CN86104238A - The new technology and the equipment of electron beam irradiation sterilization Chinese crude drug - Google Patents
The new technology and the equipment of electron beam irradiation sterilization Chinese crude drug Download PDFInfo
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- CN86104238A CN86104238A CN86104238.7A CN86104238A CN86104238A CN 86104238 A CN86104238 A CN 86104238A CN 86104238 A CN86104238 A CN 86104238A CN 86104238 A CN86104238 A CN 86104238A
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Abstract
A kind of technology of electron beam irradiation sterilization Chinese crude drug adopts the electron beam irradiation sterilization behind pharmacy mixed dust formulation production link.Finishing the equipment of this technology is made up of accelerator, irradiation capsule, spiral propeller, powder blender, vibrating adjustable inlet device, charging and discharging level-sensing device and pipeline.The titanium window is housed on the front and back walls of irradiation capsule.Vibrating adjustable inlet device is made up of fixed fence, movable fence, drive rod and driving wheel.Pipeline in irradiation capsule is vertical, in the pipeline employing labyrinth type of charging aperture, discharging opening.This improvement is compared with prior art, not only makes the hygienic quality of medicine reach the sanitary standard that country issues, and economical and practical.
Description
Technical field is under of the present invention: electron beam is to the irradiation sterilization technology and the equipment of Chinese crude drug.
As prior art: honeyed pill is the conventional dosage forms of Chinese medicine preparation, and its technology schematic flow diagram of traditional handicraft that most pharmaceutical factories of traditional Chinese medicine produce honeyed pill as shown in Figure 2.The subject matter of traditional handicraft is that germ contamination is serious, and assorted bacterium adds up to hundreds of thousands～millions of/gram.Ministry of Public Health, the Ministry of Chemical Industry, the Ministry of Commerce in 1978 unite and have formulated " medicine sanitary standard ", have wherein stipulated the limit (assorted bacterium＜10000/gram) of assorted bacterium sum in the different medicines (comprising honeyed pill), and pathogenic bacterium, the demodicid mite that lives can not detect.According to the regulation of above-mentioned " medicine sanitary standard ", honeyed pill is tested, find that most of product does not reach the requirement of sanitary standard, total number of bacteria far goes beyond the limit.In order to ensure drug quality, can not adopt the characteristics of heat sterilization at honeyed pill, the finished product of indivedual pharmaceutical factories of traditional Chinese medicine after to packing adopts the sterilization of irradiation sterilization method.Use 60C
o 
Its technology schematic flow diagram of common process of ray, electron beam irradiation sterilization honeyed pill as shown in Figure 3, Figure 4.But, adopt 60C
o 
The common process of x ray irradiation x pill (Fig. 3), because (1) environment and operator's requirement of shelter height, so capital expenditure cost height; (2), therefore need often to increase the investment in cobalt source because the influence of half-life will decay 50% in 5 years; (3) in case have an accident in the running (for example out of control, outage etc.), the cobalt source falls less than the down-hole, personal safety can not guarantee; (4) Ministry of Public Security's regulation, the big cobalt source of sterilizing used can not be contained in urban district and suburb nearby, therefore can not form streamline in factory.(" pharmacy circular " rolled up the 12nd page of the 9th phase in 1981 the 16th and adopt the common process (Fig. 4) of electron beam irradiation pill, the phase number of the edition is 2～232) because the radiation penetration power of electron beam is lower, the thick sample of radiation treatment has certain difficulty, therefore efficient is low, and sterilizing rate is low during same dosage.In addition, the water content height of patent medicine, the poor stability of chemical analysis behind the irradiation.
The objective of the invention is: the reform of making essence from the old pharmaceutical technology of pharmaceutical factory and equipment, introduce radiotechnology, design and both meet practical requirement, can reduce the irradiation absorbed dose again and improve sterilizing rate, energy savings and improve irradiation efficiency, reduce the water content of sample, the influence of irradiation reaction is reached MIN new technology and realizes the equipment of new technology, the hygienic quality of control medicine reaches the sanitary standard of country's promulgation.
