 1, it is characterised in that the gelatin,
Glycerine, water are 1 in proportion：0.35~0.6：0.9~1.35.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010619A (en) * | 2018-09-26 | 2018-12-18 | 杭州方回春堂集团有限公司 | Ginseng donkey-hide gelatin paste and preparation method thereof and method of quality control |
| CN114190555A (en) * | 2021-12-18 | 2022-03-18 | 江苏艾兰得营养品有限公司 | Drop pills with antioxidation efficacy and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN86104238A (en) * | 1986-06-24 | 1988-01-06 | 北京师范大学 | The new technology and the equipment of electron beam irradiation sterilization Chinese crude drug |
| CN1840079A (en) * | 2005-03-30 | 2006-10-04 | 海口绿科南药研究开发有限公司 | Soft capsule preparation with ultramicro powder and preparation method thereof |
| CN101703562A (en) * | 2009-10-13 | 2010-05-12 | 肖军平 | Eucommia bark ultra-micro powder with activity of resisting osteoporosis and preparation method thereof |
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2017
- 2017-11-09 CN CN201711094314.2A patent/CN107752017A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN86104238A (en) * | 1986-06-24 | 1988-01-06 | 北京师范大学 | The new technology and the equipment of electron beam irradiation sterilization Chinese crude drug |
| CN1840079A (en) * | 2005-03-30 | 2006-10-04 | 海口绿科南药研究开发有限公司 | Soft capsule preparation with ultramicro powder and preparation method thereof |
| CN101703562A (en) * | 2009-10-13 | 2010-05-12 | 肖军平 | Eucommia bark ultra-micro powder with activity of resisting osteoporosis and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010619A (en) * | 2018-09-26 | 2018-12-18 | 杭州方回春堂集团有限公司 | Ginseng donkey-hide gelatin paste and preparation method thereof and method of quality control |
| CN114190555A (en) * | 2021-12-18 | 2022-03-18 | 江苏艾兰得营养品有限公司 | Drop pills with antioxidation efficacy and preparation method thereof |
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