Content of the present invention is: because primary pollution source on crude drug [1], experiment showed, germ contamination and not serious in making the process of finished product, can control fully by carrying out production strictly in line with rules and regulations.Therefore, the present invention adopts electron beam irradiation sterilization [6] in pharmacy mixed dust formulation production link [4] back, and its technology schematic flow diagram as shown in Figure 1.Realize that the equipment of this technology is made up of accelerator [12], irradiation capsule [19], spiral propeller [17], powder agitator [24], vibrating adjustable inlet device [Fig. 8], charging and discharging level-sensing device [16] and pipeline.The electron beam that irradiation bomb uses the BF-5 type accelerator of Beijing Radiation Center to produce.Because the atomic structure density of titanium is rare, ray and titanium collision effect probability are low, so ray energy loss little (titanium electron energy 5～10MeV that 0.1mm is thick only loses tens KeV), scattering effect is low, thereby irradiation uniformity is good.Antetheca titanium window [21] and rear wall titanium window [22] therefore are housed on the front and back walls of irradiation capsule [19].Spiral propeller [17] is to utilize silicon controlled angle of flow control rotating speed, thereby dose is advanced in control.Powder blender [24] evenly discharges powder by the stirring to powder.Vibrating adjustable inlet device [Fig. 8] is made up of fixed fence [23], movable fence [25], drive rod [26] and driving wheel [27].Movable fence of original state [25] and fixed fence [23] dislocation.Drive rod [26] and driving wheel [27] are controlled the stroke in movable fence [25] unit interval.Regulate the radius of driving wheel " 27 " and can control interior stroke of movable fence " 25 " unit interval.Two level-sensing devices " 16 " are observed charging, discharging situation, the observation situation is fed back to accelerator " 12 ", charging, drawing mechanism adjust accordingly.Pipeline in irradiation capsule " 19 " is vertical, and the pipeline of charging aperture, discharging opening adopts labyrinth type, prevents the ray contamination environment.
The new technology of electron beam irradiation powder and 60C
o 
The leading indicator of the common process of x ray irradiation x pill is listed in table 1, table 2.
Table 1:
Sterilizing rate accumulated dose energy line
（KGy） （MeV） （μA）
Electron beam irradiation powder 90% 1.93 * 105 5 10
60C
o90% 2.81×105 1.25
The x ray irradiation x pill
Table 2:
Sterilizing rate accumulated dose energy line
（KGy） （MeV） （μA）
Electron beam irradiation powder 93% 2 * 10
55 10
60C
o64% 2×10
51.25
Can learn that by table 1 if reach identical sterilizing rate, the used accumulated dose of electron beam irradiation powder is than 60C
o 
The used accumulated dose of x ray irradiation x pill is low, and the treating capacity that has therefore improved irradiation efficiency is about 1.46 times.
Can learn that by table 2 if select identical accumulated dose for use, sterilizing rate is just different.The electron beam irradiation powder compares 60C
o 
The x ray irradiation x pill has improved sterilizing rate and has been about 1.45 times.
The leading indicator of the common process of the new technology of electron beam irradiation powder and electron beam irradiation pill is listed in table 3, table 4, table 5.
Table 3
Sterilizing rate accumulated dose time energy line
(KGy) (second) (MeV) (μ A)
Electron beam irradiation powder 90% 2.6 80 5 10
Electron beam irradiation pill 90% 4 125 5 10
Table 4
Sterilizing rate accumulated dose time energy line
(KGy) (second) (MeV) (μ A)
Electron beam irradiation powder 99.28% 3.4 105 5 10
Electron beam irradiation pill 70.45% 3.4 105 5 10
Table 5
Sterilizing rate accumulated dose time energy line
(KGy) (second) (MeV) (μ A)
Electron beam irradiation powder 90% 2.6 125 5 6.3
Electron beam irradiation pill 90% 4 125 5 10
Can learn by table 3, if reach identical sterilizing rate, the used accumulated dose accumulated dose more used than electron beam irradiation pill of electron beam irradiation powder reduced 1.4KGy, few 45 seconds used of the time of time ratio electron beam irradiation pill that the electron beam irradiation powder is used, therefore new technology is compared with common process and has been saved the energy, has improved efficient.
Can learn that by table 4 if select identical irradiation dose for use, the sterilizing rate of electron beam irradiation powder has improved 28.83% than the sterilizing rate of electron beam irradiation pill.
As shown in Table 5, if reach identical sterilizing rate, when selecting the identical time for use, the electron beam irradiation powder has reduced by 3.7 μ A than its line of electron beam irradiation pill, and the output of accelerator has been reduced.
The invention has the advantages that: adopt the new technology of irradiation powder can reduce the irradiation absorbed dose and improve sterilizing rate; Can energy savings and improve irradiation efficiency; Can reduce the water content of sample, the influence of irradiation reaction is reached bottom line, make the hygienic quality of medicine reach the sanitary standard of country's promulgation.The device structure of realizing this technology is reasonable, and is easy and simple to handle, handles rapidly, economical and practical.
Accompanying drawing 2 is traditional handicraft schematic flow diagrams.
Accompanying drawing 5 is overall construction drawings of finishing the equipment of new technology.[10] accelerator control room among the figure, [11] accelerator machine room, [12] accelerator, [13] electron gun.[14] magnetron, [15] discharge chamber, [16] level-sensing device, [17] spiral propeller, [18] radiation chamber, [19] irradiation capsule, [20] scan box.
Accompanying drawing 6 is spiral propellers.
Accompanying drawing 7 is irradiation capsule structure charts.[21] antetheca titanium window among the figure, [22] rear wall titanium window, [23] fixed fence, [24] powder blender.
Accompanying drawing 8 is vibrating adjustable inlet device structure charts.[23] fixed fence among the figure, [24] powder blender, [25] movable fence, [26] drive rod, [27] driving wheel.
Claims (4)
1, a kind of technology of electron beam irradiation sterilization Chinese crude drug is characterized in that adopting electron beam irradiation sterilization [6] in pharmacy mixed dust formulation production link [4] back.
2, a kind of equipment of finishing electron beam irradiation sterilization Chinese crude drug technology is characterized in that it is made up of accelerator [12], irradiation capsule [19], spiral propeller [17], powder blender [24], vibrating adjustable inlet device (Fig. 8), charging and discharging level-sensing device [16] and pipeline.
3, a kind of according to the said equipment of claim 2, it is characterized in that on the front and back walls of irradiation capsule [19] antetheca titanium window [21] and rear wall titanium window [22] being housed.
4, a kind of according to the said equipment of claim 2 to 3, it is characterized in that vibrating adjustable inlet device [Fig. 8] is made up of fixed fence [23], movable fence [25], drive rod [26] and driving wheel [27].
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 86104238 CN1012319B (en) | 1986-06-24 | 1986-06-24 | Method and apparatus for sterilizing traditional chinese medince by electronic beam radiation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 86104238 CN1012319B (en) | 1986-06-24 | 1986-06-24 | Method and apparatus for sterilizing traditional chinese medince by electronic beam radiation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN86104238A true CN86104238A (en) | 1988-01-06 |
| CN1012319B CN1012319B (en) | 1991-04-10 |
Family
ID=4802400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 86104238 Expired CN1012319B (en) | 1986-06-24 | 1986-06-24 | Method and apparatus for sterilizing traditional chinese medince by electronic beam radiation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1012319B (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103372223A (en) * | 2012-04-11 | 2013-10-30 | 克朗斯股份公司 | Method and device for radiation-based sterilisation of container closure |
| CN103889463A (en) * | 2011-10-17 | 2014-06-25 | 日立造船株式会社 | Shield structure for electron beam sterilization equipment |
| CN104010666A (en) * | 2011-11-10 | 2014-08-27 | 西拉克集团公司 | Article treatment plant using electronic bombardment |
| CN105311652A (en) * | 2014-07-31 | 2016-02-10 | 上海敏杰制药机械有限公司 | Constant powder particle sterilizing machine |
| CN105923213A (en) * | 2016-05-03 | 2016-09-07 | 重庆多普泰制药股份有限公司 | Electron irradiation sterilization device and sterilization method for medical hirudo |
| CN107375965A (en) * | 2017-07-18 | 2017-11-24 | 江门华大生物科技有限公司 | The prepared slices of Chinese crude drugs are without sulphur desinsection method for preserving |
| CN107752017A (en) * | 2017-11-09 | 2018-03-06 | 王慧 | A kind of preparation method of ginseng submicron powder soft capsule |
-
1986
- 1986-06-24 CN CN 86104238 patent/CN1012319B/en not_active Expired
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103889463A (en) * | 2011-10-17 | 2014-06-25 | 日立造船株式会社 | Shield structure for electron beam sterilization equipment |
| CN103889463B (en) * | 2011-10-17 | 2016-01-27 | 日立造船株式会社 | The shielding construction of electron ray disinfection equipment |
| CN104010666A (en) * | 2011-11-10 | 2014-08-27 | 西拉克集团公司 | Article treatment plant using electronic bombardment |
| CN104010666B (en) * | 2011-11-10 | 2017-05-03 | 西拉克集团公司 | Article treatment plant using electronic bombardment |
| CN103372223A (en) * | 2012-04-11 | 2013-10-30 | 克朗斯股份公司 | Method and device for radiation-based sterilisation of container closure |
| CN103372223B (en) * | 2012-04-11 | 2016-08-24 | 克朗斯股份公司 | Based on radiation, container-closure is carried out equipment and the method for sterilizing |
| CN105311652A (en) * | 2014-07-31 | 2016-02-10 | 上海敏杰制药机械有限公司 | Constant powder particle sterilizing machine |
| CN105311652B (en) * | 2014-07-31 | 2018-04-03 | 上海敏杰制药机械有限公司 | Normal temperature powder particle sterilizer |
| CN105923213A (en) * | 2016-05-03 | 2016-09-07 | 重庆多普泰制药股份有限公司 | Electron irradiation sterilization device and sterilization method for medical hirudo |
| CN107375965A (en) * | 2017-07-18 | 2017-11-24 | 江门华大生物科技有限公司 | The prepared slices of Chinese crude drugs are without sulphur desinsection method for preserving |
| CN107375965B (en) * | 2017-07-18 | 2019-02-15 | 江门华大生物科技有限公司 | The prepared slices of Chinese crude drugs are without sulphur desinsection method for preserving |
| CN107752017A (en) * | 2017-11-09 | 2018-03-06 | 王慧 | A kind of preparation method of ginseng submicron powder soft capsule |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1012319B (en) | 1991-04-10 |
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